ES2134213T3 - Nuevos glicoesfingolipidos y empleo de los mismos. - Google Patents
Nuevos glicoesfingolipidos y empleo de los mismos.Info
- Publication number
- ES2134213T3 ES2134213T3 ES92909489T ES92909489T ES2134213T3 ES 2134213 T3 ES2134213 T3 ES 2134213T3 ES 92909489 T ES92909489 T ES 92909489T ES 92909489 T ES92909489 T ES 92909489T ES 2134213 T3 ES2134213 T3 ES 2134213T3
- Authority
- ES
- Spain
- Prior art keywords
- sphingoglycolipid
- glycosphingolipids
- employment
- new
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE PRESENTA UN NUEVO SFINGOGLICOLIPIDO REPRESENTADO POR LA FORMULA GENERAL (A), EN DONDE E REPRESENTA -CH(R2)-(CH2)X-H O (CH2)7CH=CH(CH2)7-CH3; R1 REPRESENTA -CH(R2)-(CH2)Y-R3 O -CH=CH(CH2)Y-CH3; R2 REPRESENTA H O OH; R3 REPRESENTA METILO, ISOPROPILO O SEC-BUTILO; X REPRESENTA UN ENTERO ENTRE 0 Y 26; E Y REPRESENTA UN ENTERO ENTRE 5 Y 17. TAMBIEN SE PRESENTA UN AGENTE ANTINEOPLASTICO Y UN INMUNOPOTENCIADOR QUE CONTIENEN AL MENOS UNO DE LOS COMPUESTOS ANTES MENCIONADOS COMO INGREDIENTE ACTIVO. ASIMISMO SE PRESENTA UN PROCESO PARA PREPARAR UN SFINGOGLICOLIPIDO TOMANDO EL SFINGOGLICOLIPIDO ESPECIFICO DE UNA ESPONJA "AGELAS MAURITIANUS".
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3244384A JPH0559081A (ja) | 1991-08-29 | 1991-08-29 | 新規スフインゴ糖脂質、その製造法および使用 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2134213T3 true ES2134213T3 (es) | 1999-10-01 |
Family
ID=17117885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92909489T Expired - Lifetime ES2134213T3 (es) | 1991-08-29 | 1992-04-28 | Nuevos glicoesfingolipidos y empleo de los mismos. |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0609437B1 (es) |
JP (2) | JPH0559081A (es) |
KR (1) | KR100220793B1 (es) |
AT (1) | ATE181922T1 (es) |
AU (1) | AU665536B2 (es) |
CA (1) | CA2116442C (es) |
DE (1) | DE69229557T2 (es) |
DK (1) | DK0609437T3 (es) |
ES (1) | ES2134213T3 (es) |
FI (1) | FI105189B (es) |
GR (1) | GR3030723T3 (es) |
HK (1) | HK1009967A1 (es) |
HU (1) | HU223839B1 (es) |
NO (1) | NO180338C (es) |
PT (1) | PT100736B (es) |
SG (1) | SG44031A1 (es) |
TW (1) | TW197446B (es) |
WO (1) | WO1993005055A1 (es) |
ZA (1) | ZA923239B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5936076A (en) * | 1991-08-29 | 1999-08-10 | Kirin Beer Kabushiki Kaisha | αgalactosylceramide derivatives |
TW261533B (es) * | 1992-07-16 | 1995-11-01 | Kirin Brewery | |
WO1994009020A1 (en) * | 1992-10-22 | 1994-04-28 | Kirin Beer Kabushiki Kaisha | Novel shingoglycolipid and use thereof |
EP0694558B1 (en) * | 1993-04-15 | 1999-01-27 | Kirin Beer Kabushiki Kaisha | Novel sphingoglycolipid and use thereof |
TW555562B (en) | 1996-12-27 | 2003-10-01 | Kirin Brewery | Method for activation of human antigen-presenting cells, activated human antigen-presenting cells and use thereof |
TW575420B (en) * | 1997-09-22 | 2004-02-11 | Kirin Brewery | Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides |
