ES2149995T3 - Derivados piridil imidazolicos y sus procedimientos de preparacion. - Google Patents

Derivados piridil imidazolicos y sus procedimientos de preparacion.

Info

Publication number
ES2149995T3
ES2149995T3 ES95922774T ES95922774T ES2149995T3 ES 2149995 T3 ES2149995 T3 ES 2149995T3 ES 95922774 T ES95922774 T ES 95922774T ES 95922774 T ES95922774 T ES 95922774T ES 2149995 T3 ES2149995 T3 ES 2149995T3
Authority
ES
Spain
Prior art keywords
sub
sup
branched
group
linear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95922774T
Other languages
English (en)
Inventor
Sung Eun Yoo
Kyu Yang Yi
Sang Hee Lee
Hye Ryung Kim
Jee Hee Suh
Nak Jeong Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Research Institute of Chemical Technology KRICT
Original Assignee
Korea Research Institute of Chemical Technology KRICT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Research Institute of Chemical Technology KRICT filed Critical Korea Research Institute of Chemical Technology KRICT
Application granted granted Critical
Publication of ES2149995T3 publication Critical patent/ES2149995T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NUEVOS DERIVADOS PIRIDIL IMIDAZOL DE FORMULA (I), QUE INHIBEN DE FORMA EFECTIVA LA ACCION DE LA ANGIOTENSINA II, Y PRESENTAN UNA ACTIVIDAD HIPERTENSIVA IMPORTANTE, DONDE A ES UN GRUPO ALQUENILO O ALQUILO C{SUB,1}-C{SUB,6}, LINEAL, RAMIFICADO, O CICLICO, OR{SUP,1} (DONDE R{SUP,1} ES HIDROGENO, O UN RADICAL ALQUENILO, O ALQUILO C{SUB,1}-C{SUB,6} LINEAL, RAMIFICADO O CICLICO), O NR{SUP,2}R{SUP,3} (DONDE R{SUP,2} Y R{SUP,3} SON, INDEPENDIENTEMENTE, HIDROGENO, O UN RADICAL ALQUILO C{SUB,1}C{SUB,6} LINEAL, RAMIFICADO O CICLICO); B ES UN GRUPO DE FORMULA (II); D ES UN HIDROGENO; UN HALOGENO; UN GRUPO ALQUILO C{SUB,1}C{SUB,6} LINEAL, RAMIFICADO O CICLICO, UN GRUPO ALQUENILO C{SUB,2}-C{SUB,6} O UN GRUPO ALQUINILO C{SUB,2}-C{SUB,6}, OPCIONALMENTE SUSTITUIDO CON OH, UN RADICAL ALCOXI C{SUB,1}C{SUB,4}, CO{SUB,2}R{SUP,1}, COR{SUP,1}, CON(R{SUP,1}){SUB,2} O N(R{SUP,1}){SUB,2}, DONDE R{SUP,1} ES IGUAL AL DEFINIDO ANTERIORMENTE; TETRAZOL-5-IL; UN GRUPO PERFLUORO-ALQUILO C{SUB,1}-C{SUB,4}; O N(R{SUP,1){SUB,2}}, OR{SUP,1}, CO{SUB,2}R{SUP,1} O CON(R{SUP,1}){SUB,2}, DONDE R{SUP,1} ES TAL Y COMO SE LO DEFINIO ANTERIORMENTE; E ES UN HIDROGENO; UN HALOGENO; UN GRUPO ALQUILO C{SUB,1}-C{SUB,6} LINEAL O RAMIFICADO, ALQUENILO C{SUB,2}-C{SUB,6} O ALQUINILO C{SUB,2}-C{SUB,6}, OPCIONALMENTE SUSTITUIDO CON OH, UN RADICAL ALCOXI C{SUB,1}C{SUB,4}, CO{SUB,2}R{SUP,1}, COR{SUP,1}, CON(R{SUP,1}){SUB,2}, O N(R{SUP,1}){SUB,2}, DONDE R{SUP,1} ES TAL Y COMO SE DEFINIO ANTERIORMENTE; UN GRUPO PERFLUORO-ALQUILO C{SUB,1}-C{SUB,4}; NO{SUB,2}; O N(R{SUP,1}){SUB,2} O OR{SUP,1}, DONDE R{SUP,1} ES IGUAL AL DEFINIDO ANTERIORMENTE; Y N ES UN ENTERO DE 1 A 4.
ES95922774T 1994-06-11 1995-06-07 Derivados piridil imidazolicos y sus procedimientos de preparacion. Expired - Lifetime ES2149995T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19940013163 1994-06-11
KR1019950011100A KR0151819B1 (ko) 1994-06-11 1995-05-08 신규의 피리딜 n-옥사이드로 치환된 피디딜이미다졸 유도체 및 그의 제조방법

