ES2130162T3 - Formas topicas de alta dosificacion de colagenasa. - Google Patents
Formas topicas de alta dosificacion de colagenasa.Info
- Publication number
- ES2130162T3 ES2130162T3 ES92310008T ES92310008T ES2130162T3 ES 2130162 T3 ES2130162 T3 ES 2130162T3 ES 92310008 T ES92310008 T ES 92310008T ES 92310008 T ES92310008 T ES 92310008T ES 2130162 T3 ES2130162 T3 ES 2130162T3
- Authority
- ES
- Spain
- Prior art keywords
- colagenase
- high dosage
- topical forms
- collagenase
- provides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
LA INVENCION SUMINISTRA COMPOSICIONES FARMACEUTICAS PARA APLICACION TOPICA QUE CONTIENEN ALTAS CONCENTRACIONES DE COLAGENASA DE ENZIMAS EN EXCIPIENTES NO ACUOSOS. LA INVENCION TAMBIEN SUMINISTRA UN EXCIPIENTE PARTICUAR, DEXTRANO, QUE ES ESPECIALMENTE UTIL PARA MEZCLAR CON LA COLAGENASA Y QUE TAMBIEN PUEDE USARSE DE FORMA VENTAJOSA CON OTROS MATERIALES FARMACEUTICAMENTE ACTIVOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79591591A | 1991-11-20 | 1991-11-20 | |
US07/963,995 US5393792A (en) | 1991-11-20 | 1992-10-29 | High dosage topical forms of collagenase |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2130162T3 true ES2130162T3 (es) | 1999-07-01 |
Family
ID=27121667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92310008T Expired - Lifetime ES2130162T3 (es) | 1991-11-20 | 1992-11-02 | Formas topicas de alta dosificacion de colagenasa. |
Country Status (12)
Country | Link |
---|---|
US (3) | US5393792A (es) |
EP (1) | EP0543521B1 (es) |
JP (1) | JPH0789871A (es) |
AT (1) | ATE179612T1 (es) |
AU (1) | AU654881B2 (es) |
CA (1) | CA2083333C (es) |
DE (1) | DE69229098T2 (es) |
ES (1) | ES2130162T3 (es) |
HU (1) | HUT62802A (es) |
RU (1) | RU2129862C1 (es) |
SI (1) | SI9200334A (es) |
YU (1) | YU98792A (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2173158T3 (es) * | 1994-12-15 | 2002-10-16 | Advance Biofactures Curacao | Reduccion del tejido adiposo utilizando colagenasa |
US6958150B2 (en) | 1994-12-15 | 2005-10-25 | Advance Biofactures Of Curacao, N.V. | Reduction of adipose tissue |
DE19503338C2 (de) * | 1995-02-02 | 1998-07-30 | Lohmann Therapie Syst Lts | Arzneiform zur Abgabe von Kollagenase an Wunden und Verfahren zu ihrer Herstellung und ihre Verwendung |
US5718897A (en) * | 1995-06-07 | 1998-02-17 | Trustees Of Tufts College | Enhancing keratinocyte migration and proliferation |
US5851522A (en) * | 1995-06-07 | 1998-12-22 | Trustees Of Tufts College | Enhancing keratinocyte migration |
DE19521829A1 (de) * | 1995-06-16 | 1996-12-19 | Knoll Ag | Neue Verwendung von Collagenase |
US6086872A (en) * | 1997-03-27 | 2000-07-11 | Advance Biofactures Of Curacao, Nv | Amelioration of dupuytren's disease |
AU3954199A (en) * | 1998-06-03 | 1999-12-20 | Hwa Seong Kim | Adhesion / fixation / cooling remedies for burn and therapeutic method for relieving burn scar |
DE19825794A1 (de) * | 1998-06-10 | 1999-12-16 | Knoll Ag | Collagenase-Applikationsform |
IL127209A0 (en) * | 1998-11-23 | 1999-09-22 | Bio Silk Ltd | Composition and method for treatment of hypertrophic skin accumulations and their prevention |
US20030198631A1 (en) * | 2002-04-18 | 2003-10-23 | Healthpoint, Ltd. | Thermolysin enzymatic wound debrider |
US7169405B2 (en) * | 2003-08-06 | 2007-01-30 | Warsaw Orthopedic, Inc. | Methods and devices for the treatment of intervertebral discs |
US20050220821A1 (en) * | 2004-03-31 | 2005-10-06 | Allergan, Inc. | Pressure sore treatment |
EP1773379A4 (en) * | 2004-07-13 | 2009-07-15 | Mediwound Ltd | COMPOSITIONS AND METHODS OF HEALING FOR DERMATOLOGICAL DISEASES |
US20070224184A1 (en) * | 2006-02-22 | 2007-09-27 | The Research Foundation Of The State University Of New York | Method for treating cellulite |
ITPD20050207A1 (it) | 2005-07-07 | 2007-01-08 | Fidia Farmaceutici | Nuove composizioni farmaceutiche contenenti acido ialuronico e collagenas nel trattamento topico di ferite, ustioni ed ulcere |
CN1935262B (zh) * | 2005-09-23 | 2010-12-29 | 沈阳胜宝康生物制药有限公司 | 红色诺卡氏菌细胞壁骨架在制备抗人乳头瘤病毒药物的用途 |
US20070141106A1 (en) * | 2005-10-19 | 2007-06-21 | Bonutti Peter M | Drug eluting implant |
US7811560B2 (en) * | 2006-01-30 | 2010-10-12 | Auxilium Us Holdings, Llc | Compositions and methods for treating collagen-mediated diseases |
US8642060B2 (en) * | 2006-04-24 | 2014-02-04 | Warsaw Orthopedic, Inc. | Controlled release systems and methods for osteal growth |
US8642059B2 (en) * | 2006-04-24 | 2014-02-04 | Warsaw Orthopedic, Inc. | Controlled release systems and methods for intervertebral discs |
US7771414B2 (en) * | 2006-04-24 | 2010-08-10 | Warsaw Orthopedic, Inc. | Controlled release devices for therapeutic treatments of spinal discs |
US7879027B2 (en) * | 2006-04-24 | 2011-02-01 | Warsaw Orthopedic, Inc. | Controlled release devices for fusion of osteal structures |
US8323642B2 (en) * | 2006-12-13 | 2012-12-04 | Depuy Mitek, Inc. | Tissue fusion method using collagenase for repair of soft tissue |
US10071143B1 (en) | 2007-05-03 | 2018-09-11 | The Research Foundation For The State University Of New York | Methods for non-surgical treatment of carpal tunnel syndrome |
US20100159564A1 (en) * | 2007-11-30 | 2010-06-24 | Dwulet Francis E | Protease resistant recombinant bacterial collagenases |
WO2010050980A1 (en) * | 2008-10-31 | 2010-05-06 | Laboratory Skin Care, Inc. | Topical formulations comprising hydroxyapatite particles for stimulation and maintenance of collagen fibers |
NZ600403A (en) | 2009-12-08 | 2014-01-31 | Smith & Nephew Orthopaedics Ag | Enzymatic wound debriding compositions with enhanced enzymatic activity |
US10119131B2 (en) | 2011-03-16 | 2018-11-06 | Biospecifics Technologies Corp. | Compositions and methods for producing clostridial collagenases |
PT2802652T (pt) | 2012-01-12 | 2019-09-10 | Endo Global Ventures | Enzimas de clostridium histolyticum |
CN103764038A (zh) * | 2012-02-21 | 2014-04-30 | 株式会社东芝 | X射线ct装置、图像显示装置、图像显示方法 |
US9636385B2 (en) | 2012-10-24 | 2017-05-02 | The Research Foundation For The State University Of New York | Use of collagenase to treat glaucoma |
WO2017130204A1 (en) | 2016-01-31 | 2017-08-03 | Mediwound Ltd. | Debriding composition for treating wounds |
WO2017183018A1 (en) | 2016-04-18 | 2017-10-26 | Mediwound Ltd | Methods of debridement of chronic wounds |
CN115969318A (zh) | 2017-03-01 | 2023-04-18 | 恩多风投有限公司 | 用于评估和治疗橘皮组织的装置和方法 |
AU2018244426B2 (en) | 2017-03-28 | 2024-09-19 | Endo Ventures Limited | Improved method of producing collagenase |
US20220362327A1 (en) * | 2021-05-13 | 2022-11-17 | Nasser Diab | Compositions and methods for wound healing |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH437641A (de) * | 1961-05-30 | 1967-06-15 | Bernburg Serum Werk Veb | Verfahren zur Herstellung von fettfreien Salbengrundlagen |
US3392161A (en) * | 1964-10-15 | 1968-07-09 | Gen Tire & Rubber Co | Gel-free halogenated polybutadiene rubber-resins |
US3705083A (en) * | 1966-07-08 | 1972-12-05 | Agricultural Biolog Corp | Process for producing collagenase |
US3792161A (en) * | 1970-05-18 | 1974-02-12 | Research Corp | Burn ointment comprising silver sulfadiazine and collagenase |
US3678158A (en) * | 1971-05-11 | 1972-07-18 | Worthington Bio Chem Corp | Treatment of herniated intervertebral discs of mammals |
US4089333A (en) * | 1972-10-28 | 1978-05-16 | Nippi, Incorporated | Method of treating a wound or burn |
US3876501A (en) * | 1973-05-17 | 1975-04-08 | Baxter Laboratories Inc | Binding enzymes to activated water-soluble carbohydrates |
US4174389A (en) * | 1977-05-13 | 1979-11-13 | Cope Louise A | Ophthalmic use of collagenase |
US4338300A (en) * | 1981-02-05 | 1982-07-06 | The Regents Of The University Of California | Use of purified clostridial collangenase in the treatment of Peyronie's disease |
US4485088A (en) * | 1982-03-26 | 1984-11-27 | Bio-Products, Inc. | Method of treatment of fibrotic lesions by topical administration of lathyrogenic drugs |
US4524065A (en) * | 1983-08-04 | 1985-06-18 | Bio-Specifics N.V. | Method for the prevention and treatment of scars with enzymes |
GB2150833B (en) * | 1983-12-08 | 1987-04-15 | Ceskoslovenska Akademie Ved | Proteolytic wounds dressing |
NZ226171A (en) * | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
US5173295A (en) * | 1990-10-05 | 1992-12-22 | Advance Biofactures Of Curacao, N.V. | Method of enhancing the regeneration of injured nerves and adhesive pharamaceutical formulation therefor |
-
1992
- 1992-10-29 US US07/963,995 patent/US5393792A/en not_active Expired - Lifetime
- 1992-11-02 ES ES92310008T patent/ES2130162T3/es not_active Expired - Lifetime
- 1992-11-02 DE DE69229098T patent/DE69229098T2/de not_active Expired - Lifetime
- 1992-11-02 AT AT92310008T patent/ATE179612T1/de not_active IP Right Cessation
- 1992-11-02 EP EP92310008A patent/EP0543521B1/en not_active Expired - Lifetime
- 1992-11-16 YU YU98792A patent/YU98792A/sh unknown
- 1992-11-19 RU RU92004549A patent/RU2129862C1/ru active
- 1992-11-19 CA CA002083333A patent/CA2083333C/en not_active Expired - Fee Related
- 1992-11-19 SI SI19929200334A patent/SI9200334A/sl unknown
- 1992-11-19 JP JP33527792A patent/JPH0789871A/ja active Pending
- 1992-11-19 HU HU929203623A patent/HUT62802A/hu unknown
- 1992-11-20 AU AU28535/92A patent/AU654881B2/en not_active Ceased
-
1993
- 1993-11-24 US US08/157,935 patent/US5422103A/en not_active Expired - Lifetime
-
1994
- 1994-11-07 US US08/335,261 patent/US5514370A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
RU2129862C1 (ru) | 1999-05-10 |
CA2083333A1 (en) | 1993-05-21 |
CA2083333C (en) | 2000-05-30 |
YU98792A (sh) | 1995-12-04 |
HU9203623D0 (en) | 1993-01-28 |
AU654881B2 (en) | 1994-11-24 |
EP0543521A3 (en) | 1993-07-28 |
DE69229098T2 (de) | 1999-09-09 |
EP0543521B1 (en) | 1999-05-06 |
EP0543521A2 (en) | 1993-05-26 |
JPH0789871A (ja) | 1995-04-04 |
US5393792A (en) | 1995-02-28 |
AU2853592A (en) | 1993-05-27 |
HUT62802A (en) | 1993-06-28 |
DE69229098D1 (de) | 1999-06-10 |
US5514370A (en) | 1996-05-07 |
SI9200334A (en) | 1993-06-30 |
ATE179612T1 (de) | 1999-05-15 |
US5422103A (en) | 1995-06-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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