ATE210120T1 - Dihetrocyclische acrylonitrile als inhibitoren der glatten muskelzellen-proliferation - Google Patents
Dihetrocyclische acrylonitrile als inhibitoren der glatten muskelzellen-proliferationInfo
- Publication number
- ATE210120T1 ATE210120T1 AT96917921T AT96917921T ATE210120T1 AT E210120 T1 ATE210120 T1 AT E210120T1 AT 96917921 T AT96917921 T AT 96917921T AT 96917921 T AT96917921 T AT 96917921T AT E210120 T1 ATE210120 T1 AT E210120T1
- Authority
- AT
- Austria
- Prior art keywords
- dihetrocyclic
- acrylonitriles
- inhibitors
- cell proliferation
- smooth muscle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/470,603 US5710164A (en) | 1995-06-06 | 1995-06-06 | Diheterocyclic styryl nitriles |
| PCT/US1996/008376 WO1996039387A1 (en) | 1995-06-06 | 1996-06-03 | Diheterocyclic acrylonitriles as smooth muscle cell proliferation inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE210120T1 true ATE210120T1 (de) | 2001-12-15 |
Family
ID=23868264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96917921T ATE210120T1 (de) | 1995-06-06 | 1996-06-03 | Dihetrocyclische acrylonitrile als inhibitoren der glatten muskelzellen-proliferation |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5710164A (de) |
| EP (1) | EP0835244B1 (de) |
| JP (1) | JPH11506754A (de) |
| KR (1) | KR19990022523A (de) |
| CN (1) | CN1192202A (de) |
| AR (1) | AR002750A1 (de) |
| AT (1) | ATE210120T1 (de) |
| AU (1) | AU711619B2 (de) |
| BR (1) | BR9608976A (de) |
| CA (1) | CA2223388A1 (de) |
| DE (1) | DE69617686T2 (de) |
| ES (1) | ES2166447T3 (de) |
| HU (1) | HUP9900660A3 (de) |
| IL (1) | IL118386A0 (de) |
| MX (1) | MX9709462A (de) |
| NZ (1) | NZ309995A (de) |
| PT (1) | PT835244E (de) |
| WO (1) | WO1996039387A1 (de) |
| ZA (1) | ZA964620B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4496586B2 (ja) * | 2000-01-24 | 2010-07-07 | 日産化学工業株式会社 | キノリルアクリロニトリルの製造法及びその中間体 |
| US8124625B2 (en) | 2001-09-14 | 2012-02-28 | Shionogi & Co., Ltd. | Method of enhancing the expression of apolipoprotein AI using olefin derivatives |
| US8697742B2 (en) * | 2005-03-30 | 2014-04-15 | Kabushiki Kaisha Yakult Honsha | BCRP/ABCG2 inhibitor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0525109A4 (en) * | 1990-04-16 | 1993-06-30 | Rhone-Poulenc Rorer International (Holdings) Inc. | Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit egf receptor tyrosine kinase |
| US5302606A (en) * | 1990-04-16 | 1994-04-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase |
| CA2080582A1 (en) * | 1990-04-16 | 1991-10-17 | Alfred P. Spada | Heterocyclicethenediyl compounds which inhibit egf receptor tyrosine kinase |
-
1995
- 1995-06-06 US US08/470,603 patent/US5710164A/en not_active Expired - Lifetime
-
1996
- 1996-05-22 IL IL11838696A patent/IL118386A0/xx unknown
- 1996-05-30 AR ARP960102800A patent/AR002750A1/es unknown
- 1996-06-03 JP JP9500995A patent/JPH11506754A/ja active Pending
- 1996-06-03 WO PCT/US1996/008376 patent/WO1996039387A1/en not_active Application Discontinuation
- 1996-06-03 CN CN96195887A patent/CN1192202A/zh active Pending
- 1996-06-03 CA CA002223388A patent/CA2223388A1/en not_active Abandoned
- 1996-06-03 HU HU9900660A patent/HUP9900660A3/hu unknown
- 1996-06-03 NZ NZ309995A patent/NZ309995A/en unknown
- 1996-06-03 AU AU60304/96A patent/AU711619B2/en not_active Ceased
- 1996-06-03 AT AT96917921T patent/ATE210120T1/de not_active IP Right Cessation
- 1996-06-03 KR KR1019970709004A patent/KR19990022523A/ko not_active Application Discontinuation
- 1996-06-03 EP EP96917921A patent/EP0835244B1/de not_active Expired - Lifetime
- 1996-06-03 ES ES96917921T patent/ES2166447T3/es not_active Expired - Lifetime
- 1996-06-03 DE DE69617686T patent/DE69617686T2/de not_active Expired - Fee Related
- 1996-06-03 BR BR9608976A patent/BR9608976A/pt not_active Application Discontinuation
- 1996-06-03 PT PT96917921T patent/PT835244E/pt unknown
- 1996-06-03 MX MX9709462A patent/MX9709462A/es unknown
- 1996-06-04 ZA ZA9604620A patent/ZA964620B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU711619B2 (en) | 1999-10-21 |
| ES2166447T3 (es) | 2002-04-16 |
| CA2223388A1 (en) | 1996-12-12 |
| JPH11506754A (ja) | 1999-06-15 |
| DE69617686D1 (de) | 2002-01-17 |
| ZA964620B (en) | 1997-12-04 |
| EP0835244B1 (de) | 2001-12-05 |
| DE69617686T2 (de) | 2002-08-08 |
| IL118386A0 (en) | 1996-09-12 |
| AR002750A1 (es) | 1998-04-29 |
| US5710164A (en) | 1998-01-20 |
| WO1996039387A1 (en) | 1996-12-12 |
| AU6030496A (en) | 1996-12-24 |
| MX9709462A (es) | 1998-02-28 |
| HUP9900660A2 (hu) | 2000-03-28 |
| CN1192202A (zh) | 1998-09-02 |
| EP0835244A1 (de) | 1998-04-15 |
| HUP9900660A3 (en) | 2001-09-28 |
| PT835244E (pt) | 2002-04-29 |
| BR9608976A (pt) | 1999-06-29 |
| NZ309995A (en) | 2000-07-28 |
| KR19990022523A (ko) | 1999-03-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |