ES2146718T3 - Derivados del acido pirrolidinadicarboxilico como agonistas de receptores metabotropicos de glutamato. - Google Patents
Derivados del acido pirrolidinadicarboxilico como agonistas de receptores metabotropicos de glutamato.Info
- Publication number
- ES2146718T3 ES2146718T3 ES95308031T ES95308031T ES2146718T3 ES 2146718 T3 ES2146718 T3 ES 2146718T3 ES 95308031 T ES95308031 T ES 95308031T ES 95308031 T ES95308031 T ES 95308031T ES 2146718 T3 ES2146718 T3 ES 2146718T3
- Authority
- ES
- Spain
- Prior art keywords
- pirrolidinadicarboxilico
- derivatives
- acid
- receptor agonists
- metabotropic receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
LA PRESENTE INVENCION PROPORCIONA PIRROLIDINAS SUSTITUIDAS QUE AFECTAN A CIERTOS RECEPTORES DE ACIDO AMINO EXCITANTES, Y QUE SON UTILES EN EL TRATAMIENTO DE DESORDENES NEUROLOGICOS Y PSIQUIATRICOS. ESPECIALMENTE, LOS COMPUESTOS DE LA PRESENTE INVENCION SON ACTIVOS COMO AGONISTAS DEL SUBTIPO DEL RECEPTOR DE GLUTAMATO METABOTROPICO MGLUR2. LOS COMPUESTOS TIENEN LA FORMULA DONDE R{SUP,1} Y R{SUP,2} SON INDEPENDIENTEMENTE ACIDO CARBOXILICO O 5-TETRAZOLIL, O UNA SAL O SOLVATO FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/337,801 US5473077A (en) | 1994-11-14 | 1994-11-14 | Pyrrolidinyl di-carboxylic acid derivatives as metabotropic glutamate receptor agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2146718T3 true ES2146718T3 (es) | 2000-08-16 |
Family
ID=23322078
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95308031T Expired - Lifetime ES2146718T3 (es) | 1994-11-14 | 1995-11-09 | Derivados del acido pirrolidinadicarboxilico como agonistas de receptores metabotropicos de glutamato. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5473077A (es) |
EP (1) | EP0711755B1 (es) |
JP (1) | JPH10508855A (es) |
AT (1) | ATE193529T1 (es) |
AU (1) | AU4281896A (es) |
CA (1) | CA2204767A1 (es) |
DE (1) | DE69517286T2 (es) |
ES (1) | ES2146718T3 (es) |
WO (1) | WO1996015108A1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5607973A (en) * | 1995-06-28 | 1997-03-04 | Theriault; Elizabeth | Method of treating traumatic CNS tissue injury with a metabotropic glutamate receptor agonist |
US5824662A (en) * | 1996-09-27 | 1998-10-20 | Guilford Pharmaceuticals Inc. | Treatment of global and focal ischemia using naaladase inhibitors |
US6017903A (en) | 1996-09-27 | 2000-01-25 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors |
PL332413A1 (en) | 1996-09-27 | 1999-09-13 | Guilford Pharm Inc | Compositions containing inhibitors of naaladase as well as methods of treating glutamatic anomaly and influencing neuronic functions among animals |
AU5478799A (en) * | 1998-09-14 | 2000-04-03 | Warner-Lambert Company | Branched alkyl pyrrolidine-3-carboxylic acids |
US20040082783A1 (en) * | 2002-08-06 | 2004-04-29 | Schafmeister Christian E. | Bis (amino acid) molecular scaffolds |
WO2005030128A2 (en) * | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Pyrazole modulators of metabotropic glutamate receptors |
EP1604978A1 (en) * | 2004-06-02 | 2005-12-14 | Faust Pharmaceuticals | Trans pyrrolidinyl derivatives and their pharmaceutical uses |
EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス,インコーポレイティド | Pde阻害による神経新生の調節 |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
TWI417095B (zh) * | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
AU2007249435A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
