ES2158905T3 - Procedimiento de preparacion de 3-metil-5-(1-alquil-2(s)-pirrolidinil)isoxazoles enantiomericamente puros. - Google Patents

Procedimiento de preparacion de 3-metil-5-(1-alquil-2(s)-pirrolidinil)isoxazoles enantiomericamente puros.

Info

Publication number
ES2158905T3
ES2158905T3 ES94931741T ES94931741T ES2158905T3 ES 2158905 T3 ES2158905 T3 ES 2158905T3 ES 94931741 T ES94931741 T ES 94931741T ES 94931741 T ES94931741 T ES 94931741T ES 2158905 T3 ES2158905 T3 ES 2158905T3
Authority
ES
Spain
Prior art keywords
methyl
pirrolidinil
isoxazoles
rent
enantiomerically pure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94931741T
Other languages
English (en)
Inventor
Nan-Horng Lin
Yun He
Richard L Elliott
Mukund S Chorghade
Steven J Wittenberger
William H Bunnelle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2158905T3 publication Critical patent/ES2158905T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN NUEVO PROCEDIMENTO PARA PREPARAR 3-METIL-5-(1-(C 1}C{SUB,3}-ALQUIL)-2-PIRROLIDINIL)ISOXAZOL ENANTIOMERICAMENTE PUROS EN RENDIMIENTO ALTO, EN DONDE UNA PIRROLIDINA PROTEGIDA O UN MATERIAL DE INICIO DE 2-OXO-PIRROLIDINA SE REACCIONA CON UN ANION ORGANICO ADECUADO Y UN INTERMEDIARIO DE OXIMA BETA-CETO RESULTANTE ES PRODUCIDO EN CICLOS Y DESHIDRATADO, ASI COMO INTERMEDIARIOS UTILES EN LA PREPARACION DEL MISMO.
ES94931741T 1993-09-08 1994-08-30 Procedimiento de preparacion de 3-metil-5-(1-alquil-2(s)-pirrolidinil)isoxazoles enantiomericamente puros. Expired - Lifetime ES2158905T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11781993A 1993-09-08 1993-09-08
US08/234,442 US5424444A (en) 1992-11-25 1994-04-28 Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2(S)-pyrrolidinyl) isoxazoles

Publications (1)

Publication Number Publication Date
ES2158905T3 true ES2158905T3 (es) 2001-09-16

Family

ID=26815678

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94931741T Expired - Lifetime ES2158905T3 (es) 1993-09-08 1994-08-30 Procedimiento de preparacion de 3-metil-5-(1-alquil-2(s)-pirrolidinil)isoxazoles enantiomericamente puros.

Country Status (11)

Country Link
US (4) US5424444A (es)
EP (1) EP0717741B1 (es)
JP (1) JPH09502439A (es)
AT (1) ATE201681T1 (es)
CA (1) CA2167833A1 (es)
DE (1) DE69427361T2 (es)
DK (1) DK0717741T3 (es)
ES (1) ES2158905T3 (es)
GR (1) GR3036387T3 (es)
PT (1) PT717741E (es)
WO (1) WO1995007277A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6299296A (en) * 1995-06-29 1997-01-30 Novo Nordisk A/S Novel substituted azacyclic compounds
CN109096168A (zh) * 2018-09-18 2018-12-28 广东肇庆星湖生物科技股份有限公司 一种l-脯氨酸苄脂的制备方法
CN110746466B (zh) * 2019-10-22 2023-08-15 合肥工业大学 一种手性铂配合物的制备及用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6375073A (ja) * 1986-09-17 1988-04-05 Yoshio Ichikawa コ−テイング方法
DE3812156A1 (de) * 1988-04-12 1989-10-26 Heliotronic Gmbh Das durchtreten von fluiden gestattendes keramisches material auf basis von in gegenwart von kohlenstoff reaktionsgebundenem siliciumpulver
WO1992021339A1 (en) * 1991-05-29 1992-12-10 Abbott Laboratories Isoxazole and isothiazole compounds that enhance cognitive function

Also Published As

Publication number Publication date
EP0717741B1 (en) 2001-05-30
US5424444A (en) 1995-06-13
ATE201681T1 (de) 2001-06-15
EP0717741A1 (en) 1996-06-26
DE69427361T2 (de) 2002-04-18
DK0717741T3 (da) 2001-08-20
US5508418A (en) 1996-04-16
US5559242A (en) 1996-09-24
GR3036387T3 (en) 2001-11-30
DE69427361D1 (de) 2001-07-05
CA2167833A1 (en) 1995-03-16
PT717741E (pt) 2001-10-31
WO1995007277A1 (en) 1995-03-16
US5516912A (en) 1996-05-14
JPH09502439A (ja) 1997-03-11

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