ATE190065T1 - Stoffe zur aufhebung von arzneimittelresistenzen - Google Patents

Stoffe zur aufhebung von arzneimittelresistenzen

Info

Publication number
ATE190065T1
ATE190065T1 AT94915684T AT94915684T ATE190065T1 AT E190065 T1 ATE190065 T1 AT E190065T1 AT 94915684 T AT94915684 T AT 94915684T AT 94915684 T AT94915684 T AT 94915684T AT E190065 T1 ATE190065 T1 AT E190065T1
Authority
AT
Austria
Prior art keywords
obzl
glu
otbu
boc
trp
Prior art date
Application number
AT94915684T
Other languages
English (en)
Inventor
Balazs Sarkadi
Janos Seprodi
Orsolya Csuka
Maria Magocsi
Imre Mezo
Istvan Teplan
Zsolt Vadasz
Borbala Vincze
Istvan Palyi
Original Assignee
Balazs Sarkadi
Janos Seprodi
Orsolya Csuka
Maria Magocsi
Imre Mezo
Istvan Teplan
Zsolt Vadasz
Borbala Vincze
Istvan Palyi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Balazs Sarkadi, Janos Seprodi, Orsolya Csuka, Maria Magocsi, Imre Mezo, Istvan Teplan, Zsolt Vadasz, Borbala Vincze, Istvan Palyi filed Critical Balazs Sarkadi
Application granted granted Critical
Publication of ATE190065T1 publication Critical patent/ATE190065T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicon Polymers (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Indole Compounds (AREA)
AT94915684T 1994-05-12 1994-05-12 Stoffe zur aufhebung von arzneimittelresistenzen ATE190065T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB1994/000144 WO1995031474A1 (en) 1994-05-12 1994-05-12 Compounds for reversing drug resistance

Publications (1)

Publication Number Publication Date
ATE190065T1 true ATE190065T1 (de) 2000-03-15

Family

ID=11004299

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94915684T ATE190065T1 (de) 1994-05-12 1994-05-12 Stoffe zur aufhebung von arzneimittelresistenzen

Country Status (8)

Country Link
US (1) US6297216B1 (de)
EP (1) EP0770091B1 (de)
AT (1) ATE190065T1 (de)
AU (1) AU693791B2 (de)
DE (1) DE69423243T2 (de)
DK (1) DK0770091T3 (de)
ES (1) ES2146651T3 (de)
WO (1) WO1995031474A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162616A (en) * 1997-04-16 2000-12-19 Millennium Pharmaceuticals, Inc. Multidrug resistance-associated polypeptide
US7601494B2 (en) * 1999-03-17 2009-10-13 The University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
EP1163517B1 (de) * 1999-03-17 2006-04-12 University Of North Carolina At Chapel Hill Screening-verfahren von kandidaten verbindungen für empfindlichkeit gegenüber gallenexkretion
US7199102B2 (en) * 2000-08-24 2007-04-03 The Regents Of The University Of California Orally administered peptides synergize statin activity
US7723303B2 (en) * 2000-08-24 2010-05-25 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
US7148197B2 (en) * 2000-08-24 2006-12-12 The Regents Of The University Of California Orally administered small peptides synergize statin activity
US20050255084A1 (en) * 2001-10-24 2005-11-17 Solvo Biotechnology Use of a half-transporter protein of the abcg-family for selecting cells and in gene therapy
CA2465886A1 (en) * 2001-11-07 2003-05-15 Kathleen S. Crowley Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells
NZ551424A (en) * 2004-05-14 2009-10-30 Childrenaes Cancer Inst Austra Small molecule inhibitors for MRP1 and other multidrug transporters
EP1799242A4 (de) * 2004-09-16 2009-11-11 Univ California Peptide vom typ g und andere wirkstoffe zur linderung von atherosklerose und anderen erkrankungen
CA2595067A1 (en) * 2004-12-06 2006-06-15 The Regents Of The University Of California Methods for improving the structure and function of arterioles
US20080293639A1 (en) * 2005-04-29 2008-11-27 The Regents Of The University Of California Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
FR2950888B1 (fr) * 2009-10-06 2011-12-09 Centre Nat Rech Scient Modulateurs peptidiques et peptidomimetiques non competitifs specifiques de la glycoproteine p
FR3101709A1 (fr) * 2019-10-04 2021-04-09 Biomarqueurs Méthode de détection, localisation et quantification de protéines MDR

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862925A (en) * 1973-07-05 1975-01-28 American Home Prod Preparation of somatotropin release inhibiting factor and intermediates therefor
US3882098A (en) * 1974-01-03 1975-05-06 American Home Prod Synthesis of des-Ala{hu 1{b , Gly{hu 2{b , Asn{hu 5{b -SRIF and intermediates
US4028319A (en) * 1976-05-07 1977-06-07 G. D. Searle & Co. 2 and 3-substituted enkephalins
JPS5850213B2 (ja) * 1977-06-20 1983-11-09 株式会社第一ラジオアイソト−プ研究所 カルチトニンの定量法
JPS5828867B2 (ja) * 1979-07-13 1983-06-18 財団法人 微生物化学研埋会 新テトラペプチド誘導体類
US4497801A (en) * 1982-09-17 1985-02-05 Fujisawa Pharmaceutical Co., Ltd. New peptides, process for preparation thereof and use thereof
FR2559157B1 (fr) * 1984-02-07 1986-08-01 Inst Nat Sante Rech Med Nouvel hexapeptide, son procede d'obtention et les compositions pharmaceutiques qui le contiennent
FR2567524B1 (fr) * 1984-07-10 1987-11-27 Sanofi Sa Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires
DE3684633D1 (de) * 1985-04-16 1992-05-07 Suntory Ltd Dipeptid-derivate von fettsaeure, verfahren zu ihrer herstellung, heilmittel, das sie enthaelt und anwendung.
EP0201741B1 (de) * 1985-04-16 1991-07-31 Suntory Limited Dipeptid-Derivate, Verfahren zur Herstellung, pharmazeutische Zusammensetzungen und ihre Anwendung
SU1544778A1 (ru) * 1987-10-26 1990-02-23 Институт элементоорганических соединений им.А.Н.Несмеянова Способ получени пептидов

Also Published As

Publication number Publication date
US6297216B1 (en) 2001-10-02
DE69423243T2 (de) 2000-11-02
EP0770091B1 (de) 2000-03-01
DK0770091T3 (da) 2000-08-14
AU693791B2 (en) 1998-07-09
ES2146651T3 (es) 2000-08-16
AU6760694A (en) 1995-12-05
EP0770091A1 (de) 1997-05-02
DE69423243D1 (de) 2000-04-06
WO1995031474A1 (en) 1995-11-23

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee