ES2168092T3 - Procedimientos de ensayo que utilizan la luminiscencia inducida. - Google Patents

Procedimientos de ensayo que utilizan la luminiscencia inducida.

Info

Publication number
ES2168092T3
ES2168092T3 ES92304630T ES92304630T ES2168092T3 ES 2168092 T3 ES2168092 T3 ES 2168092T3 ES 92304630 T ES92304630 T ES 92304630T ES 92304630 T ES92304630 T ES 92304630T ES 2168092 T3 ES2168092 T3 ES 2168092T3
Authority
ES
Spain
Prior art keywords
analyte
pacc
medium
sbp
luminiscence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92304630T
Other languages
English (en)
Inventor
Edwin F Ullman
Hrair Kirakossian
John S Pease
Daniel B Wagner
Yuri Daniloff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Dade Behring Marburg GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/704,569 external-priority patent/US6251581B1/en
Priority claimed from US07/718,490 external-priority patent/US5340716A/en
Application filed by Dade Behring Marburg GmbH filed Critical Dade Behring Marburg GmbH
Application granted granted Critical
Publication of ES2168092T3 publication Critical patent/ES2168092T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Nanotechnology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Luminescent Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

SE DESCRIBEN METODOS PARA LA DETERMINACION DE UNA ANALITA EN UN MEDIO QUE SE SOSPECHA CONTIENE LA ANALITA. UN METODO COMPRENDE EL TRATAMIENTO DE UN MEDIO QUE SE SOSPECHA CONTIENE UNA ANALITA BAJO CONDICIONES TALES QUE LA ANALITA; SI ESTA PRESENTE, HACE QUE UN FOTOSENSIBILIZADOR Y UN COMPUESTO QUIMICOLUMINISCENTE SE PONGAN EN CONTACTO. EL FOTOSENSIBILIZADOR GENERA OXIGENO DE SINGLETE Y ACTIVA EL COMPUESTO QUIMICOLUMINISCENTE CUANDO ESTA EN CONTACTO. POR CONSIGUIENTE LOS COMPUESTOS QUIMICOLUMINISCENTES ACTIVADOS PRODUCEN LUZ. LA CANTIDAD DE LUZ PRODUCIDA ESTA RELACIONADA CON LA CANTIDAD DE ANALITA EN EL MEDIO. PREFERIBLEMENTE, AL MENOS UN COMPUESTO DEL FOTOSENSIBILIZADOR Y EL QUIMICOLUMINISCENTE ESTA ASOCIADO A UNA SUPERFICIE QUE ES NORMALMENTE UNA PARTICULA SUSPENDIBLE, Y UN ELEMENTO DEL PAR DE FUSION ESPECIFICO ESTA LIMITADO A LA MISMA. OTRO METODO COMPRENDE EL PROPORCIONAR (1) UN MEDIO QUE SE SOSPECHA CONTIENE LA ANALITA, (2) UN REACTIVO DE ETIQUETA QUE COMPRENDE UN PRIMER ELEMENTO DEL PARDE FUSION ESPECIFICO (PFS) ASOCIADO A UN COMPUESTO QUIMICOLUMINISCENTE ACTIVABLE FOTOQUIMICAMENTE EN DONDE EL PRIMER ELEMENTO PFS ES CAPAZ DE FUNDIR LA PRIMERA ANALITA O UN SEGUNDO ELEMENTO PFS PARA FORMAR UN COMPLEJO RELACIONADO EN LA PRESENCIA DE LA ANALITA. ESTE METODO COMPRENDE ADEMAS LA ACTIVACION FOTOQUIMICAMENTE DEL COMPUESTO QUIMICOLUMINISCENTE. SE DETECTA LA CANTIDAD DE LUMINISCENCIA GENERADA POR EL COMPUESTO QUIMICOLUMINISCENTE. LA CANTIDAD DEL MISMO ESTA RELACIONADA CON LA CANTIDAD DE ANALITA EN EL MEDIO. TAMBIEN SE DESCRIBEN COMPOSICIONES Y APARATOS.
ES92304630T 1991-05-22 1992-05-21 Procedimientos de ensayo que utilizan la luminiscencia inducida. Expired - Lifetime ES2168092T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/704,569 US6251581B1 (en) 1991-05-22 1991-05-22 Assay method utilizing induced luminescence
US07/718,490 US5340716A (en) 1991-06-20 1991-06-20 Assay method utilizing photoactivated chemiluminescent label

