ES2116989T3 - Parche con elevado contenido de sustancias suavizantes. - Google Patents
Parche con elevado contenido de sustancias suavizantes.Info
- Publication number
- ES2116989T3 ES2116989T3 ES91110409T ES91110409T ES2116989T3 ES 2116989 T3 ES2116989 T3 ES 2116989T3 ES 91110409 T ES91110409 T ES 91110409T ES 91110409 T ES91110409 T ES 91110409T ES 2116989 T3 ES2116989 T3 ES 2116989T3
- Authority
- ES
- Spain
- Prior art keywords
- parts
- weight
- patch
- high content
- softening substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000126 substance Substances 0.000 title 1
- 239000012190 activator Substances 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 229920000058 polyacrylate Polymers 0.000 abstract 2
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 239000011241 protective layer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
- A61L15/585—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Materials Engineering (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Botany (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Developing Agents For Electrophotography (AREA)
- Road Signs Or Road Markings (AREA)
- Laminated Bodies (AREA)
- Tea And Coffee (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Abstract
LA INVENCION TRATA DE UN DISPOSITIVO PARA SUMINISTRAR TOPICA Y SISTEMATICAMENTE EN Y A TRAVES DE LA PIEL, QUE CONSTE DE UNA TAPA QUE SE PEGUE SOLA Y UNA CAPA PROTECTORA QUE SE APARTE OTRA VEZ LA CUAL ESTA CARACTERIZADA POR QUE LA CAPA DE AUTOPEGADO A) SE COMPONGA DE 100 PARTES DE PESO DE UN ADHESIVO DE POLIACRILATO, B) DE 5 A 150 PREFERENTEMENTE DE 10 A 100 Y ESPECIALMENTE MEJOR DE 15 A 50 PARTES DE PESO DE UN MODELADOR DE UNA PELICULA TOLERANTE CON POLIACRILATO, C) DE 0 A 250 PARTES DE PESO DE ACTIVADOR Y/O MATERIAS AUXILIARES QUE NO SE ABLANDEN Y D) DE 10 A 250 PARTES DE PESO DE ACTIVADOR Y/O MATERIALES AUXILIARES QUE SE PLASTIFIQUEN.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4020144A DE4020144A1 (de) | 1990-06-25 | 1990-06-25 | Pflaster mit hohem gehalt an weichmachenden inhaltsstoffen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2116989T3 true ES2116989T3 (es) | 1998-08-01 |
Family
ID=6409004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91110409T Expired - Lifetime ES2116989T3 (es) | 1990-06-25 | 1991-06-24 | Parche con elevado contenido de sustancias suavizantes. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5306503A (es) |
| EP (1) | EP0464573B1 (es) |
| JP (1) | JP2700362B2 (es) |
| AT (1) | ATE164769T1 (es) |
| CA (1) | CA2045290C (es) |
| DE (2) | DE4020144A1 (es) |
| DK (1) | DK0464573T3 (es) |
| ES (1) | ES2116989T3 (es) |
| FI (1) | FI111338B (es) |
| IE (1) | IE912181A1 (es) |
| NO (1) | NO301049B1 (es) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW221970B (es) * | 1991-06-26 | 1994-04-01 | Tbs Lab Inc | |
| DE4229230C2 (de) * | 1992-09-02 | 1997-01-16 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit Pentetrazol als Wirkstoff |
| DE4336557C2 (de) * | 1993-05-06 | 1997-07-17 | Lohmann Therapie Syst Lts | Estradiolhaltiges transdermales therapeutisches System, Verfahren zu seiner Herstellung und seine Verwendung |
| DE4333595A1 (de) * | 1993-10-01 | 1995-04-06 | Labtec Gmbh | Transdermales therapeutisches System zur Applikation von Arzneimitteln auf die Haut |
| DE4403487C2 (de) * | 1994-02-04 | 2003-10-16 | Lohmann Therapie Syst Lts | Arznei-Pflaster mit UV-vernetzbaren Acrylat-Copolymeren |
