ES2179839T3 - Macrocapsulas microporosas. - Google Patents

Macrocapsulas microporosas.

Info

Publication number
ES2179839T3
ES2179839T3 ES94902302T ES94902302T ES2179839T3 ES 2179839 T3 ES2179839 T3 ES 2179839T3 ES 94902302 T ES94902302 T ES 94902302T ES 94902302 T ES94902302 T ES 94902302T ES 2179839 T3 ES2179839 T3 ES 2179839T3
Authority
ES
Spain
Prior art keywords
macrocapsules
microporous
jacket
microporous macrocapsules
external jacket
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94902302T
Other languages
English (en)
Inventor
Frank T Gentile
Patrick A Tresco
Tyrone Hazlett
Thomas Flanagan
Edward J Doherty
David Rein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brown University Research Foundation Inc
Original Assignee
Brown University Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brown University Research Foundation Inc filed Critical Brown University Research Foundation Inc
Application granted granted Critical
Publication of ES2179839T3 publication Critical patent/ES2179839T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals

Abstract

LAS CAPSULAS MICROPOROSAS SE REVELAN COMO UTILES MECANISMOS DE IMPLANTACION EN LA TERAPIA CELULAR. LA MACROCAPSULA SE COMPONE DE CELULAS VIVAS QUE SECRETAN SUBSTANCIAS BIOLOGICAS CON VALOR TERAPEUTICO QUE SE LIBERAN DESDE LA MACROCAPSULA AL LUGAR DE IMPLANTACION. LAS CAPSULAS PUEDEN TENER UNAS CARACTERISTICAS DE PERMEABILIDAD SELECTIVAS DEPENDIENDO DE SU USO CONCRETO Y LAS CARACTERISTICAS DE COERCIVIDAD VIRICA DESEADAS.
ES94902302T 1992-11-16 1993-11-16 Macrocapsulas microporosas. Expired - Lifetime ES2179839T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97535492A 1992-11-16 1992-11-16

Publications (1)

Publication Number Publication Date
ES2179839T3 true ES2179839T3 (es) 2003-02-01

Family

ID=25522938

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94902302T Expired - Lifetime ES2179839T3 (es) 1992-11-16 1993-11-16 Macrocapsulas microporosas.

Country Status (20)

Country Link
US (1) US6337088B1 (es)
EP (1) EP0674497B1 (es)
JP (1) JPH08503472A (es)
KR (1) KR950703910A (es)
AT (1) ATE220883T1 (es)
AU (1) AU687371B2 (es)
BR (1) BR9307455A (es)
CA (1) CA2149420C (es)
CZ (1) CZ122795A3 (es)
DE (1) DE69332149T2 (es)
DK (1) DK0674497T3 (es)
ES (1) ES2179839T3 (es)
FI (1) FI952322A (es)
HU (1) HUT72986A (es)
LV (1) LV10906B (es)
NZ (1) NZ258720A (es)
PL (1) PL309012A1 (es)
PT (1) PT674497E (es)
SK (1) SK62495A3 (es)
WO (1) WO1994010950A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965125A (en) * 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
US6419920B1 (en) 1995-10-25 2002-07-16 Trans Karyotic Therapies, Inc. Hybrid matrix implants and explants
WO2007047420A2 (en) 2005-10-13 2007-04-26 Synthes (U.S.A.) Drug-impregnated encasement
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
TWI590843B (zh) 2011-12-28 2017-07-11 信迪思有限公司 膜及其製造方法
US20160144067A1 (en) 2013-06-21 2016-05-26 DePuy Synthes Products, Inc. Films and methods of manufacture
CN110709137A (zh) * 2017-04-06 2020-01-17 塞拉克西斯股份有限公司 大胶囊化的治疗性细胞及其使用方法
US11141508B2 (en) 2018-03-01 2021-10-12 Seraxis, Inc. Macro-encapsulated therapeutic cells, devices, and methods of using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4353888A (en) * 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
US4806355A (en) * 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4803168A (en) * 1983-09-01 1989-02-07 Damon Biotech, Inc. Microencapsulation with polymers
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5015476A (en) * 1989-08-11 1991-05-14 Paravax, Inc. Immunization implant and method
ATE156344T1 (de) * 1991-04-25 1997-08-15 Univ Brown Res Found Implantierbare, biokompatible immunisolator- trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte

Also Published As

Publication number Publication date
AU5671394A (en) 1994-06-08
LV10906B (en) 1996-06-20
AU687371B2 (en) 1998-02-26
PL309012A1 (en) 1995-09-18
US6337088B1 (en) 2002-01-08
NZ258720A (en) 1997-07-27
FI952322A (fi) 1995-07-11
CA2149420C (en) 2007-04-17
DK0674497T3 (da) 2002-11-18
BR9307455A (pt) 1999-06-01
EP0674497A1 (en) 1995-10-04
SK62495A3 (en) 1995-11-08
CZ122795A3 (en) 1996-02-14
EP0674497A4 (en) 1997-08-20
ATE220883T1 (de) 2002-08-15
DE69332149T2 (de) 2003-02-27
WO1994010950A1 (en) 1994-05-26
FI952322A0 (fi) 1995-05-12
DE69332149D1 (de) 2002-08-29
LV10906A (lv) 1995-12-20
PT674497E (pt) 2002-12-31
KR950703910A (ko) 1995-11-17
JPH08503472A (ja) 1996-04-16
CA2149420A1 (en) 1994-05-26
HU9501426D0 (en) 1995-06-28
EP0674497B1 (en) 2002-07-24
HUT72986A (en) 1996-06-28

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