ES2160129T3 - Compuestos para la prevencion y tratamiento de infecciones por helmintos. - Google Patents
Compuestos para la prevencion y tratamiento de infecciones por helmintos.Info
- Publication number
- ES2160129T3 ES2160129T3 ES94929200T ES94929200T ES2160129T3 ES 2160129 T3 ES2160129 T3 ES 2160129T3 ES 94929200 T ES94929200 T ES 94929200T ES 94929200 T ES94929200 T ES 94929200T ES 2160129 T3 ES2160129 T3 ES 2160129T3
- Authority
- ES
- Spain
- Prior art keywords
- vehicle
- vertebrate
- synpol
- compound
- coopurium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 208000015181 infectious disease Diseases 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 4
- 229920013625 Synpol Polymers 0.000 abstract 3
- 230000003308 immunostimulating effect Effects 0.000 abstract 2
- 108010003272 Hyaluronate lyase Proteins 0.000 abstract 1
- 102000001974 Hyaluronidases Human genes 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 229960002773 hyaluronidase Drugs 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 229960001438 immunostimulant agent Drugs 0.000 abstract 1
- 239000003022 immunostimulating agent Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
- C08G73/0622—Polycondensates containing six-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms
- C08G73/0633—Polycondensates containing six-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms with only two nitrogen atoms in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0003—Invertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C12N11/091—Phenol resins; Amino resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polyethers (AREA)
- Enzymes And Modification Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
COMPUESTO PARA PROTEGER A UN VERTEBRADO CONTRA LA INFECCION POR HELMINTIDOS QUE INCLUYE HIALURONIDASA ACOPLADA DE FORMA COVALENTE A UN VEHICULO INMUNOESTUMLADOR, EN LA FORMA PREFERIDA, EL VEHICULO DE INMUNOESTIMULACION AL QUE SE ACOPLA COVALENTEMENTE LA HIALURONIDASA TIENE UN COPOLIMERO DE BROMURO DE ETILENEPIPERAZINA N-OXIDO Y N-ETILACETILETILENOPIPERAZINO ( EN LO SUCESIVO LLAMADO "SYNPOL"), Y UN PROCESO PARA PROTEGER AL VERTEBRADO CONTRA LA INFECCION POR HELMINTIDOS QUE SUPONE LA ADMINISTRACION AL VERTEBRADO DE UNA CANTIDAD EFECTIVA TERAPEUTICAMENTE DE UN COMPUESTO QUE INCLUYE HIALURONIDASA ACOPLADA DE FORMA COVALENTE A UN VEHICULO INMUNOESTIMULANTE, PREFERIBLEMENTE SYNPOL, EN LA FORMA PREFERIDA, SIENDO ADMINISTRANDO EL COMPUESTO AL VERTEBRADO EN FORMA DE UNA VACUNA QUE INCLUYE, DE FORMA MEZCLADA CON EL COMPUESTO, SYNPOL, Y UN PROCESO QUE SUPONE LA REACCION DE HIALURONIDASA Y UN VEHICULO INMUNOESTIMULANTE BAJO CONDICIONES DE TIEMPO Y TEMPERATURA QUE SE PUEDAN ACOPLAR COVALENTEMENTE LA HIALURONIDASA Y DICHO VEHICULO INMUNOGENICO.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/120,001 US5503830A (en) | 1993-09-10 | 1993-09-10 | Compounds having immunostimulating activity and methods of use thereof |
| US20748694A | 1994-03-07 | 1994-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2160129T3 true ES2160129T3 (es) | 2001-11-01 |
Family
ID=26817942
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94929200T Expired - Lifetime ES2160129T3 (es) | 1993-09-10 | 1994-09-12 | Compuestos para la prevencion y tratamiento de infecciones por helmintos. |
| ES00125257T Expired - Lifetime ES2194666T3 (es) | 1993-09-10 | 1994-09-12 | Portador inmunoestimulante para vacunas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00125257T Expired - Lifetime ES2194666T3 (es) | 1993-09-10 | 1994-09-12 | Portador inmunoestimulante para vacunas. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5811100A (es) |
| EP (2) | EP0789586B1 (es) |
| JP (1) | JP3138476B2 (es) |
| KR (2) | KR100270980B1 (es) |
| CN (1) | CN1116076C (es) |
| AT (2) | ATE236948T1 (es) |
| AU (1) | AU696748B2 (es) |
| BR (1) | BR9407533A (es) |
| CA (1) | CA2171462C (es) |
