ES2120485T3 - Analogos de glutation y paneles paralogos que comprenden imitadores de glutation. - Google Patents

Analogos de glutation y paneles paralogos que comprenden imitadores de glutation.

Info

Publication number
ES2120485T3
ES2120485T3 ES93307676T ES93307676T ES2120485T3 ES 2120485 T3 ES2120485 T3 ES 2120485T3 ES 93307676 T ES93307676 T ES 93307676T ES 93307676 T ES93307676 T ES 93307676T ES 2120485 T3 ES2120485 T3 ES 2120485T3
Authority
ES
Spain
Prior art keywords
glutation
analogs
imitators
chem
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93307676T
Other languages
English (en)
Inventor
Lawrence Kauvar
Matthew Lyttle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Terrapin Technologies Inc
Original Assignee
Telik Inc
Terrapin Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc, Terrapin Technologies Inc filed Critical Telik Inc
Application granted granted Critical
Publication of ES2120485T3 publication Critical patent/ES2120485T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Confectionery (AREA)
  • Cosmetics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

COMPUESTOS DE LA FORMULA (1) O LAS ALQUILO (1-6C) O ARILALQUILO (7-12C) AMIDAS O SALES QUE INCLUYEN LAS FORMAS CICLOAMINO DE ELLOS; EN DONDE N ES 1 O 2; EN DONDE CUANDO N ES 1, X ES UNA FRACCION MONOO DISUBSTITUIDA O INSUBSTITUIDA DE HIDROCARBILO (1-20C) QUE OPCIONALMENTE CONTIENE 1 O 2 HETEROATOMOS NO ADYACENTES (O, S O N), Y EN DONDE DICHA SUSTITUCION ES SELECCIONADA DEL GRUPO COMPUESTO DE HALO, OR, Y SR, EN DONDE R ES H O ALQUILO INFERIOR (1-4C); CUANDO N ES 2, UNA X ES COMO SE DEFINIO ANTERIORMENTE Y LA OTRA X ES ALQUILO INFERIOR (1-4C); Y SE SELECCIONA DEL GRUPO COMPUESTO DE EN DONDE M ES 1 O 2; Y AAC ES UN AMINO ACIDO ACOPLADO A TRAVES DE UN ENLACE PEPTIDO AL RESTO DEL COMPUESTO DE FORMULA 1. SE USAN COMO LIGANTES DE AFINIDAD, REACTIVOS DE ELUCION, INHIBIDORES DE SOLUCION, REACTIVOS PARA DIAGNOSTICO Y TERAPEUTICOS. ESTOS COMPUESTOS Y TRIPEPTIDOS ANALOGOS, ANALOGOS DE GLUTATIONA, PUEDEN SER USADOS COMO MIEMBROS DE PANELES PARA OBTENER PERFILES DE CARACTERISTICAS ESPECIFICAS DE VARIAS GLUTATIONA-S-TRANSFERASAS.
ES93307676T 1993-09-03 1993-09-28 Analogos de glutation y paneles paralogos que comprenden imitadores de glutation. Expired - Lifetime ES2120485T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA002105492A CA2105492C (en) 1993-09-03 1993-09-03 Glutathione analogs and paralog panels comprising glutathione mimics
EP93307676A EP0645397B1 (en) 1993-09-03 1993-09-28 Glutathione analogs and paralog panels comprising glutathione mimics
AU48733/93A AU671855B2 (en) 1993-09-03 1993-09-30 Novel glutathione analogs and paralog panels comprising glutathione mimics
JP24723893A JP3542040B2 (ja) 1993-09-03 1993-10-01 グルタチオン模倣体を含有する新規グルタチオンアナログおよびパラログパネル

Publications (1)

Publication Number Publication Date
ES2120485T3 true ES2120485T3 (es) 1998-11-01

Family

ID=27423327

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93307676T Expired - Lifetime ES2120485T3 (es) 1993-09-03 1993-09-28 Analogos de glutation y paneles paralogos que comprenden imitadores de glutation.

Country Status (8)

Country Link
EP (1) EP0645397B1 (es)
JP (1) JP3542040B2 (es)
AT (1) ATE170869T1 (es)
AU (1) AU671855B2 (es)
CA (1) CA2105492C (es)
DE (1) DE69320961T2 (es)
DK (1) DK0645397T3 (es)
ES (1) ES2120485T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2794122B1 (fr) * 1999-05-27 2001-09-07 Centre Nat Rech Scient Nouveaux antioxydants, procedes de preparation et utilisations
US7172905B2 (en) 2001-08-07 2007-02-06 The University Of Chicago Polypeptide immobilization
NZ555362A (en) * 2005-01-06 2009-05-31 Telik Inc Tripeptide and tetrapeptide thioethers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61162175A (ja) * 1985-01-11 1986-07-22 Kiyomi Sato グルタチオン−ｓ−トランスフエラ−ゼの精製法
US5133866A (en) 1988-03-24 1992-07-28 Terrapin Technologies, Inc. Method to identify analyte-bending ligands
WO1992019767A1 (en) * 1991-04-29 1992-11-12 Terrapin Technologies, Inc. Methods to profile and treat abnormal cells

Also Published As

Publication number Publication date
JP3542040B2 (ja) 2004-07-14
EP0645397A1 (en) 1995-03-29
JPH07145142A (ja) 1995-06-06
CA2105492A1 (en) 1995-03-04
DE69320961T2 (de) 1999-01-28
DK0645397T3 (da) 1999-03-01
EP0645397B1 (en) 1998-09-09
AU671855B2 (en) 1996-09-12
AU4873393A (en) 1995-05-04
CA2105492C (en) 2000-02-01
ATE170869T1 (de) 1998-09-15
DE69320961D1 (de) 1998-10-15

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