ES2154757T3 - Derivados de tiopirano. - Google Patents

Derivados de tiopirano.

Info

Publication number
ES2154757T3
ES2154757T3 ES96110051T ES96110051T ES2154757T3 ES 2154757 T3 ES2154757 T3 ES 2154757T3 ES 96110051 T ES96110051 T ES 96110051T ES 96110051 T ES96110051 T ES 96110051T ES 2154757 T3 ES2154757 T3 ES 2154757T3
Authority
ES
Spain
Prior art keywords
sub
group
disturbation
useful
blocking action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96110051T
Other languages
English (en)
Inventor
Akira Mizuno
Makoto Shibata
Tomoe Iwamori
Norio Inomata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ES2154757T3 publication Critical patent/ES2154757T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

UN DERIVADO DE TIOPIRANO REPRESENTADO POR LA SIGUIENTE FORMULA (I) O (I`), O LA SAL DEL MISMO. EN DONDE A ES S O -CH=CH-, LA LINEA DE PUNTOS INDICA QUE EL ENLACE PUEDE ESTAR PRESENTE O AUSENTE, Z Y Z`SON TIPICAMENTE L ES UN GRUPO ETILENO O TRIMETILENO, Y ES CH O N, N ES 2, B ES UN GRUPO CARBONILO, M ES 0 O 1, D ES UN GRUPO FENILO, Y E{SUB,1} Y E{SUB,2} SON ATOMOS DE HIDROGENO. ESTOS COMPUESTOS MUESTRAN UNA FUERTE ACCION DE BLOQUEO DE LA SEROTONINA-2 Y SON ALTAMENTE SEGUROS. ALGUNOS COMPONENTES TAMBIEN MUESTRAN UNA ACCION DE BLOQUEO {AL}{SUB,1} Y POR LO TANTO SON UTILES COMO UN AGENTE ANTIHIPERTENSIVO CON MENOS EFECTOS SECUNDARIOS. DE ESTE MODO, LOS DERIVADOS DE TIOPIRANO SON UTILES COMO MEDICAMENTO PARA EL TRATAMIENTO DE ENFERMEDADES CIRCULATORIAS EN GENERAL COMO HIPERTENSION, ENFERMEDAD CARDIACA ISQUEMICA, PERTURBACION CEROBROVASCULAR, Y PERTURBACION CIRCULATORIA PERIFERICA.
ES96110051T 1995-06-23 1996-06-21 Derivados de tiopirano. Expired - Lifetime ES2154757T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17970195 1995-06-23

Publications (1)

Publication Number Publication Date
ES2154757T3 true ES2154757T3 (es) 2001-04-16

Family

ID=16070370

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96110051T Expired - Lifetime ES2154757T3 (es) 1995-06-23 1996-06-21 Derivados de tiopirano.

Country Status (9)

Country Link
US (3) US5977111A (es)
EP (1) EP0749971B1 (es)
JP (1) JPH0967367A (es)
KR (1) KR100425953B1 (es)
AT (1) ATE199720T1 (es)
CA (1) CA2179680A1 (es)
DE (1) DE69612037T2 (es)
ES (1) ES2154757T3 (es)
HU (1) HUP9601751A3 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001827A (en) 1993-12-24 1999-12-14 Suntory Limited Benzothiazine derivative
JPH0967367A (ja) 1995-06-23 1997-03-11 Suntory Ltd チオピラン誘導体
US7117382B2 (en) * 2002-05-30 2006-10-03 Sun Microsystems, Inc. Variably controlled delay line for read data capture timing window
CN111093662B (zh) 2017-06-20 2023-10-03 安布里亚制药公司 用于提高心脏代谢效率的组合物和方法
WO2020081361A1 (en) 2018-10-17 2020-04-23 Imbria Pharmaceuticals, Inc. Methods of treating rheumatic diseases using trimetazidine-based compounds
EP3976101A4 (en) 2019-05-31 2023-06-21 Imbria Pharmaceuticals, Inc. FIBROSIS TREATMENT METHODS USING COMPOUNDS THAT PROMOTE GLUCOSE OXIDATION
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine
CN113582970B (zh) * 2021-07-02 2023-07-14 凯里学院 含酰胺及肟或肟醚结构的硫色满-4-酮衍生物的制备方法及应用
KR20230056074A (ko) 2021-10-18 2023-04-27 최복기 안전교통 비상 이동식 시그날시스템
CN113956247B (zh) * 2021-10-27 2023-07-11 凯里学院 含1,3,4-噁二唑硫醚及肟醚结构的硫色满-4-酮衍生物的制备方法及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888873A (en) * 1973-08-27 1975-06-10 Colgate Palmolive Co 4h(1)benzothiopyrano(3,4-d)-isoxazoles
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
DE69018864D1 (de) * 1989-03-22 1995-06-01 Ciba Geigy Ag Neue Benzothiopyranylamine.
FR2662696A2 (fr) * 1989-12-13 1991-12-06 Rhone Poulenc Sante Antagonistes de la serotonine, leur preparation et medicaments les contenant.
US5091409A (en) * 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides
JPH0830067B2 (ja) * 1991-10-15 1996-03-27 メルク エンド カムパニー インコーポレーテッド 三環チエノチオピラン類
SG65570A1 (en) * 1992-02-25 1999-06-22 Recordati Chem Pharm Heterobicyclic compounds
US5407897A (en) * 1993-03-03 1995-04-18 American Cyanamid Company Method for safening herbicides in crops using substituted benzopyran and tetrahydronaphthalene compounds
US5874429A (en) * 1993-12-24 1999-02-23 Suntory Limited Benzothiazine derivative
JPH0967367A (ja) 1995-06-23 1997-03-11 Suntory Ltd チオピラン誘導体

Also Published As

Publication number Publication date
JPH0967367A (ja) 1997-03-11
HUP9601751A2 (hu) 1998-05-28
US6294677B1 (en) 2001-09-25
EP0749971A1 (en) 1996-12-27
HUP9601751A3 (en) 1999-03-01
US5977111A (en) 1999-11-02
ATE199720T1 (de) 2001-03-15
HU9601751D0 (en) 1996-08-28
KR970001348A (ko) 1997-01-24
DE69612037D1 (de) 2001-04-19
KR100425953B1 (ko) 2004-07-12
EP0749971B1 (en) 2001-03-14
CA2179680A1 (en) 1996-12-24
DE69612037T2 (de) 2001-10-25
US6100265A (en) 2000-08-08

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