ES2173968T3 - Compuesto oxidente heterociclico de tres ciclos fusinados. - Google Patents

Compuesto oxidente heterociclico de tres ciclos fusinados.

Info

Publication number
ES2173968T3
ES2173968T3 ES95932928T ES95932928T ES2173968T3 ES 2173968 T3 ES2173968 T3 ES 2173968T3 ES 95932928 T ES95932928 T ES 95932928T ES 95932928 T ES95932928 T ES 95932928T ES 2173968 T3 ES2173968 T3 ES 2173968T3
Authority
ES
Spain
Prior art keywords
group
compound
oxidative
promising
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95932928T
Other languages
English (en)
Inventor
Shuji Jinno
Yasuyo Kogure
Hiroyuki Onuki
Takaaki Okita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissui Corp
Original Assignee
Nippon Suisan Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Suisan Kaisha Ltd filed Critical Nippon Suisan Kaisha Ltd
Application granted granted Critical
Publication of ES2173968T3 publication Critical patent/ES2173968T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/14—[b,f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)

Abstract

SE PRESENTA UN NUEVO COMPUESTO HETEROCICLICO CONDENSADO TRICICLICO QUE POSEE UNA ACCION ANTIOXIDANTE Y ES ADECUADO PARA SU USO EN AGENTES FARMACEUTICOS, COSMETICOS, PRODUCTOS QUIMICOS Y SIMILARES. MEDIANTE UNA SINTESIS QUIMICA SE OBTIENEN UN NUEVO COMPUESTO HETEROCICLICO CONDENSADO, TRICICLICO, ANTIOXIDANTE REPRESENTADO POR LA FORMULA SIGUIENTE: (EN LA QUE X E Y REPRESENTAN CH{SUB,2} ENTA O, S O S=O; DE R{SUB,1} A R{SUB,8} REPRESENTAN, INDEPENDIENTEMENTE, AQUELLOS SELECCIONADOS DEL GRUPO QUE CONSISTE EN UN ATOMO DE HIDROGENO, UN GRUPO HIDROXILO, UN GRUPO HALOGENO, UN GRUPO ALKILO INFERIOR, UN GRUPO ALCOXI INFERIOR, UN GRUPO ALKILCETONA INFERIOR Y CF{SUB,3}; AL MENOS DOS DE ENTRE R{SUB,1} A R{SUB,4} SON GRUPOS HIDROXILO); Y LAS SALES DEL MISMO. EL COMPUESTO TIENE UNA ACTIVIDAD ANTIOXIDANTE AL GRADO DE VENTA IGUAL O SUPERIOR QUE LA ACTIVIDAD DEL {AL} EL COMPUESTO ES UTIL COMO FARMACO TERAPEUTICO PARA UNA VARIEDAD DE ENFERMEDADES, TALES COMO EL CANCER, ARTERIOSCLEROSIS, O ENFERMEDADES HEPATICAS, EN LAS QUE SE CREE QUE PUEDEN INTERVENIR PEROXIDOS DE LIPIDOS BIOLOGICOS.
ES95932928T 1994-09-28 1995-09-28 Compuesto oxidente heterociclico de tres ciclos fusinados. Expired - Lifetime ES2173968T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP25878194 1994-09-28
JP3317895 1995-01-30

Publications (1)

Publication Number Publication Date
ES2173968T3 true ES2173968T3 (es) 2002-11-01

Family

ID=26371823

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95932928T Expired - Lifetime ES2173968T3 (es) 1994-09-28 1995-09-28 Compuesto oxidente heterociclico de tres ciclos fusinados.

Country Status (10)

Country Link
US (1) US5734067A (es)
EP (1) EP0805155B1 (es)
JP (1) JP3328673B2 (es)
AT (1) ATE214386T1 (es)
CA (1) CA2200598C (es)
DE (1) DE69525859T2 (es)
DK (1) DK0805155T3 (es)
ES (1) ES2173968T3 (es)
PT (1) PT805155E (es)
WO (1) WO1996010021A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997025985A1 (fr) * 1996-01-19 1997-07-24 Nippon Suisan Kaisha, Ltd. Relaxant des muscles lisses de la trachee
HUP0201203A3 (en) * 1999-06-03 2004-12-28 Nippon Suisan Kaisha Ltd Tricyclic fused heterocycle compounds, process for preparing the same and use thereof and pharmaceutical compositions containing the compounds
IL147593A0 (en) * 1999-07-19 2002-08-14 Sankyo Co Pharmaceutical compositions containing fused hetrocyclic compounds
JP2007230866A (ja) * 2004-02-20 2007-09-13 Nippon Suisan Kaisha Ltd 高尿酸血症治療剤
CA2676413A1 (en) * 2007-01-19 2008-07-31 Mallinckrodt Inc. Diagnostic and therapeutic cyclooxygenase-2 binding ligands

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0029587B1 (en) * 1979-11-27 1984-06-13 Merck Sharp & Dohme (I.A.) Corp. 3-hydroxymethyldibenzo(b,f)thiepins and dibenzo(b,f)thiepin-3-carboxaldehydes as prostaglandin antagonists, process for their preparation and pharmaceutical compositions
JPS56166180A (en) * 1980-05-28 1981-12-21 Chugai Pharmaceut Co Ltd Dibenzoxazepine derivative and its preparation
JPH05153990A (ja) * 1991-12-06 1993-06-22 Nippon Suisan Kaisha Ltd 新規ジベンゾオキセピン誘導体

Also Published As

Publication number Publication date
WO1996010021A1 (fr) 1996-04-04
CA2200598A1 (en) 1996-04-04
DE69525859D1 (de) 2002-04-18
EP0805155A4 (en) 1998-01-07
DE69525859T2 (de) 2002-10-24
US5734067A (en) 1998-03-31
JP3328673B2 (ja) 2002-09-30
DK0805155T3 (da) 2002-07-08
CA2200598C (en) 1999-12-07
EP0805155A1 (en) 1997-11-05
ATE214386T1 (de) 2002-03-15
PT805155E (pt) 2002-09-30
EP0805155B1 (en) 2002-03-13

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