ES2148916T3 - Derivados del 3-(piperid-4-il)-1,2-benzoisoxazol y del 3-(piperazin-4-il)-1,2-benzoisoxazol como antipsicoticos. - Google Patents

Derivados del 3-(piperid-4-il)-1,2-benzoisoxazol y del 3-(piperazin-4-il)-1,2-benzoisoxazol como antipsicoticos.

Info

Publication number
ES2148916T3
ES2148916T3 ES97401243T ES97401243T ES2148916T3 ES 2148916 T3 ES2148916 T3 ES 2148916T3 ES 97401243 T ES97401243 T ES 97401243T ES 97401243 T ES97401243 T ES 97401243T ES 2148916 T3 ES2148916 T3 ES 2148916T3
Authority
ES
Spain
Prior art keywords
benzoisoxazole
atoms
radical
piperid
antipsychotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97401243T
Other languages
English (en)
Inventor
Jean-Louis Peglion
Mark Millan
Mauricette Brocco
Valerie Audinot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2148916T3 publication Critical patent/ES2148916T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

NUEVOS COMPUESTOS DE FORMULA EN LA QUE A REPRESENTA UN RADICAL ALQUILO LINEAL O RAMIFICADO DE 1 A 10 ATOMOS DE CARBONO O UN RADICAL FENILO EVENTUALMENTE SUSTITUIDO POR UNO O VARIOS ATOMOS DE HALOGENO O GRUPOS HIDROXI O ALCOXI, M REPRESENTA CERO O 1 N REPRESENTA 1 O 2, E REPRESENTA N O CH, E Y REPRESENTA UN ATOMO DE HIDROGENO O DE HALOGENO O UN RADICAL ALCOXI DE 1 A 5 ATOMOS DE CARBONO. ESTOS NUEVOS COMPUESTOS Y SUS SALES FISIOLOGICAMENTE TOLERABLES PUEDEN UTILIZARSE COMO MEDICAMENTOS.
ES97401243T 1996-06-04 1997-06-04 Derivados del 3-(piperid-4-il)-1,2-benzoisoxazol y del 3-(piperazin-4-il)-1,2-benzoisoxazol como antipsicoticos. Expired - Lifetime ES2148916T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9606866A FR2749304B1 (fr) 1996-06-04 1996-06-04 Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2148916T3 true ES2148916T3 (es) 2000-10-16

Family

ID=9492694

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97401243T Expired - Lifetime ES2148916T3 (es) 1996-06-04 1997-06-04 Derivados del 3-(piperid-4-il)-1,2-benzoisoxazol y del 3-(piperazin-4-il)-1,2-benzoisoxazol como antipsicoticos.

Country Status (19)

Country Link
US (1) US5780474A (es)
EP (1) EP0811622B1 (es)
JP (1) JPH1059967A (es)
CN (1) CN1073565C (es)
AT (1) ATE192745T1 (es)
AU (1) AU715266B2 (es)
BR (1) BR9703447A (es)
CA (1) CA2207835C (es)
DE (1) DE69701923T2 (es)
DK (1) DK0811622T3 (es)
ES (1) ES2148916T3 (es)
FR (1) FR2749304B1 (es)
GR (1) GR3033996T3 (es)
HU (1) HUP9700992A3 (es)
NO (1) NO308360B1 (es)
NZ (1) NZ314992A (es)
PL (1) PL187005B1 (es)
PT (1) PT811622E (es)
ZA (1) ZA974919B (es)

Families Citing this family (30)

