ES2149995T3 - Derivados piridil imidazolicos y sus procedimientos de preparacion. - Google Patents
Derivados piridil imidazolicos y sus procedimientos de preparacion.Info
- Publication number
- ES2149995T3 ES2149995T3 ES95922774T ES95922774T ES2149995T3 ES 2149995 T3 ES2149995 T3 ES 2149995T3 ES 95922774 T ES95922774 T ES 95922774T ES 95922774 T ES95922774 T ES 95922774T ES 2149995 T3 ES2149995 T3 ES 2149995T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- sup
- branched
- group
- linear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- WGNUNYPERJMVRM-UHFFFAOYSA-N 3-pyridylacetic acid Chemical compound OC(=O)CC1=CC=CN=C1 WGNUNYPERJMVRM-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 1
- 102000005862 Angiotensin II Human genes 0.000 abstract 1
- 101800000733 Angiotensin-2 Proteins 0.000 abstract 1
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
- 229950006323 angiotensin ii Drugs 0.000 abstract 1
- 230000001631 hypertensive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
NUEVOS DERIVADOS PIRIDIL IMIDAZOL DE FORMULA (I), QUE INHIBEN DE FORMA EFECTIVA LA ACCION DE LA ANGIOTENSINA II, Y PRESENTAN UNA ACTIVIDAD HIPERTENSIVA IMPORTANTE, DONDE A ES UN GRUPO ALQUENILO O ALQUILO C{SUB,1}-C{SUB,6}, LINEAL, RAMIFICADO, O CICLICO, OR{SUP,1} (DONDE R{SUP,1} ES HIDROGENO, O UN RADICAL ALQUENILO, O ALQUILO C{SUB,1}-C{SUB,6} LINEAL, RAMIFICADO O CICLICO), O NR{SUP,2}R{SUP,3} (DONDE R{SUP,2} Y R{SUP,3} SON, INDEPENDIENTEMENTE, HIDROGENO, O UN RADICAL ALQUILO C{SUB,1}C{SUB,6} LINEAL, RAMIFICADO O CICLICO); B ES UN GRUPO DE FORMULA (II); D ES UN HIDROGENO; UN HALOGENO; UN GRUPO ALQUILO C{SUB,1}C{SUB,6} LINEAL, RAMIFICADO O CICLICO, UN GRUPO ALQUENILO C{SUB,2}-C{SUB,6} O UN GRUPO ALQUINILO C{SUB,2}-C{SUB,6}, OPCIONALMENTE SUSTITUIDO CON OH, UN RADICAL ALCOXI C{SUB,1}C{SUB,4}, CO{SUB,2}R{SUP,1}, COR{SUP,1}, CON(R{SUP,1}){SUB,2} O N(R{SUP,1}){SUB,2}, DONDE R{SUP,1} ES IGUAL AL DEFINIDO ANTERIORMENTE; TETRAZOL-5-IL; UN GRUPO PERFLUORO-ALQUILO C{SUB,1}-C{SUB,4}; O N(R{SUP,1){SUB,2}}, OR{SUP,1}, CO{SUB,2}R{SUP,1} O CON(R{SUP,1}){SUB,2}, DONDE R{SUP,1} ES TAL Y COMO SE LO DEFINIO ANTERIORMENTE; E ES UN HIDROGENO; UN HALOGENO; UN GRUPO ALQUILO C{SUB,1}-C{SUB,6} LINEAL O RAMIFICADO, ALQUENILO C{SUB,2}-C{SUB,6} O ALQUINILO C{SUB,2}-C{SUB,6}, OPCIONALMENTE SUSTITUIDO CON OH, UN RADICAL ALCOXI C{SUB,1}C{SUB,4}, CO{SUB,2}R{SUP,1}, COR{SUP,1}, CON(R{SUP,1}){SUB,2}, O N(R{SUP,1}){SUB,2}, DONDE R{SUP,1} ES TAL Y COMO SE DEFINIO ANTERIORMENTE; UN GRUPO PERFLUORO-ALQUILO C{SUB,1}-C{SUB,4}; NO{SUB,2}; O N(R{SUP,1}){SUB,2} O OR{SUP,1}, DONDE R{SUP,1} ES IGUAL AL DEFINIDO ANTERIORMENTE; Y N ES UN ENTERO DE 1 A 4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR19940013163 | 1994-06-11 | ||
| KR1019950011100A KR0151819B1 (ko) | 1994-06-11 | 1995-05-08 | 신규의 피리딜 n-옥사이드로 치환된 피디딜이미다졸 유도체 및 그의 제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2149995T3 true ES2149995T3 (es) | 2000-11-16 |
Family
ID=26630434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95922774T Expired - Lifetime ES2149995T3 (es) | 1994-06-11 | 1995-06-07 | Derivados piridil imidazolicos y sus procedimientos de preparacion. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5691348A (es) |
| EP (1) | EP0765328B1 (es) |
| JP (1) | JP2903260B2 (es) |
| KR (1) | KR0151819B1 (es) |
| AU (1) | AU691307B2 (es) |
