ES2129421T3 - Anticuerpos monoclonales que reconocen el extremo c de hbnp. - Google Patents

Anticuerpos monoclonales que reconocen el extremo c de hbnp.

Info

Publication number
ES2129421T3
ES2129421T3 ES92119353T ES92119353T ES2129421T3 ES 2129421 T3 ES2129421 T3 ES 2129421T3 ES 92119353 T ES92119353 T ES 92119353T ES 92119353 T ES92119353 T ES 92119353T ES 2129421 T3 ES2129421 T3 ES 2129421T3
Authority
ES
Spain
Prior art keywords
hbnp
monoclonal antibody
immunoassay
monoclonal antibodies
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92119353T
Other languages
English (en)
Inventor
Tetsuo Tsuji
Ken Inouye
Akira Yamauchi
Masao Kono
Ken Ichi Igano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2129421T3 publication Critical patent/ES2129421T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors

Abstract

UN HIBRIDOMA QUE PRODUCE UN ANTICUERPO MONOCLONAL QUE RECONOCE EL TERMINO C DE PEPTIDO NATRIURETICO DE CEREBRO HUMANO (HBNP) SE CULTIVA EN UN MEDIO O LA CAVIDAD ABDOMINAL DE UN RATON PARA RECUPERAR EL ANTICUERPO MONOCLONAL DEL MEDIO O ASCITIS ACUMULADA EN LA CAVIDAD ABDOMINAL. SE ESTABLECE UN INMUNOENSAYO DE HBNP UTILIZANDO EL ANTICUERPO MONOCLONAL. EL INMUNOENSAYO DE HBNP DEL INVENTO ES TAN SENSIBLE QUE EL LIMITE DE DETECCION MINIMO ES 1 PG/ML Y PUEDE POR TANTO DETERMINAR UN NIVEL DE HBNP EN EL PLASMA SANGUINEO DIRECTAMENTE, ES DECIR, SIN LA EXTRACCION DE HBNP DEL PLASMA SANGUINEO. ES UTIL EN EL DIAGNOSTICO DE ENFERMEDADES COMO HIPERTENSION Y SIMILARES Y ESTADO DEL CORAZON, HIGADO Y SIMILARES SIN TOMAR EL INCREMENTO/REDUCCION DE UN NIVEL DE HBNP COMO INDICE.
ES92119353T 1991-11-14 1992-11-12 Anticuerpos monoclonales que reconocen el extremo c de hbnp. Expired - Lifetime ES2129421T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3326961A JP2665850B2 (ja) 1991-11-14 1991-11-14 ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体

Publications (1)

Publication Number Publication Date
ES2129421T3 true ES2129421T3 (es) 1999-06-16

Family

ID=18193724

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92119353T Expired - Lifetime ES2129421T3 (es) 1991-11-14 1992-11-12 Anticuerpos monoclonales que reconocen el extremo c de hbnp.

Country Status (10)

Country Link
US (2) US6677124B2 (es)
EP (1) EP0542255B1 (es)
JP (1) JP2665850B2 (es)
KR (1) KR100248315B1 (es)
AT (1) ATE176804T1 (es)
DE (1) DE69228436T2 (es)
DK (1) DK0542255T3 (es)
ES (1) ES2129421T3 (es)
GR (1) GR3029904T3 (es)
TW (1) TW230787B (es)

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JP2665850B2 (ja) * 1991-11-14 1997-10-22 塩野義製薬株式会社 ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体
GB9211686D0 (en) * 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
PT914344E (pt) 1996-03-04 2005-10-31 Scios Inc Ensaio e reagentes para a quantificacao de hbnp
US6117644A (en) * 1998-06-04 2000-09-12 Ottawa Heart Institute Research Corporation Predicting and detecting cardiac allograft rejection
US7432060B2 (en) 2000-11-09 2008-10-07 The Brigham And Women's Hospital, Inc. Methods for diagnosis of cardiovascular disease
US20040253242A1 (en) * 2000-12-05 2004-12-16 Bowdish Katherine S. Rationally designed antibodies
US7396917B2 (en) 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
EP1498429A3 (en) 2000-12-05 2005-08-03 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
US7524635B2 (en) 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
PT3072978T (pt) 2002-05-09 2018-10-15 Brigham & Womens Hospital Inc 1l1rl-1 como um marcador de doença cardiovascular
EP2260942A3 (en) 2002-05-13 2011-03-09 Becton, Dickinson and Company Protease Inhibitor Sample Collection System
US8263325B2 (en) 2002-11-15 2012-09-11 Ottawa Heart Institute Research Corporation Predicting, detecting and monitoring treatment of cardiomyopathies and myocarditis
CN100558398C (zh) 2002-11-26 2009-11-11 拜奥康有限公司 修饰的钠尿化合物、缀合物及其应用
US7648962B2 (en) * 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US7476363B2 (en) * 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
CA2522747C (en) 2003-05-12 2012-08-14 F. Hoffmann-La Roche Ag Method of detecting native probnp with a monoclonal antibody binding to the amino acids 38-43
GB2403533A (en) 2003-06-30 2005-01-05 Orion Corp Atrial natriuretic peptide and brain natriuretic peptide and assays and uses thereof
US20080207505A1 (en) * 2005-01-12 2008-08-28 James Kenneth D Bna Conjugates and Methods of Use
US7731965B2 (en) 2005-02-17 2010-06-08 Abbott Lab Human ring specific BNP antibodies
US7939069B2 (en) 2005-11-09 2011-05-10 Abbott Laboratories Human BNP immunospecific antibodies
CA2629438C (en) 2005-11-09 2014-02-25 Abbott Laboratories Human bnp immunospecific antibodies
ATE527544T1 (de) 2006-04-24 2011-10-15 Critical Care Diagnostics Inc Vorhersage von letalität und detektion von schweren erkrankungen
ATE545032T1 (de) 2006-05-01 2012-02-15 Critical Care Diagnostics Inc Diagnose von herz-kreislauf-erkrankung
US20080064045A1 (en) 2006-09-07 2008-03-13 Huaiqin Wu Biomarker fragments for the detection of human BNP
US20080280377A1 (en) * 2007-05-08 2008-11-13 Abbott Laboratories Human b-type natriuretic peptide assay having reduced cross-reactivity with other peptide forms
US20090203038A1 (en) * 2007-12-27 2009-08-13 Abbott Laboratories Negative Mimic Antibody For Use as a Blocking Reagent In BNP Immunoassays
PL2269063T3 (pl) 2008-04-18 2014-04-30 Critical Care Diagnostics Inc Rokowanie ryzyka głównych niekorzystnych zdarzeń sercowych
US20090286329A1 (en) * 2008-05-19 2009-11-19 Abbott Laboratoires Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides
US20090286256A1 (en) * 2008-05-19 2009-11-19 Abbott Laboratories Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides
JP5810514B2 (ja) * 2009-12-07 2015-11-11 東ソー株式会社 タグペプチド
CN111834009A (zh) 2012-08-21 2020-10-27 重症监护诊断股份有限公司 多标记风险分层
CN103869085A (zh) * 2014-04-04 2014-06-18 郑州安图生物工程股份有限公司 一种检测人源n端-b型钠尿肽前体的试剂盒
CN104880446B (zh) * 2015-06-01 2018-11-20 上海凯创生物技术有限公司 一种脑钠肽近红外荧光检测试剂盒及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271140A (en) * 1978-01-23 1981-06-02 Baxter Travenol Laboratories, Inc. Method and composition for double receptor, specific binding assays
DE3509958A1 (de) * 1985-03-20 1986-09-25 Bayer Ag, 5090 Leverkusen Monoklonale antikoerper gegen atriale, natriuretische peptide vom menschen
CA1335082C (en) 1987-09-01 1995-04-04 Hiroo Imura Monoclonal antibody recognizing –-hanp and a reagent for immunoassay of –-hanp
JP2665850B2 (ja) * 1991-11-14 1997-10-22 塩野義製薬株式会社 ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体
GB9211686D0 (en) * 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
PT914344E (pt) * 1996-03-04 2005-10-31 Scios Inc Ensaio e reagentes para a quantificacao de hbnp

Also Published As

Publication number Publication date
DE69228436T2 (de) 1999-07-22
US6677124B2 (en) 2004-01-13
KR100248315B1 (ko) 2000-03-15
GR3029904T3 (en) 1999-07-30
DE69228436D1 (de) 1999-03-25
US20040253655A1 (en) 2004-12-16
JP2665850B2 (ja) 1997-10-22
EP0542255A1 (en) 1993-05-19
TW230787B (es) 1994-09-21
ATE176804T1 (de) 1999-03-15
KR930010191A (ko) 1993-06-22
US20020025559A1 (en) 2002-02-28
JPH05184384A (ja) 1993-07-27
DK0542255T3 (da) 1999-05-10
EP0542255B1 (en) 1999-02-17

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