ES2171985T3 - Procedimiento para la preparacion de agentes de contraste destinados a la tomografia por resonancia magnetica. - Google Patents

Procedimiento para la preparacion de agentes de contraste destinados a la tomografia por resonancia magnetica.

Info

Publication number
ES2171985T3
ES2171985T3 ES97936669T ES97936669T ES2171985T3 ES 2171985 T3 ES2171985 T3 ES 2171985T3 ES 97936669 T ES97936669 T ES 97936669T ES 97936669 T ES97936669 T ES 97936669T ES 2171985 T3 ES2171985 T3 ES 2171985T3
Authority
ES
Spain
Prior art keywords
tomography
procedure
preparation
magnetic resonance
contrast agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97936669T
Other languages
English (en)
Inventor
Werner Weitschies
Thomas Rheinlander
Wolfgang Ebert
Bernard Better
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2171985T3 publication Critical patent/ES2171985T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • B01D35/06—Filters making use of electricity or magnetism
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Water Supply & Treatment (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Filtering Materials (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Manipulator (AREA)

Abstract

LA INVENCION TRATA DE UN DISPOSITIVO PARA LA SEPARACION MAGNETICA DE PREPARACIONES FARMACEUTICAS, SUS PRODUCTOS DE PARTIDA O PRODUCTOS INTERMEDIOS, QUE CONTIENEN UN ESPACIO DE SEPARACION, EN EL CUAL REINA UN CAMPO DE GRADIENTE MAGNETICO Y TIENE UNA ENTRADA Y UNA SALIDA, TENIENDO EL DISPOSITIVO LA FORMA DE UN FILTRO ADICIONAL PARA INSTRUMENTOS DE INYECCION O DE PERFUSION.
ES97936669T 1996-08-05 1997-07-29 Procedimiento para la preparacion de agentes de contraste destinados a la tomografia por resonancia magnetica. Expired - Lifetime ES2171985T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19632416 1996-08-05

Publications (1)

Publication Number Publication Date
ES2171985T3 true ES2171985T3 (es) 2002-09-16

Family

ID=7802388

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97936669T Expired - Lifetime ES2171985T3 (es) 1996-08-05 1997-07-29 Procedimiento para la preparacion de agentes de contraste destinados a la tomografia por resonancia magnetica.

Country Status (19)

