ATE206396T1 - Piperidenyl-2-alkyl substituierte lineare polyamine zur senkung intrazellulärer, endogener polyaminkonzentrationen wie z.b. putrescin, spermidin und spermin und ihr einfluss auf die zellvermehrung - Google Patents

Piperidenyl-2-alkyl substituierte lineare polyamine zur senkung intrazellulärer, endogener polyaminkonzentrationen wie z.b. putrescin, spermidin und spermin und ihr einfluss auf die zellvermehrung

Info

Publication number
ATE206396T1
ATE206396T1 AT96906733T AT96906733T ATE206396T1 AT E206396 T1 ATE206396 T1 AT E206396T1 AT 96906733 T AT96906733 T AT 96906733T AT 96906733 T AT96906733 T AT 96906733T AT E206396 T1 ATE206396 T1 AT E206396T1
Authority
AT
Austria
Prior art keywords
polyamine
influence
endogene
piperidenyl
putrescine
Prior art date
Application number
AT96906733T
Other languages
English (en)
Inventor
Joerg Frei
Jaroslav Stanek
Original Assignee
Novartis Erfind Verwalt Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Erfind Verwalt Gmbh filed Critical Novartis Erfind Verwalt Gmbh
Application granted granted Critical
Publication of ATE206396T1 publication Critical patent/ATE206396T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT96906733T 1995-03-15 1996-03-04 Piperidenyl-2-alkyl substituierte lineare polyamine zur senkung intrazellulärer, endogener polyaminkonzentrationen wie z.b. putrescin, spermidin und spermin und ihr einfluss auf die zellvermehrung ATE206396T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH74495 1995-03-15
PCT/EP1996/000898 WO1996028425A1 (en) 1995-03-15 1996-03-04 Piperidinyl-2-alkyl subst. linear polyamines for the reduction of intracellular, endogenic polyamine levels such as putrescine, spermidine and spermine, and their impact on cell proliferation

Publications (1)

Publication Number Publication Date
ATE206396T1 true ATE206396T1 (de) 2001-10-15

Family

ID=4194199

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96906733T ATE206396T1 (de) 1995-03-15 1996-03-04 Piperidenyl-2-alkyl substituierte lineare polyamine zur senkung intrazellulärer, endogener polyaminkonzentrationen wie z.b. putrescin, spermidin und spermin und ihr einfluss auf die zellvermehrung

Country Status (11)

Country Link
US (1) US5834486A (de)
EP (1) EP0815081B1 (de)
JP (1) JP3979664B2 (de)
AT (1) ATE206396T1 (de)
AU (1) AU5003096A (de)
CA (1) CA2212118C (de)
DE (1) DE69615669T2 (de)
DK (1) DK0815081T3 (de)
ES (1) ES2164875T3 (de)
PT (1) PT815081E (de)
WO (1) WO1996028425A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998015531A1 (fr) 1996-10-07 1998-04-16 Koei Chemical Co., Ltd. PROCEDE DE PREPARATION DE SELS ACIDES D'ACIDE η-(PIPERIDYL)BUTYRIQUE
US5843959A (en) * 1997-03-19 1998-12-01 University Of Florida Research Foundation, Inc. Methods and bicyclic polyamine compositions for the treatment of inflammation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2739981A (en) * 1952-08-26 1956-03-27 American Home Prod Diamines and salts thereof
US3872171A (en) * 1971-05-24 1975-03-18 Pfizer Polyamines as antiviral agents in animals
US4315859A (en) * 1979-01-15 1982-02-16 Ciba-Geigy Corporation 1,3,5-Triazines containing at least one piperidine radical
GB2104060A (en) * 1981-08-19 1983-03-02 Merrell Toraude & Co Fluorinated hexene diamine derivatives
GB2104059A (en) * 1981-08-19 1983-03-02 Merrell Toraude & Co Acetylenic diaminobutane derivatives
JPS6325654A (ja) * 1986-07-18 1988-02-03 Fuji Photo Film Co Ltd カラ−写真現像液組成物及びハロゲン化銀カラ−写真感光材料の処理方法
US5091576A (en) * 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
CA1305425C (en) * 1986-12-02 1992-07-21 Raymond J. Bergeron Anti-neoplastic spermine derivative
WO1988006641A1 (en) * 1987-02-25 1988-09-07 Aquanautics Corporation Polyalkylamine complexes for ligand extraction and generation
UA24004A1 (uk) * 1988-05-24 1998-08-31 Сосьєте Насьональ Елф Акітен (Продюксьон) Абсорбеhт для очищеhhя промислових газів від кислих компоhеhтів та спосіб очищеhhя промислових газів від кислих компоhеhтів
US5096724A (en) * 1988-06-03 1992-03-17 Aquanautics Corporation Methods, compositions, and systems for ligand extraction
EP0495750A3 (en) * 1991-01-14 1992-09-16 Ciba-Geigy Ag Heterocyclic hydroxylamine
EP0495749A1 (de) * 1991-01-14 1992-07-22 Ciba-Geigy Ag Bipyridyle
TW214545B (de) * 1992-02-17 1993-10-11 Ciba Geigy Ag

Also Published As

Publication number Publication date
US5834486A (en) 1998-11-10
PT815081E (pt) 2002-03-28
AU5003096A (en) 1996-10-02
JPH11501639A (ja) 1999-02-09
WO1996028425A1 (en) 1996-09-19
DK0815081T3 (da) 2002-01-21
EP0815081B1 (de) 2001-10-04
CA2212118C (en) 2007-07-31
DE69615669D1 (de) 2001-11-08
JP3979664B2 (ja) 2007-09-19
DE69615669T2 (de) 2002-07-11
ES2164875T3 (es) 2002-03-01
CA2212118A1 (en) 1996-09-19
EP0815081A1 (de) 1998-01-07

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Legal Events

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UEP Publication of translation of european patent specification
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