ES2171985T3 - Procedimiento para la preparacion de agentes de contraste destinados a la tomografia por resonancia magnetica. - Google Patents

Procedimiento para la preparacion de agentes de contraste destinados a la tomografia por resonancia magnetica.

Info

Publication number
ES2171985T3
ES2171985T3 ES97936669T ES97936669T ES2171985T3 ES 2171985 T3 ES2171985 T3 ES 2171985T3 ES 97936669 T ES97936669 T ES 97936669T ES 97936669 T ES97936669 T ES 97936669T ES 2171985 T3 ES2171985 T3 ES 2171985T3
Authority
ES
Spain
Prior art keywords
tomography
procedure
preparation
magnetic resonance
contrast agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97936669T
Other languages
English (en)
Inventor
Werner Weitschies
Thomas Rheinlander
Wolfgang Ebert
Bernard Better
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2171985T3 publication Critical patent/ES2171985T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • B01D35/06—Filters making use of electricity or magnetism
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Water Supply & Treatment (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Manipulator (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Filtering Materials (AREA)

Abstract

LA INVENCION TRATA DE UN DISPOSITIVO PARA LA SEPARACION MAGNETICA DE PREPARACIONES FARMACEUTICAS, SUS PRODUCTOS DE PARTIDA O PRODUCTOS INTERMEDIOS, QUE CONTIENEN UN ESPACIO DE SEPARACION, EN EL CUAL REINA UN CAMPO DE GRADIENTE MAGNETICO Y TIENE UNA ENTRADA Y UNA SALIDA, TENIENDO EL DISPOSITIVO LA FORMA DE UN FILTRO ADICIONAL PARA INSTRUMENTOS DE INYECCION O DE PERFUSION.
ES97936669T 1996-08-05 1997-07-29 Procedimiento para la preparacion de agentes de contraste destinados a la tomografia por resonancia magnetica. Expired - Lifetime ES2171985T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19632416 1996-08-05

Publications (1)

Publication Number Publication Date
ES2171985T3 true ES2171985T3 (es) 2002-09-16

Family

ID=7802388

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97936669T Expired - Lifetime ES2171985T3 (es) 1996-08-05 1997-07-29 Procedimiento para la preparacion de agentes de contraste destinados a la tomografia por resonancia magnetica.

Country Status (19)

Country Link
US (2) US6517813B1 (es)
EP (1) EP0915738B1 (es)
JP (1) JP2000516131A (es)
KR (1) KR100502881B1 (es)
CN (1) CN1151846C (es)
AR (1) AR008817A1 (es)
AT (1) ATE211950T1 (es)
AU (1) AU727764B2 (es)
CA (1) CA2262685C (es)
DE (2) DE29713847U1 (es)
DK (1) DK0915738T3 (es)
ES (1) ES2171985T3 (es)
HU (1) HUP0001608A3 (es)
IL (1) IL128057A (es)
NO (1) NO318377B1 (es)
NZ (1) NZ333962A (es)
PT (1) PT915738E (es)
WO (1) WO1998005430A1 (es)
ZA (1) ZA976967B (es)

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
JP2000516131A (ja) 1996-08-05 2000-12-05 シエーリング アクチエンゲゼルシヤフト 薬剤組成物、その出発材料又は中間生成物から磁気材料を分離するための方法及び装置及びこの装置を用いて製造された薬剤
DE19938372A1 (de) * 1999-08-09 2001-03-08 Diagnostikforschung Inst Verfahren und Vorrichtung zur Trennung magnetischer Teilchen
DE10010638A1 (de) 2000-03-03 2001-09-13 Osram Opto Semiconductors Gmbh Verfahren zur Herstellung eines lichtabstrahlenden Halbleiterkörpers mit Lumineszenzkonversionselement
DE10046514A1 (de) 2000-09-15 2002-04-25 Diagnostikforschung Inst Verfahren zur bildlichen Darstellung und Diagnose von Thromben mittels Kernspintomographie unter Verwendung partikulärer Kontrastmittel
DE10137515A1 (de) * 2001-07-26 2003-02-13 Diagnostikforschung Inst Verfahren zur Herstellung pharmazeutischer Zubereitungen
EP2366455B1 (en) 2004-02-17 2015-03-25 E.I. Du Pont De Nemours And Company Magnetic field and field gradient enhanced centrifugation solid-liquid separations
CN101022931A (zh) * 2004-09-09 2007-08-22 格伦达·费伊·贝尔 食品和药品中的塑料以及弹性体的分离
US8066877B2 (en) * 2005-02-17 2011-11-29 E. I. Du Pont De Nemours And Company Apparatus for magnetic field and magnetic gradient enhanced filtration
US8075771B2 (en) * 2005-02-17 2011-12-13 E. I. Du Pont De Nemours And Company Apparatus for magnetic field gradient enhanced centrifugation
EP1738774A1 (de) * 2005-06-29 2007-01-03 Schering AG Magnetische Eisenoxidpartikel enthaltende Zusammensetzungen und deren Verwendung in bildgebenden Verfahren
EP1738773A1 (de) * 2005-06-29 2007-01-03 Schering AG Magnetische Eisenoxidpartikel enthaltende Zusammensetzung und deren Vervendung in bildgebenden Verfahren
FR2918868A1 (fr) * 2006-06-06 2009-01-23 Guerbet Sa Methode d'imagerie de diagnostic utilisant en combinaison avec l'imagerie de diffusion de l'eau, des agents de contraste
CN102178986A (zh) * 2011-04-13 2011-09-14 李明 一种血液体外循环磁性杀菌装置
CN103006589B (zh) * 2011-09-27 2015-11-25 闫亚梅 阿莫西林分散片及其生产方法
CN106975567B (zh) * 2017-05-17 2018-10-09 谢齐容 药材中铁质杂质去除装置及其方法
CN108287236B (zh) * 2017-11-24 2020-03-13 中国农业大学 一种基于高梯度磁分离和量子点的荧光生物传感器及其应用