Country Link
US (2) US6517813B1 (es)
EP (1) EP0915738B1 (es)
JP (1) JP2000516131A (es)
KR (1) KR100502881B1 (es)
CN (1) CN1151846C (es)
AR (1) AR008817A1 (es)
AT (1) ATE211950T1 (es)
AU (1) AU727764B2 (es)
CA (1) CA2262685C (es)
DE (2) DE59706019D1 (es)
DK (1) DK0915738T3 (es)
ES (1) ES2171985T3 (es)
HU (1) HUP0001608A3 (es)
IL (1) IL128057A (es)
NO (1) NO318377B1 (es)
NZ (1) NZ333962A (es)
PT (1) PT915738E (es)
WO (1) WO1998005430A1 (es)
ZA (1) ZA976967B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59706019D1 (de) * 1996-08-05 2002-02-21 Schering Ag Vorrichtung und verfahren zur abtrennung magnetischer materialien aus pharmazeutischen zubereitungen, deren ausgangs- oder zwischenprodukten sowie mit hilfe dieser vorrichtung hergestellte mittel
DE19938372A1 (de) * 1999-08-09 2001-03-08 Diagnostikforschung Inst Verfahren und Vorrichtung zur Trennung magnetischer Teilchen
DE10010638A1 (de) 2000-03-03 2001-09-13 Osram Opto Semiconductors Gmbh Verfahren zur Herstellung eines lichtabstrahlenden Halbleiterkörpers mit Lumineszenzkonversionselement
DE10046514A1 (de) 2000-09-15 2002-04-25 Diagnostikforschung Inst Verfahren zur bildlichen Darstellung und Diagnose von Thromben mittels Kernspintomographie unter Verwendung partikulärer Kontrastmittel
DE10137515A1 (de) * 2001-07-26 2003-02-13 Diagnostikforschung Inst Verfahren zur Herstellung pharmazeutischer Zubereitungen
WO2006107288A2 (en) 2004-02-17 2006-10-12 E.I.Dupont De Nemours And Company Magnetic field enhanced cake-filtration solid-liquid separations
JP2008512655A (ja) * 2004-09-09 2008-04-24 ベル，グレンダ，フェイ 食品および医薬品用のプラスチックおよびエラストマーの分離
US8066877B2 (en) * 2005-02-17 2011-11-29 E. I. Du Pont De Nemours And Company Apparatus for magnetic field and magnetic gradient enhanced filtration
US8075771B2 (en) * 2005-02-17 2011-12-13 E. I. Du Pont De Nemours And Company Apparatus for magnetic field gradient enhanced centrifugation
EP1738774A1 (de) * 2005-06-29 2007-01-03 Schering AG Magnetische Eisenoxidpartikel enthaltende Zusammensetzungen und deren Verwendung in bildgebenden Verfahren
EP1738773A1 (de) * 2005-06-29 2007-01-03 Schering AG Magnetische Eisenoxidpartikel enthaltende Zusammensetzung und deren Vervendung in bildgebenden Verfahren
FR2918868A1 (fr) 2006-06-06 2009-01-23 Guerbet Sa Methode d'imagerie de diagnostic utilisant en combinaison avec l'imagerie de diffusion de l'eau, des agents de contraste
CN102178986A (zh) * 2011-04-13 2011-09-14 李明 一种血液体外循环磁性杀菌装置
CN103006589B (zh) * 2011-09-27 2015-11-25 闫亚梅 阿莫西林分散片及其生产方法
CN106975567B (zh) * 2017-05-17 2018-10-09 谢齐容 药材中铁质杂质去除装置及其方法
CN108287236B (zh) * 2017-11-24 2020-03-13 中国农业大学 一种基于高梯度磁分离和量子点的荧光生物传感器及其应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817389A (en) * 1973-01-15 1974-06-18 Sherwood Medical Ind Inc Filter device in tubular fitting for medical injection equipment and the like
JPS5913521B2 (ja) * 1975-06-19 1984-03-30 メイトウサンギヨウ カブシキガイシヤ 磁性酸化鉄・デキストラン複合体の製造法
GB8408127D0 (en) * 1984-03-29 1984-05-10 Nyegaard & Co As Contrast agents
JPS60241914A (ja) * 1984-05-16 1985-11-30 Hitachi Plant Eng & Constr Co Ltd 電磁フイルタ用耐食性濾過材
US4641517A (en) 1984-12-20 1987-02-10 United Technologies Corporation Control system actuator position synthesis for failure detection
JPS6211519A (ja) * 1985-07-05 1987-01-20 Agency Of Ind Science & Technol 磁選機用選別素子
US5160726A (en) * 1990-02-15 1992-11-03 Advanced Magnetics Inc. Filter sterilization for production of colloidal, superparamagnetic MR contrast agents
US5055288A (en) 1987-06-26 1991-10-08 Advanced Magnetics, Inc. Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides
NO159162C (no) 1986-07-29 1988-12-07 Fjeldsend As Olaf Apparat for magnetisk paavirkning av stroemmende vaeske.
US5045304A (en) * 1988-08-31 1991-09-03 Wayne State University Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same
ES2067018T3 (es) * 1988-12-28 1995-03-16 Stefan Miltenyi Procedimiento y materiales para la separacion en alto gradiente magnetico de materiales biologicos.
US5268165A (en) * 1990-10-16 1993-12-07 Biomedical Frontiers, Inc. Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging
WO1992012735A1 (fr) 1991-01-19 1992-08-06 Meito Sangyo Kabushiki Kaisha Composition contenant des particules ultra fines d'oxyde de metal magnetique
EP0543020B1 (en) 1991-06-11 1997-12-29 Meito Sangyo Kabushiki Kaisha Oxidized composite comprising water-soluble carboxypolysaccharide and magnetic iron oxide
US5225282A (en) * 1991-12-13 1993-07-06 Molecular Bioquest, Inc. Biodegradable magnetic microcluster comprising non-magnetic metal or metal oxide particles coated with a functionalized polymer
ES2130406T5 (es) 1992-08-05 2003-12-16 Meito Sangyo Kk Material compuesto de pequeño diametro compuesto de carboxipolisacarido soluble en agua y oxido de hierro magnetico.
DE4309333A1 (de) * 1993-03-17 1994-09-22 Silica Gel Gmbh Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben
DE59403734D1 (de) * 1993-03-17 1997-09-18 Silica Gel Gmbh Superparamagnetische teilchen, verfahren zu ihrer herstellung und verwendung derselben
US5411730A (en) * 1993-07-20 1995-05-02 Research Corporation Technologies, Inc. Magnetic microparticles
US5514340A (en) * 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
DE4428851C2 (de) 1994-08-04 2000-05-04 Diagnostikforschung Inst Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie
AU687093B2 (en) * 1994-09-27 1998-02-19 Nycomed Imaging As Contrast agent
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US5855868A (en) 1996-04-01 1999-01-05 Nycomed Imaging As Method of T1 -weighted resonance imaging of RES organs
DE59706019D1 (de) 1996-08-05 2002-02-21 Schering Ag Vorrichtung und verfahren zur abtrennung magnetischer materialien aus pharmazeutischen zubereitungen, deren ausgangs- oder zwischenprodukten sowie mit hilfe dieser vorrichtung hergestellte mittel

