ES2178672T3 - Anticuerpos monoclonales frente al vih-1 y vacunas hechas a partir de ellos. - Google Patents

Anticuerpos monoclonales frente al vih-1 y vacunas hechas a partir de ellos.

Info

Publication number
ES2178672T3
ES2178672T3 ES95916676T ES95916676T ES2178672T3 ES 2178672 T3 ES2178672 T3 ES 2178672T3 ES 95916676 T ES95916676 T ES 95916676T ES 95916676 T ES95916676 T ES 95916676T ES 2178672 T3 ES2178672 T3 ES 2178672T3
Authority
ES
Spain
Prior art keywords
antibodies
monoclonal antibodies
mixtures
antibodies against
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95916676T
Other languages
English (en)
Inventor
Hermann Katinger
Andrea Buchacher
Wolfgang Ernst
Claudia Ballaun
Martin Purtscher
Alexandra Trkola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polymun Scientific Immunbiologische Forschung GmbH
Original Assignee
Polymun Scientific Immunbiologische Forschung GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polymun Scientific Immunbiologische Forschung GmbH filed Critical Polymun Scientific Immunbiologische Forschung GmbH
Application granted granted Critical
Publication of ES2178672T3 publication Critical patent/ES2178672T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4216—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig
    • C07K16/4225—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig against anti-HIV Ig
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

LA PRESENTE INVENCION DESCUBRE ANTICUERPOS QUE PUEDEN SER UTILIZADOS PARA LA FABRICACION DE VACUNAS PARA LA INMUNIZACION ACTIVA Y/O PASIVA DE PERSONAS QUE NECESITEN DE DICHO TRATAMIENTO. LA INVENCION PROPORCIONA ASIMISMO ANTICUERPOS MONOCLONALES HUMANOS QUE SON FUNCIONALMENTE EQUIVALENTES A LOS ANTICUERPOS MENCIONADOS ANTERIORMENTE PRODUCIDOS POR CUALQUIERA DE LAS LINEAS CELULARES CL1 A CL6 (DEPOSITADAS EN LA COLECCION EUROPEA DE CULTIVOS CELULARES ANIMALES (ECACC) EN EL PHLS EN PORT DOWN, SALISBURY, GB). ES ASIMISMO UN OBJETIVO DE LA PRESENTE INVENCION EL PROPORCIONAR LINEAS CELULARES DE HIBRIDOMA Y/O CHO QUE PRODUZCAN CUALQUIERA DE LOS ANTICUERPOS DESCUBIERTOS Y REIVINDICADOS AQUI. LA INVENCION SE DIRIGE ADICIONALMENTE A MEZCLAS DE LOS ANTICUERPOS DE LA PRESENTE INVENCION, ASI COMO A METODOS PARA UTILIZAR ANTICUERPOS INDIVIDUALES O MEZCLAS DE LOS MISMOS PARA LA DETECCION, PREVENCION Y/O TRATAMIENTO TERAPEUTICO DE INFECCIONES POR HIV-1 IN VITRO E IN VIVO.
ES95916676T 1995-04-19 1995-04-19 Anticuerpos monoclonales frente al vih-1 y vacunas hechas a partir de ellos. Expired - Lifetime ES2178672T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP1995/001481 WO1996033219A1 (en) 1995-04-19 1995-04-19 Monoclonal antibodies against hiv-1 and vaccines made thereof
CA002218515A CA2218515C (en) 1995-04-19 1995-04-19 Monoclonal antibodies against hiv-1 and vaccines made thereof

Publications (1)

Publication Number Publication Date
ES2178672T3 true ES2178672T3 (es) 2003-01-01

Family

ID=25679733

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95916676T Expired - Lifetime ES2178672T3 (es) 1995-04-19 1995-04-19 Anticuerpos monoclonales frente al vih-1 y vacunas hechas a partir de ellos.

