ES2137223T3 - Procedimiento y compuestos para la preparacion de carbocefems. - Google Patents

Procedimiento y compuestos para la preparacion de carbocefems.

Info

Publication number
ES2137223T3
ES2137223T3 ES93301079T ES93301079T ES2137223T3 ES 2137223 T3 ES2137223 T3 ES 2137223T3 ES 93301079 T ES93301079 T ES 93301079T ES 93301079 T ES93301079 T ES 93301079T ES 2137223 T3 ES2137223 T3 ES 2137223T3
Authority
ES
Spain
Prior art keywords
compounds
preparation
group
carboxide
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93301079T
Other languages
English (en)
Inventor
Jack Wayne Fisher
Lowell Deloss Hatfield
Richard Charles Hoying
James Edward Ray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2137223T3 publication Critical patent/ES2137223T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE PRESENTAN COMPUESTOS Y METODOS PARA LA PREPARACION DE CARBACEFEMS, UTILES EN LA PREPARACION DE ANALOGOS DE LA CEFALOSPORINA. LOS COMPUESTOS SON COMPUESTOS 4,6 BICICLO QUE SE CARACTERIZAN POR LA PRESENCIA TANTO DE UN GRUPO QUIRAL PROTECTOR DEL AMINO COMO DE UN GRUPO PROTECTOR DEL CARBOXIDO. LOS METODOS SITUAN AMBOS GRUPOS PROTECTORES SOBRE LA ESTRUCTURA BASICA DEL COMPUESTO DE MANERA TEMPRANA EN EL ESQUEMA DE SINTESIS Y RETIENEN TIPICAMENTE A AMBOS A TRAVES DEL PROCESO, CONSIGUIENDO DE ESTA FORMA SIMPLIFICAR EL PROCEDIMIENTO COMPLETO Y UN EFICIENTE Y ALTO RENDIMIENTO. LA SEPARACION DEL GRUPO AUXILIAR QUIRAL Y DEL GRUPO PROTECTOR DE CARBOXIDO SE REALIZA CON IODURO DE TRIMETILSILIL PARA DAR COMO RESULTADO EL NUCLEO DE CARBACEFEM.
ES93301079T 1992-02-18 1993-02-15 Procedimiento y compuestos para la preparacion de carbocefems. Expired - Lifetime ES2137223T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/837,173 US5521307A (en) 1992-02-18 1992-02-18 Methods and compounds for the preparation of carbacephems

Publications (1)

Publication Number Publication Date
ES2137223T3 true ES2137223T3 (es) 1999-12-16

Family

ID=25273723

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93301079T Expired - Lifetime ES2137223T3 (es) 1992-02-18 1993-02-15 Procedimiento y compuestos para la preparacion de carbocefems.

Country Status (12)

Country Link
US (3) US5521307A (es)
EP (1) EP0558215B1 (es)
JP (1) JPH05255325A (es)
KR (1) KR930017901A (es)
BR (1) BR9300541A (es)
CA (1) CA2089544A1 (es)
DE (1) DE69326367T2 (es)
ES (1) ES2137223T3 (es)
HU (1) HUT64541A (es)
IL (1) IL104700A (es)
MX (1) MX9300765A (es)
TW (1) TW242628B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69734321T2 (de) 1996-02-23 2006-08-10 Eli Lilly And Co., Indianapolis Non-peptidische vasopressin via antagonisten

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4095107A (en) * 1976-04-15 1978-06-13 Sebastian Genna Transaxial radionuclide emission camera apparatus and method
US4665171A (en) * 1985-07-17 1987-05-12 Harvard University Process and intermediates for β-lactam antibiotics
KR0169096B1 (ko) * 1988-10-11 1999-01-15 리로이 휘테커 카바세팔로스포린의 아제티디논 중간체 화합물 및 제조방법
US5095107A (en) * 1990-11-05 1992-03-10 Eli Lilly And Company Process for cleavage of esters during the production of cephalosporins

Also Published As

Publication number Publication date
BR9300541A (pt) 1993-08-24
CA2089544A1 (en) 1993-08-19
DE69326367T2 (de) 2000-02-03
JPH05255325A (ja) 1993-10-05
US5644051A (en) 1997-07-01
TW242628B (es) 1995-03-11
HUT64541A (en) 1994-01-28
MX9300765A (es) 1993-09-01
IL104700A (en) 1998-02-08
US5521307A (en) 1996-05-28
IL104700A0 (en) 1993-06-10
EP0558215B1 (en) 1999-09-15
US5700933A (en) 1997-12-23
EP0558215A1 (en) 1993-09-01
HU9300383D0 (en) 1993-04-28
DE69326367D1 (de) 1999-10-21
KR930017901A (ko) 1993-09-20

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