ES2159361T3 - Aparato y proceso para multiples reacciones quimicas. - Google Patents

Aparato y proceso para multiples reacciones quimicas.

Info

Publication number
ES2159361T3
ES2159361T3 ES96933842T ES96933842T ES2159361T3 ES 2159361 T3 ES2159361 T3 ES 2159361T3 ES 96933842 T ES96933842 T ES 96933842T ES 96933842 T ES96933842 T ES 96933842T ES 2159361 T3 ES2159361 T3 ES 2159361T3
Authority
ES
Spain
Prior art keywords
block
manifold valve
valve block
reaction
channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96933842T
Other languages
English (en)
Inventor
Raju Mohan
Brad O Buckman
Michael M Morrissey
Andrew I Chitty
John T Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Berlex Laboratories Inc
Original Assignee
Berlex Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Laboratories Inc filed Critical Berlex Laboratories Inc
Application granted granted Critical
Publication of ES2159361T3 publication Critical patent/ES2159361T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
    • B01J2219/0031—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks the racks or blocks being mounted in stacked arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00331—Details of the reactor vessels
    • B01J2219/00333—Closures attached to the reactor vessels
    • B01J2219/00335—Septa
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B01J2219/00391—Rotary valves
    • B01J2219/00394—Rotary valves in multiple arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00414—Means for dispensing and evacuation of reagents using suction
    • B01J2219/00416—Vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00452—Means for the recovery of reactants or products
    • B01J2219/00454—Means for the recovery of reactants or products by chemical cleavage from the solid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B01J2219/00484—Means for mixing reactants or products in the reaction vessels by shaking, vibrating or oscillating of the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547—Bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Degasification And Air Bubble Elimination (AREA)

Abstract

SE LLEVAN A CABO MULTIPLES REACCIONES QUIMICAS EN VARIOS RECIPIENTES DE REACCION (12) MONTADOS EN LAS ENTRADAS DE UN BLOQUE DE VALVULAS DE DISTRIBUCION (30). EL BLOQUE DE VALVULAS DE DISTRIBUCION (30) ESTA CONECTADO A UN BLOQUE DE CANAL (34) QUE SE UTILIZA EN UNION CON UN SISTEMA DE SUMINISTRO DE SOLVENTE (21) COMO PARTE DEL CICLO DE REACCION. EL FLUIDO SOLVENTE ES PURGADO DE LOS RECIPIENTES DE REACCION (12) CUANDO LAS VALVULAS DEL BLOQUE DE VALVULAS DE DISTRIBUCION (30) ESTAN ABIERTAS MIENTRAS SE APLICA VACIO. OPCIONALMENTE, UN BLOQUE TERMICO (40) PUEDE SER UTILIZADO EN UNION CON EL BLOQUE DE VALVULAS DE DISTRIBUCION (30) Y EL BLOQUE DE CANAL (34) PARA FACILITAR LA REACCION. UNA VEZ COMPLETADO EL CICLO REACTIVO, EL BLOQUE DE VALVULAS DE DISTRIBUCION (30) SE DESCONECTA DEL BLOQUE DE CANAL (34) Y SE CONECTA A UN MECANISMO DE BLOQUE DE DISOCIACION (120, 121) QUE CONTIENE VIALES (128) PARA RECOGER LOS PRODUCTOS DE REACCION. EL PRODUCTO DISOCIADO ES PURGADO DE LOS RECIPIENTES DE REACCION (12) ATRAVES DEL BLOQUE DE VALVULAS DE DISTRIBUCION (30) A LOS VIALES (128) TRAS LA APERTURA DE LAS VALVULAS DEL BLOQUE DE VALVULAS DE DISTRIBUCION (30) Y LA APLICACION DE VACIO AL BLOQUE DE CANAL (34).
ES96933842T 1995-09-22 1996-09-23 Aparato y proceso para multiples reacciones quimicas. Expired - Lifetime ES2159361T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53227995A 1995-09-22 1995-09-22

Publications (1)

Publication Number Publication Date
ES2159361T3 true ES2159361T3 (es) 2001-10-01

Family

ID=24121110

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96933842T Expired - Lifetime ES2159361T3 (es) 1995-09-22 1996-09-23 Aparato y proceso para multiples reacciones quimicas.