Publications (1)

Publication Number Publication Date
ES2168092T3 true ES2168092T3 (es) 2002-06-01

Family

ID=27107346

Family Applications (3)

Application Number Title Priority Date Filing Date
ES92304630T Expired - Lifetime ES2168092T3 (es) 1991-05-22 1992-05-21 Procedimientos de ensayo que utilizan la luminiscencia inducida.
ES99121547T Expired - Lifetime ES2280110T3 (es) 1991-05-22 1992-05-21 Procedimiento para determinar un analito en una muestra.
ES99121551T Expired - Lifetime ES2204050T3 (es) 1991-05-22 1992-05-21 Particulas que tienen una composicion incorporada que comprende un compuesto quimioluminiscente.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES99121547T Expired - Lifetime ES2280110T3 (es) 1991-05-22 1992-05-21 Procedimiento para determinar un analito en una muestra.
ES99121551T Expired - Lifetime ES2204050T3 (es) 1991-05-22 1992-05-21 Particulas que tienen una composicion incorporada que comprende un compuesto quimioluminiscente.

Country Status (10)

Country Link
EP (4) EP0515194B1 (es)
JP (1) JP3892912B2 (es)
AT (3) ATE208039T1 (es)
AU (1) AU657134B2 (es)
CA (1) CA2069145C (es)
DE (3) DE69232161T2 (es)
DK (1) DK0984282T3 (es)
ES (3) ES2168092T3 (es)
IL (1) IL101945A (es)
PT (1) PT984282E (es)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578498A (en) * 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
JP3464798B2 (ja) * 1992-07-31 2003-11-10 デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 光活性化化学発光基質
CA2170873A1 (en) * 1993-09-03 1995-03-09 Dariush Davalian Fluorescent oxygen channeling immunoassays
US5783453A (en) * 1995-06-29 1998-07-21 Chiron Diagnostics Corporation Non-separation specific binding chemiluminescent assay
EP0793970A1 (en) * 1996-03-08 1997-09-10 Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srk Photodynamic inactivation of viruses
EP0852012B1 (en) * 1996-05-01 2006-07-26 Dade Behring Marburg GmbH Chemiluminescent compositions and their use in the detection of hydrogen peroxide
DE19756782A1 (de) 1997-12-19 1999-06-24 Dade Behring Marburg Gmbh Nachweis und Bestimmung festphasenassoziierter Faktoren
DE19756773A1 (de) 1997-12-19 1999-06-24 Dade Behring Marburg Gmbh Neues Verfahren und Diagnosemittel zur Hämostase-Diagnostik
US6365346B1 (en) * 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
WO1999042838A1 (en) 1998-02-18 1999-08-26 Dade Behring Inc. Chemiluminescent compositions for use in detection of multiple analytes
DE19811017A1 (de) 1998-03-13 1999-09-16 Dade Behring Marburg Gmbh Neues Verfahren zur Bestimmung von Plasmaproteinen und Faktoren der Hämostase sowie ein neues, implantierbares Meßgerät
US6303325B1 (en) 1998-05-29 2001-10-16 Dade Behring Inc. Method for detecting analytes
AUPP405098A0 (en) * 1998-06-12 1998-07-02 Access Pharmaceuticals Australia Pty Limited Novel methods of preparation of vitamin b12 derivatives suitable for conjugation to pharmaceuticals
US6703248B1 (en) * 1999-12-15 2004-03-09 Dade Behring Marburg Gmbh Particles for diagnostic and therapeutic use
EP1110970B1 (de) 1999-12-22 2008-05-14 Dade Behring Marburg GmbH Gegen Procalcitonin gerichtete Antikörper, ihre Herstellung und Verwendung
EP1111050B1 (de) 1999-12-22 2007-03-14 Dade Behring Marburg GmbH Lösungen von humanem Procalcitonin
CA2401360A1 (en) * 2000-02-28 2001-08-30 Daiichi Pure Chemicals Co., Ltd. Method for measurement by using long-lived excitation fluorescence
ES2287006T3 (es) 2000-03-06 2007-12-16 Dade Behring Marburg Gmbh Vehiculos revestidos con polisacaridos, su preparacion y uso.
US6346384B1 (en) * 2000-03-27 2002-02-12 Dade Behring Inc. Real-time monitoring of PCR using LOCI
JP4796259B2 (ja) * 2000-05-04 2011-10-19 シーメンス・ヘルスケア・ダイアグノスティックス・プロダクツ・ゲーエムベーハー 複数のアナライトの検出において使用するための組成物
DE10064827A1 (de) 2000-12-22 2002-06-27 Dade Behring Marburg Gmbh Nachweisverfahren
NZ528714A (en) * 2001-03-16 2005-07-29 Univ Utah Res Found Fluorescent cobalamins and uses thereof to detect cancerous cells
