ES2180032T3 - Procedimiento para preparar un compuesto intermedio util en la sintesis de cisaprida. - Google Patents
Procedimiento para preparar un compuesto intermedio util en la sintesis de cisaprida.Info
- Publication number
- ES2180032T3 ES2180032T3 ES97913145T ES97913145T ES2180032T3 ES 2180032 T3 ES2180032 T3 ES 2180032T3 ES 97913145 T ES97913145 T ES 97913145T ES 97913145 T ES97913145 T ES 97913145T ES 2180032 T3 ES2180032 T3 ES 2180032T3
- Authority
- ES
- Spain
- Prior art keywords
- fluorophenoxy
- cis
- methoxy
- propyl
- cisaprida
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A UN NUEVO PROCEDIMIENTO DE PREPARACION DE CISAPRIDA, Y DE LAS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES DE LA MISMA, MEDIANTE UNA AMINACION REDUCTIVA DE 1 - [3 - (4 - FLUOROFENOXI) - PROPIL] - 3 - METOXI - 4 - PIPERIDINONA, EN PRESENCIA DE BENCILAMINA, CON HIDROGENO Y EN UN DISOLVENTE INERTE, PARA PRODUCIR 1 - [3 - (4 FLUOROFENOXI) - PROPIL] - 3 - METOXI - 4 - PIPERIDINAMINA, CON UNA RELACION CIS/TRANS DE APROX. 93/7. DICHA PIPERIDINAMINA SE ENRIQUECE EN CIS - ESTEREOISOMERO MEDIANTE CONVERSION EN SU SAL DE ADICION ACIDA, POR TRATAMIENTO CON UN ACIDO INORGANICO ADECUADO, EN UN DISOLVENTE APROPIADO; POSTERIOR CRISTALIZACION; Y CONVERSION EN SU FORMA DE BASE LIBRE POR TRATAMIENTO CON UNA BASE APROPIADA, PRODUCIENDO 1 - [3 - (4 - FLUOROFENOXI) PROPIL] - 3 - METOXI -4 - PIPERIDINAMINA, CON UNA RELACION CIS/TRANS IGUAL O SUPERIOR A 98/2. POSTERIORMENTE, DICHA PIPERAMIDINA SE HACE REACCIONAR CON EL ANHIDRIDO MIXTO FORMADO POR EL ACIDO 4 - AMINO - 5 - CLORO - 2 - METOXI BENZOICO Y POR CLOROFORMIATO DE ETILO, EN UN DISOLVENTE INERTE A LA REACCION, PRODUCIENDO CISAPRIDA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96202860 | 1996-10-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2180032T3 true ES2180032T3 (es) | 2003-02-01 |
Family
ID=8224493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97913145T Expired - Lifetime ES2180032T3 (es) | 1996-10-15 | 1997-10-09 | Procedimiento para preparar un compuesto intermedio util en la sintesis de cisaprida. |
Country Status (12)
Country | Link |
---|---|
US (1) | US6218542B1 (es) |
EP (1) | EP0934272B1 (es) |
JP (1) | JP2001501960A (es) |
KR (1) | KR100469030B1 (es) |
CN (1) | CN1135222C (es) |
AT (1) | ATE221049T1 (es) |
AU (1) | AU5050098A (es) |
CA (1) | CA2263692C (es) |
DE (1) | DE69714279T2 (es) |
ES (1) | ES2180032T3 (es) |
WO (1) | WO1998016511A1 (es) |
ZA (1) | ZA979194B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100336400B1 (ko) * | 2000-03-29 | 2002-05-13 | 김건복 | 시사프라이드의 제조 방법 |
KR20100026641A (ko) * | 2008-09-01 | 2010-03-10 | 동아제약주식회사 | 신규한 벤즈아미드 유도체 화합물 및 그의 제조방법 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH19942A (en) | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
CA1192218A (en) * | 1981-09-16 | 1985-08-20 | Zeneca Ag Products Inc. | Isomer enrichment process for cyclopropanecarboxylates |
CA1183847A (en) * | 1981-10-01 | 1985-03-12 | Georges Van Daele | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
US4962115A (en) * | 1981-10-01 | 1990-10-09 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
US5137896A (en) * | 1981-10-01 | 1992-08-11 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
US5057525A (en) * | 1981-10-01 | 1991-10-15 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl) benzamide derivatives |
ES2002640A6 (es) * | 1987-03-11 | 1988-09-01 | Alonga Lab | Procedimiento de obtencion de un derivado del acido-4-amino-5-cloro-2-metoxibenzoico |
US5047581A (en) * | 1989-08-25 | 1991-09-10 | Fmc Corporation | Isolation of cis-isomers from isomeric mixtures of cis/transcyclopropanecarboxylates |
AU4666393A (en) * | 1992-07-07 | 1994-01-31 | Sepracor, Inc. | Methods of using (-) cisapride for the treatment of gastro-esophageal reflux disease and other disorders |
EP1170010A3 (en) * | 1992-07-07 | 2004-05-19 | Sepracor Inc. | Method of using (+) cisapride for the treatment of gastro-esophageal reflux disease and other disorders |
US5712293A (en) * | 1995-06-07 | 1998-01-27 | Sepracor, Inc. | Methods for treating gastro-esophageal reflux disease and other disorders associated with the digestive tract using optically pure (-) norcisapride |
US5739151A (en) * | 1996-07-19 | 1998-04-14 | Sepracor Inc. | Method for treating emesis and central nervous system disorders using optically pure (+) norcisapride |
-
1997
- 1997-10-09 JP JP10518028A patent/JP2001501960A/ja active Pending
- 1997-10-09 EP EP97913145A patent/EP0934272B1/en not_active Expired - Lifetime
- 1997-10-09 WO PCT/EP1997/005692 patent/WO1998016511A1/en active IP Right Grant
- 1997-10-09 DE DE69714279T patent/DE69714279T2/de not_active Expired - Fee Related
- 1997-10-09 US US09/284,513 patent/US6218542B1/en not_active Expired - Fee Related
- 1997-10-09 CA CA002263692A patent/CA2263692C/en not_active Expired - Fee Related
- 1997-10-09 ES ES97913145T patent/ES2180032T3/es not_active Expired - Lifetime
- 1997-10-09 AU AU50500/98A patent/AU5050098A/en not_active Abandoned
- 1997-10-09 AT AT97913145T patent/ATE221049T1/de not_active IP Right Cessation
- 1997-10-09 CN CNB971987475A patent/CN1135222C/zh not_active Expired - Fee Related
- 1997-10-09 KR KR10-1999-7001350A patent/KR100469030B1/ko not_active IP Right Cessation
- 1997-10-14 ZA ZA979194A patent/ZA979194B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2263692A1 (en) | 1998-04-23 |
CA2263692C (en) | 2004-06-22 |
JP2001501960A (ja) | 2001-02-13 |
DE69714279T2 (de) | 2003-03-06 |
ZA979194B (en) | 1999-04-14 |
KR100469030B1 (ko) | 2005-01-31 |
CN1135222C (zh) | 2004-01-21 |
WO1998016511A1 (en) | 1998-04-23 |
KR20000035794A (ko) | 2000-06-26 |
ATE221049T1 (de) | 2002-08-15 |
US6218542B1 (en) | 2001-04-17 |
CN1233240A (zh) | 1999-10-27 |
EP0934272B1 (en) | 2002-07-24 |
DE69714279D1 (de) | 2002-08-29 |
EP0934272A1 (en) | 1999-08-11 |
AU5050098A (en) | 1998-05-11 |
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