ES2159232B1 - Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos. - Google Patents

Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos.

Info

Publication number
ES2159232B1
ES2159232B1 ES009900730A ES9900730A ES2159232B1 ES 2159232 B1 ES2159232 B1 ES 2159232B1 ES 009900730 A ES009900730 A ES 009900730A ES 9900730 A ES9900730 A ES 9900730A ES 2159232 B1 ES2159232 B1 ES 2159232B1
Authority
ES
Spain
Prior art keywords
resolution
enantiomeric mixtures
organic acids
propionic
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009900730A
Other languages
English (en)
Other versions
ES2159232A1 (es
Inventor
Franco Fernando Cardenas
Montero Jose Maria Sanchez
Gago Jose Vicente Sinisterra
W Steve Elson
Ruiz Emilio Alvarez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham SA
Original Assignee
SmithKline Beecham SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham SA filed Critical SmithKline Beecham SA
Priority to ES009900730A priority Critical patent/ES2159232B1/es
Publication of ES2159232A1 publication Critical patent/ES2159232A1/es
Application granted granted Critical
Publication of ES2159232B1 publication Critical patent/ES2159232B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Procedimientos enzimáticos para la resolución de mezclas enantioméricas de ácidos orgánicos. La presente invención se refiere a un procedimiento para la resolución de mezclas enantioméricas de ácidos orgánicos, en particular, a la resolución de mezclas enantioméricas de ácidos propiónicos, y más en particular, a la resolución de los ácidos (R,S) 2(4- isobutilfenil) propiónico y (R,S) 2-(3-benzoilfenil) propiónico. El procedimiento consiste en hacer reaccionar en el seno de un disolvente orgánico apolar la mezcla a resolver con un alcohol en presencia de un biocatalizador, y la posterior separación del éster enantioméricamente enriquecido de los productos de partida. Dicho biocatalizador es una lipasa, o mezcla de lipasas, en diversos grados de purificación, producida por un microorganismo seleccionado del siguiente grupo: Fusarium oxysporum, Arthroderma ciferrii, Monascus mucoroides, Ovadendron sulphureoochraceum, Brevibacterium linens, Streptomyces fradiae y Rhodotorula araucariae. Dichosprocedimientos son de interés en la industria farmacéutica e industria de química fina.
ES009900730A 1999-04-09 1999-04-09 Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos. Expired - Fee Related ES2159232B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES009900730A ES2159232B1 (es) 1999-04-09 1999-04-09 Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009900730A ES2159232B1 (es) 1999-04-09 1999-04-09 Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos.

Publications (2)

Publication Number Publication Date
ES2159232A1 ES2159232A1 (es) 2001-09-16
ES2159232B1 true ES2159232B1 (es) 2002-04-01

Family

ID=8307964

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009900730A Expired - Fee Related ES2159232B1 (es) 1999-04-09 1999-04-09 Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos.

Country Status (1)

Country Link
ES (1) ES2159232B1 (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK289083A (da) * 1983-06-23 1984-12-24 Novo Industri As Lipase, fremgangsmaade til fremstilling deraf og anvendelse deraf
CA2023856A1 (en) * 1989-09-26 1991-03-27 Jeffrey M. Howell Enzymatic resolution process
CA2132411A1 (en) * 1994-09-19 1996-03-20 Michael Trani Enzymatic esterification of long-chain racemic acids and alcohols

Also Published As

Publication number Publication date
ES2159232A1 (es) 2001-09-16

Similar Documents

Publication Publication Date Title
Klunder et al. Enzymic optical resolution and absolute configuration of tricyclo [5.2. 1.02, 6] decadienones
JPH04248993A (ja) 光学的に純粋な（Ｓ）−α−〔（ターシヤリー−ブチルスルホニル）メチル〕ヒドロ桂皮酸の製造方法
Yamamoto et al. Asymmetric Synthesis of Optically Active Lactones from Cyclic Acid Anhydrides Using Lipase in Organic Solvents1
AU708725B2 (en) Process for the fractionation of fatty acids
DE3378206D1 (en) Process for the preparation of a free alpha-l-amino acid
Lanser Conversion of oleic acid to 10‐ketostearic acid by aStaphylococcus species
ES2159232B1 (es) Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos.
López-Garcı́a et al. Desymmetrization of dimethyl 3-substituted glutarates through enzymatic ammonolysis and aminolysis reactions
KR940000459A (ko) (r,s)-3-퀴누클리디놀의 에난티오머 증가방법
CA2161849A1 (en) Production of optically active compounds
EP0178553A3 (en) Process for the production of aromatic substituted l-amino acids
JPH0889282A (ja) 立体異性アルコール混合物の分解方法
EP0997534A3 (de) Verfahren zur Racematspaltung von Arylalkylcarbonsäureestern
ES2159231B1 (es) Procedimiento de resolucion de mezclas enantiomericas de alcoholes catalizada por lipasas.
ATE170771T1 (de) Verfahren zur desodorierung und stabilisierung biotechnologisch gewonnener wertstoffe und ihrer wässrigen zubereitungen
JP2707642B2 (ja) リゾリン脂質の製造法
JPH01500004A (ja) 光学活性１，２―ジヒドロ―３Ｈ―ピロロ［１，２ａ］ピロール―１―カルボン酸誘導体の調製方法
JPH09124564A (ja) 光学活性体混合物ならびにその製造方法
JP4331896B2 (ja) リゾスフィンゴ脂質の製造方法
EP0467132B1 (en) 4-Substituted-2-hydroxybutanoates and a process for producing them
JPH08275796A (ja) 光学活性シクロプロパン誘導体の製造法
JPS6258992A (ja) エステル合成法
Kiełbasiński On the applicability of the Jones active site model of pig liver esterase to S-chiral and prochiral sulfinyl substrates
KR100554437B1 (ko) 숙시닐-사이클로덱스트린를 키랄 선택제로 이용한2-아릴프로피온산 에스테르 라세미체를 원료로 한광학활성 (에스)-2-아릴프로피온산의 효소적 제조법
JP2001169794A (ja) 共役リノール酸異性体の精製方法

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 20160120

Kind code of ref document: A1

Effective date: 20160120

PC2A Transfer of patent
FD2A Announcement of lapse in spain

Effective date: 20180807