WO2004005917A1 (ja) 2002-07-08 2004-01-15 Daiichi Pure Chemicals Co., Ltd. 蛍光プローブ
US6764819B2 (en) * 2002-07-16 2004-07-20 Emp Biotech Gmbh Method for chemiluminescent detection
US7696245B2 (en) 2003-03-28 2010-04-13 Sekisui Medical Co., Ltd. Fluorescent probe for zinc
WO2005062048A1 (de) 2003-12-01 2005-07-07 Dade Behring Marburg Gmbh Homogenes nachweisverfahren
JP2005194244A (ja) 2004-01-09 2005-07-21 Shigenobu Yano 亜鉛イオン蛍光センサー
DE102005026163A1 (de) 2004-08-24 2006-03-02 Dade Behring Marburg Gmbh Gegen den Marburg I Polymorphismus der Faktor VII aktivierenden Protease (FSAP) gerichtete Antikörper, ihre Herstellung und Verwendung
DE102004042124B4 (de) * 2004-08-30 2006-07-06 Dade Behring Marburg Gmbh Homogenes Verfahren zur Bestimmung eines Analyten in Gegenwart eines Überschusses von kreuzreagierenden Substanzen
JP2008513794A (ja) * 2004-09-17 2008-05-01 ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド 三価金属媒介均一発光近接アッセイ
US20060166376A1 (en) 2005-01-21 2006-07-27 Craig Alan R Compositions for use as a signal generation component and methods of using same
US7682839B2 (en) * 2005-03-14 2010-03-23 Lumigen, Inc. Methods using novel chemiluminescent labels
IL168184A (en) * 2005-04-21 2011-11-30 Univ Ariel Res & Dev Co Ltd Use of a ligand-photosensitizer conjugate in combination with a chemiluminescent agent in the manufacture of a medicament for photodynamic therapy
DE102005022047A1 (de) 2005-05-09 2006-11-30 Dade Behring Marburg Gmbh Bindungspartner des Plazentalen Wachstumsfaktors insbesondere gegen den Plazentalen Wachstumsfaktor gerichtete Antikörper, ihre Herstellung und Verwendung
GB0520436D0 (en) * 2005-10-07 2005-11-16 Photobiotics Ltd Biological materials and uses thereof
US7732153B2 (en) * 2006-05-09 2010-06-08 Beckman Coulter, Inc. Nonseparation assay methods
JP5553615B2 (ja) * 2007-03-01 2014-07-16 アボット・ラボラトリーズ プロゾーン現象の低減を示すイムノアッセイ
DE102007017906A1 (de) 2007-04-17 2008-10-23 Dade Behring Marburg Gmbh Verfahren zur Bestimmung der Reaktions-Lag-Phase in einer analytabhängigen Reaktion
US7790401B2 (en) * 2007-08-06 2010-09-07 Siemens Healthcare Diagnostics Methods for detection of immunosuppressant drugs
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
DE102008049601A1 (de) 2008-09-30 2010-04-01 Siemens Healthcare Diagnostics Products Gmbh Antikörper zur Bestimmung des Prothrombin-Fragments F2/F1+2 in einem homogenen Immunoassay
EP2177624A1 (en) * 2008-10-02 2010-04-21 Siemens Healthcare Diagnostics Products GmbH Blood coagulation assays
JP5419775B2 (ja) * 2010-03-30 2014-02-19 日本電信電話株式会社 測定用基板、並びに、これを用いた生化学的結合形成および生化学的結合量の測定方法
EP2395354A1 (de) 2010-06-10 2011-12-14 Siemens Healthcare Diagnostics Products GmbH Homogener Aktivitätstest zur Bestimmung von enzymatischen Reaktionen
EP2471945A1 (de) 2010-12-30 2012-07-04 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Bestimmung von Inhibitoren der Gerinnung
RU2473885C2 (ru) * 2011-02-02 2013-01-27 Государственное образовательное учреждение высшего профессионального образования "Самарский государственный университет" Количественный анализ тиомочевины и флуоресцеина натрия при их совместном присутствии в пластовых водах
DE102011007546A1 (de) 2011-04-15 2012-10-18 Humboldt-Universität Zu Berlin Messvorrichtung für eine Messung einer Singulettsauerstoff-Lumineszenz
WO2013044099A1 (en) 2011-09-23 2013-03-28 Siemens Healthcare Diagnostics Inc. Cell response assay for cancer and methods of producing and using same
EP2708892B1 (de) 2012-09-18 2015-04-15 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Bestimmung Plättchen-assoziierter Analyten
DE102012220083B3 (de) * 2012-11-05 2014-03-06 Technische Universität Dresden Verfahren und System zum direkten, strahlungslosen Energietransfer über flüssige Phasengrenzen
WO2014152322A1 (en) 2013-03-15 2014-09-25 Siemens Healthcare Diagnostics Inc. Heterogeneous luminescent oxygen channeling immunoassays
EP2790019A1 (de) 2013-04-10 2014-10-15 Siemens Healthcare Diagnostics Products GmbH High Dose Hook Erkennung
US10124072B2 (en) * 2013-09-18 2018-11-13 Caliper Life Sciences, Inc. In-vivo reactive species imaging
GB201319180D0 (en) * 2013-10-30 2013-12-11 Mast Group Ltd Nucleic acid probe
EP2919013B1 (de) 2014-03-11 2016-11-02 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Detektion von Modulatoren der GPIb-Thrombin-Interaktion
ES2884930T3 (es) * 2014-03-26 2021-12-13 Siemens Healthcare Diagnostics Inc Inmunoensayo de canalización de oxígeno luminiscente utilizando tres anticuerpos y métodos de producción y uso de los mismos
EP2955517A1 (de) 2014-06-10 2015-12-16 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Stabilisierung von Körperflüssigkeitsproben durch die Zugabe von Detergenz
WO2018106959A1 (en) * 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
ES2826394T3 (es) 2017-06-09 2021-05-18 Siemens Healthcare Diagnostics Products Gmbh Ensayo de activación para el diagnóstico de una trombocitopenia inducida por heparina
ES2862434T3 (es) 2017-08-02 2021-10-07 Siemens Healthcare Diagnostics Products Gmbh Prueba de unión para el diagnóstico de trombocitopenia inducida por heparina
WO2019043553A1 (en) * 2017-08-31 2019-03-07 3M Innovative Properties Company IDENTIFICATION OF MACHINE READABLE PERIODIC PATTERNS
EP3514541A1 (de) 2018-01-17 2019-07-24 Siemens Healthcare Diagnostics Products GmbH Verfahren zur quantitativen bestimmung eines therapeutischen tnf-alpha inhibitors
CN108676555B (zh) * 2018-05-28 2020-11-20 青岛农业大学 一种含铕离子液体红光材料及制备方法和应用
CN110736737A (zh) * 2018-07-18 2020-01-31 博阳生物科技（上海）有限公司 一种用于化学发光检测的微球组合物及其应用
CN116577512A (zh) * 2019-07-19 2023-08-11 科美博阳诊断技术(上海)有限公司 一种供体试剂在诊断主体心肌损伤中的用途
CN116859057A (zh) * 2019-12-31 2023-10-10 科美诊断技术(苏州)有限公司 一种肌红蛋白的均相检测试剂盒及其应用
US11733219B2 (en) * 2020-03-19 2023-08-22 Industrial Technology Research Institute Detection reagent, detection device, and method for detecting primary amide compound
CN111795960B (zh) * 2020-08-10 2022-08-09 齐齐哈尔大学 一种光谱法和比色法检测不同形式碘的分子平台及其制备方法和应用
KR20230172515A (ko) * 2021-05-07 2023-12-22 주식회사 씨젠 현탁액에서의 자성 비드 농도 결정 방법 및 시스템
EP4239338A1 (de) 2022-03-03 2023-09-06 Siemens Healthcare Diagnostics Products GmbH Globaltest zur feststellung des status des blutgerinnungssystems
EP4325224A1 (de) 2022-08-18 2024-02-21 Siemens Healthcare Diagnostics Products GmbH Thrombozytenaktivierungstest zur diagnose einer heparin-induzierten thrombozytopenie
CN116429752A (zh) * 2023-02-13 2023-07-14 科美博阳诊断技术(上海)有限公司 Afp检测试剂盒及其使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3720622A (en) * 1970-01-02 1973-03-13 American Cyanamid Co Generation of light from the decomposition of dioxetaneones in the presence of a fluorescer
AU517292B2 (en) * 1978-06-20 1981-07-23 Syva Co. Fluorescence quenching system
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
CA1273552A (en) * 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US4959182A (en) * 1986-07-17 1990-09-25 Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US5004565A (en) * 1986-07-17 1991-04-02 The Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US5616729A (en) * 1986-07-17 1997-04-01 Board Of Governors Of Wayne State University Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers
US4891324A (en) * 1987-01-07 1990-01-02 Syntex (U.S.A.) Inc. Particle with luminescer for assays
US4881191A (en) * 1987-01-13 1989-11-14 Hewlett-Packard Company Multichannel decimation/interpolation filter
JP2681061B2 (ja) * 1988-06-08 1997-11-19 ロンドン・ダイアグノスティック・インコーポレーテッド 検出可能なシグナルのセンシタイザー誘導発生を利用したアッセイ
EP0441948A4 (en) * 1989-09-06 1992-06-03 Tropix, Inc. Synthesis of stable, water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
WO1991005605A1 (en) 1989-10-10 1991-05-02 Kosak Kenneth M Cyclodextrin labels for immunoassay and biochemical analysis
DE69125992T2 (de) * 1990-09-14 1997-08-21 Tosoh Corp Verfahren und Kit für Immunoassay

