ES2174524T3 - Procedimiento de preparacion de hidroxiapatita sustituida por magnesio y carbonato. - Google Patents
Procedimiento de preparacion de hidroxiapatita sustituida por magnesio y carbonato.Info
- Publication number
- ES2174524T3 ES2174524T3 ES98961319T ES98961319T ES2174524T3 ES 2174524 T3 ES2174524 T3 ES 2174524T3 ES 98961319 T ES98961319 T ES 98961319T ES 98961319 T ES98961319 T ES 98961319T ES 2174524 T3 ES2174524 T3 ES 2174524T3
- Authority
- ES
- Spain
- Prior art keywords
- magnesium
- preparation
- carbonate
- hydroxiapatist
- replaced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000011777 magnesium Substances 0.000 title abstract 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title abstract 4
- 229910052749 magnesium Inorganic materials 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 title abstract 2
- 239000011575 calcium Substances 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 229910052791 calcium Inorganic materials 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 abstract 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical group [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Un proceso para la preparación de una composición monofásica de hidroxiapatita sustituida con magnesio y carbonato, cuyo proceso comprende las fases de (iv) preparación de una solución acuosa que contiene iones CO3 2y PO4 3, en ausencia sustancial de cationes distintos a los iones H + ; (v) mezcla de la solución de la fase (i) con una solución o suspensión acuosa que contenga calcio y magnesio; y (vi) recogida y secado del precipitado formado en la fase (ii); manteniéndose la relación de (Ca+Mg/P) en la solución o suspensión que contenga calcio y magnesio y la solución que contiene fósforo, en 1,67 o por encima, al mezclarlas juntas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9727048.2A GB9727048D0 (en) | 1997-12-22 | 1997-12-22 | Process for the preparation of magnesium and carbonate substituted hydroxyapatite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2174524T3 true ES2174524T3 (es) | 2002-11-01 |
Family
ID=10824039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98961319T Expired - Lifetime ES2174524T3 (es) | 1997-12-22 | 1998-12-17 | Procedimiento de preparacion de hidroxiapatita sustituida por magnesio y carbonato. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6585946B1 (es) |
| EP (1) | EP1042222B1 (es) |
| JP (1) | JP4540225B2 (es) |
| AU (1) | AU1677999A (es) |
| DE (1) | DE69804506T2 (es) |
| ES (1) | ES2174524T3 (es) |
| GB (1) | GB9727048D0 (es) |
| WO (1) | WO1999032400A1 (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7204876B2 (en) | 2000-07-13 | 2007-04-17 | Calcitec, Inc. | Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same |
| US6921544B2 (en) * | 2001-03-06 | 2005-07-26 | Rutgers, The State University | Magnesium-substituted hydroxyapatites |
| KR100460685B1 (ko) * | 2002-04-10 | 2004-12-09 | 재단법인서울대학교산학협력재단 | 인산칼슘계 화합물을 이용한 인공 골 충진재 및 그 제조방법 |
| JP3806061B2 (ja) * | 2002-05-21 | 2006-08-09 | 富士通株式会社 | 金属修飾アパタイト含有膜の形成方法、これに用いられるコーティング液、および金属修飾アパタイト含有膜で被覆された部位を有する電子機器 |
| US9199005B2 (en) * | 2003-10-01 | 2015-12-01 | New York University | Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate |
| US7419680B2 (en) * | 2003-10-01 | 2008-09-02 | New York University | Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate |
| ITFI20040048A1 (it) * | 2004-02-27 | 2004-05-27 | Menarini Farma Ind | Composti biomimetici contenenti idrossiapatiti sostituite con magnesio e carbonato e processi per ottenerli |
| US7498043B2 (en) | 2004-04-07 | 2009-03-03 | Warsaw Orthopedic, Inc. | Silicon substituted oxyapatite |
| WO2005102281A2 (en) * | 2004-04-16 | 2005-11-03 | University Of Massachusetts | Porous calcium phosphate networks for synthetic bone material |
| FR2869893B1 (fr) * | 2004-05-06 | 2006-07-28 | Rhodia Chimie Sa | Nouveaux granules de phosphates de calcium de type hydroxyapatite, leur procede de preparation et leurs applications |
| EP1846325A4 (en) | 2005-01-04 | 2010-04-21 | Univ Rutgers | HYDROXYAPATITE WITH CONTROLLABLE SIZE AND MORPHOLOGY |
