IL118386A0 - Diheterocyclic styryl nitriles and pharmaceutical compositions containing them - Google Patents

Diheterocyclic styryl nitriles and pharmaceutical compositions containing them

Info

Publication number
IL118386A0
IL118386A0 IL11838696A IL11838696A IL118386A0 IL 118386 A0 IL118386 A0 IL 118386A0 IL 11838696 A IL11838696 A IL 11838696A IL 11838696 A IL11838696 A IL 11838696A IL 118386 A0 IL118386 A0 IL 118386A0
Authority
IL
Israel
Prior art keywords
diheterocyclic
styryl
nitriles
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL11838696A
Other languages
English (en)
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of IL118386A0 publication Critical patent/IL118386A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57Nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL11838696A 1995-06-06 1996-05-22 Diheterocyclic styryl nitriles and pharmaceutical compositions containing them IL118386A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/470,603 US5710164A (en) 1995-06-06 1995-06-06 Diheterocyclic styryl nitriles

Publications (1)

Publication Number Publication Date
IL118386A0 true IL118386A0 (en) 1996-09-12

Family

ID=23868264

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11838696A IL118386A0 (en) 1995-06-06 1996-05-22 Diheterocyclic styryl nitriles and pharmaceutical compositions containing them

Country Status (19)

Country Link
US (1) US5710164A (es)
EP (1) EP0835244B1 (es)
JP (1) JPH11506754A (es)
KR (1) KR19990022523A (es)
CN (1) CN1192202A (es)
AR (1) AR002750A1 (es)
AT (1) ATE210120T1 (es)
AU (1) AU711619B2 (es)
BR (1) BR9608976A (es)
CA (1) CA2223388A1 (es)
DE (1) DE69617686T2 (es)
ES (1) ES2166447T3 (es)
HU (1) HUP9900660A3 (es)
IL (1) IL118386A0 (es)
MX (1) MX9709462A (es)
NZ (1) NZ309995A (es)
PT (1) PT835244E (es)
WO (1) WO1996039387A1 (es)
ZA (1) ZA964620B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4496586B2 (ja) * 2000-01-24 2010-07-07 日産化学工業株式会社 キノリルアクリロニトリルの製造法及びその中間体
US8124625B2 (en) 2001-09-14 2012-02-28 Shionogi & Co., Ltd. Method of enhancing the expression of apolipoprotein AI using olefin derivatives
EP2332905B1 (en) * 2005-03-30 2017-03-01 Kabushiki Kaisha Yakult Honsha BCRP/ABCG2 Inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302606A (en) * 1990-04-16 1994-04-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase
EP0527181A4 (en) * 1990-04-16 1993-04-07 Rorer International (Holdings) Heterocyclicethenediyl compounds which inhibit egf receptor tyrosine kinase
WO1991016051A1 (en) * 1990-04-16 1991-10-31 Rhône-Poulenc Rorer International (Holdings) Inc. Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit egf receptor tyrosine kinase

Also Published As

Publication number Publication date
ES2166447T3 (es) 2002-04-16
DE69617686T2 (de) 2002-08-08
ATE210120T1 (de) 2001-12-15
WO1996039387A1 (en) 1996-12-12
ZA964620B (en) 1997-12-04
US5710164A (en) 1998-01-20
AU6030496A (en) 1996-12-24
MX9709462A (es) 1998-02-28
KR19990022523A (ko) 1999-03-25
EP0835244B1 (en) 2001-12-05
DE69617686D1 (de) 2002-01-17
HUP9900660A3 (en) 2001-09-28
BR9608976A (pt) 1999-06-29
NZ309995A (en) 2000-07-28
EP0835244A1 (en) 1998-04-15
AU711619B2 (en) 1999-10-21
JPH11506754A (ja) 1999-06-15
HUP9900660A2 (hu) 2000-03-28
PT835244E (pt) 2002-04-29
CA2223388A1 (en) 1996-12-12
AR002750A1 (es) 1998-04-29
CN1192202A (zh) 1998-09-02

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