AU2002210542A1 - Process for preparing optically active 4-hydroxy-2-pyrrolidinone and n-substituted 4-hydroxy-2-pyrrolidinones by enzymatic hydroxylation - Google Patents

Process for preparing optically active 4-hydroxy-2-pyrrolidinone and n-substituted 4-hydroxy-2-pyrrolidinones by enzymatic hydroxylation

Info

Publication number
AU2002210542A1
AU2002210542A1 AU2002210542A AU1054202A AU2002210542A1 AU 2002210542 A1 AU2002210542 A1 AU 2002210542A1 AU 2002210542 A AU2002210542 A AU 2002210542A AU 1054202 A AU1054202 A AU 1054202A AU 2002210542 A1 AU2002210542 A1 AU 2002210542A1
Authority
AU
Australia
Prior art keywords
hydroxy
pyrrolidinones
pyrrolidinone
substituted
microorganisms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002210542A
Inventor
Dongliang Chang
Zhi Li
Bernard Witholt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eidgenoessische Technische Hochschule Zurich ETHZ
Original Assignee
Eidgenoessische Technische Hochschule Zurich ETHZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eidgenoessische Technische Hochschule Zurich ETHZ filed Critical Eidgenoessische Technische Hochschule Zurich ETHZ
Publication of AU2002210542A1 publication Critical patent/AU2002210542A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

This invention provides a process for the preparation of optically active 4-hydroxy-2-pyrrolidinone or N-substituted 4-hydroxy-2-pyrrolidinones, wherein an oxygen atom is inserted regio- and stereoselectively into the corresponding non-hydroxylated 2-pyrrolidinones, by using, as a biocatalyst, a microorganism having hydroxylation activity, or a host-organism having the gene(s) necessary for the hydroxylation enzymes derived from the said microorganism, or an enzyme having hydroxylation activity derived from the above microorganisms. The microorganism may be selected from the group consisting of microorganisms that degrade alkanes or cyclic hydrocarbons, microorganisms having alkane hydroxylase(s), or microorganisms that are able to oxidize hydrocarbons.
AU2002210542A 2000-10-13 2001-10-12 Process for preparing optically active 4-hydroxy-2-pyrrolidinone and n-substituted 4-hydroxy-2-pyrrolidinones by enzymatic hydroxylation Abandoned AU2002210542A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00203579.8 2000-10-13
EP00203579A EP1197561A1 (en) 2000-10-13 2000-10-13 Process for preparing optically active 4-hydroxy-2-pyrrolidinone and N-substituted 4-hydroxy-2-pyrrolidinones by enzymatic hydroxylation
PCT/EP2001/011931 WO2002031174A2 (en) 2000-10-13 2001-10-12 Process for preparing optically active 4-hydroxy-2-pyrrolidinone and n-substituted 4-hydroxy-2-pyrrolidinones by enzymatic hydroxylation

Publications (1)

Publication Number Publication Date
AU2002210542A1 true AU2002210542A1 (en) 2002-04-22

Family

ID=8172140

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002210542A Abandoned AU2002210542A1 (en) 2000-10-13 2001-10-12 Process for preparing optically active 4-hydroxy-2-pyrrolidinone and n-substituted 4-hydroxy-2-pyrrolidinones by enzymatic hydroxylation

Country Status (6)

Country Link
US (1) US20040009562A1 (en)
EP (2) EP1197561A1 (en)
AT (1) ATE312938T1 (en)
AU (1) AU2002210542A1 (en)
DE (1) DE60115935T2 (en)
WO (1) WO2002031174A2 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1002871A1 (en) * 1998-11-17 2000-05-24 Eidgenössische Technische Hochschule (ETH) Zürich Process for preparing optically active 3-hydroxy-pyrrolidine derivatives by enzymatic hydroxylation

Also Published As

Publication number Publication date
EP1325146B1 (en) 2005-12-14
DE60115935D1 (en) 2006-01-19
US20040009562A1 (en) 2004-01-15
EP1197561A1 (en) 2002-04-17
ATE312938T1 (en) 2005-12-15
EP1325146A2 (en) 2003-07-09
WO2002031174A3 (en) 2002-11-28
DE60115935T2 (en) 2006-08-03
WO2002031174A2 (en) 2002-04-18

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