Also Published As

Publication number Publication date
CA2069145C (en) 2007-07-31
EP0515194B1 (en) 2001-10-31
DE69232161D1 (de) 2001-12-06
DE69232161T2 (de) 2002-05-16
PT984282E (pt) 2003-12-31
EP0984281A2 (en) 2000-03-08
ATE246360T1 (de) 2003-08-15
AU657134B2 (en) 1995-03-02
EP0984282B1 (en) 2003-07-30
JP3892912B2 (ja) 2007-03-14
EP1418430A3 (en) 2004-09-01
EP0984281A3 (en) 2000-06-07
ATE350665T1 (de) 2007-01-15
DE69233674T2 (de) 2007-10-18
DE69233146D1 (de) 2003-09-04
CA2069145A1 (en) 1992-11-23
JPH05180773A (ja) 1993-07-23
IL101945A0 (en) 1992-12-30
EP0984282A2 (en) 2000-03-08
EP1418430A2 (en) 2004-05-12
EP0515194A3 (en) 1993-10-20
ES2204050T3 (es) 2004-04-16
DK0984282T3 (da) 2003-11-17
EP0984282A3 (en) 2000-06-07
ES2280110T3 (es) 2007-09-01
AU1706892A (en) 1992-11-26
EP0984281B1 (en) 2007-01-03
EP0515194A2 (en) 1992-11-25
DE69233674D1 (de) 2007-02-15
DE69233146T2 (de) 2004-04-29
ATE208039T1 (de) 2001-11-15
IL101945A (en) 1998-02-08

Similar Documents

Publication Publication Date Title
ES2168092T3 (es) Procedimientos de ensayo que utilizan la luminiscencia inducida.
DE69616243D1 (de) Testvorrichtung mit einem stabilen Kopplungsfarbstoff zur Bestimmung von Analyten
DE69535522D1 (de) Kupplungsfarbstoff zur spektrophotometrischen Bestimmung von Analyten
ATE204383T1 (de) Eine integrierte vorrichtung fuer packungshalter fuer immunochromatographische assays in durchfluss - oder teststreifen-ausfuehrung
LV10538A (lv) Imunologiski saistamas vielas noteiksanas panemiens biologiska skidruma un diagnostikas lidzeklis
DE69623458T2 (de) Einstufige immunochromatographische vorrichtung und verfahren zu ihrer verwendung
DE69521104T2 (de) Spezifische Bindungstests und Reagenzien dafür
CA2131317A1 (en) Test for Helicobacter Pylori
BR9811406A (pt) Dispositivo para detenção da presença de pelo menos um analito em uma amostra biológica, kit para detenção da presença de pelo menos um analito em uma amostra biológica, e, processo de detecção da presença de pelo menos um analito em uma amostra biológica
ATE254286T1 (de) Zwei-inkubations mit markiertem antigen verwendenes immunoassay
NO20011353L (no) Cobalamin-måling
ATE157403T1 (de) Reagenz zur bestimmung von (1-3)-beta-glucan
ES2056132T3 (es) Agente para ensayos inmunoquimicos que contiene oxidos de amina.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 515194

Country of ref document: ES