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US3817389A (en) * 1973-01-15 1974-06-18 Sherwood Medical Ind Inc Filter device in tubular fitting for medical injection equipment and the like
JPS5913521B2 (ja) * 1975-06-19 1984-03-30 メイトウサンギヨウ カブシキガイシヤ 磁性酸化鉄・デキストラン複合体の製造法
GB8408127D0 (en) * 1984-03-29 1984-05-10 Nyegaard & Co As Contrast agents
JPS60241914A (ja) * 1984-05-16 1985-11-30 Hitachi Plant Eng & Constr Co Ltd 電磁フイルタ用耐食性濾過材
US4641517A (en) 1984-12-20 1987-02-10 United Technologies Corporation Control system actuator position synthesis for failure detection
JPS6211519A (ja) * 1985-07-05 1987-01-20 Agency Of Ind Science & Technol 磁選機用選別素子
US5055288A (en) 1987-06-26 1991-10-08 Advanced Magnetics, Inc. Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides
US5160726A (en) * 1990-02-15 1992-11-03 Advanced Magnetics Inc. Filter sterilization for production of colloidal, superparamagnetic MR contrast agents
NO159162C (no) 1986-07-29 1988-12-07 Fjeldsend As Olaf Apparat for magnetisk paavirkning av stroemmende vaeske.
US5045304A (en) * 1988-08-31 1991-09-03 Wayne State University Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same
ATE114507T1 (de) * 1988-12-28 1994-12-15 Stefan Miltenyi Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien.
US5268165A (en) * 1990-10-16 1993-12-07 Biomedical Frontiers, Inc. Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging
DE10199065I2 (de) 1991-01-19 2004-09-23 Meito Sangyo Kk Ultrafeine magnetische metalloxidteilchen enthalten de zusammensetzung
JP2939336B2 (ja) 1991-06-11 1999-08-25 名糖産業株式会社 水溶性カルボキシ多糖−磁性酸化鉄酸化複合体
US5225282A (en) * 1991-12-13 1993-07-06 Molecular Bioquest, Inc. Biodegradable magnetic microcluster comprising non-magnetic metal or metal oxide particles coated with a functionalized polymer
DK0656368T4 (da) 1992-08-05 2003-09-29 Meito Sangyo Kk Kompositmateriale med lille diameter, som indeholder et vandopløseligt carboxypolysaccharid og magnetisk jernoxid
DE4309333A1 (de) * 1993-03-17 1994-09-22 Silica Gel Gmbh Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben
EP0689430B1 (de) * 1993-03-17 1997-08-13 Silica Gel Ges.M.B.H Superparamagnetische teilchen, verfahren zu ihrer herstellung und verwendung derselben
US5411730A (en) * 1993-07-20 1995-05-02 Research Corporation Technologies, Inc. Magnetic microparticles
US5514340A (en) * 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
DE4428851C2 (de) 1994-08-04 2000-05-04 Diagnostikforschung Inst Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie
DE69421943T2 (de) * 1994-09-27 2000-05-18 Nycomed Imaging As, Oslo Kontrastmittel
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US5855868A (en) 1996-04-01 1999-01-05 Nycomed Imaging As Method of T1 -weighted resonance imaging of RES organs
JP2000516131A (ja) 1996-08-05 2000-12-05 シエーリング アクチエンゲゼルシヤフト 薬剤組成物、その出発材料又は中間生成物から磁気材料を分離するための方法及び装置及びこの装置を用いて製造された薬剤

Also Published As

Publication number Publication date
HUP0001608A1 (hu) 2000-09-28
HUP0001608A3 (en) 2001-01-29
CA2262685A1 (en) 1998-02-12
AU3941597A (en) 1998-02-25
CN1151846C (zh) 2004-06-02
EP0915738B1 (de) 2002-01-16
AR008817A1 (es) 2000-02-23
JP2000516131A (ja) 2000-12-05
ZA976967B (en) 1998-02-19
KR100502881B1 (ko) 2005-07-25
DK0915738T3 (da) 2002-05-06
CN1230136A (zh) 1999-09-29
PT915738E (pt) 2002-07-31
WO1998005430A1 (de) 1998-02-12
CA2262685C (en) 2008-09-23
NO318377B1 (no) 2005-03-14
KR20000029821A (ko) 2000-05-25
AU727764B2 (en) 2000-12-21
NO990523D0 (no) 1999-02-04
IL128057A (en) 2001-08-26
NZ333962A (en) 2000-07-28
EP0915738A1 (de) 1999-05-19
DE29713847U1 (de) 1997-12-18
IL128057A0 (en) 1999-11-30
US6517813B1 (en) 2003-02-11
DE59706019D1 (de) 2002-02-21
US20030108613A1 (en) 2003-06-12
ATE211950T1 (de) 2002-02-15
NO990523L (no) 1999-03-30

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