ES2164714T3 - Liposomas que contienen materiales en particulas. - Google Patents

Liposomas que contienen materiales en particulas.

Info

Publication number
ES2164714T3
ES2164714T3 ES94928490T ES94928490T ES2164714T3 ES 2164714 T3 ES2164714 T3 ES 2164714T3 ES 94928490 T ES94928490 T ES 94928490T ES 94928490 T ES94928490 T ES 94928490T ES 2164714 T3 ES2164714 T3 ES 2164714T3
Authority
ES
Spain
Prior art keywords
liposomes
water insoluble
particulate
mum
materials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94928490T
Other languages
English (en)
Inventor
Gregory Gregoriadis
Sophia George Antimisiaris
Ihsan Gursel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UK Secretary of State for Defence
Original Assignee
UK Secretary of State for Defence
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UK Secretary of State for Defence filed Critical UK Secretary of State for Defence
Application granted granted Critical
Publication of ES2164714T3 publication Critical patent/ES2164714T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y10S977/907—Liposome
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/918—Immunological

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Detergent Compositions (AREA)

Abstract

SE SUMINISTRA UN METODO PARA LA FORMULACION DE LIPOSOMAS DE ENTRE 0.1 Y 50 {MI}M DE DIAMETRO QUE TIENEN UNA ESTRUCTURA MONOLAMINILLA O MULTILAMINILLA Y QUE CONTIENE MATERIALES EN PARTICULAS INSOLUBLES O NO DISUELTOS EN AGUA. EL METODO COMPRENDE A) LA FORMACION DE LIPOSOMAS Y LA ELIMINACION SUSTANCIAL DE CUALQUIER SOLVENTE ORGANICO UTILIZADO EN SU PREPARACION, B) LA LIOFILIZACION DE LOS LIPOSOMAS ASI FORMADOS Y C) LA REHIDRATACION DE LOS LIPOSOMAS EN UNA MEZCLA INTIMA CON EL MATERIAL EN PARTICULAS. LOS MATERIALES ENCAPSULADOS PREFERIDOS SON MATERIALES EN PARTICULAS, MAS PREFERIBLEMENTE MICROORGANISMOS, CELULAS DE PLANTAS O DE ANIMALES O DE ESTRUCTURAS INSOLUBLES EN AGUA QUE TENGAN ACTIVIDAD BIOQUIMICA LABIL DE SOLVENTES ORGANICOS O ACTIVIDAD INMUNOLOGICA, PERO CUALQUIER MATERIAL EN PARTICULAS INSOLUBLE EN AGUA PUEDE ENCAPSULARSE UTILIZANDO ESTE METODO. POR EJEMPLO, LOS CATALIZADORES O LAS DROGAS QUE SEAN DIFICILMENTE SOLUBLES TAMBIEN PUEDEN SER INCORPORADAS DE MANERA QUE SE PUEDA SUMINISTRARUNA LIBERACION LENTA EN EL CUERPO DEL PACIENTE MIENTRAS QUE SE EVITA LA LIBERACION DE LOS DETERGENTES INCLUIDOS EN MUCHOS PROTOCOLOS DE PREPARACION DE LIPOSOMAS.
ES94928490T 1993-10-07 1994-10-07 Liposomas que contienen materiales en particulas. Expired - Lifetime ES2164714T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939320668A GB9320668D0 (en) 1993-10-07 1993-10-07 Liposomes containing particulare materials

Publications (1)

Publication Number Publication Date
ES2164714T3 true ES2164714T3 (es) 2002-03-01

Family

ID=10743157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94928490T Expired - Lifetime ES2164714T3 (es) 1993-10-07 1994-10-07 Liposomas que contienen materiales en particulas.

Country Status (15)

Country Link
US (2) US6322809B1 (es)
EP (1) EP0722317B1 (es)
JP (1) JPH09503225A (es)
KR (1) KR100357804B1 (es)
CN (1) CN1108789C (es)
AT (1) ATE209029T1 (es)
AU (1) AU687893B2 (es)
BR (1) BR9407769A (es)
DE (1) DE69429186T2 (es)
DK (1) DK0722317T3 (es)
ES (1) ES2164714T3 (es)
GB (2) GB9320668D0 (es)
NZ (1) NZ274006A (es)
RU (1) RU2145212C1 (es)
WO (1) WO1995009610A1 (es)