Also Published As

Publication number Publication date
PT915738E (pt) 2002-07-31
CN1230136A (zh) 1999-09-29
WO1998005430A1 (de) 1998-02-12
KR100502881B1 (ko) 2005-07-25
AR008817A1 (es) 2000-02-23
US20030108613A1 (en) 2003-06-12
CA2262685C (en) 2008-09-23
HUP0001608A3 (en) 2001-01-29
NO990523L (no) 1999-03-30
ATE211950T1 (de) 2002-02-15
IL128057A (en) 2001-08-26
AU727764B2 (en) 2000-12-21
IL128057A0 (en) 1999-11-30
NO990523D0 (no) 1999-02-04
JP2000516131A (ja) 2000-12-05
KR20000029821A (ko) 2000-05-25
HUP0001608A1 (hu) 2000-09-28
NZ333962A (en) 2000-07-28
CN1151846C (zh) 2004-06-02
CA2262685A1 (en) 1998-02-12
AU3941597A (en) 1998-02-25
DE29713847U1 (de) 1997-12-18
EP0915738A1 (de) 1999-05-19
US6517813B1 (en) 2003-02-11
DE59706019D1 (de) 2002-02-21
DK0915738T3 (da) 2002-05-06
ZA976967B (en) 1998-02-19
NO318377B1 (no) 2005-03-14
EP0915738B1 (de) 2002-01-16

Similar Documents

Publication Publication Date Title
ES2171985T3 (es) Procedimiento para la preparacion de agentes de contraste destinados a la tomografia por resonancia magnetica.
CY1108740T1 (el) ΕΞΑΝΘΡΩΠΙΣΜΕΝΑ ΑΝΤΙΣΩΜΑΤΑ ΤΑ ΟΠΟΙΑ ΑΝΑΓΝΩΡΙΖΟΥΝ ΤΟ ΠΕΠΤΙΔΙΟ β-ΑΜΥΛΟΕΙΔΟΥΣ
ES2189873T3 (es) Agentes de imagen de resonancia magnetica para la deteccion de agentes fisiologicos.
ATE268187T1 (de) Bioaktivierte diagnostische bilderzeugungskontrastmittel
BR0000126A (pt) Adjuvantes para uso em vacinas
UY29282A1 (es) Anticuerpos humanizados que reconocen el peptido beta amiloideo
UY27721A1 (es) Anticuerpos humanizados que reconocen el peptido amiloide beta.
BR0016022A (pt) Vacina para a prevenção e tratamento da doença de alzheimer e doenças relacionadas ao amilóide
MX9207222A (es) Procedimiento para la preparacion de compuestos farmaceuticos que reducen selectivamente el nivel de lipidos de la sangre.
BR0115482A (pt) Composição de sacralose melhorada e processo para sua preparação
MX9701969A (es) Recipiente con composicion de multiples fase para usarse en aplicaciones de diagnostico y terapeuticas.
DE69102912D1 (de) Tragbare Pumpe zur Verabreichung therapeutischer Flüssigkeiten.
BR9610262A (pt) Compostos e métodos para a imunoterapia e diagnose de tuberculose
AR003415A1 (es) Compuestos analogos de lactacistina, metodo para inhibir la proteolisis dependiente de proteasoma, metodo para identificar un proceso biologico mediado por proteolisis dependiente de proteasoma, uso de dichos compuestos para preparar un medicamento para tratar una condicion mediada por proteolisis dependiente de proteasoma.
SE9903185D0 (sv) Terapeutisk metod och anordning baserad på magnetism
ES2172572T3 (es) Emulsion farmaceutica.
FI953442A0 (fi) Gonadotropiinia sisältäviä pakastekuivattuja pallosia
DE69534049D1 (de) System zur Bildgebung mittels magnetischer Resonanz
DE59610469D1 (de) Vorrichtung zur Verabreichung von Substanzen, insbesondere Inhalationspräparate
AR032074A1 (es) Microparticulas lipidicas por micronizacion criogenica
NO20002115D0 (no) Magnetisk resonansavbilding for leveringen av terapeutiske midler
GEP20053423B (en) Method of Inhibiting Amyloid Protein Aggregation and Method for Imaging of Amyloid Deposits
DK1353948T3 (da) Oplöselige biologiske analoge til bata-amyloidpeptid
AR030662A1 (es) Beta-tio-alfa-aminoacidos, procedimiento para su fabricacion, medicamentos que contienen estos compuestos y el uso de los tioaminoacidos para la preparacion de medicamentos
DE60037258D1 (de) System zur verwaltung des endpunktschlages

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 915738

Country of ref document: ES