| ITMI20050343A1 (it) * | 2005-03-04 | 2006-09-05 | Fin Ceramica Faenza S R L | Sostituto cartilagineo e osteocindrale comprendente una struttura multistrato e relativo impiego |
| CN100391829C (zh) * | 2005-11-17 | 2008-06-04 | 江苏大学 | 一种纳米羟基磷灰石的合成方法 |
| US8287914B2 (en) * | 2006-01-12 | 2012-10-16 | Rutgers, The State University Of New Jersey | Biomimetic hydroxyapatite synthesis |
| US20100040668A1 (en) * | 2006-01-12 | 2010-02-18 | Rutgers, The State University Of New Jersey | Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof |
| EP2029480B1 (en) | 2006-05-30 | 2017-05-03 | Coswell S.p.A. | Biologicallly active nanoparticles of a carbonate-substituted hydroxyapatite, process for their preparation and compositions incorporating the same |
| KR101494909B1 (ko) | 2006-09-11 | 2015-02-23 | 엔바이오 리미티드 | 표면 도핑 방법 |
| US20080221688A1 (en) * | 2007-03-09 | 2008-09-11 | Warsaw Orthopedic, Inc. | Method of Maintaining Fatigue Performance In A Bone-Engaging Implant |
| US20080221681A1 (en) * | 2007-03-09 | 2008-09-11 | Warsaw Orthopedic, Inc. | Methods for Improving Fatigue Performance of Implants With Osteointegrating Coatings |
| JP2013508262A (ja) | 2009-10-26 | 2013-03-07 | ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー | 制御可能なサイズおよび形態を有するハイドロキシアパタイト |
| CA2796274A1 (en) | 2010-04-16 | 2011-10-20 | Apatech Limited | Biomaterial |
| PT3628342T (pt) | 2010-10-26 | 2025-09-19 | Cap Biomaterials Llc | Compósitos de hidroxiapatita e carbonato de cálcio e métodos relacionados de preparação e utilização |
| US8551525B2 (en) | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
| US11805784B2 (en) | 2015-05-18 | 2023-11-07 | Ndg Natural Development Group S.R.L. | Use of hydroxyapatite as a carrier of bioactive substances for treating vascular diseases in plants |
| ITUB20150693A1 (it) * | 2015-05-18 | 2016-11-18 | Ndg Natural Dev Group S R L | Uso di idrossiapatite come veicolo di sostanze bioattive per trattare malattie vascolari nelle piante |
| CN106268614B (zh) * | 2016-10-18 | 2019-08-13 | 南京信息工程大学 | 一种镁-羟基磷灰石吸附剂的制备方法 |
| WO2018198296A1 (ja) * | 2017-04-27 | 2018-11-01 | ブレイニー株式会社 | ハイドロキシアパタイト、化粧品及び食品、並びにその製造方法 |
| CN109046238B (zh) * | 2018-07-18 | 2021-06-04 | 上海纳米技术及应用国家工程研究中心有限公司 | 复合型氨氮吸附剂的制备方法及其再生方法 |
| RU2736048C1 (ru) * | 2020-04-24 | 2020-11-11 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Способ получения наноразмерного гидроксиапатита |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0631570B2 (ja) | 1987-06-30 | 1994-04-27 | 株式会社京浜精機製作所 | 船外機用気化器 |
| JP2732055B2 (ja) * | 1987-09-24 | 1998-03-25 | 京セラ株式会社 | リン酸カルシウム系生体補綴材とその製造方法 |
| US5962028A (en) * | 1988-04-20 | 1999-10-05 | Norian Corporation | Carbonated hydroxyapatite compositions and uses |
| JP3082503B2 (ja) * | 1993-02-26 | 2000-08-28 | 株式会社神戸製鋼所 | 人工骨製造用前駆体および人工骨の製法 |
| GB9310321D0 (en) * | 1993-05-19 | 1993-06-30 | Queen Mary & Westfield College | Method for the preparation of carbonated hydroxyapatite compositions |
| US5783217A (en) * | 1995-11-07 | 1998-07-21 | Etex Corporation | Low temperature calcium phosphate apatite and a method of its manufacture |
-
1997
- 1997-12-22 GB GBGB9727048.2A patent/GB9727048D0/en not_active Ceased
-
1998
- 1998-12-17 AU AU16779/99A patent/AU1677999A/en not_active Abandoned
- 1998-12-17 DE DE69804506T patent/DE69804506T2/de not_active Expired - Lifetime
- 1998-12-17 US US09/581,202 patent/US6585946B1/en not_active Expired - Lifetime
- 1998-12-17 WO PCT/GB1998/003817 patent/WO1999032400A1/en not_active Ceased
- 1998-12-17 ES ES98961319T patent/ES2174524T3/es not_active Expired - Lifetime
- 1998-12-17 EP EP98961319A patent/EP1042222B1/en not_active Expired - Lifetime
- 1998-12-17 JP JP2000525342A patent/JP4540225B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1042222A1 (en) | 2000-10-11 |
| JP2001526169A (ja) | 2001-12-18 |
| GB9727048D0 (en) | 1998-02-18 |
| JP4540225B2 (ja) | 2010-09-08 |
| WO1999032400A1 (en) | 1999-07-01 |
| AU1677999A (en) | 1999-07-12 |
| DE69804506T2 (de) | 2002-10-31 |
| EP1042222B1 (en) | 2002-03-27 |
| US6585946B1 (en) | 2003-07-01 |
| DE69804506D1 (de) | 2002-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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