ES2175987T3 - Composicion para ahuyentar parasitos. - Google Patents
Composicion para ahuyentar parasitos.Info
- Publication number
- ES2175987T3 ES2175987T3 ES99927997T ES99927997T ES2175987T3 ES 2175987 T3 ES2175987 T3 ES 2175987T3 ES 99927997 T ES99927997 T ES 99927997T ES 99927997 T ES99927997 T ES 99927997T ES 2175987 T3 ES2175987 T3 ES 2175987T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- haloalkyl
- cyano
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
- A01N25/06—Aerosols
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
- A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/16—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N2300/00—Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedimiento no terapéutico para ahuyentar parásitos de animales de sangre caliente, caracterizado porque un compuesto de fórmula (I): o sus sales de adición de ácido, en donde: R es hidrógeno, alquilo de 1 a 20 átomos de carbono o -C(O)-R8 en donde R8 es alquilo de 1 a 20 átomos de carbono, alcoxi de 1 a 20 átomos de carbono, fenilo insustituido o fenilo que está sustituido una o muchas veces por alquilo de 1 a 3 átomos de carbono, haloalquilo de 1 a 3 átomos de carbono, haloalcoxi de 1 a 3 átomos de carbono, halógeno, ciano, hidroxilo, alcoxi, amino, o nitro; R1 es hidrógeno, alquilo de 1 a 20 átomos de carbono, -C(O)-R3, -C(S)-R4, C(O)-O-R5-, -C(O)-NHR6 o -C(S)-NH-R7; en donde R3, R4, R5, R6 y R7 independientemente unos de otros, significan alquilo de1 a 10 átomos de carbono, acetoxi, haloalquilo de 1 a 10 átomos de carbono, alcoxi de 1 a 10 átomos de carbono, o haloalcoxi de 1 a 10 átomos de carbono, o independientemente unos de otros representan fenilo insustituido o fenilo que estásustituido una o muchas veces por alquilo de 1 a 4 átomos de carbono, haloalquilode1 a 3 átomosdecarbono,haloalcoxide1 a 3 átomos de carbono, halógeno, ciano, hidroxilo, alcoxide1 a3 átomos de carbono, amino, CHO o nitro; R2 y R3, independientemente uno del otro, son hidrógeno, alquilo de 1 a 3 átomos de carbono, haloalquilo de 1 a 3 átomos de carbono, haloalcoxi de 1 a 3 átomos de carbono, halógeno, ciano, hidroxilo, amino o nitro; Ra es hidrógeno, alquilo de 1 a 20 átomos de carbono insustituido o alquilo de 1 a 20 átomos de carbono que está sustituido una o muchas veces por halógeno, ciano, hidroxilo, alcoxi, nitro, fenilo, bifenilo, benciloxilo o fenoxifenilo, en donde cada fenilo, bifenilo, benciloxilo o fenoxifenilo a su vez está insustituido o sustituido una o muchas veces por alquilo de 1 a 3 átomos de carbono, haloalquilo de 1 a 3 átomos de carbono, haloalcoxi de 1 a 3 átomos de carbono,alcoxide1 a 3 átomos de carbono, halógeno, ciano, hidroxilo, amino o nitro; o representa cicloalquilo de 3 a 8 átomos de carbono, fenilo, bifenilo, fenoxifenilo o heterociclilo, en donde cada uno de estos radicales cíclicos está insustituido o sustituido una o muchas veces por alquilo de 1 a 3 átomos de carbono, alquenilo de 2 a 6 átomos de carbono, haloalquilo de 1 a 3 átomos de carbono, haloalcoxi de 1 a 3 átomos de carbono, alcoxi de 1 a 3 átomos de carbono, halógeno, ciano, hidroxilo, amino, (alquilo de 1 a 3 átomos de carbono) 2N, acetilo o nitro; o representa alquilen(1 a 6 átomos de carbono)arilo en donde el radical arilo está insustituido o sustituido una o muchas veces