ES2124231T3 - Procedimiento mejorado para sintesis de oligomeros. - Google Patents
Procedimiento mejorado para sintesis de oligomeros.Info
- Publication number
- ES2124231T3 ES2124231T3 ES91919675T ES91919675T ES2124231T3 ES 2124231 T3 ES2124231 T3 ES 2124231T3 ES 91919675 T ES91919675 T ES 91919675T ES 91919675 T ES91919675 T ES 91919675T ES 2124231 T3 ES2124231 T3 ES 2124231T3
- Authority
- ES
- Spain
- Prior art keywords
- oligomers
- synthesis
- improved procedure
- methods
- result
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60579090A | 1990-10-26 | 1990-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2124231T3 true ES2124231T3 (es) | 1999-02-01 |
Family
ID=24425218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91919675T Expired - Lifetime ES2124231T3 (es) | 1990-10-26 | 1991-10-21 | Procedimiento mejorado para sintesis de oligomeros. |
Country Status (14)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993012135A1 (en) | 1991-12-12 | 1993-06-24 | Gilead Sciences, Inc. | Nuclease stable and binding competent oligomers and methods for their use |
| WO1994001446A2 (en) * | 1992-07-09 | 1994-01-20 | Beckman Instruments, Inc. | Derivatized organic solid support for nucleic acid synthesis |
| FR2707296B1 (fr) * | 1993-07-09 | 1995-09-29 | Genset Sa | Procédé de synthèse d'acides nucléiques sur support solide et composés utiles notamment comme support solide dans ledit procédé. |
| ATE239787T1 (de) * | 1993-07-19 | 2003-05-15 | Gen Probe Inc | Oligonukleotide mit wirkung gegen den menschlichen immunodefiziens-virus |
| US5739309A (en) * | 1993-07-19 | 1998-04-14 | Gen-Probe Incorporated | Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens |
| AU692816B2 (en) * | 1993-07-19 | 1998-06-18 | Gen-Probe Incorporated | Oligonucleotide screening assay |
| US5733781A (en) | 1994-07-19 | 1998-03-31 | Gen-Probe Incorporated | Oligonucleotides and methods for inhibiting propagation of human immunodeficiency virus |
| EP0805876B1 (en) * | 1995-01-19 | 2000-07-05 | Gen-Probe Incorporated | Nucleic acid amplification oligonucleotides and probes to lyme disease associated borrelia |
| US5716846A (en) * | 1995-06-07 | 1998-02-10 | Gen-Probe Incorporated | Method for inhibiting cellular proliferation using antisense oligonucleotides to interleukin-6 receptor mRNA |
| US5731148A (en) * | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
| US5674995A (en) * | 1995-06-07 | 1997-10-07 | Gen-Probe Incorporated | Oligonucleotides specific for cytokine signal transducer gp130 mRNA |
| US5747252A (en) * | 1995-06-07 | 1998-05-05 | Gen-Probe Incorporated | Nucleic acid probes and amplification oligonucleotides for Neisseria species |
| US5747470A (en) * | 1995-06-07 | 1998-05-05 | Gen-Probe Incorporated | Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA |
| US6025133A (en) * | 1996-12-30 | 2000-02-15 | Gen-Probe Incorporated | Promoter-sequestered oligonucleoside and method of use |
| US6146833A (en) * | 1997-02-11 | 2000-11-14 | Beckman Coulter, Inc. | Polymeric reagents for immobilizing biopolymers |
| US6932943B1 (en) | 2001-01-26 | 2005-08-23 | Third Wave Technologies | Nucleic acid synthesizers |
| US7435390B2 (en) * | 2001-01-26 | 2008-10-14 | Third Wave Technologies, Inc. | Nucleic acid synthesizers |
| US20030072689A1 (en) * | 2001-08-15 | 2003-04-17 | Third Wave Technologies, Inc. | Polymer synthesizer |
| EP2765202B1 (en) | 2006-08-01 | 2017-02-01 | Gen-Probe Incorporated | Methods of nonspecific target capture of nucleic acids |
