ES2174756B2 - Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de enfermedades respiratorias. - Google Patents
Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de enfermedades respiratorias.Info
- Publication number
- ES2174756B2 ES2174756B2 ES200100817A ES200100817A ES2174756B2 ES 2174756 B2 ES2174756 B2 ES 2174756B2 ES 200100817 A ES200100817 A ES 200100817A ES 200100817 A ES200100817 A ES 200100817A ES 2174756 B2 ES2174756 B2 ES 2174756B2
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- derivatives
- respiratory diseases
- azolilcarbinoles
- heteroaril
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 208000023504 respiratory system disease Diseases 0.000 abstract 2
- PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical class NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 206010011224 Cough Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000009961 allergic asthma Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Derivados de aril(o heteroaril)azolilcarbinoles para el tratamiento de enfermedades respiratorias. Los derivados de aril(o heteroaril)azolilcarbinoles de fórmula general (I), en la cual Ar representa un radical fenilo o un radical tienilo, opcionalmente sustituidos, R1 representa un átomo de hidrógeno o un grupo alquilo inferior, R2 representa un radical dialquilaminoalquilo o azaheterociclilalquil y Het representa un azol no sustituido u opcionalmente sustituido por uno o dos sustituyentes, así como sus sales fisiológicamente aceptables; son útiles como medicamentos en terapéutica humana y/o veterinaria para el tratamiento de enfermedades respiratorias especialmente para el tratamiento de la tos, bronquitis, enfermedades pulmonares obstructivas crónicas, rinitis alérgica y asma.
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200100817A ES2174756B2 (es) | 2001-04-06 | 2001-04-06 | Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de enfermedades respiratorias. |
PT02714232T PT1384476E (pt) | 2001-04-06 | 2002-03-21 | Derivados azolilcarbinol de arilo (ou heteroarilo) para o tratamento de doencas respiratorias |
AU2002246151A AU2002246151B2 (en) | 2001-04-06 | 2002-03-21 | Azolylcarbynol derivatives of aryl (or heteroaryl) for the treatment of respiratory diseases |
MXPA03009125A MXPA03009125A (es) | 2001-04-06 | 2002-03-21 | Derivados de aril (o heteroaril), azolilcarbinoles para el tratamiento de enfermedades respiratorias. |
CA002443015A CA2443015A1 (en) | 2001-04-06 | 2002-03-21 | Aryl (or heteroaryl) azolylcarbinole derivatives for the treatment of respiratory diseases |
PL02365251A PL365251A1 (en) | 2001-04-06 | 2002-03-21 | Azolylcarbynol derivatives of aryl (or heteroaryl) for the treatment of respiratory diseases |
EP02714232A EP1384476B1 (en) | 2001-04-06 | 2002-03-21 | Azolylcarbynol derivatives of aryl (or heteroaryl) for the treatment of respiratory diseases |
JP2002578947A JP2004531511A (ja) | 2001-04-06 | 2002-03-21 | 呼吸器疾患治療用アリール(又はヘテロアリール)アゾリルカルビノール誘導体 |
ES02714232T ES2236497T3 (es) | 2001-04-06 | 2002-03-21 | Derivados de aril(o heteroaril)azolilcarbinoles para el tratamiento de enfermedades respiratorias. |
BR0208807-0A BR0208807A (pt) | 2001-04-06 | 2002-03-21 | Uso de uma arila um derivado de (heterolaril) azolilcarbinole e composição farmacêutica |
KR10-2003-7013063A KR20040025913A (ko) | 2001-04-06 | 2002-03-21 | 호흡기 질환의 치료를 위한 아릴(또는 헤테로아릴)아졸릴카르비놀 유도체 |
CNB028098943A CN1230165C (zh) | 2001-04-06 | 2002-03-21 | 治疗呼吸疾病的芳基(或杂芳基)氮杂茂基甲醇衍生物 |
NZ529303A NZ529303A (en) | 2001-04-06 | 2002-03-21 | Azolylcarbynol derivatives of aryl (or heteroaryl) for the treatment of respiratory diseases |
US10/474,232 US20040142994A1 (en) | 2001-04-06 | 2002-03-21 | Azolylcarbynol derivatives of aryl (or heteroaryl) for the treatment of respiratory diseases |