| CZ (1) | CZ296577B6 (es) |
| DE (2) | DE69432493T2 (es) |
| DK (2) | DK1108738T3 (es) |
| ES (2) | ES2160129T3 (es) |
| GR (1) | GR3036780T3 (es) |
| HU (1) | HU222189B1 (es) |
| NZ (1) | NZ274343A (es) |
| PT (2) | PT789586E (es) |
| SI (1) | SI1108738T1 (es) |
| WO (1) | WO1995007100A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001046127A1 (fr) * | 1999-12-22 | 2001-06-28 | Om Pharma | Pseudodipeptides acyles porteurs d'un bras auxiliaire fonctionnalise |
| KR101162241B1 (ko) * | 2009-12-30 | 2012-07-04 | 박정자 | 양식어류 기생충 구충용 조성물 |
| RU2616528C1 (ru) | 2015-12-04 | 2017-04-17 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НПО Петровакс Фарм" | Способ получения конъюгата гиалуронидазы с производными полиэтиленпиперазина и применение полученного конъюгата |
| RU2737271C2 (ru) * | 2018-06-27 | 2020-11-26 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НПО Петровакс Фарм" | Сополимеры ди-N-оксидов поли-1,4-этиленпиперазина и способы их получения |
| EP4261243A1 (en) * | 2020-10-14 | 2023-10-18 | Limited Liability Company "NPO Petrovax Pharm" | Method for synthesizing poly-1,4-ethylenepiperazine and a copolymer of n-oxidized 1,4-ethylenepiperazine and (n-carboxymethyl)-1,4-ethylenepiperazinium bromide and their derivatives |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3390148A (en) * | 1965-07-28 | 1968-06-25 | Pfizer & Co C | Novel thiazine and thiazoline anthelmintic agents |
| US3579510A (en) * | 1967-08-30 | 1971-05-18 | Pfizer | 3-(hydroxy-phenyl) substituted amidines and derivatives thereof as anthelmintic agents |
| US3896227A (en) * | 1971-08-04 | 1975-07-22 | Pfizer | 1-(3-hydroxystyryl pyridinium salts and their derivatives as whipworm control agents |
| US5503830A (en) * | 1993-09-10 | 1996-04-02 | Petrovax, L.L.C. | Compounds having immunostimulating activity and methods of use thereof |
-
1994
- 1994-09-12 HU HU9600591A patent/HU222189B1/hu active IP Right Grant
- 1994-09-12 CZ CZ0073796A patent/CZ296577B6/cs not_active IP Right Cessation
- 1994-09-12 WO PCT/US1994/010346 patent/WO1995007100A1/en active IP Right Grant
- 1994-09-12 ES ES94929200T patent/ES2160129T3/es not_active Expired - Lifetime
- 1994-09-12 EP EP94929200A patent/EP0789586B1/en not_active Expired - Lifetime
- 1994-09-12 BR BR9407533A patent/BR9407533A/pt not_active Application Discontinuation
- 1994-09-12 SI SI9430448T patent/SI1108738T1/xx unknown
- 1994-09-12 KR KR1019960701239A patent/KR100270980B1/ko not_active IP Right Cessation
- 1994-09-12 ES ES00125257T patent/ES2194666T3/es not_active Expired - Lifetime
- 1994-09-12 AU AU78347/94A patent/AU696748B2/en not_active Ceased
- 1994-09-12 AT AT00125257T patent/ATE236948T1/de active
- 1994-09-12 DE DE69432493T patent/DE69432493T2/de not_active Expired - Lifetime
- 1994-09-12 EP EP00125257A patent/EP1108738B1/en not_active Expired - Lifetime
- 1994-09-12 PT PT94929200T patent/PT789586E/pt unknown
- 1994-09-12 JP JP07508836A patent/JP3138476B2/ja not_active Expired - Fee Related
- 1994-09-12 AT AT94929200T patent/ATE202710T1/de active
- 1994-09-12 PT PT00125257T patent/PT1108738E/pt unknown
- 1994-09-12 DK DK00125257T patent/DK1108738T3/da active
- 1994-09-12 DK DK94929200T patent/DK0789586T3/da active
- 1994-09-12 CA CA002171462A patent/CA2171462C/en not_active Expired - Fee Related
- 1994-09-12 DE DE69427653T patent/DE69427653T2/de not_active Expired - Lifetime
- 1994-09-12 CN CN94193357A patent/CN1116076C/zh not_active Expired - Fee Related
- 1994-09-12 NZ NZ27434394A patent/NZ274343A/xx not_active IP Right Cessation
-
1996
- 1996-05-15 US US08/655,282 patent/US5811100A/en not_active Expired - Lifetime
-
2000
- 2000-06-13 KR KR1020000032523A patent/KR100296970B1/ko not_active IP Right Cessation
-
2001
- 2001-10-03 GR GR20010401641T patent/GR3036780T3/el not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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