ES2181478T3 - Construcciones quimicas y sus usos. - Google Patents
Construcciones quimicas y sus usos.Info
- Publication number
- ES2181478T3 ES2181478T3 ES99947748T ES99947748T ES2181478T3 ES 2181478 T3 ES2181478 T3 ES 2181478T3 ES 99947748 T ES99947748 T ES 99947748T ES 99947748 T ES99947748 T ES 99947748T ES 2181478 T3 ES2181478 T3 ES 2181478T3
- Authority
- ES
- Spain
- Prior art keywords
- cleavage site
- fragment
- groups
- cleavable
- chemical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00572—Chemical means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Una construcción química para ser usada en síntesis en fase sólida, que comprende un soporte sólido Q al que están enlazados grupos Y1R e Y2R; en los que R es un sustrato o una marca de codificación y los grupos Y1 e Y2 son grupos de conexión cada uno de los cuales tiene un primer sitio de escisión, teniendo al menos uno de los grupos Y1 e Y2 un segundo sitio de escisión situado entre el primer sitio de escisión y el grupo R, siendo el primer sitio de escisión ortogonalmente y selectivamente escindible con respecto al segundo sitio de escisión, y siendo el segundo sitio de escisión en Y1, cuando ambos grupos Y1 e Y2 contienen un segundo sitio de escisión, selectivamente y ortogonalmente escindible con respecto al segundo sitio de escisión en Y2; siendo el segundo sitio de escisión escindible para liberar el sustrato; y siendo el primer sitio de escisión selectivamente escindible para liberar un fragmento Fr que comprende el sustrato R yal menos una parte del grupo de conexión Y; y en la que: (i) el fragmento químico Fr contiene un grupo de sensibilización G que sensibiliza al fragmento químico Fr para el análisis instrumental, por ejemplo espectroscópico de masas, y/o: (ii) el fragmento Fr contiene un medio para conferir una firma característica al espectro de masas del fragmento.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9821669.0A GB9821669D0 (en) | 1998-10-05 | 1998-10-05 | Chemical constructs and their uses |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2181478T3 true ES2181478T3 (es) | 2003-02-16 |
Family
ID=10840013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99947748T Expired - Lifetime ES2181478T3 (es) | 1998-10-05 | 1999-10-05 | Construcciones quimicas y sus usos. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1119528B1 (es) |
JP (1) | JP2002526753A (es) |
AT (1) | ATE222884T1 (es) |
AU (1) | AU6112099A (es) |
DE (1) | DE69902678T2 (es) |
DK (1) | DK1119528T3 (es) |
ES (1) | ES2181478T3 (es) |
GB (1) | GB9821669D0 (es) |
PT (1) | PT1119528E (es) |
WO (1) | WO2000020112A2 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2363499C (en) | 1999-03-05 | 2010-06-01 | Massachusetts Institute Of Technology | Linkers for synthesis of oligosaccharides on solid supports |
ATE344456T1 (de) * | 2000-05-05 | 2006-11-15 | Purdue Research Foundation | Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen |
US6787635B2 (en) * | 2001-04-05 | 2004-09-07 | 3M Innovative Properties Company | Solid phase synthesis supports and methods |
DE10117274B4 (de) * | 2001-04-06 | 2005-03-03 | Hte Ag The High Throughput Experimentation Company | Verfahren zur Analyse und Archivierung von wenigstens einer Materialbibliothek |
CA2488584C (en) | 2003-01-30 | 2011-10-11 | Applera Corporation | Methods, mixtures, kits and compositions pertaining to analyte determination |
US20050148087A1 (en) | 2004-01-05 | 2005-07-07 | Applera Corporation | Isobarically labeled analytes and fragment ions derived therefrom |
US20070048752A1 (en) | 2004-07-12 | 2007-03-01 | Applera Corporation | Mass tags for quantitative analyses |
EP2575897A4 (en) * | 2010-06-01 | 2016-06-01 | Advanced Proteome Therapeutics Inc | CROSSLINKING OF PROTEINS AND OTHER ENTITIES THROUGH ALPHA-HALO-ACETOPHENONES CONJUGATES, BENZYL HALIDES, QUINONES |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5565324A (en) * | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
AU739256B2 (en) * | 1996-04-08 | 2001-10-04 | Glaxo Group Limited | Mass-based encoding and qualitative analysis of combinatorial libraries |
-
1998
- 1998-10-05 GB GBGB9821669.0A patent/GB9821669D0/en not_active Ceased
-
1999
- 1999-10-05 EP EP99947748A patent/EP1119528B1/en not_active Expired - Lifetime
- 1999-10-05 AT AT99947748T patent/ATE222884T1/de not_active IP Right Cessation
- 1999-10-05 DE DE69902678T patent/DE69902678T2/de not_active Expired - Fee Related
- 1999-10-05 ES ES99947748T patent/ES2181478T3/es not_active Expired - Lifetime
- 1999-10-05 WO PCT/GB1999/003284 patent/WO2000020112A2/en active IP Right Grant
- 1999-10-05 JP JP2000573466A patent/JP2002526753A/ja active Pending
- 1999-10-05 AU AU61120/99A patent/AU6112099A/en not_active Abandoned
- 1999-10-05 PT PT99947748T patent/PT1119528E/pt unknown
- 1999-10-05 DK DK99947748T patent/DK1119528T3/da active
Also Published As
Publication number | Publication date |
---|---|
DK1119528T3 (da) | 2002-12-30 |
JP2002526753A (ja) | 2002-08-20 |
ATE222884T1 (de) | 2002-09-15 |
AU6112099A (en) | 2000-04-26 |
GB9821669D0 (en) | 1998-12-02 |
DE69902678T2 (de) | 2003-04-24 |
WO2000020112A3 (en) | 2000-10-26 |
PT1119528E (pt) | 2002-12-31 |
DE69902678D1 (de) | 2002-10-02 |
WO2000020112A2 (en) | 2000-04-13 |
EP1119528B1 (en) | 2002-08-28 |
EP1119528A2 (en) | 2001-08-01 |
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