ATE262350T1 - Flüssige pharmazeutische zusammensetzung zur oralen verabreichung bitterschmeckender hydrolyseempfindlicher aktivstoffe - Google Patents
Flüssige pharmazeutische zusammensetzung zur oralen verabreichung bitterschmeckender hydrolyseempfindlicher aktivstoffeInfo
- Publication number
- ATE262350T1 ATE262350T1 AT00935230T AT00935230T ATE262350T1 AT E262350 T1 ATE262350 T1 AT E262350T1 AT 00935230 T AT00935230 T AT 00935230T AT 00935230 T AT00935230 T AT 00935230T AT E262350 T1 ATE262350 T1 AT E262350T1
- Authority
- AT
- Austria
- Prior art keywords
- bitter
- hydrolysis
- pharmaceutical composition
- oral administration
- liquid pharmaceutical
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000013543 active substance Substances 0.000 abstract 3
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 235000013162 Cocos nucifera Nutrition 0.000 abstract 1
- 244000060011 Cocos nucifera Species 0.000 abstract 1
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 239000001856 Ethyl cellulose Substances 0.000 abstract 1
- 240000007049 Juglans regia Species 0.000 abstract 1
- 235000009496 Juglans regia Nutrition 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 240000008790 Musa x paradisiaca Species 0.000 abstract 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 abstract 1
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 229960003405 ciprofloxacin Drugs 0.000 abstract 1
- 235000020186 condensed milk Nutrition 0.000 abstract 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 abstract 1
- 229920001249 ethyl cellulose Polymers 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 abstract 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 abstract 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 abstract 1
- 229960005489 paracetamol Drugs 0.000 abstract 1
- 229950008882 polysorbate Drugs 0.000 abstract 1
- 229920000136 polysorbate Polymers 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 229960001462 sodium cyclamate Drugs 0.000 abstract 1
- 235000010199 sorbic acid Nutrition 0.000 abstract 1
- 239000004334 sorbic acid Substances 0.000 abstract 1
- 229940075582 sorbic acid Drugs 0.000 abstract 1
- 239000008347 soybean phospholipid Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 239000002562 thickening agent Substances 0.000 abstract 1
- 150000003626 triacylglycerols Chemical class 0.000 abstract 1
- 235000020234 walnut Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009901281A ES2153786B1 (es) | 1999-06-10 | 1999-06-10 | Composicion farmaceutica liquida para la administracion oral de principios activos amargos y susceptibles de hidrolisis. |
| PCT/ES2000/000206 WO2000076549A1 (es) | 1999-06-10 | 2000-06-08 | Composicion farmaceutica liquida para la administracion oral de principios activos amargos y susceptibles de hidrolisis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE262350T1 true ATE262350T1 (de) | 2004-04-15 |
Family
ID=8308775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00935230T ATE262350T1 (de) | 1999-06-10 | 2000-06-08 | Flüssige pharmazeutische zusammensetzung zur oralen verabreichung bitterschmeckender hydrolyseempfindlicher aktivstoffe |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1190720B1 (de) |
| AT (1) | ATE262350T1 (de) |
| DE (1) | DE60009290D1 (de) |
| ES (2) | ES2153786B1 (de) |
| WO (1) | WO2000076549A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03008056A (es) * | 2001-03-05 | 2004-10-15 | Johnson & Johnson | Composiciones farmaceuticas liquidas con sabor oculto. |
| JP5051865B2 (ja) * | 2001-05-29 | 2012-10-17 | タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド | レシチンでのプロドラッグエステル非乳化調合物の経口バイオアベイラビリティの向上 |
| GB2380936B (en) * | 2001-10-18 | 2003-07-09 | Reckitt Benckiser Healthcare | Improvements in or relating to compositions |
| WO2008135957A2 (en) | 2007-05-07 | 2008-11-13 | Koninklijke Philips Electronics N.V. | A method for cleaning dental plaque from teeth using an adherent peelable gel |
| GB0720967D0 (en) * | 2007-10-25 | 2007-12-05 | Protophama Ltd | Anti-material pharmaceutical composition |