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IT1289938B1 (it) * 1997-02-20 1998-10-19 Angelini Ricerche Spa Preparazione farmaceutica comprendente liposomi liofilizzati in cui e' incapsulato un principio attivo altamente insolubile in acqua e
JP4467789B2 (ja) 1997-09-18 2010-05-26 パシラ ファーマシューティカルズ インコーポレーテッド 持続放出性リポソーム麻酔組成物
IL135989A0 (en) 1997-11-14 2001-05-20 Skyepharma Inc Processes for the production of multivesicular liposomes
ATE428371T1 (de) 1998-07-17 2009-05-15 Pacira Pharmaceuticals Inc Biologisch abbaubare anordnungen zur kontrollierten freigabe eingeschlossener substanzen
FR2802422B1 (fr) 1999-12-21 2002-08-09 Capsulis Structures mixtes resultant de l'incorporation d'une macromolecule biologique, en particulier d'adn, dans une phase structuree d'amphiphiles et vesicules obtenues a partir de ces structures
DE60123583T2 (de) * 2000-02-04 2007-08-09 Lipoxen Technologies Ltd. Dehydratisierungs-/rehydratisierungsverfahren zur herstellung von liposome
WO2002096368A2 (en) * 2001-05-31 2002-12-05 Skyepharma Inc. Encapsulation of nanosuspensions in liposomes and microspheres
US20040005352A1 (en) * 2002-04-16 2004-01-08 Lopez Gabriel P. Biologically functionalized porous microspheres
SE0300795D0 (sv) 2003-03-24 2003-03-24 Isconova Ab Composition comprising iscom particles and live micro-organisms
WO2005002546A1 (en) * 2003-06-27 2005-01-13 Smithkline Beecham Corporation Stabilized topotecan liposomal composition and methods
CA2624362C (en) * 2005-10-03 2015-05-26 Mark A. Pinsky Liposomes comprising collagen and their use in improved skin care
FR2900576B1 (fr) * 2006-05-03 2008-09-19 Centre Nat Rech Scient Procede de concentration extemporanee et reversible de liposomes.
WO2008040557A1 (en) * 2006-10-06 2008-04-10 Scil Technology Gmbh A spinal nucleus pulposus implant
US9456983B1 (en) 2006-12-08 2016-10-04 Advanced Cardiovascular Systems, Inc. Therapeutic composition with enhanced vessel targeting
US8372427B2 (en) * 2007-03-05 2013-02-12 Abbott Cardiovascular Systems Inc. Therapeutic composition with enhanced endothelium targeting
US9044385B2 (en) * 2007-05-16 2015-06-02 Abbott Cardiovascular Systems Inc. Therapeutic compositions for targeted vessel delivery
US20090047318A1 (en) 2007-08-16 2009-02-19 Abbott Cardiovascular Systems Inc. Nanoparticle-coated medical devices and formulations for treating vascular disease
US8709472B1 (en) 2007-11-13 2014-04-29 Abbott Cardiovascular Systems Inc. Bioactive agent-loaded heart-targeting nanoparticles
US20090169615A1 (en) * 2007-12-26 2009-07-02 Pinsky Mark A Collagen Formulations for Improved Skin Care
WO2010135714A2 (en) 2009-05-22 2010-11-25 The Methodist Hospital Research Institute Methods for modulating adipocyte expression using microrna compositions
WO2011123525A1 (en) * 2010-04-01 2011-10-06 The Regents Of The University Of California Forming an artificial cell with controlled membrane composition, asymmetry and contents
RU2567746C2 (ru) * 2010-05-28 2015-11-10 ДИАГОН Кфт. Способ двухфазного получения липосом и способы их применения при изготовлении диагностических реагентов
CN102240531B (zh) * 2011-03-21 2013-07-10 徐涵 一种植物细胞微球及其应用
EP2682106A1 (en) * 2012-07-03 2014-01-08 Phares Pharmaceutical Research N.V. Method of solubilizing biologically active compounds
SG11201607396WA (en) * 2014-03-25 2016-10-28 Government Of The Us Secretary Of The Army Non-toxic adjuvant formulation comprising a monophosphoryl lipid a (mpla)-containing liposome composition and a saponin
RU2589822C2 (ru) * 2014-12-02 2016-07-10 Федеральное государственное бюджетное учреждение науки Институт ядерной физики им. Г.И. Будкера Сибирского отделения РАН (ИЯФ СО РАН) Способ доставки борсодержащих препаратов для бор-нейтронозахватной терапии
JP6316182B2 (ja) 2014-12-19 2018-04-25 富士フイルム株式会社 リポソームの製造方法及びリポソーム製造装置
US20170049701A1 (en) * 2015-08-05 2017-02-23 Steven M. Kushner Clustoidal multilamellar soy lecithin phospholipid structures for transdermal, transmucosal, or oral delivery, improved intestinal absorption, and improved bioavailability of nutrients
KR101687735B1 (ko) * 2015-09-18 2016-12-19 서울대학교 산학협력단 신규의 동결건조보조제 및 새로운 인지질 용해용 혼합용매를 이용한 리포좀 동결분체의 제조방법
EP3371349A1 (en) 2015-11-02 2018-09-12 Bioatla, LLC Conditionally active polypeptides
CN105483076B (zh) * 2015-12-23 2019-01-25 中国科学院生物物理研究所 一种脂肪体的制备方法及其应用
WO2018094253A1 (en) 2016-11-18 2018-05-24 Pacira Pharmaceuticals, Inc. Zinc meloxicam complex microparticle multivesicular liposome formulations and processes for making the same
EP3415140A1 (en) * 2017-06-16 2018-12-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. A method for preparing a functional synthetic cell in form of a giant unilamellar vesicle
US10849924B2 (en) 2017-09-26 2020-12-01 New York Medical College Compositions and methods for restoring endothelial glycocalyx
JP7157999B2 (ja) * 2018-05-07 2022-10-21 国立研究開発法人産業技術総合研究所 微生物を封入したベシクルを用いた微生物の培養方法
MX2023003104A (es) 2020-09-16 2023-06-22 Aviceda Therapeutics Inc Agentes terapéuticos decorados con ligando de ácido siálico.
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
WO2023129737A1 (en) 2021-12-31 2023-07-06 Aviceda Therapeutics, Inc. Glycomimetic ligands