Country Status (14)

Country Link
EP (1) EP0859661B1 (es)
JP (1) JPH11511381A (es)
KR (1) KR19990063660A (es)
CN (1) CN1197413A (es)
AT (1) ATE201149T1 (es)
AU (1) AU723605B2 (es)
CA (1) CA2232505A1 (es)
DE (1) DE69612866T2 (es)
DK (1) DK0859661T3 (es)
ES (1) ES2159361T3 (es)
GR (1) GR3035958T3 (es)
IL (1) IL123662A (es)
PT (1) PT859661E (es)
WO (1) WO1997010896A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888830A (en) 1995-09-22 1999-03-30 Berlex Laboratories, Inc. Apparatus and process for multiple chemical reactions
JP2001500426A (ja) * 1996-09-12 2001-01-16 カイロン コーポレイション モジュラー反応容器の配列を含む固相化学合成における使用のための作動手段
US5866342A (en) * 1996-09-27 1999-02-02 Glaxo Group Limited Systems and methods for the synthesis of organic compounds
CA2267769A1 (en) * 1996-10-07 1998-04-16 Irori Matrices with memories in automated drug discovery and units therefor
US6042789A (en) * 1996-10-23 2000-03-28 Glaxo Group Limited System for parallel synthesis of organic compounds
US6149869A (en) * 1996-10-23 2000-11-21 Glaxo Wellcome Inc. Chemical synthesizers
US6083761A (en) * 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
US6054325A (en) * 1996-12-02 2000-04-25 Glaxo Wellcom Inc. Method and apparatus for transferring and combining distinct chemical compositions with reagents
US6274094B1 (en) 1997-01-13 2001-08-14 Weller, Iii Harold Norris Nestable, modular apparatus for synthesis of multiple organic compounds
US6045755A (en) * 1997-03-10 2000-04-04 Trega Biosciences,, Inc. Apparatus and method for combinatorial chemistry synthesis
US5961925A (en) * 1997-09-22 1999-10-05 Bristol-Myers Squibb Company Apparatus for synthesis of multiple organic compounds with pinch valve block
KR100279552B1 (ko) 1997-10-18 2001-11-30 박한오 다중단속밸브장치
US6083682A (en) 1997-12-19 2000-07-04 Glaxo Group Limited System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
WO1999054031A1 (en) * 1998-04-23 1999-10-28 Otter Coast Automation, Inc. Method and apparatus for synthesis of libraries of organic compounds
JP4569850B2 (ja) * 1998-09-24 2010-10-27 株式会社島津製作所 自動合成機
US6485692B1 (en) * 1998-12-04 2002-11-26 Symyx Technologies, Inc. Continuous feed parallel reactor
EP1159063B1 (en) * 1999-02-11 2005-08-24 Scynexis, Inc. Method for synthesizing, purifying and characterizing combinatorial libraries
GB0004456D0 (en) 2000-02-26 2000-04-19 Glaxo Group Ltd Medicament dispenser
US6824738B1 (en) 2000-04-14 2004-11-30 Discovery Partners International, Inc. System and method for treatment of samples on solid supports
US6503457B1 (en) 2000-04-14 2003-01-07 Discovery Partners International, Inc. Container and method for high volume treatment of samples on solid supports
US6432365B1 (en) 2000-04-14 2002-08-13 Discovery Partners International, Inc. System and method for dispensing solution to a multi-well container
GB0012465D0 (en) 2000-05-24 2000-07-12 Glaxo Group Ltd Monitoring method
US6994827B2 (en) 2000-06-03 2006-02-07 Symyx Technologies, Inc. Parallel semicontinuous or continuous reactors
GB0013619D0 (en) 2000-06-06 2000-07-26 Glaxo Group Ltd Sample container
JP2004503338A (ja) 2000-07-15 2004-02-05 グラクソ　グループ　リミテッド 薬剤取り出し装置
US6923939B1 (en) * 2001-07-05 2005-08-02 Uop Llc Heat activated membrane introduction apparatus and method for screening materials
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
US7998986B2 (en) 2001-12-21 2011-08-16 Exelixis Patent Company Llc Modulators of LXR
US6893613B2 (en) * 2002-01-25 2005-05-17 Bristol-Myers Squibb Company Parallel chemistry reactor with interchangeable vessel carrying inserts
CN1313197C (zh) * 2003-11-21 2007-05-02 苏为科 模拟工业化生产的中试试验装置
DE102005016755B3 (de) * 2005-04-11 2006-11-30 Eppendorf Ag Vorrichtung, System mit einer solchen Vorrichtung und Verfahren zum Trocknen von Kavitäten in Mikrotiterfilterplatten und von darin angeordneten Filtern
KR100793819B1 (ko) * 2006-06-16 2008-01-10 주식회사 펩트론 히트 블록 어셈블리 및 그를 이용한 유기 화합물 합성 반응장치
DE102014103692A1 (de) * 2014-03-18 2015-09-24 Basf Se System und Verfahren zum Rückgewinnen von flüssigen oder fließfähigen Chemikalien
CN104232467A (zh) * 2014-08-21 2014-12-24 广东凯普生物科技股份有限公司 分子杂交反应室
JP6944049B2 (ja) * 2017-09-29 2021-10-06 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 試験管真空保持装置
JP6481187B1 (ja) * 2018-02-05 2019-03-13 エイブル株式会社 試料計測方法、マルチウエルプレートの蓋、試料計測キット、及び、試料計測装置
JP6589190B6 (ja) * 2019-04-03 2019-12-11 ヤマト科学株式会社 反応容器の液体排出装置
CN111018931A (zh) * 2019-12-30 2020-04-17 江苏东玄基因科技有限公司 一种低聚物自动化固相合成系统