Publications (1)

Publication Number Publication Date
ES2149995T3 true ES2149995T3 (es) 2000-11-16

Family

ID=26630434

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95922774T Expired - Lifetime ES2149995T3 (es) 1994-06-11 1995-06-07 Derivados piridil imidazolicos y sus procedimientos de preparacion.

Country Status (9)

Country Link
US (1) US5691348A (es)
EP (1) EP0765328B1 (es)
JP (1) JP2903260B2 (es)
KR (1) KR0151819B1 (es)
AU (1) AU691307B2 (es)
CA (1) CA2191947C (es)
DE (1) DE69518647T2 (es)
ES (1) ES2149995T3 (es)
WO (1) WO1995034564A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0151819B1 (ko) * 1994-06-11 1998-10-15 강박광 신규의 피리딜 n-옥사이드로 치환된 피디딜이미다졸 유도체 및 그의 제조방법
BR9810508A (pt) 1997-07-03 2000-09-05 Du Pont Pharm Co Composto, composição farmacêutica e método de tratamento de uma desordem
US6465484B1 (en) * 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
US8372862B2 (en) * 2009-06-02 2013-02-12 Korea Research Institute Of Chemical Technology Pharmaceutical composition for preventing or treating osteoporosis or obesity comprising phenyltetrazole derivative
WO2011134019A1 (en) * 2010-04-30 2011-11-03 The University Of Melbourne Novel biphenyl sartans
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
SI3762368T1 (sl) 2018-03-08 2022-06-30 Incyte Corporation Aminopirazin diolne spojine kot zaviralci PI3K-y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
US5332744A (en) * 1989-05-30 1994-07-26 Merck & Co., Inc. Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
IL96019A0 (en) * 1989-10-31 1991-07-18 Fujisawa Pharmaceutical Co Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
EP0434038A1 (en) * 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Fused imidazole derivatives, their production and use
EP0470543A1 (de) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung
US5066586A (en) * 1990-08-20 1991-11-19 Merck & Co., Inc. Process for preparation of novel angiotensin II antagonists
GB9201715D0 (en) * 1992-01-28 1992-03-11 Ici Plc Chemical process
KR0151819B1 (ko) * 1994-06-11 1998-10-15 강박광 신규의 피리딜 n-옥사이드로 치환된 피디딜이미다졸 유도체 및 그의 제조방법

Also Published As

Publication number Publication date
EP0765328A1 (en) 1997-04-02
AU691307B2 (en) 1998-05-14
CA2191947A1 (en) 1995-12-21
EP0765328B1 (en) 2000-08-30
DE69518647T2 (de) 2000-12-28
DE69518647D1 (de) 2000-10-05
US5691348A (en) 1997-11-25
JP2903260B2 (ja) 1999-06-07
JPH09507856A (ja) 1997-08-12
WO1995034564A1 (en) 1995-12-21
KR960000884A (ko) 1996-01-25
CA2191947C (en) 1999-06-15
KR0151819B1 (ko) 1998-10-15
AU2753895A (en) 1996-01-05

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