DK0941065T3 - Ionoforformidlet fyldning af liposomer med svagt basiske lægemidler - Google Patents

Ionoforformidlet fyldning af liposomer med svagt basiske lægemidler

Info

Publication number
DK0941065T3
DK0941065T3 DK97911086T DK97911086T DK0941065T3 DK 0941065 T3 DK0941065 T3 DK 0941065T3 DK 97911086 T DK97911086 T DK 97911086T DK 97911086 T DK97911086 T DK 97911086T DK 0941065 T3 DK0941065 T3 DK 0941065T3
Authority
DK
Denmark
Prior art keywords
liposomes
weakly basic
ion
basic drugs
mediated loading
Prior art date
Application number
DK97911086T
Other languages
English (en)
Inventor
David B Fenske
Pieter R Cullis
Kim Wong
Johanna Maria Leenhouts
Nancy Boman
Norbert Maurer
Elisabeth Maurer
Original Assignee
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia filed Critical Univ British Columbia
Application granted granted Critical
Publication of DK0941065T3 publication Critical patent/DK0941065T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1277Processes for preparing; Proliposomes
    • A61K9/1278Post-loading, e.g. by ion or pH gradient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
DK97911086T 1996-10-30 1997-10-30 Ionoforformidlet fyldning af liposomer med svagt basiske lægemidler DK0941065T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/741,622 US5837282A (en) 1996-10-30 1996-10-30 Ionophore-mediated liposome loading
PCT/CA1997/000821 WO1998018450A1 (en) 1996-10-30 1997-10-30 Ionophore-mediated liposome loading of weakly basic drug

Publications (1)

Publication Number Publication Date
DK0941065T3 true DK0941065T3 (da) 2002-10-14

Family

ID=24981485

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97911086T DK0941065T3 (da) 1996-10-30 1997-10-30 Ionoforformidlet fyldning af liposomer med svagt basiske lægemidler

Country Status (10)

