DK0552060T3 - Imidazolderivater med anti-HIV-virkning - Google Patents
Imidazolderivater med anti-HIV-virkningInfo
- Publication number
- DK0552060T3 DK0552060T3 DK93300278T DK93300278T DK0552060T3 DK 0552060 T3 DK0552060 T3 DK 0552060T3 DK 93300278 T DK93300278 T DK 93300278T DK 93300278 T DK93300278 T DK 93300278T DK 0552060 T3 DK0552060 T3 DK 0552060T3
- Authority
- DK
- Denmark
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- imidazole derivatives
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/62—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with triarylmethyl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP557792 | 1992-01-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0552060T3 true DK0552060T3 (da) | 1999-08-02 |
Family
ID=11615084
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95203023T DK0700911T3 (da) | 1992-01-16 | 1993-01-15 | Imidazolderivater med anti-HIV-aktivitet |
| DK93300278T DK0552060T3 (da) | 1992-01-16 | 1993-01-15 | Imidazolderivater med anti-HIV-virkning |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95203023T DK0700911T3 (da) | 1992-01-16 | 1993-01-15 | Imidazolderivater med anti-HIV-aktivitet |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5326780A (da) |
| EP (2) | EP0700911B1 (da) |
| JP (1) | JP3464498B2 (da) |
| KR (1) | KR100259309B1 (da) |
| AT (2) | ATE173470T1 (da) |
| AU (1) | AU649906B2 (da) |
| CA (1) | CA2087112A1 (da) |
| DE (2) | DE69322106T2 (da) |
| DK (2) | DK0700911T3 (da) |
| ES (2) | ES2157291T3 (da) |
| GR (1) | GR3035646T3 (da) |
| HU (1) | HU219917B (da) |
| NZ (1) | NZ245674A (da) |
| PT (1) | PT700911E (da) |
| TW (1) | TW235963B (da) |
| ZA (1) | ZA93217B (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5300519A (en) * | 1988-07-06 | 1994-04-05 | The University Of Sheffield | Immunosuppressive agents |
| US5514781A (en) * | 1994-04-11 | 1996-05-07 | Bayer Corporation | Use of azoles as virucidal agents in solutions of biologically active proteins |
| US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
| WO1996010019A1 (fr) * | 1994-09-26 | 1996-04-04 | Shionogi & Co., Ltd. | Derive imidazole |
| WO1997035843A1 (fr) * | 1996-03-28 | 1997-10-02 | Shionogi & Co., Ltd. | Derives d'imidazole absorbables par la lymphe |
| US5891889A (en) * | 1996-04-03 | 1999-04-06 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| EP0891339A1 (en) * | 1996-04-03 | 1999-01-20 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU712071B2 (en) * | 1996-04-04 | 1999-10-28 | Shionogi & Co., Ltd. | Anti-HIV composition containing imidazole derivatives |
| US6544193B2 (en) * | 1996-09-04 | 2003-04-08 | Marcio Marc Abreu | Noninvasive measurement of chemical substances |
| KR100399463B1 (ko) * | 1996-12-26 | 2003-09-29 | 시오노기세이야쿠가부시키가이샤 | 이미다졸 유도체의 제조 방법 |
| TWI232214B (en) * | 1998-04-16 | 2005-05-11 | Shionogi & Co | Preparation of aryl sulfenyl halide |
| US6184241B1 (en) | 1998-08-24 | 2001-02-06 | Kansas State University Research Foundation | Aspartic protease inhibitors |
| CZ20012338A3 (cs) | 1998-12-24 | 2001-12-12 | Fujisawa Pharmaceutical Co., Ltd. | Imidazolové sloučeniny |
