ES2145268T3 - Derivados ureido de los acidos naftaleno-fosfonicos y su procedimiento de preparacion. - Google Patents

Derivados ureido de los acidos naftaleno-fosfonicos y su procedimiento de preparacion.

Info

Publication number
ES2145268T3
ES2145268T3 ES95909683T ES95909683T ES2145268T3 ES 2145268 T3 ES2145268 T3 ES 2145268T3 ES 95909683 T ES95909683 T ES 95909683T ES 95909683 T ES95909683 T ES 95909683T ES 2145268 T3 ES2145268 T3 ES 2145268T3
Authority
ES
Spain
Prior art keywords
ureid
derivatives
naphthalene
phosphonic acids
preparation procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95909683T
Other languages
English (en)
Inventor
Nicola Mongelli
Angelo Crugnola
Borgia Andrea Lombardi
Enrico Pesenti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of ES2145268T3 publication Critical patent/ES2145268T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)

Abstract

EL OBJETO DE LA PRESENTE INVENCION SON NUEVOS DERIVADOS DE UREIDO DE ACIDOS NAFTALENFOSFONICOS QUE TIENEN FORMULA (I), EN DONDE CADA UNO DE M Y N, QUE SON LOS MISMOS, ES UN ENTERO DE 1 A 4; CADA UNO DE P Y Q, QUE SON LOS MISMOS, ES UN ENTERO DE 1 A 3; Y CADA UNO DE LOS GRUPOS R, QUE SON LOS MISMOS, ES UN GRUPO DE ACIDO FOSFONICO LIBRE O ESTERIFICADO; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS.
ES95909683T 1994-03-01 1995-02-08 Derivados ureido de los acidos naftaleno-fosfonicos y su procedimiento de preparacion. Expired - Lifetime ES2145268T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9403909A GB9403909D0 (en) 1994-03-01 1994-03-01 Ureido derivatives of naphthalenephosphonic acids and process for their preparation

Publications (1)

Publication Number Publication Date
ES2145268T3 true ES2145268T3 (es) 2000-07-01

Family

ID=10751089

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95909683T Expired - Lifetime ES2145268T3 (es) 1994-03-01 1995-02-08 Derivados ureido de los acidos naftaleno-fosfonicos y su procedimiento de preparacion.

Country Status (26)