Country Link
US (1) US5837282A (da)
EP (1) EP0941065B1 (da)
JP (2) JP4672817B2 (da)
AT (1) ATE219661T1 (da)
AU (1) AU718460B2 (da)
CA (1) CA2269921C (da)
DE (1) DE69713615T2 (da)
DK (1) DK0941065T3 (da)
ES (1) ES2176710T3 (da)
WO (1) WO1998018450A1 (da)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972379A (en) * 1995-02-14 1999-10-26 Sequus Pharmaceuticals, Inc. Liposome composition and method for administering a quinolone
US5837282A (en) * 1996-10-30 1998-11-17 University Of British Columbia Ionophore-mediated liposome loading
DK1014946T3 (da) 1997-09-18 2010-06-28 Pacira Pharmaceuticals Inc Liposomale anæstetiske sammensætninger med forsinket frigivelse
EP1030652B1 (en) 1997-11-14 2012-04-25 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
JP2002500169A (ja) * 1998-01-06 2002-01-08 セウサ,ニコラス・エイ テオレル−マイヤー勾配に基づく薬投与形
BR9914601A (pt) 1998-09-16 2001-10-23 Alza Corp Inibidor de topoisomerase capturado por lipossoma
BRPI0009448B8 (pt) 1999-04-01 2021-05-25 Univ Texas kit para uso no tratamento de uma neoplasia em um mamífero
US7244450B2 (en) * 1999-04-01 2007-07-17 Inex Pharmaceuticals Corporation Compositions and methods for treating lymphoma
US7311924B2 (en) * 1999-04-01 2007-12-25 Hana Biosciences, Inc. Compositions and methods for treating cancer
US6723338B1 (en) * 1999-04-01 2004-04-20 Inex Pharmaceuticals Corporation Compositions and methods for treating lymphoma
US7189705B2 (en) 2000-04-20 2007-03-13 The University Of British Columbia Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
US7452550B2 (en) 2000-06-30 2008-11-18 Hana Biosciences, Inc. Liposomal antineoplastic drugs and uses thereof
JP2004501955A (ja) * 2000-06-30 2004-01-22 アイネックス ファーマシューティカルズ コーポレイション リポソーム抗新生物薬剤およびその使用
PL363618A1 (en) 2000-11-09 2004-11-29 Neopharm, Inc. Sn-38 lipid complexes and methods of use
WO2002083741A2 (en) * 2001-04-17 2002-10-24 Genencor International, Inc. Method to bind enzyme to carrier using cationic copolymers and product produced thereby
WO2002089772A1 (en) * 2001-05-09 2002-11-14 Inex Pharmaceuticals Corporation Anti-angiogenic therapy using liposome-encapsulated chemotherapeutic agents
WO2003030864A1 (en) 2001-05-29 2003-04-17 Neopharm, Inc. Liposomal formulation of irinotecan
TWI235066B (en) * 2001-10-03 2005-07-01 Celator Technologies Inc Liposome loading with metal ions
US7184663B2 (en) * 2002-05-29 2007-02-27 Fujitsu Limited Optical ring network with hub node and method
US7273620B1 (en) 2002-05-20 2007-09-25 University Of British Columbia Triggered release of liposomal drugs following mixing of cationic and anionic liposomes
US7879351B2 (en) 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
PT1581236E (pt) * 2002-10-29 2013-12-24 Insmed Inc Libertação prolongada de anti-infecciosos
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
ME02251B (me) 2004-02-02 2015-12-31 Engeneic Molecular Delivery Pty Ltd Kompozicije i postupci in vitro i in vivo, ciljanog oslobađanja leka u ćelijama sisara, preko intaktnih minićelija izvedenih iz bakterija
US8772013B2 (en) 2004-02-02 2014-07-08 Engeneic Molecular Delivery Pty Ltd Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
AT500143A1 (de) * 2004-04-22 2005-11-15 Sanochemia Pharmazeutika Ag Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung
EP2407169A1 (en) 2004-04-22 2012-01-18 Celator Pharmaceuticals, Inc. Combination formulations of anthracycline agents and cytidine analogs
US7811602B2 (en) * 2004-05-17 2010-10-12 Tekmira Pharmaceuticals Corporation Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof
JP4433918B2 (ja) * 2004-07-15 2010-03-17 コニカミノルタエムジー株式会社 画像形成方法
BRPI0514898A (pt) * 2004-09-03 2008-06-24 Piedmont Pharmaceuticals Llc métodos para tratamento e prevenção transmembrana da otite média
CN101072588B (zh) * 2004-10-06 2012-11-28 不列颠哥伦比亚抗癌机构 用于治疗癌症的具有改善的药物保留的脂质体
WO2006047323A2 (en) * 2004-10-21 2006-05-04 University Of Cincinnati Selectively permeable membranes on porous substrates
EP1807051A2 (en) 2004-11-05 2007-07-18 Inex Pharmaceuticals Corporation Compositions and methods for stabilizing liposomal camptothecin formulations
KR100651728B1 (ko) * 2004-11-10 2006-12-06 한국전자통신연구원 정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법
US20060222695A1 (en) * 2005-04-01 2006-10-05 Filiberto Zadini Deoxycholic acid liposome-based dermatological topical preparation
US8304383B2 (en) 2005-11-22 2012-11-06 Atheronova Operations, Inc. Dissolution of arterial plaque
US20090035348A1 (en) * 2005-11-22 2009-02-05 Z & Z Medical Holdings, Inc. Dissolution of arterial plaque
EP3067046B1 (en) 2005-12-08 2020-03-25 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections
EP2012750B1 (en) 2006-04-06 2018-02-21 Insmed Incorporated Methods for coacervation induced liposomal encapsulation and formulations thereof
US20100196455A1 (en) 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
WO2008144458A1 (en) * 2007-05-15 2008-11-27 Z & Z Medical Holdings, Inc. Dissolution of arterial cholesterol plaques by pharmacologically induced elevation of endogenous bile salts