| ES2633786T3 (es) | 2008-04-01 | 2017-09-25 | Biosearch Technologies, Inc. | Sondas de fluoróforo atenuadoras oscuras de ácido nucleico estabilizado |
| US10913767B2 (en) * | 2010-04-22 | 2021-02-09 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising acyclic and abasic nucleosides and analogs |
| US9403865B2 (en) | 2012-08-15 | 2016-08-02 | Ionis Pharmaceuticals, Inc. | Method of preparing oligomeric compounds using modified capping protocols |
| CN106536483B (zh) | 2014-05-09 | 2020-02-07 | 生物检索技术股份有限公司 | Cosmic猝灭剂 |
| WO2016160646A1 (en) * | 2015-04-02 | 2016-10-06 | Merck Sharp & Dohme Corp. | Process for making phosphoramidate protected nucleoside compounds |
| MY181693A (en) | 2015-04-15 | 2021-01-01 | Biosearch Tech Inc | Dual quencher probes |
| AU2018265274B2 (en) | 2017-05-11 | 2021-10-07 | Gen-Probe Incorporated | Compositions and methods for isolating target nucleic acids |
| EP4058187A1 (en) | 2019-11-14 | 2022-09-21 | Gen-Probe Incorporated | Compositions and methods for capturing target nucleic acids |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4500707A (en) * | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US4469863A (en) * | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US4668777A (en) * | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
| US4415732A (en) * | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
| DE3329892A1 (de) * | 1983-08-18 | 1985-03-07 | Köster, Hubert, Prof. Dr., 2000 Hamburg | Verfahren zur herstellung von oligonucleotiden |
| US4923901A (en) * | 1987-09-04 | 1990-05-08 | Millipore Corporation | Membranes with bound oligonucleotides and peptides |
-
1991
- 1991-10-21 AT AT91919675T patent/ATE171947T1/de not_active IP Right Cessation
- 1991-10-21 JP JP3518321A patent/JPH06509542A/ja active Pending
- 1991-10-21 CA CA002094803A patent/CA2094803A1/en not_active Abandoned
- 1991-10-21 EP EP91919675A patent/EP0592434B1/en not_active Expired - Lifetime
- 1991-10-21 ES ES91919675T patent/ES2124231T3/es not_active Expired - Lifetime
- 1991-10-21 WO PCT/US1991/007630 patent/WO1992007864A1/en active IP Right Grant
- 1991-10-21 DE DE69130331T patent/DE69130331T2/de not_active Expired - Fee Related
- 1991-10-21 AU AU88753/91A patent/AU669103B2/en not_active Ceased
- 1991-10-21 DK DK91919675T patent/DK0592434T3/da active
- 1991-10-23 NZ NZ240325A patent/NZ240325A/xx not_active IP Right Cessation
- 1991-10-24 IL IL9984491A patent/IL99844A/en not_active IP Right Cessation
- 1991-10-25 IE IE376191A patent/IE913761A1/en not_active Application Discontinuation
-
1992
- 1992-01-14 TW TW081100215A patent/TW216423B/zh active
-
1994
- 1994-06-15 US US08/260,392 patent/US5726300A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0592434A1 (en) | 1994-04-20 |
| DE69130331D1 (de) | 1998-11-12 |
| EP0592434B1 (en) | 1998-10-07 |
| AU8875391A (en) | 1992-05-26 |
| CA2094803A1 (en) | 1992-04-27 |
| WO1992007864A1 (en) | 1992-05-14 |
| ATE171947T1 (de) | 1998-10-15 |
| IL99844A (en) | 1995-07-31 |
| DK0592434T3 (da) | 1999-06-21 |
| US5726300A (en) | 1998-03-10 |
| DE69130331T2 (de) | 1999-03-04 |
| IE913761A1 (en) | 1992-05-22 |
| JPH06509542A (ja) | 1994-10-27 |
| NZ240325A (en) | 1993-06-25 |
| TW216423B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-11-21 |
| EP0592434A4 (en) | 1996-04-24 |
| AU669103B2 (en) | 1996-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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