ES2153786A1 - Composicion farmaceutica liquida para la administracion oral de principios activos amargos y susceptibles de hidrolisis. - Google Patents
Composicion farmaceutica liquida para la administracion oral de principios activos amargos y susceptibles de hidrolisis.Info
- Publication number
- ES2153786A1 ES2153786A1 ES009901281A ES9901281A ES2153786A1 ES 2153786 A1 ES2153786 A1 ES 2153786A1 ES 009901281 A ES009901281 A ES 009901281A ES 9901281 A ES9901281 A ES 9901281A ES 2153786 A1 ES2153786 A1 ES 2153786A1
- Authority
- ES
- Spain
- Prior art keywords
- bitter
- active substances
- hydrolysis
- pharmaceutical composition
- oral administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013543 active substance Substances 0.000 title abstract 4
- 239000007788 liquid Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 235000013162 Cocos nucifera Nutrition 0.000 abstract 1
- 244000060011 Cocos nucifera Species 0.000 abstract 1
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 239000001856 Ethyl cellulose Substances 0.000 abstract 1
- 240000007049 Juglans regia Species 0.000 abstract 1
- 235000009496 Juglans regia Nutrition 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 240000008790 Musa x paradisiaca Species 0.000 abstract 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 abstract 1
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 229960003405 ciprofloxacin Drugs 0.000 abstract 1
- 235000020186 condensed milk Nutrition 0.000 abstract 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 abstract 1
- 229920001249 ethyl cellulose Polymers 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 abstract 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 abstract 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 abstract 1
- 229960005489 paracetamol Drugs 0.000 abstract 1
- 229950008882 polysorbate Drugs 0.000 abstract 1
- 229920000136 polysorbate Polymers 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 229960001462 sodium cyclamate Drugs 0.000 abstract 1
- 235000010199 sorbic acid Nutrition 0.000 abstract 1
- 239000004334 sorbic acid Substances 0.000 abstract 1
- 229940075582 sorbic acid Drugs 0.000 abstract 1
- 239000008347 soybean phospholipid Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 239000002562 thickening agent Substances 0.000 abstract 1
- 150000003626 triacylglycerols Chemical class 0.000 abstract 1
- 235000020234 walnut Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"Composición farmacéutica líquida para la administración oral de principios activos amargos y susceptibles de hidrólisis". Por cada 100 ml comprende: 3-15 g de principio activo; 0,01-0,3 g de conservante (ácido sórbico, p-hidroxibenzoato de metilo); la cantidad suficiente para 100 ml de un vehículo oleoso comestible formado por triglicéridos de ácidos de cadena corta o media (caprílico, cáprico); una cantidad adecuada de edulcorante (sacarina sódica, ciclamato sódico, glicirrinato amónico), acompañada opcionalmente de una cantidad adecuada de aromatizante (nuez, leche condensada, coco, plátano); 0,5-2 g de lecitina de soja; 0,1-5 g de un espesante de tipo derivado de celulosa (N- etilcelulosa); y 0,05-1 g de un tensioactivo de tipo polisorbato. Opcionalmente comprende 0,5-5 g de manitol y 1-5 g de bicarbonato sódico. Es útil para administrar principios activos amargos (ciprofloxacino, paracetamol, eritromicina, etc) a niños, ancianos y pacientes poco motivados, resultando estable, fácil deingerir, y de sabor soportable.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009901281A ES2153786B1 (es) | 1999-06-10 | 1999-06-10 | Composicion farmaceutica liquida para la administracion oral de principios activos amargos y susceptibles de hidrolisis. |
| DE60009290T DE60009290D1 (de) | 1999-06-10 | 2000-06-08 | Flüssige pharmazeutische zusammensetzung zur oralen verabreichung bitterschmeckender hydrolyseempfindlicher aktivstoffe |
| ES00935230T ES2215665T3 (es) | 1999-06-10 | 2000-06-08 | Composicion farmaceutica liquida para la administracion oral de sustancias activas amargas susceptibles de hidrolisis. |
| AT00935230T ATE262350T1 (de) | 1999-06-10 | 2000-06-08 | Flüssige pharmazeutische zusammensetzung zur oralen verabreichung bitterschmeckender hydrolyseempfindlicher aktivstoffe |
| PCT/ES2000/000206 WO2000076549A1 (es) | 1999-06-10 | 2000-06-08 | Composicion farmaceutica liquida para la administracion oral de principios activos amargos y susceptibles de hidrolisis |
