DE69617686D1 - Dihetrocyclische acrylonitrile als inhibitoren der glatten muskelzellen-proliferation - Google Patents
Dihetrocyclische acrylonitrile als inhibitoren der glatten muskelzellen-proliferationInfo
- Publication number
- DE69617686D1 DE69617686D1 DE69617686T DE69617686T DE69617686D1 DE 69617686 D1 DE69617686 D1 DE 69617686D1 DE 69617686 T DE69617686 T DE 69617686T DE 69617686 T DE69617686 T DE 69617686T DE 69617686 D1 DE69617686 D1 DE 69617686D1
- Authority
- DE
- Germany
- Prior art keywords
- dihetrocyclic
- acrylonitrile
- inhibitors
- smooth muscle
- muscle proliferation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/470,603 US5710164A (en) | 1995-06-06 | 1995-06-06 | Diheterocyclic styryl nitriles |
| PCT/US1996/008376 WO1996039387A1 (en) | 1995-06-06 | 1996-06-03 | Diheterocyclic acrylonitriles as smooth muscle cell proliferation inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69617686D1 true DE69617686D1 (de) | 2002-01-17 |
| DE69617686T2 DE69617686T2 (de) | 2002-08-08 |
Family
ID=23868264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69617686T Expired - Fee Related DE69617686T2 (de) | 1995-06-06 | 1996-06-03 | Dihetrocyclische acrylonitrile als inhibitoren der glatten muskelzellen-proliferation |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5710164A (de) |
| EP (1) | EP0835244B1 (de) |
| JP (1) | JPH11506754A (de) |
| KR (1) | KR19990022523A (de) |
| CN (1) | CN1192202A (de) |
| AR (1) | AR002750A1 (de) |
| AT (1) | ATE210120T1 (de) |
| AU (1) | AU711619B2 (de) |
| BR (1) | BR9608976A (de) |
| CA (1) | CA2223388A1 (de) |
| DE (1) | DE69617686T2 (de) |
| ES (1) | ES2166447T3 (de) |
| HU (1) | HUP9900660A3 (de) |
| IL (1) | IL118386A0 (de) |
| MX (1) | MX9709462A (de) |
| NZ (1) | NZ309995A (de) |
| PT (1) | PT835244E (de) |
| WO (1) | WO1996039387A1 (de) |
| ZA (1) | ZA964620B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4496586B2 (ja) * | 2000-01-24 | 2010-07-07 | 日産化学工業株式会社 | キノリルアクリロニトリルの製造法及びその中間体 |
| US8124625B2 (en) | 2001-09-14 | 2012-02-28 | Shionogi & Co., Ltd. | Method of enhancing the expression of apolipoprotein AI using olefin derivatives |
| EP2332905B1 (de) * | 2005-03-30 | 2017-03-01 | Kabushiki Kaisha Yakult Honsha | BCRP/ABCG2-Inhibitor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5302606A (en) * | 1990-04-16 | 1994-04-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase |
| EP0527181A4 (en) * | 1990-04-16 | 1993-04-07 | Rorer International (Holdings) | Heterocyclicethenediyl compounds which inhibit egf receptor tyrosine kinase |
| WO1991016051A1 (en) * | 1990-04-16 | 1991-10-31 | Rhône-Poulenc Rorer International (Holdings) Inc. | Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit egf receptor tyrosine kinase |
-
1995
- 1995-06-06 US US08/470,603 patent/US5710164A/en not_active Expired - Lifetime
-
1996
- 1996-05-22 IL IL11838696A patent/IL118386A0/xx unknown
- 1996-05-30 AR ARP960102800A patent/AR002750A1/es unknown
- 1996-06-03 ES ES96917921T patent/ES2166447T3/es not_active Expired - Lifetime
- 1996-06-03 EP EP96917921A patent/EP0835244B1/de not_active Expired - Lifetime
- 1996-06-03 MX MX9709462A patent/MX9709462A/es unknown
- 1996-06-03 NZ NZ309995A patent/NZ309995A/en unknown
- 1996-06-03 WO PCT/US1996/008376 patent/WO1996039387A1/en not_active Application Discontinuation
- 1996-06-03 CA CA002223388A patent/CA2223388A1/en not_active Abandoned
- 1996-06-03 PT PT96917921T patent/PT835244E/pt unknown
- 1996-06-03 AU AU60304/96A patent/AU711619B2/en not_active Ceased
- 1996-06-03 DE DE69617686T patent/DE69617686T2/de not_active Expired - Fee Related
- 1996-06-03 BR BR9608976A patent/BR9608976A/pt not_active Application Discontinuation
- 1996-06-03 CN CN96195887A patent/CN1192202A/zh active Pending
- 1996-06-03 KR KR1019970709004A patent/KR19990022523A/ko not_active Application Discontinuation
- 1996-06-03 JP JP9500995A patent/JPH11506754A/ja active Pending
- 1996-06-03 AT AT96917921T patent/ATE210120T1/de not_active IP Right Cessation
- 1996-06-03 HU HU9900660A patent/HUP9900660A3/hu unknown
- 1996-06-04 ZA ZA9604620A patent/ZA964620B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2166447T3 (es) | 2002-04-16 |
| DE69617686T2 (de) | 2002-08-08 |
| ATE210120T1 (de) | 2001-12-15 |
| WO1996039387A1 (en) | 1996-12-12 |
| IL118386A0 (en) | 1996-09-12 |
| ZA964620B (en) | 1997-12-04 |
| US5710164A (en) | 1998-01-20 |
| AU6030496A (en) | 1996-12-24 |
| MX9709462A (es) | 1998-02-28 |
| KR19990022523A (ko) | 1999-03-25 |
| EP0835244B1 (de) | 2001-12-05 |
| HUP9900660A3 (en) | 2001-09-28 |
| BR9608976A (pt) | 1999-06-29 |
| NZ309995A (en) | 2000-07-28 |
| EP0835244A1 (de) | 1998-04-15 |
| AU711619B2 (en) | 1999-10-21 |
| JPH11506754A (ja) | 1999-06-15 |
| HUP9900660A2 (hu) | 2000-03-28 |
| PT835244E (pt) | 2002-04-29 |
| CA2223388A1 (en) | 1996-12-12 |
| AR002750A1 (es) | 1998-04-29 |
| CN1192202A (zh) | 1998-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: WYETH (N.D.GES.D. STAATES DELAWARE), MADISON, N.J. |
|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |