ES2166447T3 - Acrilonitrilos diheterociclicos como inhibidores de la proliferacion de las celulas de la musculatura lisa. - Google Patents

Acrilonitrilos diheterociclicos como inhibidores de la proliferacion de las celulas de la musculatura lisa.

Info

Publication number
ES2166447T3
ES2166447T3 ES96917921T ES96917921T ES2166447T3 ES 2166447 T3 ES2166447 T3 ES 2166447T3 ES 96917921 T ES96917921 T ES 96917921T ES 96917921 T ES96917921 T ES 96917921T ES 2166447 T3 ES2166447 T3 ES 2166447T3
Authority
ES
Spain
Prior art keywords
proliferation
inhibitors
cells
diheterociclic
acrylonitrils
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96917921T
Other languages
English (en)
Inventor
Hassan Mahmoud Elokdah
Chai Sie-Yearl
Theodore Sylvester Sulkowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2166447T3 publication Critical patent/ES2166447T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCUBREN COMPUESTOS DE FORMULA (I) EN LOS QUE AR 1} Y AR SUB,2} SON, INDEPENDIENTEMENTE, PIRIDINILO, QUINOLINILO, DIHIDRO - 1,4 - BENZODIOXINILO, PIRROLILO, AZAINDOLILO O CARBAZOLILO, O SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, QUE SON UTILES COMO INHIBIDORES DE LA PROLIFERACION DE CELULAS DEL MUSCULO LISO.
ES96917921T 1995-06-06 1996-06-03 Acrilonitrilos diheterociclicos como inhibidores de la proliferacion de las celulas de la musculatura lisa. Expired - Lifetime ES2166447T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/470,603 US5710164A (en) 1995-06-06 1995-06-06 Diheterocyclic styryl nitriles

Publications (1)

Publication Number Publication Date
ES2166447T3 true ES2166447T3 (es) 2002-04-16

Family

ID=23868264

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96917921T Expired - Lifetime ES2166447T3 (es) 1995-06-06 1996-06-03 Acrilonitrilos diheterociclicos como inhibidores de la proliferacion de las celulas de la musculatura lisa.

Country Status (19)

Country Link
US (1) US5710164A (es)
EP (1) EP0835244B1 (es)
JP (1) JPH11506754A (es)
KR (1) KR19990022523A (es)
CN (1) CN1192202A (es)
AR (1) AR002750A1 (es)
AT (1) ATE210120T1 (es)
AU (1) AU711619B2 (es)
BR (1) BR9608976A (es)
CA (1) CA2223388A1 (es)
DE (1) DE69617686T2 (es)
ES (1) ES2166447T3 (es)
HU (1) HUP9900660A3 (es)
IL (1) IL118386A0 (es)
MX (1) MX9709462A (es)
NZ (1) NZ309995A (es)
PT (1) PT835244E (es)
WO (1) WO1996039387A1 (es)
ZA (1) ZA964620B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4496586B2 (ja) * 2000-01-24 2010-07-07 日産化学工業株式会社 キノリルアクリロニトリルの製造法及びその中間体
US8124625B2 (en) 2001-09-14 2012-02-28 Shionogi & Co., Ltd. Method of enhancing the expression of apolipoprotein AI using olefin derivatives
BRPI0609420A2 (pt) * 2005-03-30 2010-03-30 Yakult Honsha Kk inibidor de bcrp/abcg2

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302606A (en) * 1990-04-16 1994-04-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase
WO1991016051A1 (en) * 1990-04-16 1991-10-31 Rhône-Poulenc Rorer International (Holdings) Inc. Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit egf receptor tyrosine kinase
CA2080582A1 (en) * 1990-04-16 1991-10-17 Alfred P. Spada Heterocyclicethenediyl compounds which inhibit egf receptor tyrosine kinase

Also Published As

Publication number Publication date
DE69617686T2 (de) 2002-08-08
CA2223388A1 (en) 1996-12-12
BR9608976A (pt) 1999-06-29
DE69617686D1 (de) 2002-01-17
US5710164A (en) 1998-01-20
EP0835244B1 (en) 2001-12-05
KR19990022523A (ko) 1999-03-25
MX9709462A (es) 1998-02-28
EP0835244A1 (en) 1998-04-15
AU6030496A (en) 1996-12-24
NZ309995A (en) 2000-07-28
ATE210120T1 (de) 2001-12-15
JPH11506754A (ja) 1999-06-15
ZA964620B (en) 1997-12-04
CN1192202A (zh) 1998-09-02
AU711619B2 (en) 1999-10-21
IL118386A0 (en) 1996-09-12
HUP9900660A2 (hu) 2000-03-28
WO1996039387A1 (en) 1996-12-12
AR002750A1 (es) 1998-04-29
PT835244E (pt) 2002-04-29
HUP9900660A3 (en) 2001-09-28

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