AU782539B2 (en) * | 2000-01-14 | 2005-08-04 | Meiji Dairies Corporation | Antigen-specific IgE antibody production inhibitors |
JP2002030093A (ja) * | 2000-03-13 | 2002-01-29 | Nof Corp | グリコシルセラミドの精製方法 |
CN100439383C (zh) | 2001-08-16 | 2008-12-03 | 阿斯比奥制药株式会社 | 糖脂及其作为有效成分的用于自体免疫疾病的药物 |
BR0314640A (pt) * | 2002-09-20 | 2005-08-02 | Kirin Brewery | Inibidor de vìrus de hepatite c compreendendo, como um ingrediente ativo, alfa-glicosilceramida |
JP4585172B2 (ja) * | 2003-01-31 | 2010-11-24 | 森永乳業株式会社 | 骨形成促進剤 |
HUE037560T2 (hu) * | 2003-02-14 | 2018-09-28 | Japan President Nat Ct Neurology & Psychiatry | Glikolipid-származékok, eljárás elõállításukra, szintézis-köztitermékeik, és eljárás a köztitermékek elõállítására |
JP4753089B2 (ja) * | 2004-12-20 | 2011-08-17 | 株式会社岡安商店 | 体内脂肪の分解促進作用を有する組成物及びそれを含有する食品又は食品配合剤 |
JP2007070311A (ja) * | 2005-09-09 | 2007-03-22 | Gunma Univ | α−ガラクトシルセラミドからなる感染症予防剤及び感染症治療剤 |
EP1776963A1 (en) | 2005-10-19 | 2007-04-25 | Gbf-Gesellschaft Für Biotechnologische Forschung Mbh | Hexosylceramides as adjuvants and their uses in pharmaceutical compositions |
WO2008047174A1 (en) * | 2006-10-18 | 2008-04-24 | Centre National De La Recherche Scientifique | Alpha-galactosylceramide analogs, their methods of manufacture, intermediate compounds useful in these methods, and pharmaceutical compositions containing them |
KR100868959B1 (ko) * | 2006-12-30 | 2008-11-17 | 재단법인서울대학교산학협력재단 | 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물 |
US7959907B2 (en) | 2007-02-21 | 2011-06-14 | Vib Vzw | Method of treating cancer by combination therapy using TNF and alpha-galactosylceramide |
JP4995172B2 (ja) * | 2008-10-10 | 2012-08-08 | 壽製薬株式会社 | 糖脂質誘導体、その製造方法並びにそれを有効成分とする医薬 |
RU2532222C2 (ru) | 2009-02-16 | 2014-10-27 | Серенис Терапьютикс Холдинг С.А, | Миметики аполипопротеина а-i |
JP5095683B2 (ja) * | 2009-07-06 | 2012-12-12 | 壽製薬株式会社 | 新規糖脂質誘導体及びこれを有効成分とする製剤 |
JP5025692B2 (ja) * | 2009-07-06 | 2012-09-12 | 壽製薬株式会社 | 糖脂質誘導体の製造方法 |
JP2010254718A (ja) * | 2010-08-13 | 2010-11-11 | Morinaga Milk Ind Co Ltd | 骨形成促進剤 |
NO2629776T3 (es) | 2010-10-18 | 2018-01-13 | ||
WO2012074116A1 (ja) | 2010-12-02 | 2012-06-07 | 独立行政法人理化学研究所 | アロNKT細胞を用いた免疫療法およびそのためのT細胞抗原受容体(TCR)遺伝子のα鎖領域が均一なVα-Jαに再構成されている細胞および該細胞由来NKT細胞のバンキング |
WO2014021464A1 (ja) * | 2012-08-03 | 2014-02-06 | 独立行政法人理化学研究所 | 水酸化krn7000類縁体及びその用途 |
EP2903622A1 (en) | 2012-10-03 | 2015-08-12 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with invariant nkt cell agonists |
US10151745B2 (en) | 2012-11-21 | 2018-12-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods for determining the risk of acute graft versus host disease |
WO2017207040A1 (en) | 2016-06-01 | 2017-12-07 | Vib Vzw | ANTI-CANCER THERAPY USING A LEPTIN ANTAGONIST AND AN iNKT-CELL ACTIVATOR |
KR102328367B1 (ko) * | 2019-11-05 | 2021-11-18 | 한국해양과학기술원 | 아젤록심 d를 유효성분으로 함유하는 방사선 민감성 증진용 조성물 |
