ES2170967T3 - Procedimiento para la produccion de 2h-1-benzopiranos. - Google Patents

Procedimiento para la produccion de 2h-1-benzopiranos.

Info

Publication number
ES2170967T3
ES2170967T3 ES97944779T ES97944779T ES2170967T3 ES 2170967 T3 ES2170967 T3 ES 2170967T3 ES 97944779 T ES97944779 T ES 97944779T ES 97944779 T ES97944779 T ES 97944779T ES 2170967 T3 ES2170967 T3 ES 2170967T3
Authority
ES
Spain
Prior art keywords
group
renting
general formula
formula
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97944779T
Other languages
English (en)
Inventor
Pierre Bossard
Frances Finney
Michael Gottsponer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of ES2170967T3 publication Critical patent/ES2170967T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/723,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE PRODUCCION DE 2H-1-BENZOPIRANOS DE FORMULA GENERAL (I), DONDE R1 ES HIDROGENO, UN GRUPO ALQUILO (C1-C4); R2 ES HIDROGENO, UN GRUPO ALQUILO (C1-C6) Y R3 ES HIDROGENO, UN GRUPO ALQUILO (C1-C4), UN GRUPO HALOALQUILO (C1-C4), UN GRUPO ALQUENILO (C2-C4), UN GRUPO ALCOXICARBONILO (C1-C4), UN GRUPO ALCOXIMETILO (C1-C4), UN GRUPO ALCANOILO (C1-C4), UN GRUPO ALCOXI (C1-C4), UN GRUPO ALQUILSULFONILO (C1-C4), HALOGENO, AMINO, ALQUILAMINO, DIALQUILAMINO, NITRILO, NITRO O HIDROXILO. DICHO PROCEDIMIENTO SE CARACTERIZA PORQUE, EN UNA PRIMERA FASE UN ALDEHIDO ALIFATICO DE FORMULA GENERAL (II), DONDE R1 Y R2 TIENEN LOS SIGNIFICADOS ANTERIORMENTE INDICADOS, SE TRANSFORMA CON UN ALCOHOL ALIFATICO DE FORMULA R4 OH O HO R4 OH, DONDE R4 ES UN GRUPO ALQUILO (C1-C4) O UN GRUPO ALQUILDIILO (C2-C4), EN PRESENCIA DE UN COMPUESTO DESHIDRATANTE DE FORMULA HC(OR5)3 , DONDE R5 ES UN GRUPO ALQUILO (C1-C4), Y UN CATALIZADOR DE OXIDO DE ALUMINIO/OXIDO DE SILICIO, EN UN ACETAL ALIFATICO DE FORMULA (III). EN ESTA ULTIMA R1 Y R2 TIENEN LOS SIGNIFICADOS INDICADOS ANTERIORMENTE Y R4 , COMO SE DETALLO ANTERIORMENTE, ES UN GRUPO ALQUILO (C1-C4), O BIEN LOS DOS R4 CONJUNTAMENTE FORMAN UN GRUPO ALQUILDIILO (C2-C4) CICLICO, Y ESTE SE COND ENSA A CONTINUACION EN UNA SEGUNDA FASE, CON UN FENOL DE FORMULA GENERAL (IV), DONDE R3 TIENE EL SIGNIFICADO DETALLADO ANTERIORMENTE, EN PRESENCIA DE UNA BASE, EN UN DISOLVENTE ORGANICO, HASTA PRODUCIR EL PRODUCTO FINAL DE FORMULA GENERAL (I).
ES97944779T 1996-08-13 1997-08-13 Procedimiento para la produccion de 2h-1-benzopiranos. Expired - Lifetime ES2170967T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH198496 1996-08-13

Publications (1)

Publication Number Publication Date
ES2170967T3 true ES2170967T3 (es) 2002-08-16

Family

ID=4223194

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97944779T Expired - Lifetime ES2170967T3 (es) 1996-08-13 1997-08-13 Procedimiento para la produccion de 2h-1-benzopiranos.

Country Status (21)

Country Link
EP (1) EP0882035B1 (es)
CN (1) CN1103768C (es)
AP (1) AP1006A (es)
AT (1) ATE211739T1 (es)
AU (1) AU714918B2 (es)
BG (1) BG63570B1 (es)
CO (1) CO4900048A1 (es)
CZ (1) CZ292668B6 (es)
DE (1) DE69709542T2 (es)
DK (1) DK0882035T3 (es)
EA (1) EA000696B1 (es)
ES (1) ES2170967T3 (es)
HK (1) HK1020438A1 (es)
HU (1) HU223351B1 (es)
MX (1) MX9803775A (es)
NZ (1) NZ330341A (es)
PE (1) PE107298A1 (es)
PT (1) PT882035E (es)
SK (1) SK281933B6 (es)
UA (1) UA49855C2 (es)
WO (1) WO1998006713A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005014586A1 (en) * 2003-08-08 2005-02-17 Arpida Ag Novel process for the preparation of 2h-chromenes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW310327B (es) * 1993-06-18 1997-07-11 Bristol Myers Squibb Co

Also Published As

Publication number Publication date
EP0882035A1 (en) 1998-12-09
AU714918B2 (en) 2000-01-13
CZ146998A3 (cs) 1998-10-14
AP1006A (en) 2001-08-29
EA199800370A1 (ru) 1998-10-29
HU223351B1 (hu) 2004-06-28
WO1998006713A1 (en) 1998-02-19
HUP9902584A2 (hu) 2001-05-28
DE69709542T2 (de) 2002-08-22
CZ292668B6 (cs) 2003-11-12
EP0882035B1 (en) 2002-01-09
BG63570B1 (bg) 2002-05-31
MX9803775A (es) 1998-09-30
BG102442A (en) 1999-04-30
ATE211739T1 (de) 2002-01-15
HK1020438A1 (en) 2000-04-20
EA000696B1 (ru) 2000-02-28
CO4900048A1 (es) 2000-03-27
NZ330341A (en) 2000-02-28
CN1103768C (zh) 2003-03-26
PT882035E (pt) 2002-06-28
HUP9902584A3 (en) 2001-06-28
AP9801232A0 (en) 1998-06-30
PE107298A1 (es) 1999-03-20
DE69709542D1 (de) 2002-02-14
SK61298A3 (en) 1998-12-02
DK0882035T3 (da) 2002-04-29
CN1205007A (zh) 1999-01-13
AU4617997A (en) 1998-03-06
UA49855C2 (uk) 2002-10-15
SK281933B6 (sk) 2001-09-11

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