ES2550759T3 (es) 2007-08-17 2015-11-12 Celator Pharmaceuticals, Inc. Formulaciones farmacológicas de platino mejoradas
EP2231190B1 (en) * 2007-12-06 2012-09-26 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Particulate drug carriers as desensitizing agents
WO2009136965A1 (en) * 2008-05-06 2009-11-12 Sequella, Inc. Compositions and methods comprising capuramycin analogues
WO2010034837A1 (en) * 2008-09-26 2010-04-01 Phares Pharmaceutical Research N.V. Method of solubilising biologically active compounds
US20110223675A1 (en) * 2008-11-20 2011-09-15 Terumo Kabushiki Kaisha Drug release means from liposomes and method for evaluating releasability
WO2011006510A1 (en) * 2009-07-17 2011-01-20 Technical University Of Denmark Loading technique for preparing radionuclide and ionophore containing liposomes in which the ionophore is 2-hydroxyquionoline (carbostyril) or structurally related 2-hydroxyquinolines
US11357728B2 (en) * 2009-10-26 2022-06-14 Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Liposome having inner water phase containing sulfobutyl ether cyclodextrin salt
SG181904A1 (en) 2009-12-23 2012-07-30 Novartis Ag Lipids, lipid compositions, and methods of using them
JP5947807B2 (ja) * 2010-12-14 2016-07-06 テクニカル ユニバーシティ オブ デンマークTechnical University Of Denmark ナノ粒子組成物への放射性核種の封入
EP2680820B1 (en) * 2011-03-01 2022-11-02 2-BBB Medicines B.V. Advanced active liposomal loading of poorly water-soluble substances
CN103370055B (zh) 2011-03-25 2015-06-24 泰尔茂株式会社 缓释性脂质体组合物及其制造方法
SI2852391T1 (sl) 2012-05-21 2022-04-29 Insmed Incorporated Sistemi za obravnavo pljučnih infekcij
CA2879139C (en) 2012-07-18 2021-05-11 Onyx Therapeutics, Inc. Liposomal compositions of epoxyketone-based proteasome inhibitors
TR201908531T4 (tr) 2012-11-20 2019-08-21 Arbutus Biopharma Corp Terapöti̇k kullanim i̇çi̇n li̇pozom kapsüllü vi̇nkri̇sti̇ni̇n preparasyonuna yöneli̇k geli̇şti̇ri̇lmi̇ş yöntem
CA2891487A1 (en) 2012-11-29 2014-06-05 Insmed Incorporated Stabilized vancomycin formulations
ES2964512T3 (es) 2013-02-01 2024-04-08 Celator Pharmaceuticals Inc Carga remota de fármacos escasamente solubles en agua en liposomas
BR112015021791B1 (pt) 2013-03-08 2022-08-30 Novartis Ag Compostos de lipídio catiônico e composições de lipídios e farmacêuticas
PL3083556T3 (pl) 2013-12-19 2020-06-29 Novartis Ag Lipidy i kompozycje lipidowe dla dostarczania środków czynnych
EP4019506A1 (en) 2013-12-19 2022-06-29 Novartis AG Lipids and lipid compositions for the delivery of active agents
DK3466432T3 (da) 2014-05-15 2020-09-28 Insmed Inc Fremgangsmåder til behandling af pulmonale non-tuberkuløse mykobakterielle infektioner
EP4223285A3 (en) 2014-07-16 2023-11-22 Novartis AG Method of encapsulating a nucleic acid in a lipid nanoparticle host
AU2015301234A1 (en) 2014-08-04 2017-06-15 Zoneone Pharma, Inc. Remote loading of sparingly water-soluble drugs into lipid vesicles
EP3188760B1 (en) 2014-09-05 2023-12-06 Novartis AG Lipids and lipid compositions for the delivery of active agents
TWI678213B (zh) 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物
US11633502B2 (en) 2016-03-07 2023-04-25 Memorial Sloan Kettering Cancer Center Bone marrow-, reticuloendothelial system-, and/or lymph node-targeted radiolabeled liposomes and methods of their diagnostic and therapeutic use
WO2019191627A1 (en) 2018-03-30 2019-10-03 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
EP3849515A1 (en) * 2018-09-11 2021-07-21 Memorial Sloan Kettering Cancer Center Bone marrow-, reticuloendothelial system-, and/or lymph node-targeted radiolabeled liposomes and methods of their diagnostic and therapeutic use
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310506A (en) * 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
US5169637A (en) * 1983-03-24 1992-12-08 The Liposome Company, Inc. Stable plurilamellar vesicles
JPS59218956A (ja) * 1983-05-27 1984-12-10 Fujirebio Inc 膜融合測定方法
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
US5077056A (en) * 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5525232A (en) * 1990-03-02 1996-06-11 The Liposome Company, Inc. Method for entrapment of cationic species in lemellar vesicles
US5593688A (en) * 1993-06-25 1997-01-14 Nexstar Pharmaceuticals, Inc. Liposomal targeting of ischemic tissue
US5800833A (en) * 1995-02-27 1998-09-01 University Of British Columbia Method for loading lipid vesicles
EP0825852B1 (en) * 1995-04-18 2004-07-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome drug-loading method and composition
US5837282A (en) * 1996-10-30 1998-11-17 University Of British Columbia Ionophore-mediated liposome loading

Also Published As

Publication number Publication date
ES2176710T3 (es) 2002-12-01
AU718460B2 (en) 2000-04-13
CA2269921A1 (en) 1998-05-07
CA2269921C (en) 2007-06-26
US5837282A (en) 1998-11-17
ATE219661T1 (de) 2002-07-15
EP0941065B1 (en) 2002-06-26
DE69713615D1 (de) 2002-08-01
JP2007284460A (ja) 2007-11-01
EP0941065A1 (en) 1999-09-15
JP2001510451A (ja) 2001-07-31
WO1998018450A1 (en) 1998-05-07
DE69713615T2 (de) 2003-01-02
JP4672817B2 (ja) 2011-04-20
AU4859497A (en) 1998-05-22

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