Country Status (11)

Country Link
US (1) US5911989A (es)
EP (1) EP0822941B1 (es)
AT (1) ATE219105T1 (es)
AU (1) AU2308595A (es)
BR (1) BR9510575A (es)
CA (1) CA2218515C (es)
DE (1) DE69527089T2 (es)
ES (1) ES2178672T3 (es)
MX (1) MX9708008A (es)
WO (1) WO1996033219A1 (es)
ZA (1) ZA962629B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2252210C2 (ru) * 1999-08-31 2005-05-20 Асахи Гласс Компани, Лимитед Способ получения vic-дихлорфторангидрида
US8623379B2 (en) 2000-03-02 2014-01-07 Emory University Compositions and methods for generating an immune response
US20040105871A1 (en) * 2000-03-02 2004-06-03 Robinson Harriet L. Compositions and methods for generating an immune response
US20020106798A1 (en) 2000-03-02 2002-08-08 Robinson Harriet L. DNA expression vectors and methods of use
CN1339319A (zh) * 2000-08-18 2002-03-13 清华大学 一种治疗艾滋病的药物及其制备方法
ES2334335T3 (es) * 2001-03-08 2010-03-09 The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Mva que expresa genes de envoltura, gag y pol de vih modificados.
US7591994B2 (en) 2002-12-13 2009-09-22 Immunomedics, Inc. Camptothecin-binding moiety conjugates
EP1572963A4 (en) * 2002-10-11 2007-08-22 Univ Maryland Biotech Inst SYNTHETIC VACCINES CARBOHYDRATE BASE AGAINST HIV
WO2004101738A2 (en) * 2003-05-06 2004-11-25 The Scripps Research Institute Domain-exchanged binding molecules, methods of use and methods of production
TW200726479A (en) 2005-04-12 2007-07-16 Univ Duke Method of inducing neutralizing antibodies to human immunodeficiency virus
KR20090040906A (ko) * 2006-08-02 2009-04-27 유나이티드 세러퓨틱스 코오포레이션 바이러스 감염의 리포솜 치료
US8956627B2 (en) 2007-04-13 2015-02-17 Duke University Method of inducing antibodies to human immunodeficiency virus involving the administration of MPER peptide-liposome conjugates
KR20100127842A (ko) * 2008-03-26 2010-12-06 유니버시티 오브 옥스퍼드 소포체 표적화 리포좀
US20110305700A1 (en) * 2008-09-05 2011-12-15 Duke University Anti-lipid antibodies
JP2012502030A (ja) * 2008-09-05 2012-01-26 デューク ユニバーシティー 抗脂質抗体
US20100081575A1 (en) * 2008-09-22 2010-04-01 Robert Anthony Williamson Methods for creating diversity in libraries and libraries, display vectors and methods, and displayed molecules
AU2009293640A1 (en) * 2008-09-22 2010-03-25 Calmune Corporation Methods and vectors for display of 2G12 -derived domain exchanged antibodies
LT3912643T (lt) 2009-02-13 2023-02-10 Immunomedics Inc. Imunokonjugatai su ląstelės viduje skaldoma jungtimi
CN102427804A (zh) 2009-03-27 2012-04-25 牛津大学之校长及学者 降低胆固醇水平的脂质体
US20110189183A1 (en) 2009-09-18 2011-08-04 Robert Anthony Williamson Antibodies against candida, collections thereof and methods of use
WO2011119920A2 (en) 2010-03-25 2011-09-29 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
EP2492279A1 (en) 2011-02-25 2012-08-29 Laboratorios Del. Dr. Esteve, S.A. Rapid immunogen selection method using lentiviral display
CA2831572C (en) 2011-05-02 2019-11-26 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
DK2691530T3 (en) 2011-06-10 2018-05-22 Univ Oregon Health & Science CMV GLYCOPROTEIN AND RECOMBINANT VECTORS
AU2012216792A1 (en) 2011-09-12 2013-03-28 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing HIV-1 proteins by broadly neutralizing antibodies
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