| EP00935230A EP1190720B1 (en) | 1999-06-10 | 2000-06-08 | Liquid pharmaceutical composition for oral administration of bitter hydrolysis-susceptible active substances |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009901281A ES2153786B1 (es) | 1999-06-10 | 1999-06-10 | Composicion farmaceutica liquida para la administracion oral de principios activos amargos y susceptibles de hidrolisis. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2153786A1 true ES2153786A1 (es) | 2001-03-01 |
| ES2153786B1 ES2153786B1 (es) | 2001-10-16 |
Family
ID=8308775
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES009901281A Withdrawn - After Issue ES2153786B1 (es) | 1999-06-10 | 1999-06-10 | Composicion farmaceutica liquida para la administracion oral de principios activos amargos y susceptibles de hidrolisis. |
| ES00935230T Expired - Lifetime ES2215665T3 (es) | 1999-06-10 | 2000-06-08 | Composicion farmaceutica liquida para la administracion oral de sustancias activas amargas susceptibles de hidrolisis. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00935230T Expired - Lifetime ES2215665T3 (es) | 1999-06-10 | 2000-06-08 | Composicion farmaceutica liquida para la administracion oral de sustancias activas amargas susceptibles de hidrolisis. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1190720B1 (es) |
| AT (1) | ATE262350T1 (es) |
| DE (1) | DE60009290D1 (es) |
| ES (2) | ES2153786B1 (es) |
| WO (1) | WO2000076549A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2440412A1 (en) * | 2001-03-05 | 2002-09-19 | Ortho-Mcneil Pharmaceutical, Inc. | Taste masked liquid pharmaceutical compositions |
| WO2002096354A2 (en) * | 2001-05-29 | 2002-12-05 | Tap Pharmaceutical Products Inc. | Enhancement of oral bioavailability of non-emulsified formulation of prodrug esters with lecithin |
| GB2380936B (en) * | 2001-10-18 | 2003-07-09 | Reckitt Benckiser Healthcare | Improvements in or relating to compositions |
| EP2197555B1 (en) | 2007-05-07 | 2015-12-02 | Koninklijke Philips N.V. | A method for cleaning dental plaque from teeth using an adherent peelable gel |
| GB0720967D0 (en) * | 2007-10-25 | 2007-12-05 | Protophama Ltd | Anti-material pharmaceutical composition |
| DE102010015143A1 (de) * | 2010-04-16 | 2011-10-20 | Cts Chemical Industries Ltd. | Stabile flüssige ölige gebrauchsfertige Formulierungen, Herstellung davon und Verwendung davon |
| LT3069733T (lt) * | 2013-11-13 | 2022-11-25 | National Defense Education And Research Foundation | Nauja acetaminofeno junginio sudėtis be šalutinio poveikio kepenims |
| JP6858729B2 (ja) * | 2018-05-25 | 2021-04-14 | ▲財▼▲団▼法人国防教育研究基金会Ｎａｔｉｏｎａｌ Ｄｅｆｅｎｓｅ Ｅｄｕｃａｔｉｏｎ Ａｎｄ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 肝臓に対する副作用がない、新しいアセトアミノフェン複合組成 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992004893A1 (en) * | 1990-09-13 | 1992-04-02 | Smithkline Beecham Corporation | Non-aqueous liquid oral suspensions |
| EP0750849A1 (en) * | 1995-06-06 | 1997-01-02 | Kao Corporation | Taste modifier |
| ES2105970B1 (es) * | 1995-08-02 | 1998-07-01 | S A L V A T Lab Sa | Composicion farmaceutica oral de ciprofloxacino, no acuosa, estable y con caracteristicas organolepticas mejoradas. |
-
1999
- 1999-06-10 ES ES009901281A patent/ES2153786B1/es not_active Withdrawn - After Issue
-
2000
- 2000-06-08 ES ES00935230T patent/ES2215665T3/es not_active Expired - Lifetime
- 2000-06-08 DE DE60009290T patent/DE60009290D1/de not_active Expired - Lifetime
- 2000-06-08 EP EP00935230A patent/EP1190720B1/en not_active Expired - Lifetime
- 2000-06-08 WO PCT/ES2000/000206 patent/WO2000076549A1/es active IP Right Grant
- 2000-06-08 AT AT00935230T patent/ATE262350T1/de not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992004893A1 (en) * | 1990-09-13 | 1992-04-02 | Smithkline Beecham Corporation | Non-aqueous liquid oral suspensions |
| EP0750849A1 (en) * | 1995-06-06 | 1997-01-02 | Kao Corporation | Taste modifier |
| ES2105970B1 (es) * | 1995-08-02 | 1998-07-01 | S A L V A T Lab Sa | Composicion farmaceutica oral de ciprofloxacino, no acuosa, estable y con caracteristicas organolepticas mejoradas. |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000076549A1 (es) | 2000-12-21 |
| ES2153786B1 (es) | 2001-10-16 |
| ATE262350T1 (de) | 2004-04-15 |
| EP1190720A1 (en) | 2002-03-27 |
| ES2215665T3 (es) | 2004-10-16 |
| EP1190720B1 (en) | 2004-03-24 |
| DE60009290D1 (de) | 2004-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20010301 Kind code of ref document: A1 Effective date: 20010301 |
|
| FA2A | Application withdrawn |
Effective date: 20031120 |