ES2157291T3 - Derivados imidazol con actividad anti-hiv. - Google Patents
Derivados imidazol con actividad anti-hiv.Info
- Publication number
- ES2157291T3 ES2157291T3 ES95203023T ES95203023T ES2157291T3 ES 2157291 T3 ES2157291 T3 ES 2157291T3 ES 95203023 T ES95203023 T ES 95203023T ES 95203023 T ES95203023 T ES 95203023T ES 2157291 T3 ES2157291 T3 ES 2157291T3
- Authority
- ES
- Spain
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- aryl
- hiv activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/62—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with triarylmethyl radicals attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
UN NUEVO DERIVADO DE IMIDAZOL DE LA FORMULA I: EN LA QUE: R{SUP,1} ES HIDROGENO; ALQUILO C{SUB,1}-C{SUB,10}; HALOGENO; O ARILO C{SUB,6}-C{SUB,12} QUE ES INSUSTITUIDO O PUEDE SER SUSTITUIDO POR ALQUILO C{SUB,1}-C{SUB,10}, HALOGENO, NITRO, AMINO, HIDROXI, ALCOXI C{SUB,1}-C{SUB,10} O ARALQUILOXI; R{SUP,2} ES PIRIDILO; PIRIMIDINILO; PIRIDAZINILO; PIRAZINILO; IMIDAZOLILO; OXAZOLILO; O TIAZOLILO, CADA UNO DE LOS CUALES ES INSUSTITUIDO O PUEDE SER SUSTITUIDO POR ALQUILO C{SUB,1}C{SUB,10}, HALOGENO, NITRO, AMINO, HIDROXI, ALCOXI C{SUB,1}C{SUB,10} O ARIL-C{SUB,6}C{SUB,12}-ALCOXI-C{SUB,1}-C{SUB,10}; R{SUP,3} ES HIDROGENO; ALQUILO C{SUB,1}-C{SUB,10}; ARILO C{SUB,6}-C{SUB,12} QUE ES INSUSTITUIDO O PUEDE SER SUSTITUIDO POR ALQUILO C{SUB,1}-C{SUB,10}, HALOGENO, NITRO, AMINO, HIDROXI, ALCOXI C{SUB,1}-C{SUB,10} O ARIL-C{SUB,6}-C{SUB,12}-ALCOXIC{SUB,1}-C{SUB,10}; ARIL-C{SUB,6}-C{SUB,12}-ALQUILO-C{SUB,1}C{SUB,10} QUE ES INSUSTITUIDO O PUEDE SER SUSTITUIDO POR ALQUILO C{SUB,1}-C{SUB,10}, HALOGENO, NITRO, AMINO, HIDROXI, ALCOXI C{SUB,1}-C{SUB,10} O ARIL-C{SUB,6}-C{SUB,12}-ALCOXI-C{SUB,1}C{SUB,10}; O HIDROXIALQUILO C{SUB,1}-C{SUB,10} QUE ES INSUSTITUIDO O PUEDE SER SUSTITUIDO POR ARILO C{SUB,6}-C{SUB,12}, ALQUILO C{SUB,1}-C{SUB,10}, ARIL-C{SUB,6}-C{SUB,12}-ALQUILOC{SUB,1}-C{SUB,10}, BENZOILO, 4-NITROBENZOILO, 4-TERCBUTILBENZOILO, BENCENOSULFONILO, TOLUENOSULFONILO, FORMILO, ACETILO, PROPIONILO, BUTIRILO O VALERILO; R{SUP,4} ES HIDROGENO; ALQUILO C{SUB,1}-C{SUB,10}; HALOGENO; BENZOILO; 4-NITROBENZOILO; 4-TERC-BUTILBENZOILO; BENCENOSULFONILO; TOLUENOSULFONILO; FORMILO; ACETILO; PROPIONILO; BUTIRILO; VALERILO; HIDROXIALQUILO C{SUB,1}-C{SUB,10} QUE ES INSUSTITUIDO O PUEDE SER SUSTITUIDO POR ARILO C{SUB,6}-C{SUB,12}, ALQUILO C{SUB,1}-C{SUB,10}, ARIL-C{SUB,6}-C{SUB,12}-ALQUILOC{SUB,1}-C{SUB,10}, BENZOILO, 4-NITROBENZOILO, 4-TERCBUTILBENZOILO, BENCENOSULFONILO, TOLUENOSULFONILO, FORMILO, ACETILO, PROPIONILO, BUTIRILO O VALERILO; CARBOXILO; METOXICARBONILO; ETOXICARBONILO; TERC-BUTOXICARBONILO; BENCILOXICARBONILO; HIDROXI; ARILO C{SUB,6}-C{SUB,12}; O ARILTIO C{SUB,6}-C{SUB,12}; X ES S, SO, SO{SUB,2}, CH{SUB,2} O SE; Y N ES UN ENTERO DE 1 A 3, O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, EN DONDE DICHO DERIVADO POSEE UNA ACTIVIDAD ANTI-VIH Y ES UTIL PARA EL TRATAMIENTO DE LAS INFECCIONES PROVOCADAS POR EL VIH.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP557792 | 1992-01-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2157291T3 true ES2157291T3 (es) | 2001-08-16 |