ES2631608T3 (es) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Variante de la glicoproteína Env del VIH-1
CN104379169A (zh) 2012-08-14 2015-02-25 Ibc药品公司 用于治疗疾病的t-细胞重定向双特异性抗体
EP2698377A1 (en) 2012-08-17 2014-02-19 Laboratorios Del. Dr. Esteve, S.A. Enhanced rapid immunogen selection method for HIV gp120 variants
SI2900277T1 (sl) 2012-12-13 2022-05-31 Immunomedics, Inc. Odmerki imunokonjugatov protiteles in SN-38 za boljšo učinkovitost in zmanjšano toksičnost
EP2848937A1 (en) 2013-09-05 2015-03-18 International Aids Vaccine Initiative Methods of identifying novel HIV-1 immunogens
WO2015048635A1 (en) 2013-09-27 2015-04-02 Duke University Mper-liposome conjugates and uses thereof
EP2873423B1 (en) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
KR20230155600A (ko) 2014-04-03 2023-11-10 아이쥐엠 바이오사이언스 인코포레이티드 변형된 j-사슬
WO2015197919A1 (en) 2014-06-25 2015-12-30 Glykos Finland Oy Antibody drug conjugates binding to high-mannose n-glycan
EP3069730A3 (en) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
EP3072901A1 (en) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
JP6980980B2 (ja) 2015-06-25 2021-12-15 イミューノメディクス、インコーポレイテッドImmunomedics, Inc. 抗ｈｌａ‐ｄｒまたは抗ｔｒｏｐ‐２抗体と微小管阻害剤、ｐａｒｐ阻害剤、ブルトンキナーゼ阻害剤またはホスホイノシチド３‐キナーゼ阻害剤との併用は癌の治療効果を有意に改善する
EP3316885B1 (en) 2015-07-01 2021-06-23 Immunomedics, Inc. Antibody-sn-38 immunoconjugates with a cl2a linker
WO2017059387A1 (en) 2015-09-30 2017-04-06 Igm Biosciences, Inc. Binding molecules with modified j-chain
AU2016329197B2 (en) 2015-09-30 2021-01-21 Igm Biosciences, Inc. Binding molecules with modified J-chain
WO2017093985A1 (en) 2015-12-05 2017-06-08 Centre Hospitalier Universitaire Vaudois Hiv binding agents
EP4385522A1 (en) 2021-08-13 2024-06-19 Kunshan Xinyunda Biotech Co., Ltd. Microtubule inhibitor-based antibody-drug conjugate
CN117881431A (zh) 2021-08-24 2024-04-12 昆山新蕴达生物科技有限公司 一种由可断裂连接子偶联的抗体偶联药物
WO2023103854A1 (zh) 2021-12-09 2023-06-15 昆山新蕴达生物科技有限公司 一种亲和力改善的抗体-药物偶联物、其制备方法及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761470A (en) * 1985-12-16 1988-08-02 Merck & Co., Inc. Immunogenic synthetic peptide capable of eliciting herpes simplex virus neutralizing antibody
US5087557A (en) * 1986-06-23 1992-02-11 Genetic Systems Corporation Human monoclonal antibody to lymphadenopathy-associated virus
US5245015A (en) * 1991-04-26 1993-09-14 Tanox Biosystems, Inc. Monoclonal antibodies which neutralize HIV-1 through reaction with a conformational epitope in vitro
ATE135743T1 (de) * 1987-11-13 1996-04-15 Hermann Katinger Monoklonale menschliche antikörper gegen hiv-i
IL101201A0 (en) * 1991-03-11 1992-11-15 Idec Pharma Corp Methods for selecting antibody reagents,anti-idiotype antibodies and aids vaccine formulations
US5516657A (en) * 1992-05-11 1996-05-14 Cambridge Biotech Corporation Baculovirus vectors for expression of secretory and membrane-bound proteins
DE570357T1 (de) * 1992-05-14 1994-07-28 Polimun Scientific Immunbiologische Forschungsgesellschaft Mbh, Wien Peptide, die Antikörper induzieren, die genetisch divergierende HIV-1 Isolationen neutralisieren.
EP0725825B1 (en) * 1993-09-11 2001-02-21 Polymun Scientific Immunbiologische Forschung GmbH Peptides that elicit neutralizing antibodies against genetically divergent hiv-1 strains