DE60203106T DE60203106T2 (de) | 2001-04-06 | 2002-03-21 | Azolylcarbynol-derivative von aryl (oder heteroaryl) zur behandlung von atemwegserkrankungen |
RU2003132456/15A RU2294198C2 (ru) | 2001-04-06 | 2002-03-21 | Производные арил(или гетероарил)азолилкарбинола для лечения респираторных заболеваний |
PCT/ES2002/000136 WO2002080908A1 (es) | 2001-04-06 | 2002-03-21 | Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de enfermedades respiratorias |
IL15826802A IL158268A0 (en) | 2001-04-06 | 2002-03-21 | Azolylcarbinol derivatives of aryl (or heteroaryl) for the treatment of respiratory diseases |
HU0400925A HUP0400925A3 (en) | 2001-04-06 | 2002-03-21 | Azolycarbynol derivatives of aryl (or heteroaryl) for producing pharmaceutical compositions for the treatment of respiratory diseases |
DK02714232T DK1384476T3 (da) | 2001-04-06 | 2002-03-21 | Azolylcarbinolderivater af aryl (eller heteroaryl) til behandling af åndedrætssygdomme |
AT02714232T ATE289812T1 (de) | 2001-04-06 | 2002-03-21 | Azolylcarbynol-derivative von aryl (oder heteroaryl) zur behandlung von atemwegserkrankungen |
NO20034471A NO20034471L (no) | 2001-04-06 | 2003-10-06 | Aryl (eller heteroaryl)-azolylkarbinolderivater for behandling av respiratoriske sykdommer |
ZA200308630A ZA200308630B (en) | 2001-04-06 | 2003-11-05 | Azolylcarbynol derivatives of aryl (or heteroaryl) for the treatment of respiratory diseases. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200100817A ES2174756B2 (es) | 2001-04-06 | 2001-04-06 | Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de enfermedades respiratorias. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2174756A1 ES2174756A1 (es) | 2002-11-01 |
ES2174756B2 true ES2174756B2 (es) | 2003-11-16 |
Family
ID=8497368
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200100817A Expired - Fee Related ES2174756B2 (es) | 2001-04-06 | 2001-04-06 | Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de enfermedades respiratorias. |
ES02714232T Expired - Lifetime ES2236497T3 (es) | 2001-04-06 | 2002-03-21 | Derivados de aril(o heteroaril)azolilcarbinoles para el tratamiento de enfermedades respiratorias. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02714232T Expired - Lifetime ES2236497T3 (es) | 2001-04-06 | 2002-03-21 | Derivados de aril(o heteroaril)azolilcarbinoles para el tratamiento de enfermedades respiratorias. |
Country Status (22)
Country | Link |
---|---|
US (1) | US20040142994A1 (es) |
EP (1) | EP1384476B1 (es) |
JP (1) | JP2004531511A (es) |
KR (1) | KR20040025913A (es) |
CN (1) | CN1230165C (es) |
AT (1) | ATE289812T1 (es) |
AU (1) | AU2002246151B2 (es) |
BR (1) | BR0208807A (es) |
CA (1) | CA2443015A1 (es) |
DE (1) | DE60203106T2 (es) |
DK (1) | DK1384476T3 (es) |
ES (2) | ES2174756B2 (es) |
HU (1) | HUP0400925A3 (es) |
IL (1) | IL158268A0 (es) |
MX (1) | MXPA03009125A (es) |
NO (1) | NO20034471L (es) |
NZ (1) | NZ529303A (es) |
PL (1) | PL365251A1 (es) |
PT (1) | PT1384476E (es) |
RU (1) | RU2294198C2 (es) |
WO (1) | WO2002080908A1 (es) |
ZA (1) | ZA200308630B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10335566A1 (de) * | 2003-07-31 | 2005-02-24 | Grünenthal GmbH | Arzneimittel enthaltend Derivate von Aryl( oder Heteroaryl)azolylcarbinolen |
EP1584335A3 (en) * | 2004-04-05 | 2006-02-22 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination comprising a carbinol composition and an opioid |
ES2244326B1 (es) * | 2004-04-05 | 2007-02-16 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de substancias activas. |
EP1784178A1 (en) * | 2004-07-30 | 2007-05-16 | Laboratorios Del Dr. Esteve, S.A. | Aryl (or heteroaryl) azolylcarbinols |
EP1632227A1 (en) * | 2004-09-07 | 2006-03-08 | Laboratorios del Dr. Esteve S.A. | Derivatives of aryl (or heteroaryl) azolylcarbinols (in particular cizolirtin citrate) for the treatment of opioid addiction |