Family
ID=11615084
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93300278T Expired - Lifetime ES2125301T3 (es) | 1992-01-16 | 1993-01-15 | Derivados de imidazol de actividad anti-vih. |
ES95203023T Expired - Lifetime ES2157291T3 (es) | 1992-01-16 | 1993-01-15 | Derivados imidazol con actividad anti-hiv. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93300278T Expired - Lifetime ES2125301T3 (es) | 1992-01-16 | 1993-01-15 | Derivados de imidazol de actividad anti-vih. |
Country Status (16)
Country | Link |
---|---|
US (2) | US5326780A (es) |
EP (2) | EP0552060B1 (es) |
JP (1) | JP3464498B2 (es) |
KR (1) | KR100259309B1 (es) |
AT (2) | ATE173470T1 (es) |
AU (1) | AU649906B2 (es) |
CA (1) | CA2087112A1 (es) |
DE (2) | DE69322106T2 (es) |
DK (2) | DK0700911T3 (es) |
ES (2) | ES2125301T3 (es) |
GR (1) | GR3035646T3 (es) |
HU (1) | HU219917B (es) |
NZ (1) | NZ245674A (es) |
PT (1) | PT700911E (es) |
TW (1) | TW235963B (es) |
ZA (1) | ZA93217B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5300519A (en) * | 1988-07-06 | 1994-04-05 | The University Of Sheffield | Immunosuppressive agents |
US5514781A (en) * | 1994-04-11 | 1996-05-07 | Bayer Corporation | Use of azoles as virucidal agents in solutions of biologically active proteins |
US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
HUT77357A (hu) * | 1994-09-26 | 1998-03-30 | Shionogi & Co. Ltd. | AIDS-ellenes imidazolszármazékok és ilyen vegyületeket tartalmazó gyógyászati készítmények |
EP0893442B1 (en) * | 1996-03-28 | 2005-01-12 | Shionogi & Co., Ltd. | Lymph-absorbable imidazole derivatives |
US5891889A (en) * | 1996-04-03 | 1999-04-06 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
JP2000509371A (ja) * | 1996-04-03 | 2000-07-25 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質トランスフェラーゼ阻害剤 |
AU712071B2 (en) * | 1996-04-04 | 1999-10-28 | Shionogi & Co., Ltd. | Anti-HIV composition containing imidazole derivatives |
US6544193B2 (en) * | 1996-09-04 | 2003-04-08 | Marcio Marc Abreu | Noninvasive measurement of chemical substances |
JP3378017B2 (ja) * | 1996-12-26 | 2003-02-17 | 塩野義製薬株式会社 | イミダゾール誘導体の製造法 |
TWI232214B (en) * | 1998-04-16 | 2005-05-11 | Shionogi & Co | Preparation of aryl sulfenyl halide |
US6184241B1 (en) | 1998-08-24 | 2001-02-06 | Kansas State University Research Foundation | Aspartic protease inhibitors |
CZ20012338A3 (cs) | 1998-12-24 | 2001-12-12 | Fujisawa Pharmaceutical Co., Ltd. | Imidazolové sloučeniny |
GB0028484D0 (en) * | 2000-11-22 | 2001-01-10 | Hoffmann La Roche | Imidazolone derivatives for the treatment of viral diseases |
CN1555365A (zh) | 2001-02-23 | 2004-12-15 | ³�������̴�ѧ�о������� | 抑制hiv的n-氨基咪唑衍生物 |