Also Published As

Publication number Publication date
DE69527089D1 (de) 2002-07-18
BR9510575A (pt) 1998-12-15
EP0822941A1 (en) 1998-02-11
CA2218515C (en) 2008-10-07
CA2218515A1 (en) 1996-10-24
AU2308595A (en) 1996-11-07
EP0822941B1 (en) 2002-06-12
ZA962629B (en) 1997-10-02
DE69527089T2 (de) 2003-01-02
MX9708008A (es) 1998-03-31
WO1996033219A1 (en) 1996-10-24
US5911989A (en) 1999-06-15
ATE219105T1 (de) 2002-06-15

Similar Documents

Publication Publication Date Title
ES2178672T3 (es) Anticuerpos monoclonales frente al vih-1 y vacunas hechas a partir de ellos.
DE69433013D1 (de) Zubereitungen und verfahren für die behandlung von krebs und hyperproliferierenden krankheiten
Oursler et al. Identification of osteoclast-specific monoclonal antibodies.
Rosat et al. A role for gamma delta+ T cells during experimental infection of mice with Leishmania major.
ES2072323T3 (es) Compuestos de piperidina y su preparacion y empleo.
ATE330631T1 (de) Antikörperfragmente zur lokalen behandlung von augenerkrankungen
DE69131686D1 (de) EIN MIT HIV-1-GLYKOPROTEIN REAGIERENDER MENSCHLICHER MONOKLONALER IgG-1-ANTIKÖRPER UND VERWENDUNGSMETHODE
BRPI0514199A (pt) método de efetuar profilaxia ou tratar uma doença, composição farmacêutica, anticorpo monoclonal, célula de hibridoma, e, método de triar um agente, de humanizar anticorpo monoclonal 8a5 ou anticorpo monoclonal 6h7 e de produzir uma forma quimérica de anticorpo monoclonal 8a5 ou anticorpo monoclonal 6h7
JP5208975B2 (ja) アンギオテンシンｉｉタイプ１レセプターに対するモノクローナル抗体の治療的使用方法
AR033123A1 (es) Anticuerpos recombinantes asociados a gangliosidos. su uso en el diagnostico y tratamiento de tumores
ATE280783T1 (de) Monoklonale anti-cd6 antikörper zur behandlung und diagnose von psoriasis
MX9301840A (es) Tejido embriogenico y metodo para su produccion.
CN109311983A (zh) 人源化抗clever-1抗体及其用途
DE3650032T2 (de) Anticytomegaloviraler menschlicher monoklonaler antikörper und dessen herstellung.
DE69610295T3 (de) Von einem retroviralen regulationsprotein abstammende, detoxifierte immunogene, dagegen gerichtete antikörper, verfahren zur deren herstellung und diese immunogene oder antikörper enthaltende, pharmazeutische zusammensetzungen.
AR003941A1 (es) Anticuerpos monoclonales humanos neutralizadores de hiv-1
RU2003121231A (ru) Молчащие анти-cd28-антитела и их применение
CN102333447B (zh) 用于治疗和预防晶状体纤维化疾病的组合物和方法
ES2376564A1 (es) Utilización de anticuerpos contra los receptores nk1, nk2 y/o nk3, para producir apoptosis en las células tumorales y modificar el estroma, la inmunidad y la vascularización intra y peritumorales, como tratamiento del cáncer.
CA2449488A1 (en) Compositions and methods for treating hyperimmune response in the eye
DE69625682D1 (de) Verfahren zur behandlung von entzündungen und zusammensetzungen dafür
ES2064349T3 (es) Inmunoglobulinas humanas especificas del antigeno relacionado con el cancer e hibridomas humanos-humanos que pueden producir estas inmunoglobulinas humanas.
Gutterman et al. Immunoprophylaxis of Malignant Melanoma With Systemic BCG: Study of Strain, Dose, and Schedule ¹, 2
Way et al. Endothelial transdifferentiated phenotype and cell-cycle kinetics of AIDS-associated Kaposi sarcoma cells
Hochman et al. Monoclonal antibodies to immunogenic lymphoma cell variants displaying impaired neoplastic properties: characterization and applications