ES2163725T3 - Derivados 7,12-dioxa-benzo-(a)-antracenicos sustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Derivados 7,12-dioxa-benzo-(a)-antracenicos sustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2163725T3
ES2163725T3 ES97402654T ES97402654T ES2163725T3 ES 2163725 T3 ES2163725 T3 ES 2163725T3 ES 97402654 T ES97402654 T ES 97402654T ES 97402654 T ES97402654 T ES 97402654T ES 2163725 T3 ES2163725 T3 ES 2163725T3
Authority
ES
Spain
Prior art keywords
antracenicos
dioxa
benzo
derivatives
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97402654T
Other languages
English (en)
Inventor
Gerard Coudert
Siham Khatib
Pascale Moreau
Daniel-Henri Caignard
Pierre Renard
Ghanem Atassi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2163725T3 publication Critical patent/ES2163725T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/24—[b,e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A LOS COMPUESTOS DE FORMULA GENERAL (I): EN LA QUE R SUP,1}, R SUP,2}, X E Y SON TAL COMO SE DEFINEN EN LA DESCRIPCION, SUS ISOMEROS GEOMETRICOS Y/U OPTICOS, Y SUS SALES DE ADICION A UN ACIDO O UNA BASE FARMACEUTICAMENTE ACEPTABLE. LOS COMPUESTOS DE FORMULA (I) POSEEN INTERESANTES PROPIEDADES FARMACOLOGICAS. TIENEN UNA EXCELENTE CITOTOXICIDAD IN VITRO, NO SOLO EN ESTIRPES LEUCEMICAS SINO TAMBIEN EN ESTIRPES DE TUMORES SOLIDOS; TAMBIEN TIENEN ACCION SOBRE EL CICLO CELULAR Y SON ACTIVOS IN VIVO SOBRE UN MODELO LEUCEMICO. ESTAS PROPIEDADES PERMITEN SU UTILIZACION TERAPEUTICA Y COMO AGENTES ANTITUMORALES.
ES97402654T 1996-11-08 1997-11-06 Derivados 7,12-dioxa-benzo-(a)-antracenicos sustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2163725T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9613653A FR2755691B1 (fr) 1996-11-08 1996-11-08 Nouveaux derives 7,12-dioxa-benzo[a]anthraceniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2163725T3 true ES2163725T3 (es) 2002-02-01

Family

ID=9497458

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97402654T Expired - Lifetime ES2163725T3 (es) 1996-11-08 1997-11-06 Derivados 7,12-dioxa-benzo-(a)-antracenicos sustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Country Status (20)

Country Link
US (1) US5807882A (es)
EP (1) EP0841337B1 (es)
JP (1) JPH10139779A (es)
CN (1) CN1096462C (es)
AT (1) ATE205212T1 (es)
AU (1) AU716973B2 (es)
BR (1) BR9705448A (es)
CA (1) CA2220995C (es)
DE (1) DE69706502T2 (es)
DK (1) DK0841337T3 (es)
ES (1) ES2163725T3 (es)
FR (1) FR2755691B1 (es)
GR (1) GR3037037T3 (es)
HK (1) HK1010870A1 (es)
HU (1) HU222286B1 (es)
NO (1) NO974985L (es)
NZ (1) NZ329134A (es)
PL (1) PL323033A1 (es)
PT (1) PT841337E (es)
ZA (1) ZA9710059B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1070068B2 (en) * 1998-03-13 2007-01-17 The University Of British Columbia Granulatimide derivatives for use in cancer treatment
CA2245029A1 (en) 1998-03-13 1999-09-13 University Of British Columbia Granulatimide compounds as g2 checkpoint inhibitors
FR2845997B1 (fr) 2002-10-18 2004-12-24 Servier Lab Nouveaux derives de[1,4]benzodioxino[2,3-e]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2845994B1 (fr) * 2002-10-18 2006-05-19 Servier Lab Nouveaux derives de benzo[e][1,4]oxazino[3,2-g]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008142A1 (en) * 1989-01-23 1990-07-26 Texas A&M University SYNTHESIS AND APPLICATION OF 1,3,6,8- AND 2,4,6,8-SUBSTITUTED DIBENZOFURANS AND DIBENZO-p-DIOXINS AS ANTITUMORIGENIC AGENTS

Also Published As

Publication number Publication date
AU4440497A (en) 1998-05-14
NZ329134A (en) 1998-03-25
CN1096462C (zh) 2002-12-18
PT841337E (pt) 2001-12-28
DE69706502D1 (de) 2001-10-11
HU9701922D0 (en) 1998-01-28
HK1010870A1 (en) 1999-07-02
EP0841337B1 (fr) 2001-09-05
CA2220995A1 (fr) 1998-05-08
CA2220995C (fr) 2002-10-08
EP0841337A1 (fr) 1998-05-13
PL323033A1 (en) 1998-05-11
HUP9701922A2 (hu) 1998-12-28
CN1182087A (zh) 1998-05-20
JPH10139779A (ja) 1998-05-26
ATE205212T1 (de) 2001-09-15
GR3037037T3 (en) 2002-01-31
DK0841337T3 (da) 2001-11-19
FR2755691A1 (fr) 1998-05-15
NO974985D0 (no) 1997-10-29
HUP9701922A3 (en) 2000-06-28
BR9705448A (pt) 2000-03-14
DE69706502T2 (de) 2002-05-08
US5807882A (en) 1998-09-15
ZA9710059B (en) 1998-05-25
FR2755691B1 (fr) 1998-12-04
AU716973B2 (en) 2000-03-09
NO974985L (no) 1998-05-11
HU222286B1 (hu) 2003-05-28

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