KR20090064418A (ko) * | 2006-09-08 | 2009-06-18 | 브레인셀즈 인코퍼레이션 | 4-아실아미노피리딘 유도체 포함 조합물 |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
PT2200985E (pt) | 2007-09-14 | 2011-07-21 | Ortho Mcneil Janssen Pharm | 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas |
JP5433579B2 (ja) * | 2007-09-14 | 2014-03-05 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 1,3−二置換−4−フェニル−1h−ピリジン−2−オン |
UA100126C2 (en) | 2007-09-14 | 2012-11-26 | Аддекс Фарма С.А. | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones |
CN101861316B (zh) * | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
AU2009289784B2 (en) | 2008-09-02 | 2012-03-22 | Addex Pharma S.A. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
RU2517181C2 (ru) | 2008-10-16 | 2014-05-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов |
BRPI0921333A2 (pt) | 2008-11-28 | 2015-12-29 | Addex Pharmaceuticals Sa | derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
KR101753826B1 (ko) | 2009-05-12 | 2017-07-04 | 얀센 파마슈티칼즈, 인코포레이티드 | 1,2,4―트리아졸로[4,3―a]피리딘 유도체 및 신경정신 질환의 치료 또는 예방을 위한 이들의 용도 |
JP5709101B2 (ja) * | 2010-09-01 | 2015-04-30 | 東レ・ファインケミカル株式会社 | ヒドロキシプロリン誘導体の製造法 |
EP2649069B1 (en) | 2010-11-08 | 2015-08-26 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
AU2011328203B2 (en) | 2010-11-08 | 2015-03-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
MX2016009471A (es) | 2014-01-21 | 2016-10-13 | Janssen Pharmaceutica Nv | Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso. |
HUE045610T2 (hu) | 2014-01-21 | 2020-01-28 | Janssen Pharmaceutica Nv | 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk |
WO2016145082A1 (en) * | 2015-03-09 | 2016-09-15 | Northwestern University | Tetrahydrothiophene-based gaba aminotransferase inactivators |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4140696A (en) * | 1973-08-22 | 1979-02-20 | Gruppo Lepetit S.P.A. | Aminopyrrole derivatives |
US3976660A (en) * | 1974-08-15 | 1976-08-24 | E. R. Squibb & Sons, Inc. | Pyrrolidine derivatives |
AU6739390A (en) * | 1989-10-25 | 1991-05-31 | Regents Of The University Of California, The | Method of inhibiting the transport of l-glutamate |
DE4134756A1 (de) * | 1991-10-22 | 1993-04-29 | Bayer Ag | Verwendung von teilweise bekannten substituierten pyrrolidinen als arzneimittel, neue wirkstoffe und verfahren zu ihrer herstellung |
-
1994
- 1994-11-14 US US08/337,801 patent/US5473077A/en not_active Expired - Fee Related
-
1995
- 1995-11-09 AT AT95308031T patent/ATE193529T1/de not_active IP Right Cessation
- 1995-11-09 EP EP95308031A patent/EP0711755B1/en not_active Expired - Lifetime
- 1995-11-09 DE DE69517286T patent/DE69517286T2/de not_active Expired - Fee Related
- 1995-11-09 ES ES95308031T patent/ES2146718T3/es not_active Expired - Lifetime
- 1995-11-13 AU AU42818/96A patent/AU4281896A/en not_active Abandoned
- 1995-11-13 JP JP8516228A patent/JPH10508855A/ja active Pending
- 1995-11-13 WO PCT/US1995/014675 patent/WO1996015108A1/en active Search and Examination
- 1995-11-13 CA CA002204767A patent/CA2204767A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69517286D1 (de) | 2000-07-06 |
JPH10508855A (ja) | 1998-09-02 |
AU4281896A (en) | 1996-06-06 |
EP0711755A1 (en) | 1996-05-15 |
EP0711755B1 (en) | 2000-05-31 |
WO1996015108A1 (en) | 1996-05-23 |
US5473077A (en) | 1995-12-05 |
DE69517286T2 (de) | 2001-02-22 |
CA2204767A1 (en) | 1996-05-23 |
ATE193529T1 (de) | 2000-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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