por alquilo de 1 a 3 átomos de carbono, haloalquilo de 1 a 3 átomos de carbono, haloalcoxide1 a 3 átomos de carbono, halógeno, ciano, hidroxilo o nitro; o representa alquilo de 1 a 20 átomos de carbono que, dependiendo del número de átomos de carbono, está interrumpido por oxígeno en una o varias posiciones; y Rb significa hidrógeno, alquilo de 1 a 20 átomos de carbono, heterociclilo o arilo, en donde cada uno de los radicales cíclicos está insustituido o sustituido una o muchas veces por alquilo de 1 a 3 átomos de carbono,haloalquilo de 1 a 3 átomos de carbono,haloalcoxide 1 a 3 átomos de carbono, alquenilo de 2 a 6 átomos de carbono, halógeno,ciano,hidroxilo,alcoxi de 1 a 3 átomos de carbono, amino, (alquilo de 1 a 3 átomos de carbono) 2N onitro; se aplica tópicamente, junto con un aditivo extensor, a la piel, al pelo o al plumaje del animal de sangre caliente.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH131898 | 1998-06-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2175987T3 true ES2175987T3 (es) | 2002-11-16 |
Family
ID=4207641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99927997T Expired - Lifetime ES2175987T3 (es) | 1998-06-18 | 1999-06-16 | Composicion para ahuyentar parasitos. |
Country Status (18)
Country | Link |
---|---|
US (3) | US20010003646A1 (es) |
EP (1) | EP1087662B1 (es) |
JP (1) | JP2002518301A (es) |
KR (1) | KR100594551B1 (es) |
CN (1) | CN1161018C (es) |
AR (1) | AR019868A1 (es) |
AT (1) | ATE215778T1 (es) |
AU (1) | AU750446B2 (es) |
BR (1) | BR9912168A (es) |
CA (1) | CA2329932A1 (es) |
DE (1) | DE69901248T2 (es) |
DK (1) | DK1087662T3 (es) |
ES (1) | ES2175987T3 (es) |
NZ (1) | NZ507439A (es) |
PT (1) | PT1087662E (es) |
RU (1) | RU2234219C2 (es) |
WO (1) | WO1999065311A1 (es) |
ZA (1) | ZA200006205B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100248268A1 (en) * | 2001-03-27 | 2010-09-30 | Woods Daniel F | Methods to utilize invertebrate chemosensory proteins for industrial and commercial uses |
US20070003980A1 (en) * | 2001-03-27 | 2007-01-04 | Woods Daniel F | Efficient methods to isolate effectors of proteins involved in olfactory or chemosensory pathways and efficient methods to use these effectors to alter organism olfaction, chemosensation, or behavior |
AU2002250462A1 (en) * | 2001-03-27 | 2002-10-08 | Inscent, Inc | Efficient methods for isolating functional g-protein coupled receptors and identifying active effectors and efficient methods to isolate proteins involved in olfaction and efficient methods to isolate and identifying active effectors |
EP1461077A4 (en) * | 2001-11-07 | 2006-01-25 | Univ Duke | POLYVALENT IMMUNOGEN |
US7172761B2 (en) | 2001-11-07 | 2007-02-06 | Duke University | Polyvalent immunogen |
US7195768B2 (en) | 2001-11-07 | 2007-03-27 | Duke University | Polyvalent immunogen |
KR101197482B1 (ko) | 2004-03-05 | 2012-11-09 | 닛산 가가쿠 고교 가부시키 가이샤 | 이속사졸린 치환 벤즈아미드 화합물 및 유해생물 방제제 |
US20140335079A1 (en) * | 2013-05-07 | 2014-11-13 | Emory University | Solenopsin and derivatives, therapeutic compositions, and methods related thereto |
US10370763B2 (en) * | 2016-04-18 | 2019-08-06 | Tokyo Electron Limited | Plasma processing apparatus |
GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714740D0 (en) * | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