CA2926782A1 (en) | 2013-11-04 | 2015-05-07 | Covidien Lp | Surgical fastener applying apparatus |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63150266A (ja) * | 1986-12-12 | 1988-06-22 | Mitsui Petrochem Ind Ltd | ベンジルイミダゾ−ル誘導体 |
US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
-
1993
- 1993-01-11 TW TW082100124A patent/TW235963B/zh active
- 1993-01-12 CA CA002087112A patent/CA2087112A1/en not_active Abandoned
- 1993-01-12 US US08/003,126 patent/US5326780A/en not_active Expired - Lifetime
- 1993-01-13 NZ NZ245674A patent/NZ245674A/en unknown
- 1993-01-13 ZA ZA93217A patent/ZA93217B/xx unknown
- 1993-01-13 JP JP00421693A patent/JP3464498B2/ja not_active Expired - Fee Related
- 1993-01-15 AT AT93300278T patent/ATE173470T1/de not_active IP Right Cessation
- 1993-01-15 DK DK95203023T patent/DK0700911T3/da active
- 1993-01-15 DE DE69322106T patent/DE69322106T2/de not_active Expired - Fee Related
- 1993-01-15 DK DK93300278T patent/DK0552060T3/da active
- 1993-01-15 ES ES93300278T patent/ES2125301T3/es not_active Expired - Lifetime
- 1993-01-15 EP EP93300278A patent/EP0552060B1/en not_active Expired - Lifetime
- 1993-01-15 AT AT95203023T patent/ATE200082T1/de not_active IP Right Cessation
- 1993-01-15 PT PT95203023T patent/PT700911E/pt unknown
- 1993-01-15 EP EP95203023A patent/EP0700911B1/en not_active Expired - Lifetime
- 1993-01-15 ES ES95203023T patent/ES2157291T3/es not_active Expired - Lifetime
- 1993-01-15 DE DE69330072T patent/DE69330072T2/de not_active Expired - Fee Related
- 1993-01-15 HU HU9300107A patent/HU219917B/hu not_active IP Right Cessation
- 1993-01-15 AU AU31827/93A patent/AU649906B2/en not_active Ceased
- 1993-01-15 KR KR1019930000496A patent/KR100259309B1/ko not_active IP Right Cessation
-
1994
- 1994-03-14 US US08/209,627 patent/US5472965A/en not_active Expired - Fee Related
-
2001
- 2001-03-29 GR GR20010400136T patent/GR3035646T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NZ245674A (en) | 1995-06-27 |
CA2087112A1 (en) | 1993-07-17 |
EP0700911A1 (en) | 1996-03-13 |
EP0552060B1 (en) | 1998-11-18 |
KR930016402A (ko) | 1993-08-26 |
HU219917B (hu) | 2001-09-28 |
HUT63615A (en) | 1993-09-28 |
TW235963B (es) | 1994-12-11 |
GR3035646T3 (en) | 2001-06-29 |
ATE173470T1 (de) | 1998-12-15 |
PT700911E (pt) | 2001-07-31 |
ATE200082T1 (de) | 2001-04-15 |
EP0552060A1 (en) | 1993-07-21 |
DE69322106D1 (de) | 1998-12-24 |
EP0700911B1 (en) | 2001-03-28 |
DE69322106T2 (de) | 1999-04-29 |
HU9300107D0 (en) | 1993-04-28 |
DK0700911T3 (da) | 2001-05-07 |
DE69330072D1 (de) | 2001-05-03 |
DE69330072T2 (de) | 2001-08-23 |
JPH05255270A (ja) | 1993-10-05 |
AU649906B2 (en) | 1994-06-02 |
US5472965A (en) | 1995-12-05 |
ZA93217B (en) | 1993-08-18 |
ES2125301T3 (es) | 1999-03-01 |
US5326780A (en) | 1994-07-05 |
JP3464498B2 (ja) | 2003-11-10 |
KR100259309B1 (ko) | 2000-08-01 |
DK0552060T3 (da) | 1999-08-02 |
AU3182793A (en) | 1993-07-22 |
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