| DE102010015143A1 (de) * | 2010-04-16 | 2011-10-20 | Cts Chemical Industries Ltd. | Stabile flüssige ölige gebrauchsfertige Formulierungen, Herstellung davon und Verwendung davon |
| HRP20221344T1 (hr) * | 2013-11-13 | 2022-12-23 | National Defense Education And Research Foundation | Novi pripravak acetaminofenskog spoja bez nuspojave po jetru |
| JP6858729B2 (ja) * | 2018-05-25 | 2021-04-14 | ▲財▼▲団▼法人国防教育研究基金会Ｎａｔｉｏｎａｌ Ｄｅｆｅｎｓｅ Ｅｄｕｃａｔｉｏｎ Ａｎｄ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 肝臓に対する副作用がない、新しいアセトアミノフェン複合組成 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU8546591A (en) * | 1990-09-13 | 1992-04-15 | Smithkline Beecham Corporation | Non-aqueous liquid oral suspensions |
| JP3419957B2 (ja) * | 1995-06-06 | 2003-06-23 | 花王株式会社 | 味覚改質剤 |
| ES2105970B1 (es) * | 1995-08-02 | 1998-07-01 | S A L V A T Lab Sa | Composicion farmaceutica oral de ciprofloxacino, no acuosa, estable y con caracteristicas organolepticas mejoradas. |
-
1999
- 1999-06-10 ES ES009901281A patent/ES2153786B1/es not_active Expired - Lifetime
-
2000
- 2000-06-08 WO PCT/ES2000/000206 patent/WO2000076549A1/es not_active Ceased
- 2000-06-08 DE DE60009290T patent/DE60009290D1/de not_active Expired - Lifetime
- 2000-06-08 ES ES00935230T patent/ES2215665T3/es not_active Expired - Lifetime
- 2000-06-08 EP EP00935230A patent/EP1190720B1/de not_active Expired - Lifetime
- 2000-06-08 AT AT00935230T patent/ATE262350T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2153786A1 (es) | 2001-03-01 |
| ES2215665T3 (es) | 2004-10-16 |
| DE60009290D1 (de) | 2004-04-29 |
| EP1190720B1 (de) | 2004-03-24 |
| EP1190720A1 (de) | 2002-03-27 |
| ES2153786B1 (es) | 2001-10-16 |
| WO2000076549A1 (es) | 2000-12-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2314089T3 (es) | Composiciones liquidas administradas por via oral que comprenden guaifenesina y un copolimero de bloques de polioxialquileno. | |
| BR0211794A (pt) | Composição farmacêutica e método para mascarar o sabor de pelo menos um composto farmaceuticamente ativo de sabor desagradável | |
| JP2009102389A (ja) | 経口投与用医薬組成物 | |
| WO2002064148A3 (en) | Oral formulations containing mucopolysaccharide for small intestine delivery and their use in the treatment circulatory disorders | |
| JP4051717B2 (ja) | ビオチン含有内服液剤 | |
| ES2791775B2 (es) | Formulaciones de epinefrina intranasal y metodos para el tratamiento de enfermedades | |
| ATE262350T1 (de) | Flüssige pharmazeutische zusammensetzung zur oralen verabreichung bitterschmeckender hydrolyseempfindlicher aktivstoffe | |
| EP0548238A1 (de) | Nichtwässrige flüssige orale suspensionen | |
| US20250000984A1 (en) | Diphenhydramine syrup formulation or suspension | |
| BE900749A (fr) | Medicament microencapsule dans une matrice sucree. | |
| ATE429217T1 (de) | Nateglinid enthaltende hydrophile arzneimittelpräparate | |
| EP0315332B1 (de) | Phenol enthaltende, flüssige Antitussiv-Zusammensetzungen | |
| JP4373649B2 (ja) | 経口用液剤 | |
| ES2318277T3 (es) | Composicion farmaceutica que compresnde acido 5-metil-2-(2'-cloro-6'-fluoroanilino)fenilacetico. | |
| JP2003231647A (ja) | 内服液組成物 | |
| JP2905210B2 (ja) | 経皮、経粘膜吸収促進剤および経皮、経粘膜製剤 | |
| Thosar | Intra oral sprays-An overview. | |
| US6194462B1 (en) | Pharmaceutical preparation containing nimesulide for oral administration | |
| US20060198856A1 (en) | Ibuprofen suspension stabilized with docusate sodium | |
| US20060100271A1 (en) | Stabilized aqueous ranitidine compositions | |
| JPH1036252A (ja) | ベラドンナ（総）アルカロイド配合内服液剤 | |
| ES2338972B1 (es) | Composicion farmaceutica liquida de ibuprofeno y codeina para su administracion por via oral, su procedimiento de preparacion y utilizacionde la misma. | |
| BG61892B2 (bg) | Състав на основата на ибупрофен за орална употреба | |
| WO2011107617A1 (es) | Composición farmacéutica líquida de ibuprofeno y codeína para su administración por vía oral, su procedimiento de preparación y utilización de la misma | |
| JPH10203971A (ja) | 水性経口液剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |