ES2132121T3 - Procedimiento para la purificacion de inhibidores de la hmg-coa reductasa. - Google Patents
Procedimiento para la purificacion de inhibidores de la hmg-coa reductasa.Info
- Publication number
- ES2132121T3 ES2132121T3 ES92908427T ES92908427T ES2132121T3 ES 2132121 T3 ES2132121 T3 ES 2132121T3 ES 92908427 T ES92908427 T ES 92908427T ES 92908427 T ES92908427 T ES 92908427T ES 2132121 T3 ES2132121 T3 ES 2132121T3
- Authority
- ES
- Spain
- Prior art keywords
- hmg
- purification
- inhibitors
- procedure
- coa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/322—Normal bonded phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
UN PROCESO PARA LA PURIFICACION DE UN INHIBIDOR DE REDUCTASA HMG-COA QUE EMPLEA UNA CROMATOGRAFIA LIQUIDA DE ALTA PRESTACION PREPARATORIA ASI COMO UNA COMPOSICION FARMACEUTICA QUE COMPRENDE EL INHIBIDOR DE REDUCTASA HMG-COA Y PORTADOR FARMACEUTICAMENTE ACEPTABLE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/668,831 US5202029A (en) | 1991-03-13 | 1991-03-13 | Process for purification of hmg-coa reductase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2132121T3 true ES2132121T3 (es) | 1999-08-16 |
Family
ID=24683910
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92908427T Expired - Lifetime ES2132121T3 (es) | 1991-03-13 | 1992-03-09 | Procedimiento para la purificacion de inhibidores de la hmg-coa reductasa. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5202029A (es) |
EP (1) | EP0578723B1 (es) |
JP (1) | JPH06506210A (es) |
AT (1) | ATE180986T1 (es) |
CA (1) | CA2104232A1 (es) |
DE (1) | DE69229393D1 (es) |
ES (1) | ES2132121T3 (es) |
GR (1) | GR3030446T3 (es) |
WO (1) | WO1992016276A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5308479A (en) * | 1989-05-26 | 1994-05-03 | Isamu Iwai | Sewage disposal apparatus employing circulating filter media |
DE4414537A1 (de) * | 1994-04-26 | 1995-11-02 | Klinge Co Chem Pharm Fab | Kombinationspräparate mit einem Gehalt an einem p-Oxybenzoesäurederivat und einem HMG-CoA-Reduktase-Hemmer |
SI9800046A (sl) | 1998-02-18 | 1999-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti |
US7141602B2 (en) * | 1998-09-18 | 2006-11-28 | Lek Pharmaceuticals D.D. | Process for obtaining HMG-CoA reductase inhibitors of high purity |
SI20072A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
WO2001030773A2 (en) | 1999-10-27 | 2001-05-03 | Merck & Co., Inc. | Lactonization process |
EP1265604B1 (en) * | 1999-11-30 | 2006-10-18 | TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Process for recovering statin compounds from a fermentation broth |
JP2003516959A (ja) * | 1999-12-14 | 2003-05-20 | ビオガル ジョジセルジャール アール テー. | プラバスタチンナトリウムの新規フォーム |
KR20030013373A (ko) | 2000-02-24 | 2003-02-14 | 비오갈 기오기스제르갸르 알티. | 발효 브로스의 정제 방법 |
JP2003525935A (ja) | 2000-03-03 | 2003-09-02 | ビオガル ジョジセルジャール アール テー. | 低下したレベルの二量体不純物を伴うロバスタチン及びシンバスタチンの精製方法 |
JP4945876B2 (ja) * | 2000-04-05 | 2012-06-06 | 東レ株式会社 | ハイモビリティーグループタンパクの吸着材および体液浄化カラム |
US6936731B2 (en) * | 2000-10-05 | 2005-08-30 | TEVA Gyógyszergyár Részvénytársaság | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same |
IL155194A0 (en) * | 2000-10-05 | 2003-11-23 | Biogal Pharmaceutical Co Ltd | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same |
US20050215636A1 (en) * | 2000-10-05 | 2005-09-29 | Vilmos Keri | Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same |
JP3236282B1 (ja) * | 2000-10-16 | 2001-12-10 | 三共株式会社 | プラバスタチンを精製する方法 |
US7368468B2 (en) * | 2003-06-18 | 2008-05-06 | Teva Pharmaceutical Industries Ltd. | Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them |
CA2610635A1 (en) * | 2003-06-18 | 2004-12-29 | Teva Pharmaceutical Industries Ltd | Fluvastatin sodium crystal form lxxxvii, processes for preparing, compositions and methods of using |