JPWO2022118913A1 (es) | 2020-12-04 | 2022-06-09 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6157594A (ja) * | 1984-08-30 | 1986-03-24 | Suntory Ltd | ガラクトスフインゴ脂質及びその製造法 |
JP2588729B2 (ja) * | 1987-10-05 | 1997-03-12 | 塩野義製薬株式会社 | スフィンゴシン誘導体 |
DE3840044A1 (de) * | 1988-11-27 | 1990-06-07 | Behringwerke Ag | Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung |
-
1991
- 1991-08-29 JP JP3244384A patent/JPH0559081A/ja active Pending
-
1992
- 1992-04-28 KR KR1019940700662A patent/KR100220793B1/ko not_active IP Right Cessation
- 1992-04-28 ES ES92909489T patent/ES2134213T3/es not_active Expired - Lifetime
- 1992-04-28 WO PCT/JP1992/000561 patent/WO1993005055A1/ja active IP Right Grant
- 1992-04-28 SG SG1996009529A patent/SG44031A1/en unknown
- 1992-04-28 AU AU16664/92A patent/AU665536B2/en not_active Expired
- 1992-04-28 DK DK92909489T patent/DK0609437T3/da active
- 1992-04-28 EP EP92909489A patent/EP0609437B1/en not_active Expired - Lifetime
- 1992-04-28 CA CA002116442A patent/CA2116442C/en not_active Expired - Lifetime
- 1992-04-28 HU HU9400596A patent/HU223839B1/hu active IP Right Grant
- 1992-04-28 JP JP4508706A patent/JP2774194B2/ja not_active Expired - Lifetime
- 1992-04-28 DE DE69229557T patent/DE69229557T2/de not_active Expired - Lifetime
- 1992-04-28 AT AT92909489T patent/ATE181922T1/de active
- 1992-05-05 ZA ZA923239A patent/ZA923239B/xx unknown
- 1992-05-06 TW TW081103536A patent/TW197446B/zh not_active IP Right Cessation
- 1992-07-28 PT PT100736A patent/PT100736B/pt not_active IP Right Cessation
-
1994
- 1994-02-22 NO NO940598A patent/NO180338C/no not_active IP Right Cessation
- 1994-02-23 FI FI940851A patent/FI105189B/fi not_active IP Right Cessation
-
1998
- 1998-09-21 HK HK98110772A patent/HK1009967A1/xx not_active IP Right Cessation
-
1999
- 1999-07-08 GR GR990400800T patent/GR3030723T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR100220793B1 (ko) | 1999-10-01 |
NO940598L (es) | 1994-04-27 |
WO1993005055A1 (en) | 1993-03-18 |
FI940851A0 (fi) | 1994-02-23 |
SG44031A1 (en) | 1997-11-14 |
DK0609437T3 (da) | 2000-01-31 |
PT100736A (pt) | 1993-09-30 |
CA2116442C (en) | 2000-09-05 |
FI940851A (fi) | 1994-02-23 |
JP2774194B2 (ja) | 1998-07-09 |
ZA923239B (en) | 1993-05-05 |
TW197446B (es) | 1993-01-01 |
NO940598D0 (no) | 1994-02-22 |
EP0609437B1 (en) | 1999-07-07 |
HUT70435A (en) | 1995-10-30 |
DE69229557D1 (de) | 1999-08-12 |
PT100736B (pt) | 1999-04-30 |
JPH0559081A (ja) | 1993-03-09 |
AU1666492A (en) | 1993-04-05 |
AU665536B2 (en) | 1996-01-11 |
CA2116442A1 (en) | 1993-03-18 |
GR3030723T3 (en) | 1999-11-30 |
ATE181922T1 (de) | 1999-07-15 |
DE69229557T2 (de) | 1999-11-25 |
HU9400596D0 (en) | 1994-05-30 |
NO180338B (no) | 1996-12-23 |
EP0609437A1 (en) | 1994-08-10 |
HK1009967A1 (en) | 1999-09-17 |
FI105189B (fi) | 2000-06-30 |
HU223839B1 (hu) | 2005-02-28 |
EP0609437A4 (en) | 1994-08-24 |
NO180338C (no) | 1997-04-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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