ES2146651T3 - Compuestos para anular resistencias a medicamentos. - Google Patents

Compuestos para anular resistencias a medicamentos.

Info

Publication number
ES2146651T3
ES2146651T3 ES94915684T ES94915684T ES2146651T3 ES 2146651 T3 ES2146651 T3 ES 2146651T3 ES 94915684 T ES94915684 T ES 94915684T ES 94915684 T ES94915684 T ES 94915684T ES 2146651 T3 ES2146651 T3 ES 2146651T3
Authority
ES
Spain
Prior art keywords
obzl
glu
otbu
boc
trp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94915684T
Other languages
English (en)
Inventor
Balazs Sarkadi
Janos Seprodi
Orsolya Csuka
Maria Magocsi
Imre Mezo
Istvan Teplan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2146651T3 publication Critical patent/ES2146651T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Indole Compounds (AREA)
  • Silicon Polymers (AREA)

Abstract

LA INVENCION DESTACA NUEVOS DERIVADOS PEPTIDICOS DENOMINADOS REVERSINAS, Y POSIBILITA SU UTILIZACION EN UN METODO DE REDUCCION DE LA ACTIVIDAD DE LA PROTEINA TRANSPORTADORA DE MULTIPLES MEDICAMENTOS MDR1, CON EL OBJETO DE EVITAR LA RESISTENCIA A MULTIPLES MEDICAMENTOS EN MAMIFEROS. LOS DERIVADOS PEPTIDICOS, TIENEN LA FORMULA (I) X{SUP,1}{SUB,N}-X{SUP,2}-X{SUP,3}(X{SUP,4}){SUB,N}-X{SUP,5}, DONDE N ES 0 O 1, Y CADA N ES IGUAL O DISTINTO; X{SUP,1} ES BOC, BOC-ASU, Z-ASU, BENCILOXICARBONILO, GLU(OBCZL)-OBZL, TRP-OME, TRP-PHE-OME, PHE-TRP-OME, PHE-PHE-OTBU, TRP-TRP-OTBU, INDOLOACETILO, BENZOILO, UNA ALQUILAMINA DE 1-4 CARBONOS, DIBENCILAMIDA, TRIPTAMIDA, 1-AMINO-ADAMANTINO, AMINOMETILCICLOHEXANO, INDOLINA, FENILMETILAMIDA O DICICLOHEXILAMIDA; X{SUP,2} ES GLU(OBZL, ASP(OBZL), SUCCINILO, O,O-DIBENZOLITARTAROILO, DIFENOILO, MUCONILO, THX, CPA, ASU, NAL, PEN, PHG, DBT, LYS(BOC), LYS(Z), CYS(BZL), THR(BZL), GLU(OTBU), TRET-LEU, LEU, NLE, PRO, PHE, TYR(BZL), O SER(BAL); X{SUP,3} ES ASP, ASU, LYS, GLU,TRP, THX, CPA, NAL, PEN, PHG, DBT, GLU(OTBU), TERT-LEU, LEU, NLE, PRO, TYR, PHE O TYR(BZL); X{SUP,4} ES BOCGLU(OBZL), GLU(OBZL), ASU, OBCL, BZL, BOC, BOC-LYS(BOC), ZGLU(OTBU), ASP(OBZL), ASP(OBZL)-OBZL, BENCILOXICARBONILO, O(CICLO-HEXILO), ESTER DE FLUORENILMETILO, GLU(OTBU), GLU(OTBU)OBZL, 1-AMINO-ADAMANTINO, AMINOMETILCICLOHEXANO, INDOLINA, FENILETLAMINA, O DICICLOHEXILAMIDA; Y X{SUP,5} ES OME, OBZL, OTBU, PHE-OME, -O-(CICLOHEXILO), TRP-OME, (CLOROFENIL)ISOBUTILAMIDA, ESTER DEE FLUORENILMETILO, ONP, 1-AMINOADAMANTANO, AMINOMETILCICLOHEXANO, INDOLINA, FENILETILAMIDA, O DICICLOHEXILAMIDA.
ES94915684T 1994-05-12 1994-05-12 Compuestos para anular resistencias a medicamentos. Expired - Lifetime ES2146651T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB1994/000144 WO1995031474A1 (en) 1994-05-12 1994-05-12 Compounds for reversing drug resistance

Publications (1)

Publication Number Publication Date
ES2146651T3 true ES2146651T3 (es) 2000-08-16

Family

ID=11004299

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94915684T Expired - Lifetime ES2146651T3 (es) 1994-05-12 1994-05-12 Compuestos para anular resistencias a medicamentos.

Country Status (8)

Country Link
US (1) US6297216B1 (es)
EP (1) EP0770091B1 (es)
AT (1) ATE190065T1 (es)
AU (1) AU693791B2 (es)
DE (1) DE69423243T2 (es)
DK (1) DK0770091T3 (es)
ES (1) ES2146651T3 (es)
WO (1) WO1995031474A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162616A (en) * 1997-04-16 2000-12-19 Millennium Pharmaceuticals, Inc. Multidrug resistance-associated polypeptide
JP4451570B2 (ja) * 1999-03-17 2010-04-14 ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 胆汁排泄感受性の候補化合物のスクリーニング方法
US7601494B2 (en) * 1999-03-17 2009-10-13 The University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
US7723303B2 (en) * 2000-08-24 2010-05-25 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
US7148197B2 (en) * 2000-08-24 2006-12-12 The Regents Of The University Of California Orally administered small peptides synergize statin activity
US7199102B2 (en) * 2000-08-24 2007-04-03 The Regents Of The University Of California Orally administered peptides synergize statin activity
WO2003035685A1 (en) * 2001-10-24 2003-05-01 Solvo Biotechnology Inc. Use of a half-transporter protein of the abcg-family for selecting cells and in gene therapy
US20030109448A1 (en) * 2001-11-07 2003-06-12 Crowley Kathleen S. Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells
ATE396725T1 (de) * 2004-05-14 2008-06-15 Cleveland Clinic Foundation Kleinmolekülige hemmer für mrp1 und andere multiarzneimitteltransporter
JP2008513479A (ja) * 2004-09-16 2008-05-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア アテローム性動脈硬化症および他の病理を改善するためのｇ型ペプチドおよび他の薬剤
KR20070089996A (ko) * 2004-12-06 2007-09-04 더 리전트 오브 더 유니버시티 오브 캘리포니아 세동맥의 구조 및 기능의 개선 방법
US20080293639A1 (en) * 2005-04-29 2008-11-27 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
FR2950888B1 (fr) * 2009-10-06 2011-12-09 Centre Nat Rech Scient Modulateurs peptidiques et peptidomimetiques non competitifs specifiques de la glycoproteine p
FR3101709A1 (fr) * 2019-10-04 2021-04-09 Biomarqueurs Méthode de détection, localisation et quantification de protéines MDR

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862925A (en) * 1973-07-05 1975-01-28 American Home Prod Preparation of somatotropin release inhibiting factor and intermediates therefor
US3882098A (en) * 1974-01-03 1975-05-06 American Home Prod Synthesis of des-Ala{hu 1{b , Gly{hu 2{b , Asn{hu 5{b -SRIF and intermediates
US4028319A (en) * 1976-05-07 1977-06-07 G. D. Searle & Co. 2 and 3-substituted enkephalins
JPS5850213B2 (ja) * 1977-06-20 1983-11-09 株式会社第一ラジオアイソト−プ研究所 カルチトニンの定量法
JPS5828867B2 (ja) * 1979-07-13 1983-06-18 財団法人 微生物化学研埋会 新テトラペプチド誘導体類
US4497801A (en) * 1982-09-17 1985-02-05 Fujisawa Pharmaceutical Co., Ltd. New peptides, process for preparation thereof and use thereof
FR2559157B1 (fr) * 1984-02-07 1986-08-01 Inst Nat Sante Rech Med Nouvel hexapeptide, son procede d'obtention et les compositions pharmaceutiques qui le contiennent
FR2567524B1 (fr) * 1984-07-10 1987-11-27 Sanofi Sa Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires
EP0201741B1 (en) * 1985-04-16 1991-07-31 Suntory Limited Dipeptide derivatives, processes for preparing them, pharmaceutical composition and use
CA1298033C (en) * 1985-04-16 1992-03-24 Takaharu Tanaka Dipeptide derivative of fatty acid
SU1544778A1 (ru) * 1987-10-26 1990-02-23 Институт элементоорганических соединений им.А.Н.Несмеянова Способ получени пептидов

Also Published As

Publication number Publication date
DK0770091T3 (da) 2000-08-14
US6297216B1 (en) 2001-10-02
ATE190065T1 (de) 2000-03-15
DE69423243D1 (de) 2000-04-06
DE69423243T2 (de) 2000-11-02
EP0770091A1 (en) 1997-05-02
AU693791B2 (en) 1998-07-09
EP0770091B1 (en) 2000-03-01
AU6760694A (en) 1995-12-05
WO1995031474A1 (en) 1995-11-23

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