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US7168084B1 (en) 1992-12-09 2007-01-23 Sedna Patent Services, Llc Method and apparatus for targeting virtual objects
US9286294B2 (en) 1992-12-09 2016-03-15 Comcast Ip Holdings I, Llc Video and digital multimedia aggregator content suggestion engine
US6263443B1 (en) * 1997-10-11 2001-07-17 Agere Systems Guardian Corp. Simplified data link protocol processor
DK1054885T3 (da) * 1998-02-09 2007-10-15 Duphar Int Res Benzisoxasolderivater med D4-antagonistisk virkning
US6754905B2 (en) 1998-07-23 2004-06-22 Diva Systems Corporation Data structure and methods for providing an interactive program guide
BR9912385A (pt) * 1998-07-23 2002-01-15 Diva Systems Corp Interface de usuário gerada em um extremo de cabeça, guia de programa interativo, e, processos de geração e distribuição de uma interface de usuário, e de interação com um guia de programa interativo
US9924234B2 (en) 1998-07-23 2018-03-20 Comcast Ip Holdings I, Llc Data structure and methods for providing an interactive program
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
US6754271B1 (en) 1999-04-15 2004-06-22 Diva Systems Corporation Temporal slice persistence method and apparatus for delivery of interactive program guide
US6904610B1 (en) 1999-04-15 2005-06-07 Sedna Patent Services, Llc Server-centric customized interactive program guide in an interactive television environment
US7096487B1 (en) 1999-10-27 2006-08-22 Sedna Patent Services, Llc Apparatus and method for combining realtime and non-realtime encoded content
CA2383332C (en) * 1999-09-14 2006-01-10 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as d4 antagonists
US7253165B2 (en) * 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
CA2388606C (en) 1999-10-27 2009-12-29 Diva Systems Corporation Picture-in-picture and multiple video streams using slice-based encoding
FR2803298A1 (fr) * 1999-12-30 2001-07-06 Adir Nouvelles urees lineaires ou cycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2002026708A1 (fr) * 2000-09-27 2002-04-04 Toray Industries, Inc. Composes conenant de l'azote et inhibiteurs de ccr3 contenant ces composes en tant que principe actif
US7908628B2 (en) 2001-08-03 2011-03-15 Comcast Ip Holdings I, Llc Video and digital multimedia aggregator content coding and formatting
US7793326B2 (en) 2001-08-03 2010-09-07 Comcast Ip Holdings I, Llc Video and digital multimedia aggregator
PL1708790T3 (pl) * 2003-12-02 2010-10-29 Pharmaneuroboost N V Zastosowanie pipamperonu oraz antagonisty receptora D2 lub antagonisty receptora serotoniny/dopaminy do leczenia zaburzeń psychotycznych
US20050119249A1 (en) * 2003-12-02 2005-06-02 Erik Buntinx Method of treating neurodegenerative diseases using D4 and 5-HT2A antagonists, inverse agonists or partial agonists
US7884096B2 (en) * 2003-12-02 2011-02-08 Pharmaneuroboost N.V. Method of treating mental disorders using of D4 and 5-HT2A antagonists, inverse agonists or partial agonists
US7855195B2 (en) * 2003-12-02 2010-12-21 Pharmaneuroboost N.V. Method of treating mental disorders using D4 and 5-HT2A antagonists, inverse agonists or partial agonists
US20050203130A1 (en) * 2003-12-02 2005-09-15 Erik Buntinx Use of D4 and 5-HT2A antagonists, inverse agonists or partial agonists
EP1547650A1 (en) * 2003-12-02 2005-06-29 B & B Beheer NV Use of D4 and 5-HT2A antagonists, inverse agonists or partial agonists
DK1856114T3 (en) * 2005-02-25 2014-11-17 Raqualia Pharma Inc Benzisoxazol-DERIVATIVES
BRPI0918985A2 (pt) * 2008-09-23 2015-12-01 Hoffmann La Roche derivados de benzo[d]isoxazol-3-il-piperazina úteis como moduladores dos receptores d3 de dopamina
EP2337783A1 (en) * 2008-09-23 2011-06-29 F. Hoffmann-La Roche AG Isoxazolo[4,5]pyridin-3-yl-piperazin derivatives useful as modulatorsof dopamine d3 receptors
US9154813B2 (en) 2011-06-09 2015-10-06 Comcast Cable Communications, Llc Multiple video content in a composite video stream

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754641A (fr) * 1969-08-11 1971-02-10 Geigy Ag J R Derives de l'imidazolidinone et medicaments contenant de tels derives
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
US4458076A (en) * 1983-05-31 1984-07-03 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidinyl)-1,2-benzisothiazoles
CA1335289C (en) * 1987-10-26 1995-04-18 Fujio Antoku Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5599815A (en) * 1993-02-04 1997-02-04 Meiji Seika Kabushiki Kaisha Antipsychotic benzoisothiazolyl piperazine derivatives

Also Published As

Publication number Publication date
GR3033996T3 (en) 2000-11-30
CA2207835C (fr) 2001-10-02
EP0811622B1 (fr) 2000-05-10
US5780474A (en) 1998-07-14
CN1073565C (zh) 2001-10-24
FR2749304A1 (fr) 1997-12-05
NZ314992A (en) 1999-05-28
NO308360B1 (no) 2000-09-04
HUP9700992A3 (en) 1999-03-29
NO972510L (no) 1997-12-05
NO972510D0 (no) 1997-06-02
CN1171401A (zh) 1998-01-28
EP0811622A1 (fr) 1997-12-10
PL187005B1 (pl) 2004-04-30
HU9700992D0 (en) 1997-07-28
DE69701923T2 (de) 2000-12-14
JPH1059967A (ja) 1998-03-03
ATE192745T1 (de) 2000-05-15
DK0811622T3 (da) 2000-09-11
AU2464997A (en) 1997-12-11
PL320325A1 (en) 1997-12-08
ZA974919B (en) 1997-12-30
DE69701923D1 (de) 2000-06-15
CA2207835A1 (fr) 1997-12-04
BR9703447A (pt) 1998-11-10
PT811622E (pt) 2000-08-31
HUP9700992A2 (hu) 1998-12-28
AU715266B2 (en) 2000-01-20
FR2749304B1 (fr) 1998-06-26

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