ES2164875T3 - Poliaminas lineales sustituidas con piperidinil-2-alquilo para la reduccion de niveles de poliaminas endogenas intracelulares, tales como putrescina, espermidina y espermina, y su impacto sobre la profileracion celular. - Google Patents

Poliaminas lineales sustituidas con piperidinil-2-alquilo para la reduccion de niveles de poliaminas endogenas intracelulares, tales como putrescina, espermidina y espermina, y su impacto sobre la profileracion celular.

Info

Publication number
ES2164875T3
ES2164875T3 ES96906733T ES96906733T ES2164875T3 ES 2164875 T3 ES2164875 T3 ES 2164875T3 ES 96906733 T ES96906733 T ES 96906733T ES 96906733 T ES96906733 T ES 96906733T ES 2164875 T3 ES2164875 T3 ES 2164875T3
Authority
ES
Spain
Prior art keywords
polyamins
piperidinil
endogen
putrescine
spermine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96906733T
Other languages
English (en)
Inventor
Jorg Frei
Jaroslav Stanek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2164875T3 publication Critical patent/ES2164875T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION TRATA DE COMPUESTOS DE FORMULA (I), EN LA CUAL R{SUB,1} ES HIDROGENO Y R{SUB,2} ES ALQUILO INFERIOR, ALQUENILO INFERIOR O ALQUINILO INFERIOR, M ES 3 O 4, Y N ES 2 O 3; O R{SUB,1} Y R{SUB,2} JUNTOS SON TETRAMETILENO, M ES 3 O 4, Y N ES 2; O LAS SALES DE LOS MISMOS. LOS COMPUESTOS DE FORMULA (I) INFLUYEN EN LA BIOSINTESIS DE POLIAMINAS, Y POSEEN ACTIVIDAD ANTIPROLIFERATIVA Y ADEMAS ACTUAN CONTRA PROTOZOOS.
ES96906733T 1995-03-15 1996-03-04 Poliaminas lineales sustituidas con piperidinil-2-alquilo para la reduccion de niveles de poliaminas endogenas intracelulares, tales como putrescina, espermidina y espermina, y su impacto sobre la profileracion celular. Expired - Lifetime ES2164875T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH74495 1995-03-15

Publications (1)

Publication Number Publication Date
ES2164875T3 true ES2164875T3 (es) 2002-03-01

Family

ID=4194199

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96906733T Expired - Lifetime ES2164875T3 (es) 1995-03-15 1996-03-04 Poliaminas lineales sustituidas con piperidinil-2-alquilo para la reduccion de niveles de poliaminas endogenas intracelulares, tales como putrescina, espermidina y espermina, y su impacto sobre la profileracion celular.

Country Status (11)

Country Link
US (1) US5834486A (es)
EP (1) EP0815081B1 (es)
JP (1) JP3979664B2 (es)
AT (1) ATE206396T1 (es)
AU (1) AU5003096A (es)
CA (1) CA2212118C (es)
DE (1) DE69615669T2 (es)
DK (1) DK0815081T3 (es)
ES (1) ES2164875T3 (es)
PT (1) PT815081E (es)
WO (1) WO1996028425A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197961B1 (en) 1996-10-07 2001-03-06 Koei Chemical Co., Ltd. Process for preparing acid salts of γ-(piperidyl)butyric acid
US5843959A (en) * 1997-03-19 1998-12-01 University Of Florida Research Foundation, Inc. Methods and bicyclic polyamine compositions for the treatment of inflammation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2739981A (en) * 1952-08-26 1956-03-27 American Home Prod Diamines and salts thereof
US3872171A (en) * 1971-05-24 1975-03-18 Pfizer Polyamines as antiviral agents in animals
US4315859A (en) * 1979-01-15 1982-02-16 Ciba-Geigy Corporation 1,3,5-Triazines containing at least one piperidine radical
GB2104059A (en) * 1981-08-19 1983-03-02 Merrell Toraude & Co Acetylenic diaminobutane derivatives
GB2104060A (en) * 1981-08-19 1983-03-02 Merrell Toraude & Co Fluorinated hexene diamine derivatives
JPS6325654A (ja) * 1986-07-18 1988-02-03 Fuji Photo Film Co Ltd カラ−写真現像液組成物及びハロゲン化銀カラ−写真感光材料の処理方法
US5091576A (en) * 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
CA1305425C (en) * 1986-12-02 1992-07-21 Raymond J. Bergeron Anti-neoplastic spermine derivative
WO1988006641A1 (en) * 1987-02-25 1988-09-07 Aquanautics Corporation Polyalkylamine complexes for ligand extraction and generation
DE68914040T3 (de) * 1988-05-24 1998-03-12 Elf Aquitaine Flüssiges Absorptionsmittel für saure Gase mit einer tertiären Alkanolaminkomponente und einem CO2-Absorptionsaktivator, seine Anwendung zur Entsäuerung von CO2 enthaltendem Gas und möglicherweise anderen sauren Gasen.
US5096724A (en) * 1988-06-03 1992-03-17 Aquanautics Corporation Methods, compositions, and systems for ligand extraction
EP0495749A1 (de) * 1991-01-14 1992-07-22 Ciba-Geigy Ag Bipyridyle
EP0495750A3 (en) * 1991-01-14 1992-09-16 Ciba-Geigy Ag Heterocyclic hydroxylamine
TW214545B (es) * 1992-02-17 1993-10-11 Ciba Geigy Ag

Also Published As

Publication number Publication date
JPH11501639A (ja) 1999-02-09
ATE206396T1 (de) 2001-10-15
DK0815081T3 (da) 2002-01-21
PT815081E (pt) 2002-03-28
AU5003096A (en) 1996-10-02
DE69615669T2 (de) 2002-07-11
EP0815081A1 (en) 1998-01-07
EP0815081B1 (en) 2001-10-04
CA2212118A1 (en) 1996-09-19
DE69615669D1 (de) 2001-11-08
US5834486A (en) 1998-11-10
WO1996028425A1 (en) 1996-09-19
CA2212118C (en) 2007-07-31
JP3979664B2 (ja) 2007-09-19

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