Country Link
US (1) US5700788A (es)
EP (1) EP0696287B1 (es)
JP (1) JPH08509992A (es)
KR (1) KR960701881A (es)
CN (1) CN1061050C (es)
AT (1) ATE190312T1 (es)
AU (1) AU678704B2 (es)
CA (1) CA2160250A1 (es)
DE (1) DE69515390T2 (es)
DK (1) DK0696287T3 (es)
ES (1) ES2145268T3 (es)
FI (1) FI955180A7 (es)
GB (1) GB9403909D0 (es)
GR (1) GR3033356T3 (es)
HU (1) HUT74987A (es)
IL (1) IL112716A0 (es)
MX (1) MX9504381A (es)
MY (1) MY130125A (es)
NO (1) NO308005B1 (es)
NZ (1) NZ281205A (es)
PL (1) PL311339A1 (es)
PT (1) PT696287E (es)
RU (1) RU2136692C1 (es)
TW (1) TW290547B (es)
WO (1) WO1995023806A2 (es)
ZA (1) ZA951653B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225254A1 (en) 1989-08-07 2003-12-04 Rathjen Deborah Ann Tumour necrosis factor binding ligands
US5959087A (en) * 1989-08-07 1999-09-28 Peptide Technology, Ltd. Tumour necrosis factor binding ligands
CA2064915C (en) * 1989-08-07 2001-05-29 Deborah A. Rathjen Tumour necrosis factor binding ligands
US7192584B2 (en) * 1991-03-18 2007-03-20 Centocor, Inc. Methods of treating psoriasis with anti-TNF antibodies
US20040120952A1 (en) * 2000-08-07 2004-06-24 Centocor, Inc Anti-TNF antibodies and peptides of human tumor necrosis factor
US6277969B1 (en) * 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
US6284471B1 (en) 1991-03-18 2001-09-04 New York University Medical Center Anti-TNFa antibodies and assays employing anti-TNFa antibodies
US20050255104A1 (en) * 1993-01-29 2005-11-17 Centocor, Inc. Methods of treating psoriasis using anti-TNF receptor fusion proteins
GB9504065D0 (en) * 1995-03-01 1995-04-19 Pharmacia Spa Poly-pyrrolecarboxamidonaphthalenic acid derivatives
FR2736914B1 (fr) * 1995-07-21 1997-08-22 Adir Nouveaux derives d'acide aminophenylphosphonique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB2310207A (en) * 1996-02-15 1997-08-20 Pharmacia Spa Antiviral ureido derivatives of substituted heterocyclic compounds
FR2758560B1 (fr) * 1997-01-20 2000-02-04 Adir Nouveaux derives d'acides aminophenylboronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2758562B1 (fr) * 1997-01-20 1999-02-19 Adir Nouveaux derives d'acides mixtes aminobenzyliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9713732D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Substituted triazinic compounds
GB9713733D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Poly-branched polycarboxamido compounds
US6096730A (en) * 1997-07-24 2000-08-01 University Of Kentucky Research Foundation Phosphonated agents and their antiangiogenic and antitumorigenic use
WO1999005148A1 (en) * 1997-07-24 1999-02-04 University Of Kentucky Research Foundation Phosphonated agents and their antiangiogenic and antitumorigenic use
WO1999027939A1 (en) * 1997-12-04 1999-06-10 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Ureido derivatives of poly-4-amino-2-carboxy-1-methyl pyrrole compounds for inhibition of inflammation
KR100672965B1 (ko) 1998-07-06 2007-02-28 길포드 파마슈티컬스 인코포레이티드 약제학적 화합물로 유용한 나알라다제 억제제 및 그의조성물
US6395718B1 (en) 1998-07-06 2002-05-28 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
DE60045240D1 (de) * 1999-03-02 2010-12-30 Centocor Inc Antikörper gegen tnf alpha zur therapie von steroidresistentem asthma
US6348464B1 (en) * 1999-11-12 2002-02-19 Guilford Pharmaceuticals, Inc. Pyrrolecarbonylimino derivatives as naaladase inhibitors
US20050249735A1 (en) * 2000-08-07 2005-11-10 Centocor, Inc. Methods of treating ankylosing spondylitis using anti-TNF antibodies and peptides of human tumor necrosis factor
US20110195063A1 (en) * 2000-08-07 2011-08-11 Centocor, Inc. Methods of Treating Ankylosing Spondylitis Using Anti-TNF Antibodies and Peptides of Human Tumor Necrosis Factor
US20060018907A1 (en) * 2000-08-07 2006-01-26 Centocor, Inc. Anti-TNF antibodies and peptides of human tumor necrosis factor
TWI334439B (en) 2001-08-01 2010-12-11 Centocor Inc Anti-tnf antibodies, compositions, methods and uses
US20090038182A1 (en) * 2007-08-09 2009-02-12 Lans Maris J Footwear with built-in scale
US10465003B2 (en) 2016-02-05 2019-11-05 Janssen Biotech, Inc. Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes
EP3381897A1 (en) 2017-03-27 2018-10-03 Leadiant Biosciences SA Derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1h-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds as heparanase inhibitors for the treatment of cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8517922D0 (en) * 1985-07-16 1985-08-21 Erba Farmitalia Carboxamido derivatives
US5310752A (en) * 1986-05-20 1994-05-10 Farmitalia Carlo Erba Spa Site specific alkylating agents
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
CA1308516C (en) * 1987-07-06 1992-10-06 J. William Lown Oligopeptide anticancer and antiviral agents
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
IT1247878B (it) * 1991-02-15 1995-01-05 Menarini Farma Ind Derivati poli-4-aminopirrol-2-carbossiamidici,processi di preparazione e composizioni farmaceutiche che li contengono
GB9304589D0 (en) * 1993-03-05 1993-04-21 Erba Carlo Spa Biologically active ureido derivatives useful as antimetastic agents

Also Published As

Publication number Publication date
PT696287E (pt) 2000-08-31
HU9503433D0 (en) 1996-01-29
FI955180A0 (fi) 1995-10-30
DE69515390T2 (de) 2000-09-21
FI955180L (fi) 1995-10-30
ATE190312T1 (de) 2000-03-15
FI955180A7 (fi) 1995-10-30
NO308005B1 (no) 2000-07-03
JPH08509992A (ja) 1996-10-22
MX9504381A (es) 1997-01-31
GR3033356T3 (en) 2000-09-29
NO954346L (no) 1995-10-30
CN1124027A (zh) 1996-06-05
HUT74987A (en) 1997-03-28
NO954346D0 (no) 1995-10-30
ZA951653B (en) 1995-12-08
RU2136692C1 (ru) 1999-09-10
AU678704B2 (en) 1997-06-05
WO1995023806A3 (en) 1995-09-28
WO1995023806A2 (en) 1995-09-08
MY130125A (en) 2007-06-29
DE69515390D1 (de) 2000-04-13
DK0696287T3 (da) 2000-07-31
KR960701881A (ko) 1996-03-28
EP0696287B1 (en) 2000-03-08
TW290547B (es) 1996-11-11
AU1848895A (en) 1995-09-18
US5700788A (en) 1997-12-23
IL112716A0 (en) 1995-05-26
CA2160250A1 (en) 1995-09-08
CN1061050C (zh) 2001-01-24
NZ281205A (en) 1997-01-29
PL311339A1 (en) 1996-02-05
EP0696287A1 (en) 1996-02-14
GB9403909D0 (en) 1994-04-20

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