PT1641447E (pt) * | 2003-11-24 | 2008-12-10 | Teva Gyogyszergyar Zartkoeruee | Método de purificação da pravastatina |
WO2005051921A1 (en) * | 2003-11-24 | 2005-06-09 | Teva Pharmaceutical Industries Ltd. | Crystalline ammonium salts of rosuvastatin |
US7851624B2 (en) * | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
US20070179166A1 (en) * | 2003-12-24 | 2007-08-02 | Valerie Niddam-Hildesheim | Process for preparation of statins with high syn to anti ratio |
ES2239533B1 (es) * | 2004-03-01 | 2006-12-16 | Ercros Industrial, S.A. | Procedimiento para la obtencion de compactina. |
WO2006035295A1 (en) * | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Process for the purification of lovastatin |
CA2680693A1 (en) * | 2005-02-22 | 2006-08-31 | Teva Pharmaceutical Industries Ltd. | Preparation of rosuvastatin |
WO2009078033A2 (en) * | 2007-12-18 | 2009-06-25 | Themis Medicare Limited | Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth |
SG175085A1 (en) * | 2009-04-08 | 2011-11-28 | Nanyang Polytechnic | A plant extract comprising statins and preparation techniques and uses thereof |
CN102043030A (zh) * | 2009-10-22 | 2011-05-04 | 北京万全阳光医学技术有限公司 | 一种用高效液相色谱法测定烟酸辛伐他汀缓释片有关物质的方法 |
WO2012030432A1 (en) * | 2010-07-07 | 2012-03-08 | Ironstone Separations, Inc. | Chromatography methods |
EP2597092A1 (en) | 2011-11-24 | 2013-05-29 | Sterling Biotech Limited | A process for purification of lovastatin |
CN112657231B (zh) * | 2020-12-24 | 2022-06-10 | 西安蓝晓科技新材料股份有限公司 | 一种三七总皂苷的提纯工艺 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
JPS58140024A (ja) * | 1982-02-15 | 1983-08-19 | Eisai Co Ltd | セクレチンの精製方法 |
US4833258A (en) * | 1987-02-17 | 1989-05-23 | Merck & Co., Inc. | Intermediates useful in the preparation of HMG-COA reductase inhibitors |
US4719229A (en) * | 1987-05-13 | 1988-01-12 | Merck & Co., Inc. | Antihypercholesterolemic agents |
US4778600A (en) * | 1987-06-17 | 1988-10-18 | Dow Corning Corporation | Liquid chromatography dual zone packing materials |
US4997755A (en) * | 1988-04-15 | 1991-03-05 | Merck & Co., Inc. | HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455) |
US5099035A (en) * | 1989-02-27 | 1992-03-24 | E. R. Squibb & Sons, Inc. | Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same |
US5102911A (en) * | 1989-06-09 | 1992-04-07 | Merck & Co, Inc. | 4-Substituted HMG-CoA reductase inhibitors |
US4965200A (en) * | 1989-06-23 | 1990-10-23 | Merck & Co., Inc. | Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs |
US4997849A (en) * | 1989-06-23 | 1991-03-05 | Merck & Co., Inc. | Microbial transformation of simvastatin |
US5089523A (en) * | 1990-05-11 | 1992-02-18 | E. R. Squibb & Sons, Inc. | Fluorinated derivatives of mevinic acids |
-
1991
- 1991-03-13 US US07/668,831 patent/US5202029A/en not_active Expired - Fee Related
-
1992
- 1992-03-09 CA CA002104232A patent/CA2104232A1/en not_active Abandoned
- 1992-03-09 WO PCT/US1992/001864 patent/WO1992016276A1/en active IP Right Grant
- 1992-03-09 AT AT92908427T patent/ATE180986T1/de not_active IP Right Cessation
- 1992-03-09 JP JP4508303A patent/JPH06506210A/ja active Pending
- 1992-03-09 DE DE69229393T patent/DE69229393D1/de not_active Expired - Lifetime
- 1992-03-09 ES ES92908427T patent/ES2132121T3/es not_active Expired - Lifetime
- 1992-03-09 EP EP92908427A patent/EP0578723B1/en not_active Expired - Lifetime
-
1999
- 1999-06-10 GR GR990401364T patent/GR3030446T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2104232A1 (en) | 1992-09-14 |
EP0578723A1 (en) | 1994-01-19 |
EP0578723A4 (en) | 1994-06-22 |
US5202029A (en) | 1993-04-13 |
DE69229393D1 (de) | 1999-07-15 |
EP0578723B1 (en) | 1999-06-09 |
WO1992016276A1 (en) | 1992-10-01 |
GR3030446T3 (en) | 1999-09-30 |
JPH06506210A (ja) | 1994-07-14 |
ATE180986T1 (de) | 1999-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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