| GB0028484D0 (en) * | 2000-11-22 | 2001-01-10 | Hoffmann La Roche | Imidazolone derivatives for the treatment of viral diseases |
| JP2004519477A (ja) * | 2001-02-23 | 2004-07-02 | カー・イュー・ルーベン・リサーチ・アンド・ディベロップメント | Ｈｉｖ抑制ｎ−アミノイミダゾール誘導体 |
| CN105682568B (zh) | 2013-11-04 | 2018-10-23 | 柯惠Lp公司 | 手术紧固件施加装置 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63150266A (ja) * | 1986-12-12 | 1988-06-22 | Mitsui Petrochem Ind Ltd | ベンジルイミダゾ−ル誘導体 |
| US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
-
1993
- 1993-01-11 TW TW082100124A patent/TW235963B/zh active
- 1993-01-12 US US08/003,126 patent/US5326780A/en not_active Expired - Lifetime
- 1993-01-12 CA CA002087112A patent/CA2087112A1/en not_active Abandoned
- 1993-01-13 JP JP00421693A patent/JP3464498B2/ja not_active Expired - Fee Related
- 1993-01-13 NZ NZ245674A patent/NZ245674A/en unknown
- 1993-01-13 ZA ZA93217A patent/ZA93217B/xx unknown
- 1993-01-15 DE DE69322106T patent/DE69322106T2/de not_active Expired - Fee Related
- 1993-01-15 AT AT93300278T patent/ATE173470T1/de not_active IP Right Cessation
- 1993-01-15 DK DK95203023T patent/DK0700911T3/da active
- 1993-01-15 DK DK93300278T patent/DK0552060T3/da active
- 1993-01-15 KR KR1019930000496A patent/KR100259309B1/ko not_active IP Right Cessation
- 1993-01-15 AT AT95203023T patent/ATE200082T1/de not_active IP Right Cessation
- 1993-01-15 HU HU9300107A patent/HU219917B/hu not_active IP Right Cessation
- 1993-01-15 AU AU31827/93A patent/AU649906B2/en not_active Ceased
- 1993-01-15 DE DE69330072T patent/DE69330072T2/de not_active Expired - Fee Related
- 1993-01-15 EP EP95203023A patent/EP0700911B1/en not_active Expired - Lifetime
- 1993-01-15 PT PT95203023T patent/PT700911E/pt unknown
- 1993-01-15 ES ES95203023T patent/ES2157291T3/es not_active Expired - Lifetime
- 1993-01-15 EP EP93300278A patent/EP0552060B1/en not_active Expired - Lifetime
- 1993-01-15 ES ES93300278T patent/ES2125301T3/es not_active Expired - Lifetime
-
1994
- 1994-03-14 US US08/209,627 patent/US5472965A/en not_active Expired - Fee Related
-
2001
- 2001-03-29 GR GR20010400136T patent/GR3035646T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU649906B2 (en) | 1994-06-02 |
| HUT63615A (en) | 1993-09-28 |
| DE69322106T2 (de) | 1999-04-29 |
| CA2087112A1 (en) | 1993-07-17 |
| US5472965A (en) | 1995-12-05 |
| ES2157291T3 (es) | 2001-08-16 |
| KR930016402A (ko) | 1993-08-26 |
| US5326780A (en) | 1994-07-05 |
| KR100259309B1 (ko) | 2000-08-01 |
| PT700911E (pt) | 2001-07-31 |
| HU9300107D0 (en) | 1993-04-28 |
| ES2125301T3 (es) | 1999-03-01 |
| DK0700911T3 (da) | 2001-05-07 |
| EP0700911A1 (en) | 1996-03-13 |
| NZ245674A (en) | 1995-06-27 |
| JPH05255270A (ja) | 1993-10-05 |
| DE69322106D1 (de) | 1998-12-24 |
| AU3182793A (en) | 1993-07-22 |
| GR3035646T3 (en) | 2001-06-29 |
| ZA93217B (en) | 1993-08-18 |
| JP3464498B2 (ja) | 2003-11-10 |
| EP0552060B1 (en) | 1998-11-18 |
| EP0552060A1 (en) | 1993-07-21 |
| EP0700911B1 (en) | 2001-03-28 |
| DE69330072T2 (de) | 2001-08-23 |
| DE69330072D1 (de) | 2001-05-03 |
| ATE173470T1 (de) | 1998-12-15 |
| HU219917B (hu) | 2001-09-28 |
| TW235963B (da) | 1994-12-11 |
| ATE200082T1 (de) | 2001-04-15 |
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