JP7460317B2 (ja) * | 2018-01-29 | 2024-04-02 | Juki株式会社 | 縫製システム |
KR102491485B1 (ko) | 2022-03-21 | 2023-01-27 | 주식회사 아이엠비디엑스 | 순환 종양 핵산의 복제수 변이 분석 방법 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4529598A (en) * | 1979-08-24 | 1985-07-16 | Stauffer Chemical Company | Insect repellent compounds |
US4407670A (en) * | 1980-02-28 | 1983-10-04 | National Research Development Corporation | Biocidal compounds and compositions |
GB2071653B (en) * | 1980-02-28 | 1984-10-31 | Secr Defence | Biocidally active hydroxyalkyl piperidines and fused piperidines |
US4412997A (en) * | 1981-12-10 | 1983-11-01 | Stauffer Chemical Company | Insect repellent compounds |
DE3708033A1 (de) * | 1987-03-12 | 1988-09-22 | Bayer Ag | Mittel zur insekten- und milbenabwehr |
DE3801082A1 (de) * | 1987-04-28 | 1988-11-17 | Bayer Ag | Mittel zur insekten- und milbenabwehr |
PT1087660E (pt) * | 1998-06-18 | 2002-11-29 | Novartis Ag | Formulacoes para repelir vermina |
-
1999
- 1999-06-16 CA CA002329932A patent/CA2329932A1/en not_active Abandoned
- 1999-06-16 CN CNB998065196A patent/CN1161018C/zh not_active Expired - Fee Related
- 1999-06-16 EP EP99927997A patent/EP1087662B1/en not_active Expired - Lifetime
- 1999-06-16 PT PT99927997T patent/PT1087662E/pt unknown
- 1999-06-16 NZ NZ507439A patent/NZ507439A/en unknown
- 1999-06-16 AT AT99927997T patent/ATE215778T1/de not_active IP Right Cessation
- 1999-06-16 KR KR1020007014341A patent/KR100594551B1/ko not_active IP Right Cessation
- 1999-06-16 AU AU45144/99A patent/AU750446B2/en not_active Ceased
- 1999-06-16 DK DK99927997T patent/DK1087662T3/da active
- 1999-06-16 WO PCT/EP1999/004172 patent/WO1999065311A1/en active IP Right Grant
- 1999-06-16 RU RU2000132191/13A patent/RU2234219C2/ru not_active IP Right Cessation
- 1999-06-16 ES ES99927997T patent/ES2175987T3/es not_active Expired - Lifetime
- 1999-06-16 BR BR9912168-9A patent/BR9912168A/pt not_active IP Right Cessation
- 1999-06-16 JP JP2000554202A patent/JP2002518301A/ja active Pending
- 1999-06-16 DE DE69901248T patent/DE69901248T2/de not_active Expired - Fee Related
- 1999-06-16 AR ARP990102882A patent/AR019868A1/es unknown
-
2000
- 2000-11-01 ZA ZA200006205A patent/ZA200006205B/en unknown
- 2000-12-15 US US09/738,105 patent/US20010003646A1/en not_active Abandoned
-
2002
- 2002-03-25 US US10/106,004 patent/US6780876B2/en not_active Expired - Fee Related
-
2004
- 2004-01-02 US US10/751,150 patent/US20040146542A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1087662A1 (en) | 2001-04-04 |
US20010003646A1 (en) | 2001-06-14 |
AR019868A1 (es) | 2002-03-20 |
ATE215778T1 (de) | 2002-04-15 |
JP2002518301A (ja) | 2002-06-25 |
BR9912168A (pt) | 2001-04-10 |
US20020142023A1 (en) | 2002-10-03 |
US20040146542A1 (en) | 2004-07-29 |
PT1087662E (pt) | 2002-09-30 |
CA2329932A1 (en) | 1999-12-23 |
AU750446B2 (en) | 2002-07-18 |
DK1087662T3 (da) | 2002-07-29 |
ZA200006205B (en) | 2002-02-01 |
CN1302184A (zh) | 2001-07-04 |
NZ507439A (en) | 2003-08-29 |
DE69901248T2 (de) | 2002-10-02 |
KR20010052957A (ko) | 2001-06-25 |
RU2234219C2 (ru) | 2004-08-20 |
KR100594551B1 (ko) | 2006-07-03 |
EP1087662B1 (en) | 2002-04-10 |
CN1161018C (zh) | 2004-08-11 |
AU4514499A (en) | 2000-01-05 |
US6780876B2 (en) | 2004-08-24 |
DE69901248D1 (de) | 2002-05-16 |
WO1999065311A1 (en) | 1999-12-23 |
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