ES2159232A1 - Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos. - Google Patents

Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos.

Info

Publication number
ES2159232A1
ES2159232A1 ES009900730A ES9900730A ES2159232A1 ES 2159232 A1 ES2159232 A1 ES 2159232A1 ES 009900730 A ES009900730 A ES 009900730A ES 9900730 A ES9900730 A ES 9900730A ES 2159232 A1 ES2159232 A1 ES 2159232A1
Authority
ES
Spain
Prior art keywords
alcohol
reaction
organic solvent
enantiomeric mixtures
enzymatic resolution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009900730A
Other languages
English (en)
Other versions
ES2159232B1 (es
Inventor
Franco Fernando Cardenas
Montero Jose Maria Sanchez
Gago Jose Vicente Sinisterra
W Steve Elson
Ruiz Emilio Alvarez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham SA
Original Assignee
SmithKline Beecham SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham SA filed Critical SmithKline Beecham SA
Priority to ES009900730A priority Critical patent/ES2159232B1/es
Publication of ES2159232A1 publication Critical patent/ES2159232A1/es
Application granted granted Critical
Publication of ES2159232B1 publication Critical patent/ES2159232B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procedimientos enzimáticos para la resolución de mezclas enantioméricas de ácidos orgánicos. La presente invención se refiere a un procedimiento para la resolución de mezclas enantioméricas de ácidos orgánicos, en particular, a la resolución de mezclas enantioméricas de ácidos propiónicos, y más en particular, a la resolución de los ácidos (R,S) 2(4- isobutilfenil) propiónico y (R,S) 2-(3-benzoilfenil) propiónico. El procedimiento consiste en hacer reaccionar en el seno de un disolvente orgánico apolar la mezcla a resolver con un alcohol en presencia de un biocatalizador, y la posterior separación del éster enantioméricamente enriquecido de los productos de partida. Dicho biocatalizador es una lipasa, o mezcla de lipasas, en diversos grados de purificación, producida por un microorganismo seleccionado del siguiente grupo: Fusarium oxysporum, Arthroderma ciferrii, Monascus mucoroides, Ovadendron sulphureoochraceum, Brevibacterium linens, Streptomyces fradiae y Rhodotorula araucariae. Dichosprocedimientos son de interés en la industria farmacéutica e industria de química fina.
ES009900730A 1999-04-09 1999-04-09 Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos. Expired - Fee Related ES2159232B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES009900730A ES2159232B1 (es) 1999-04-09 1999-04-09 Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009900730A ES2159232B1 (es) 1999-04-09 1999-04-09 Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos.

Publications (2)

Publication Number Publication Date
ES2159232A1 true ES2159232A1 (es) 2001-09-16
ES2159232B1 ES2159232B1 (es) 2002-04-01

Family

ID=8307964

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009900730A Expired - Fee Related ES2159232B1 (es) 1999-04-09 1999-04-09 Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de acidos organicos.

Country Status (1)

Country Link
ES (1) ES2159232B1 (es)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0130064A1 (en) * 1983-06-23 1985-01-02 Novo Nordisk A/S Improvements in and relating to an enzymatic detergent additive, a detergent, and a washing method
EP0421636A1 (en) * 1989-09-26 1991-04-10 E.R. SQUIBB & SONS, INC. Enzymatic resolution process
US5561057A (en) * 1994-09-19 1996-10-01 National Research Council Of Canada Resolution of (RS)-ibuprofen by Candida antarctica catalyzed esterification with long chain alcohols while removing water

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0130064A1 (en) * 1983-06-23 1985-01-02 Novo Nordisk A/S Improvements in and relating to an enzymatic detergent additive, a detergent, and a washing method
EP0421636A1 (en) * 1989-09-26 1991-04-10 E.R. SQUIBB & SONS, INC. Enzymatic resolution process
US5561057A (en) * 1994-09-19 1996-10-01 National Research Council Of Canada Resolution of (RS)-ibuprofen by Candida antarctica catalyzed esterification with long chain alcohols while removing water

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BRAHIMI-HORN, M-Ch. et al. Synthesis of hydrolytic enzymes during production of tylosin by Streptomyces fradiae. Journal of Industrial Microbiology, 1992, Vol. 10, paginas 25-30. *
GOTO, M. et al. Enzymatic resolution of racemic ibuprofen by surfactant-coated lipases in organic media. Biotechnology Letters. 1996, Vol. 18 (7), paginas 839-844. *
HOSHINO et al. Purification and some characteristics of extracellular lipase from Fusarium oxysporum f. sp. lini. Biosci. Biotech. Biochem., 1992, Vol. 56 (4), paginas 660-664. *
MUSTRANTA, A. Use of lipases in the resolution of racemic ibuprofen. Appl. Microbiol. Biotechnol., 1992, Vol. 38, paginas 61-66. *

Also Published As

Publication number Publication date
ES2159232B1 (es) 2002-04-01

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