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HU184141B (en) * 1979-12-27 1984-07-30 Human Oltoanyagtermelo Adjuvant particles compositions containing said particles and biologically active substances adsorbed thereon and a process for the preparation thereof
DE3374837D1 (en) * 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
US4532089A (en) * 1984-01-14 1985-07-30 Northwestern University Method of preparing giant size liposomes
US4880635B1 (en) 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
EP0172007B1 (en) * 1984-08-10 1991-05-22 Syntex (U.S.A.) Inc. Stable liposomes with aqueous-soluble medicaments and methods for their preparation
JPS6150912A (ja) 1984-08-16 1986-03-13 Shionogi & Co Ltd リポソ−ム製剤の製造法
US4814270A (en) 1984-09-13 1989-03-21 Becton Dickinson And Company Production of loaded vesicles
JPS6176414A (ja) 1984-09-21 1986-04-18 Shionogi & Co Ltd リポソーム製剤の製法
GB8424115D0 (en) 1984-09-24 1984-10-31 Mead Corp Article tray
US5049390A (en) * 1987-09-02 1991-09-17 Allergy Immuno Technologies, Inc. Liposome containing immunotherapy agents for treating IgE mediated allergies
US5422120A (en) * 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
US5157207A (en) * 1990-02-06 1992-10-20 Crop Genetics International Modified plant containing a bacterial insculant
GB9018690D0 (en) * 1990-08-24 1990-10-10 Wellcome Found Vaccines
DE4136553A1 (de) * 1991-11-06 1993-05-13 Biotechnolog Forschung Gmbh Impfstoff gegen schleimhauterreger und herstellungsverfahren
DK0684812T3 (da) 1993-02-12 1998-09-21 Mayo Foundation Kondenseret-fase mikropartikel-præparat og fremgangsmåde

Also Published As

Publication number Publication date
DK0722317T3 (da) 2002-05-21
EP0722317B1 (en) 2001-11-21
US20020041895A1 (en) 2002-04-11
GB9607359D0 (en) 1996-07-03
JPH09503225A (ja) 1997-03-31
US6451338B1 (en) 2002-09-17
NZ274006A (en) 1997-02-24
CN1200668A (zh) 1998-12-02
GB2297907B (en) 1997-12-10
CN1108789C (zh) 2003-05-21
KR100357804B1 (ko) 2004-06-14
RU2145212C1 (ru) 2000-02-10
DE69429186T2 (de) 2002-07-11
EP0722317A1 (en) 1996-07-24
US6322809B1 (en) 2001-11-27
GB9320668D0 (en) 1993-11-24
BR9407769A (pt) 1997-03-18
WO1995009610A1 (en) 1995-04-13
ATE209029T1 (de) 2001-12-15
AU687893B2 (en) 1998-03-05
DE69429186D1 (de) 2002-01-03
GB2297907A (en) 1996-08-21
AU7790794A (en) 1995-05-01

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