EP1820502A1 (en) * | 2006-02-10 | 2007-08-22 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination comprising azolylcarbinol compounds |
US20100291151A1 (en) * | 2009-04-21 | 2010-11-18 | Auspex Pharmaceuticals, Inc. | 1-methylpyrazole modulators of substance p, calcitonin gene-related peptide, adrenergic receptor, and/or 5-ht receptor |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2150353B1 (es) * | 1998-04-15 | 2001-07-01 | Esteve Labor Dr | Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos. |
ES2137136B1 (es) * | 1998-05-18 | 2000-07-01 | Esteve Labor Dr | Empleo de derivados de aril (o heteroaril) azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de la inflamacion neurogenica. |
ES2150378B1 (es) * | 1998-08-07 | 2001-07-01 | Esteve Labor Dr | Empleo de derivados de aril(o heteroaril)azolilcarbinoles en la elaboracion de un medicamento para el tratamiento de los trastornos mediados por un exceso de substancia p. |
-
2001
- 2001-04-06 ES ES200100817A patent/ES2174756B2/es not_active Expired - Fee Related
-
2002
- 2002-03-21 EP EP02714232A patent/EP1384476B1/en not_active Expired - Lifetime
- 2002-03-21 NZ NZ529303A patent/NZ529303A/en unknown
- 2002-03-21 CN CNB028098943A patent/CN1230165C/zh not_active Expired - Fee Related
- 2002-03-21 DK DK02714232T patent/DK1384476T3/da active
- 2002-03-21 US US10/474,232 patent/US20040142994A1/en not_active Abandoned
- 2002-03-21 AU AU2002246151A patent/AU2002246151B2/en not_active Ceased
- 2002-03-21 BR BR0208807-0A patent/BR0208807A/pt not_active IP Right Cessation
- 2002-03-21 ES ES02714232T patent/ES2236497T3/es not_active Expired - Lifetime
- 2002-03-21 MX MXPA03009125A patent/MXPA03009125A/es active IP Right Grant
- 2002-03-21 PT PT02714232T patent/PT1384476E/pt unknown
- 2002-03-21 HU HU0400925A patent/HUP0400925A3/hu unknown
- 2002-03-21 JP JP2002578947A patent/JP2004531511A/ja not_active Withdrawn
- 2002-03-21 KR KR10-2003-7013063A patent/KR20040025913A/ko not_active Application Discontinuation
- 2002-03-21 DE DE60203106T patent/DE60203106T2/de not_active Expired - Fee Related
- 2002-03-21 IL IL15826802A patent/IL158268A0/xx unknown
- 2002-03-21 PL PL02365251A patent/PL365251A1/xx not_active Application Discontinuation
- 2002-03-21 WO PCT/ES2002/000136 patent/WO2002080908A1/es active IP Right Grant
- 2002-03-21 CA CA002443015A patent/CA2443015A1/en not_active Abandoned
- 2002-03-21 RU RU2003132456/15A patent/RU2294198C2/ru not_active IP Right Cessation
- 2002-03-21 AT AT02714232T patent/ATE289812T1/de not_active IP Right Cessation
-
2003
- 2003-10-06 NO NO20034471A patent/NO20034471L/no not_active Application Discontinuation
- 2003-11-05 ZA ZA200308630A patent/ZA200308630B/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE60203106D1 (de) | 2005-04-07 |
US20040142994A1 (en) | 2004-07-22 |
KR20040025913A (ko) | 2004-03-26 |
EP1384476A1 (en) | 2004-01-28 |
HUP0400925A2 (hu) | 2004-07-28 |
CA2443015A1 (en) | 2002-10-17 |
CN1230165C (zh) | 2005-12-07 |
WO2002080908A1 (es) | 2002-10-17 |
ZA200308630B (en) | 2004-11-05 |
HUP0400925A3 (en) | 2004-10-28 |
NZ529303A (en) | 2005-06-24 |
CN1535147A (zh) | 2004-10-06 |
AU2002246151C1 (en) | 2002-10-21 |
RU2294198C2 (ru) | 2007-02-27 |
ATE289812T1 (de) | 2005-03-15 |
IL158268A0 (en) | 2004-05-12 |
RU2003132456A (ru) | 2005-04-10 |
DK1384476T3 (da) | 2005-05-30 |
NO20034471L (no) | 2003-12-03 |
PT1384476E (pt) | 2005-05-31 |
PL365251A1 (en) | 2004-12-27 |
EP1384476B1 (en) | 2005-03-02 |
JP2004531511A (ja) | 2004-10-14 |
NO20034471D0 (no) | 2003-10-06 |
ES2174756A1 (es) | 2002-11-01 |
MXPA03009125A (es) | 2005-04-11 |
BR0208807A (pt) | 2004-07-13 |
AU2002246151B2 (en) | 2007-05-31 |
DE60203106T2 (de) | 2006-04-13 |
ES2236497T3 (es) | 2005-07-16 |
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