ES2176710T3 - Carga de farmaco debilmente basico en liposomas por medio de ionoforos. - Google Patents

Carga de farmaco debilmente basico en liposomas por medio de ionoforos.

Info

Publication number
ES2176710T3
ES2176710T3 ES97911086T ES97911086T ES2176710T3 ES 2176710 T3 ES2176710 T3 ES 2176710T3 ES 97911086 T ES97911086 T ES 97911086T ES 97911086 T ES97911086 T ES 97911086T ES 2176710 T3 ES2176710 T3 ES 2176710T3
Authority
ES
Spain
Prior art keywords
liposomes
ionophores
weightly
pharmaco
basic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97911086T
Other languages
English (en)
Inventor
David B Fenske
Pieter R Cullis
Kim Wong
Norbert Maurer
Johanna Maria Leenhouts
Elisabeth Maurer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia filed Critical University of British Columbia
Application granted granted Critical
Publication of ES2176710T3 publication Critical patent/ES2176710T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE SUMINISTRAN NUEVOS PROCEDIMIENTOS PARA CARGAR UN MEDICAMENTO DEBILMENTE BASICO DENTRO DE LIPOSOMAS UTILIZANDO UN SISTEMA DE TRANSPORTE ELECTRICAMENTE NEUTRO. EN ESTOS PROCEDIMIENTOS, SE UTILIZAN IONOFOROS CON LIPOSOMAS QUE TIENEN UN GRADIENTE DE IONES METALICOS PARA FACILITAR EL INTERCAMBIO DE LOS IONES METALICOS CON LOS PROTONES. EL ION DE METAL TRANSPORTADO, EN ALGUNAS REALIZACIONES, SE COMPLEJARA CON UN AGENTE QUELANTE QUE ESTA PRESENTE EN EL MEDIO EXTERNO.
ES97911086T 1996-10-30 1997-10-30 Carga de farmaco debilmente basico en liposomas por medio de ionoforos. Expired - Lifetime ES2176710T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/741,622 US5837282A (en) 1996-10-30 1996-10-30 Ionophore-mediated liposome loading

Publications (1)

Publication Number Publication Date
ES2176710T3 true ES2176710T3 (es) 2002-12-01

Family

ID=24981485

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97911086T Expired - Lifetime ES2176710T3 (es) 1996-10-30 1997-10-30 Carga de farmaco debilmente basico en liposomas por medio de ionoforos.

Country Status (10)

Country Link
US (1) US5837282A (es)
EP (1) EP0941065B1 (es)
JP (2) JP4672817B2 (es)
AT (1) ATE219661T1 (es)
AU (1) AU718460B2 (es)
CA (1) CA2269921C (es)
DE (1) DE69713615T2 (es)
DK (1) DK0941065T3 (es)
ES (1) ES2176710T3 (es)
WO (1) WO1998018450A1 (es)

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US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
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Also Published As

Publication number Publication date
JP2007284460A (ja) 2007-11-01
JP2001510451A (ja) 2001-07-31
DK0941065T3 (da) 2002-10-14
EP0941065A1 (en) 1999-09-15
EP0941065B1 (en) 2002-06-26
JP4672817B2 (ja) 2011-04-20
AU718460B2 (en) 2000-04-13
CA2269921A1 (en) 1998-05-07
DE69713615T2 (de) 2003-01-02
US5837282A (en) 1998-11-17
AU4859497A (en) 1998-05-22
CA2269921C (en) 2007-06-26
DE69713615D1 (de) 2002-08-01
WO1998018450A1 (en) 1998-05-07
ATE219661T1 (de) 2002-07-15

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