ES2171389T3 - Derivados anticonvulsivos de aminoacidos. - Google Patents

Derivados anticonvulsivos de aminoacidos.

Info

Publication number
ES2171389T3
ES2171389T3 ES90109596T ES90109596T ES2171389T3 ES 2171389 T3 ES2171389 T3 ES 2171389T3 ES 90109596 T ES90109596 T ES 90109596T ES 90109596 T ES90109596 T ES 90109596T ES 2171389 T3 ES2171389 T3 ES 2171389T3
Authority
ES
Spain
Prior art keywords
lower alkyl
aryl
unsubstituted
substituted
electron donating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90109596T
Other languages
English (en)
Inventor
Harold L Kohn
Darrell Watson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Application granted granted Critical
Publication of ES2171389T3 publication Critical patent/ES2171389T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

LA PRESENTE INVENCION ES RELATIVA A COMPUESTOS QUE EXHIBEN ACTIVIDAD SOBRE EL SISTEMA NERVIOSO CENTRAL (CNS), LOS CUALES SE USAN EN EL TRATAMIENTO DE LA EPILEPSIA Y OTROS DESORDENES CNS. LOS COMPUESTOS DE ESTA INVENCION TIENEN LA SIGUIENTE FORMULA GENERAL: Y SALES FARMACEUTICAMENTE ACEPTABLES DE ELLA, EN DONDE R ES ARILO, ARILO ALQUILO INFERIOR, HETEROCICLICO O HETEROCICLICO ALQUILO INFERIOR, EN DONDE R NO ESTA SUSTITUIDO O ESTA SUSTITUIDO CON AL MENOS UN GRUPO CAPTADOR DE ELECTRONES O UN GRUPO DONANTE DE ELECTRONES; R1 ES HIDROGENO O ALQUILO INFERIOR Y R1 ESTA SUSTITUIDO O NO SUSTITUIDO CON AL MENOS UN SUSTITUYENTE DONANTE DE ELECTRONES O AL MENOS UN SUSTITUYENTE DONANDO ELECTRONES; R2 Y R3 SON INDEPENDIENTEMENTE CADA UNO HIDROGENO, ALQUENILO INFERIOR, ALQUINILO INFERIOR, ARILO ALQUILO INFERIOR, HETEROCICLICO-, HETEROCICLICO- ALQUILO INFERIOR, O Z-Y, EN DONDE R2 Y R3 PUEDEN ESTAR SUSTITUIDOS O NO SUSTITUIDOS CON AL MENOS UN GRUPO CAPTADOR DE ELECTRONES, O UN GRUPO DONANTE DE ELECTRONES;Z ES O,S,NR4,PR4 O UN ENLACE QUIMICO; Y ES HIDROGENO, ALQUILO INFERIOR, ARILO, ARILO ALQUILO INFERIOR, ALQUENILO INFERIOR, ALQUINILO INFERIOR, O RADICAL HALOGENO, E Y PUEDE ESTAR SUSTITUIDO O NO SUSTITUIDO CON AL MENOS UN GRUPO CAPTADOR DE ELECTRONES O, CON UN GRUPO DONANTE DE ELECTRONES; PROVISTO QUE CUANDO Y ES HALOGENO, Z ES UN ENLACE QUIMICO O, ZY JUNTOS SON NR4NR5R6, NR4OR5, ONR4R5, OPR4R5, PR4OR5, SNR4R5, NR4SR5, SPR4R5, PR4SR5, NR4PR5R6 O, PR4NR5R6, R4,R5 Y R6 SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO INFERIOR, ARILO, ARILO ALQUILO INFERIOR, ALQUENILO INFERIOR, ALQUINILO INFERIOR, Y R4, R5 Y R6 PUEDEN ESTAR SUSTITUIDOS O NO SUSTITUIDOS CON UN GRUPO CAPTADOR DE ELECTRONES O UN GRUPO DONANTE DE ELECTRONES Y N ES 1-4.
ES90109596T 1989-05-19 1990-05-21 Derivados anticonvulsivos de aminoacidos. Expired - Lifetime ES2171389T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35405789A 1989-05-19 1989-05-19

Publications (1)

Publication Number Publication Date
ES2171389T3 true ES2171389T3 (es) 2002-09-16

Family

ID=23391718

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90109596T Expired - Lifetime ES2171389T3 (es) 1989-05-19 1990-05-21 Derivados anticonvulsivos de aminoacidos.

Country Status (10)

Country Link
EP (1) EP0400440B1 (es)
JP (1) JPH03506045A (es)
AT (1) ATE214384T1 (es)
CA (1) CA2017217C (es)
DE (1) DE69033931T2 (es)
DK (1) DK0400440T3 (es)
ES (1) ES2171389T3 (es)
NZ (1) NZ233728A (es)
PT (1) PT94103B (es)
WO (1) WO1990015069A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378729A (en) 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
US7902401B2 (en) 2006-12-14 2011-03-08 Nps Pharmaceuticals, Inc. Fluorinated compounds
EP2037965B1 (en) 2006-06-15 2017-08-30 UCB Pharma GmbH Pharmaceutical composition with synergistic anticonvulsant effect
US8450336B2 (en) 2006-12-14 2013-05-28 Nps Pharmaceuticals, Inc Use of D-serine derivatives for the treatment of anxiety disorders
CN103201263A (zh) 2010-09-08 2013-07-10 匹兹堡高等教育联邦体系大学 p53-Mdm2拮抗剂
CN108864038A (zh) * 2018-06-12 2018-11-23 浙江大学 3-酰胺基-n-芳基苯甲酰胺类化合物及制备和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH513123A (de) * 1967-09-25 1971-09-30 Bayer Ag Verfahren zur Herstellung von N-Acyl-a-aminosäureamiden bzw. -peptiden
US3887543A (en) * 1970-12-07 1975-06-03 Yoshitomi Pharmaceutical Thieno(2,3-E)(1,4)diazepine derivatives
FR2489319A1 (fr) * 1980-08-27 1982-03-05 Clin Midy Derives de l'acide amino-4 butyrique et les medicaments, actifs notamment sur le systeme nerveux central, en contenant
EP0194464B1 (en) * 1985-02-15 1991-04-03 Research Corporation Technologies, Inc. (a Delaware corp.) Amino acid derivatives and use thereof for the preparation of an anticonvulsant
NZ222045A (en) * 1986-08-21 1989-10-27 Res Corp Technologies Inc From diamides up to tetrapeptides for use as anticanvulsants
US4873241A (en) * 1988-10-31 1989-10-10 Fisons Corporation 2-amino-N-(2-phenylindan-2-yl)acetamides useful as anti-epileptics

Also Published As

Publication number Publication date
WO1990015069A2 (en) 1990-12-13
WO1990015069A3 (en) 1991-02-07
EP0400440A1 (en) 1990-12-05
ATE214384T1 (de) 2002-03-15
CA2017217C (en) 2002-02-19
CA2017217A1 (en) 1990-11-19
DK0400440T3 (da) 2002-07-01
PT94103B (pt) 1997-01-31
JPH03506045A (ja) 1991-12-26
DE69033931D1 (de) 2002-04-18
NZ233728A (en) 1993-04-28
AU641160B2 (en) 1993-09-16
AU5519590A (en) 1991-02-28
DE69033931T2 (de) 2002-11-28
PT94103A (pt) 1991-01-08
EP0400440B1 (en) 2002-03-13

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