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59638A (ja) * 1982-06-26 1984-01-05 Toshiba Corp サンプリングユニツト
DD239473A1 (de) * 1985-07-01 1986-09-24 Zeiss Jena Veb Carl Probentraeger zur diskreten analyse fluessiger analysensaetze
DK492788D0 (da) * 1988-09-02 1988-09-05 Morten Meldal Peptidsynteseapparat
WO1991007504A1 (en) * 1989-11-21 1991-05-30 Kindconi Pty. Ltd. Improved dna polymerisation device
DE4008085A1 (de) * 1990-03-14 1991-09-19 Abimed Analysen Technik Gmbh Vorrichtung zum durchfuehren chemischer, biochemischer und biologischer reaktionen in reaktionsgefaessen
EP0542422A1 (en) * 1991-11-12 1993-05-19 General Atomics Multi-well microtiter plate
US5368823A (en) * 1993-02-11 1994-11-29 University Of Georgia Research Foundation, Inc. Automated synthesis of oligonucleotides
US5472672A (en) * 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
NZ276860A (en) * 1993-11-02 1997-09-22 Affymax Tech Nv Apparatus and its use for synthesising diverse molecular products on substrates

Also Published As

Publication number Publication date
DK0859661T3 (da) 2001-08-27
JPH11511381A (ja) 1999-10-05
CA2232505A1 (en) 1997-03-27
AU723605B2 (en) 2000-08-31
EP0859661A1 (en) 1998-08-26
WO1997010896A1 (en) 1997-03-27
ATE201149T1 (de) 2001-06-15
CN1197413A (zh) 1998-10-28
KR19990063660A (ko) 1999-07-26
DE69612866T2 (de) 2001-11-08
AU7241796A (en) 1997-04-09
IL123662A (en) 2001-01-28
PT859661E (pt) 2001-10-31
IL123662A0 (en) 1998-10-30
EP0859661B1 (en) 2001-05-16
GR3035958T3 (en) 2001-08-31
DE69612866D1 (de) 2001-06-21

Similar Documents

Publication Publication Date Title
ES2159361T3 (es) Aparato y proceso para multiples reacciones quimicas.
CA2369222A1 (en) Apparatus and methods for parallel processing of multiple reaction mixtures
AU585344B2 (en) Process for producing hydrocarbon-containing liquids from biomass
CA2186896A1 (en) Integrated chemical synthesizers
CA2201486A1 (en) Method and means for hydrolysis of organic materials
BR9908212A (pt) Processos aperfeiçoados de separação
EP1632276A3 (en) Microcomponent chemical process sheet architecture
EP0335647A3 (en) Multiple membrane separation systems
WO2004101128A3 (en) Apparatus for preparing polyolefin products and methodology for using the same
ES463531A1 (es) Procedimiento para la preparacion de aminocompuestos organi-cos solubles en agua monoacilados.
IL148744A0 (en) Method for cultivating cells, a membrane module, utilization of a membrane module and reaction system for cultivation of said cells
AU6111086A (en) Simultaneous extraction of a ligand from a sample of cells and capture by anti-ligands
DE50012526D1 (de) Kit zur durchführung biochemischer reaktionen mit hohem durchsatz
WO2002092221A8 (en) A system for performing experiments, in particular for high throughput experimentation
WO1992001222A3 (fr) Procede d'injection de l'echantillon dans la colonne de separation d'un chromatographe en phase gazeuse et dispositif d'injection pour la mise en ×uvre dudit procede
GB9223709D0 (en) Process for the separation of protein from microorganisms
AU8659091A (en) Chemical reactor with a gas separator, and a frame for use in the reactor
MY102345A (en) Process for converting a gaseous feed into an at least partly liquid product.
MY139119A (en) A method of operating a dehydrogenation reactor system
JPS54141381A (en) Batch type reactor and reaction method
Sawada et al. Explosion operation and biotechnological application for effective utilization of biomass.
AU5087498A (en) Inverse filtration apparatus and method of use
JPS5588840A (en) Heating reaction furnace
RU95101138A (ru) Способ получения 6-метил-5-гептен-2-она
RU94044250A (ru) Способ риформирования нефти

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 859661

Country of ref document: ES