ES2121276T3 - Procedimiento para la preparacion de bencil-piperidilmetil-indanonas. - Google Patents

Procedimiento para la preparacion de bencil-piperidilmetil-indanonas.

Info

Publication number
ES2121276T3
ES2121276T3 ES95116888T ES95116888T ES2121276T3 ES 2121276 T3 ES2121276 T3 ES 2121276T3 ES 95116888 T ES95116888 T ES 95116888T ES 95116888 T ES95116888 T ES 95116888T ES 2121276 T3 ES2121276 T3 ES 2121276T3
Authority
ES
Spain
Prior art keywords
piperidilmetil
indanonas
bencil
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95116888T
Other languages
English (en)
Inventor
Stephen Dr Lensky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2121276T3 publication Critical patent/ES2121276T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO PROCESO PARA LA ELABORACION DE BENCIL - PIPERIDILMETIL - INDANONAS (I) CONOCIDAS COMO MEDICAMENTOS, CARACTERIZANDOSE DE TAL MODO, QUE SE HIDROGENA LA SAL PIRIDINIO SUSTITUIDA CORRESPONDIENTE EN DONDE R{SUP,1}, R{SUP,2}, R{SUP,3} Y R{SUP,4} SON IGUALES O DIFERENTES Y SIGNIFICAN HIDROGENO O ALQUILO DE CADENA RECTA O RAMIFICADA, ALCOXI O ALCOXICARBONILO CON 1 HASTA 6 ATOMOS DE CARBONO, ALQUIL - O DIALQUIL - (C{SUB,1} - C{SUB,6}) - AMINOCARBONILOXI O HALOGENO.
ES95116888T 1994-11-08 1995-10-26 Procedimiento para la preparacion de bencil-piperidilmetil-indanonas. Expired - Lifetime ES2121276T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4439822A DE4439822A1 (de) 1994-11-08 1994-11-08 Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen

Publications (1)

Publication Number Publication Date
ES2121276T3 true ES2121276T3 (es) 1998-11-16

Family

ID=6532750

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95116888T Expired - Lifetime ES2121276T3 (es) 1994-11-08 1995-10-26 Procedimiento para la preparacion de bencil-piperidilmetil-indanonas.

Country Status (10)

Country Link
US (1) US5606064A (es)
EP (1) EP0711756B1 (es)
JP (1) JPH08225527A (es)
AT (1) ATE168676T1 (es)
CA (1) CA2162081A1 (es)
DE (2) DE4439822A1 (es)
DK (1) DK0711756T3 (es)
ES (1) ES2121276T3 (es)
GR (1) GR3027698T3 (es)
SI (1) SI0711756T1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997022584A1 (en) * 1995-12-15 1997-06-26 Pfizer Inc. Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine
EP1047674B1 (en) * 1998-01-16 2005-03-30 Eisai Co., Ltd. Process for production of donepezil derivatives
US6080863A (en) * 1999-05-26 2000-06-27 Phillips Petroleum Company Process for producing piperidine
EP1285656A4 (en) * 2000-04-13 2006-07-12 Eisai Co Ltd ACETYLCHOLINESTERASE HEMMER CONTAINING 1-BENZYLPYRIDINIUM SALT
US7148354B2 (en) * 2002-07-24 2006-12-12 Dr. Reddy's Laboratories Limited Process for preparation of donepezil
IL150982A (en) 2002-07-30 2007-02-11 Ori Lerman Process for making Donafzil
US6649765B1 (en) 2003-02-12 2003-11-18 Usv Limited, Bsd Marg. Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL)
US6953856B2 (en) * 2003-02-12 2005-10-11 Usv, Limited Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI)
CN100422148C (zh) * 2003-02-27 2008-10-01 天津药物研究院 工业化生产盐酸多奈哌齐的工艺方法
EP1608371A1 (en) * 2003-03-21 2005-12-28 Ranbaxy Laboratories, Ltd. Process for the preparation of donepezil and derivatives thereof
WO2005003092A1 (en) * 2003-07-01 2005-01-13 Hetero Drugs Limited Preparation of intermediates for acetyl cholinesterase inhibitors
CN1280273C (zh) * 2003-11-05 2006-10-18 天津和美生物技术有限公司 合成多奈哌齐及其衍生物的方法
US20080114173A1 (en) * 2004-07-30 2008-05-15 Mathad Vijayavitthal Thippanna Crystalline Form of Donepezil Hydrochloride
IL171137A (en) 2004-09-29 2012-01-31 Chemagis Ltd Use of purified malt donfazil for the preparation of pure pharmaceutical amorphous donfazil hydrochloride
US20060122226A1 (en) * 2004-12-08 2006-06-08 Itai Adin Crystalline forms of Donepezil base
CA2591894C (en) * 2004-12-30 2013-08-20 Jubilant Organosys Limited Process for producing 1-benzyl-4-[(5,6-dimethoxy-1-indanon­2-yl)methyl] piperidine or its salt thereof via novel intermediate
EP1858848A1 (en) * 2005-03-17 2007-11-28 Synthon B.V. Process for making crystalline donepezil hydrochloride monohydrate
GB0515803D0 (en) * 2005-07-30 2005-09-07 Pliva Hrvatska D O O Intermediate compounds
AR057910A1 (es) 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar donepezilo
HU227474B1 (en) * 2005-12-20 2011-07-28 Richter Gedeon Nyrt Process for industrial scale production of high purity donepezil hydrochloride polymorph i.
US20100113793A1 (en) * 2006-03-20 2010-05-06 Ind-Swift Laboratories Limited Process for the Preparation of Highly Pure Donepezil
BRPI0720211A2 (pt) 2006-12-11 2013-12-24 Reviva Pharmaceuticals Inc Derivado de indanona, composição, e, uso de uma composição
NZ588252A (en) * 2008-03-25 2012-08-31 Cipla Ltd Process for the preparation of donepezil hydrochloride
US20100105916A1 (en) * 2008-10-29 2010-04-29 Sterling Biotech Limited Processes for Preparing Donepezil
EP2366378A1 (en) 2010-03-01 2011-09-21 Dexcel Pharma Technologies Ltd. Sustained-release donepezil formulations
WO2012131540A1 (en) * 2011-03-25 2012-10-04 Piramal Healthcare Limited A process for preparation of intermediates of donepezil hydrochloride
DK3033082T3 (da) 2013-08-16 2021-09-20 Univ Maastricht Behandling af kognitiv svækkelse med pde4-hæmmer
US9359315B2 (en) * 2013-09-10 2016-06-07 Arrien Pharmaceuticals Llc Substituted 2,3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis
CN104557671B (zh) * 2013-10-10 2018-04-13 池州东升药业有限公司 一种非索非那定及中间体的合成方法
KR101712708B1 (ko) * 2014-10-08 2017-03-07 영남대학교 산학협력단 인데노 피리디니움 유도체 화합물을 유효성분으로 포함하는 염증성장질환 예방 또는 치료용 조성물
KR101732776B1 (ko) * 2014-10-08 2017-05-04 영남대학교 산학협력단 신규한 인데노 피리디니움 유도체 화합물 및 이의 제조방법
CN109354580B (zh) * 2018-11-21 2020-08-07 山东罗欣药业集团股份有限公司 一种盐酸多奈哌齐的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069222A (en) * 1976-04-14 1978-01-17 Richardson-Merrell Inc. Process for preparing 2-(2,2-dicyclohexylethyl)piperidine
US4191828A (en) * 1976-04-14 1980-03-04 Richardson-Merrell Inc. Process for preparing 2-(2,2-dicyclohexylethyl)piperidine
FI95572C (fi) 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
JP2592911B2 (ja) * 1988-06-09 1997-03-19 富士通株式会社 通信パスの割り付け方法
JP3075566B2 (ja) * 1990-05-15 2000-08-14 エーザイ株式会社 光学活性インダノン誘導体
EP0535496A1 (en) 1991-09-25 1993-04-07 Hoechst-Roussel Pharmaceuticals Incorporated (1-Indanon-2yl)methylpiperidines, intermediates and a process for their preparation and their use as medicaments

Also Published As

Publication number Publication date
DE59502882D1 (de) 1998-08-27
DE4439822A1 (de) 1996-08-29
GR3027698T3 (en) 1998-11-30
EP0711756A1 (de) 1996-05-15
SI0711756T1 (en) 1998-10-31
CA2162081A1 (en) 1996-05-09
JPH08225527A (ja) 1996-09-03
ATE168676T1 (de) 1998-08-15
EP0711756B1 (de) 1998-07-22
DK0711756T3 (da) 1999-04-26
US5606064A (en) 1997-02-25

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