| CA (1) | CA2191947C (es) |
| DE (1) | DE69518647T2 (es) |
| ES (1) | ES2149995T3 (es) |
| WO (1) | WO1995034564A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0151819B1 (ko) * | 1994-06-11 | 1998-10-15 | 강박광 | 신규의 피리딜 n-옥사이드로 치환된 피디딜이미다졸 유도체 및 그의 제조방법 |
| CN1268137A (zh) | 1997-07-03 | 2000-09-27 | 杜邦药品公司 | 治疗神经失调的咪唑并嘧啶和咪唑并吡啶 |
| US6465484B1 (en) * | 1997-09-26 | 2002-10-15 | Merck & Co., Inc. | Angiogenesis inhibitors |
| US6365589B1 (en) | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
| US8372862B2 (en) * | 2009-06-02 | 2013-02-12 | Korea Research Institute Of Chemical Technology | Pharmaceutical composition for preventing or treating osteoporosis or obesity comprising phenyltetrazole derivative |
| WO2011134019A1 (en) * | 2010-04-30 | 2011-11-03 | The University Of Melbourne | Novel biphenyl sartans |
| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
| IL277071B1 (en) | 2018-03-08 | 2024-03-01 | Incyte Corp | Aminopyrizine diol compounds as PI3K–y inhibitors |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE64514B1 (en) * | 1989-05-23 | 1995-08-09 | Zeneca Ltd | Azaindenes |
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| US5332744A (en) * | 1989-05-30 | 1994-07-26 | Merck & Co., Inc. | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists |
| IL96019A0 (en) * | 1989-10-31 | 1991-07-18 | Fujisawa Pharmaceutical Co | Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| EP0434038A1 (en) * | 1989-12-22 | 1991-06-26 | Takeda Chemical Industries, Ltd. | Fused imidazole derivatives, their production and use |
| EP0470543A1 (de) * | 1990-08-10 | 1992-02-12 | Dr. Karl Thomae GmbH | Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung |
| US5066586A (en) * | 1990-08-20 | 1991-11-19 | Merck & Co., Inc. | Process for preparation of novel angiotensin II antagonists |
| GB9201715D0 (en) * | 1992-01-28 | 1992-03-11 | Ici Plc | Chemical process |
| KR0151819B1 (ko) * | 1994-06-11 | 1998-10-15 | 강박광 | 신규의 피리딜 n-옥사이드로 치환된 피디딜이미다졸 유도체 및 그의 제조방법 |
-
1995
- 1995-05-08 KR KR1019950011100A patent/KR0151819B1/ko not_active IP Right Cessation
- 1995-06-07 EP EP95922774A patent/EP0765328B1/en not_active Expired - Lifetime
- 1995-06-07 AU AU27538/95A patent/AU691307B2/en not_active Ceased
- 1995-06-07 JP JP8501959A patent/JP2903260B2/ja not_active Expired - Fee Related
- 1995-06-07 DE DE69518647T patent/DE69518647T2/de not_active Expired - Fee Related
- 1995-06-07 CA CA002191947A patent/CA2191947C/en not_active Expired - Fee Related
- 1995-06-07 ES ES95922774T patent/ES2149995T3/es not_active Expired - Lifetime
- 1995-06-07 WO PCT/KR1995/000075 patent/WO1995034564A1/en active IP Right Grant
- 1995-06-07 US US08/750,460 patent/US5691348A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2903260B2 (ja) | 1999-06-07 |
| DE69518647T2 (de) | 2000-12-28 |
| AU691307B2 (en) | 1998-05-14 |
| EP0765328A1 (en) | 1997-04-02 |
| DE69518647D1 (de) | 2000-10-05 |
| KR0151819B1 (ko) | 1998-10-15 |
| CA2191947A1 (en) | 1995-12-21 |
| WO1995034564A1 (en) | 1995-12-21 |
| KR960000884A (ko) | 1996-01-25 |
| CA2191947C (en) | 1999-06-15 |
| JPH09507856A (ja) | 1997-08-12 |
| AU2753895A (en) | 1996-01-05 |
| EP0765328B1 (en) | 2000-08-30 |
| US5691348A (en) | 1997-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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