| DE4406332C1 (de) * | 1994-02-28 | 1995-06-22 | Sanol Arznei Schwarz Gmbh | Pharmazeutische Verwendung von Nitroglycerin zur Verhinderung unerwünschter Wehentätigkeit bei Säugern in einer transdermalen Applikationsform |
| FR2719770A1 (fr) * | 1994-05-11 | 1995-11-17 | Lhd Lab Hygiene Dietetique | Système matriciel pour administration transdermique d'ibuprofène et procédé de préparation. |
| ATE194281T1 (de) * | 1994-09-14 | 2000-07-15 | Minnesota Mining & Mfg | Matrix für transdermale wirkstofffreisetzung |
| AU6032696A (en) * | 1995-06-07 | 1996-12-30 | Cygnus Therapeutic Systems | Pressure sensitive acrylate adhesive composition cross-linke d with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group |
| DE19526864A1 (de) * | 1995-07-22 | 1997-01-23 | Labtec Gmbh | Hormonpflaster |
| US8084051B1 (en) * | 1995-11-13 | 2011-12-27 | Bio Med Sciences, Inc. | Therapeutic medical garments with silicone sheeting component for scar treatment, process of manufacture and use |
| DE19650471A1 (de) * | 1996-12-05 | 1998-06-10 | Beiersdorf Ag | Wirkstoffhaltige Pflaster |
| DE19653606A1 (de) * | 1996-12-20 | 1998-06-25 | Roehm Gmbh | Haft- und Bindemittel aus (Meth)acrylatpolymer, organischer Säure und Weichmacher |
| DE19700913C2 (de) | 1997-01-14 | 2001-01-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System zur Abgabe von Hormonen |
| DE19706824C1 (de) * | 1997-02-21 | 1998-03-26 | Lohmann Therapie Syst Lts | Transdermales oder topisches Plastersystem mit Polyacrylatmatrix mit verbesserten physikalischen Eigenschaften |
| US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| DE19830649C2 (de) | 1998-07-09 | 2003-04-10 | Lohmann Therapie Syst Lts | Topisches Pflaster mit nichtsteroidalen Antirheumatika mit Säuregruppe |
| DE19830651A1 (de) * | 1998-07-09 | 2000-01-13 | Lohmann Therapie Syst Lts | Steroidhaltiges Pflaster, Verfahren zu seiner Herstellung und Verwendung |
| DE19834496B4 (de) * | 1998-07-31 | 2004-02-26 | Beiersdorf Ag | Verbesserte Freisetzung von Ibuprofen aus Heißschmelzklebemassen in wirkstoffhaltigen Pflastern durch Zusatz von pharmazeutischen Hilfsstoffen und Verwendung von Hilfsstoffen zur Verbesserung der Freisetzung von Ibuprofen |
| US6475514B1 (en) | 1998-12-03 | 2002-11-05 | Andrew Blitzer | Athletic patch |
| US20030170195A1 (en) * | 2000-01-10 | 2003-09-11 | Noven Pharmaceuticals, Inc. | Compositions and methods for drug delivery |
| EP1061900B2 (en) * | 1999-01-14 | 2008-07-09 | Noven Pharmaceuticals, Inc. | Dermal compositions |
| RO121628B1 (ro) * | 1999-02-05 | 2008-01-30 | Cipla Limited | Compoziţie medicinală, topică, pulverizabilă,dozator care o conţine, procedeu de realizare a dozatorului şi utilizarea compoziţiei menţionate |
| DE19911262C2 (de) * | 1999-03-13 | 2003-04-10 | Scs Skin Care Systems Gmbh | Vorrichtung zur Abgabe kosmetischer Wirkstoffe |
| DE19923427A1 (de) * | 1999-05-21 | 2000-11-23 | Lohmann Therapie Syst Lts | Vorrichtung und Verfahren zur Steigerung der transdermalen Permeation von Arzneistoffen |
| DE19940238A1 (de) | 1999-08-25 | 2001-03-01 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges therapeutisches System zur Applikation auf der Haut mit mindestens zwei polymerhaltigen Schichten |
| US6168028B1 (en) | 1999-11-19 | 2001-01-02 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Packaged skin product |
| DE10032537A1 (de) * | 2000-07-05 | 2002-01-31 | Labtec Gmbh | Dermales System, enthaltend 2-(3-Benzophenyl)Propionsäure |
| DE10049225A1 (de) * | 2000-09-28 | 2002-04-11 | Labtec Gmbh | Dermales System, enthaltend Diclofenac |
| TWI287455B (en) * | 2000-12-05 | 2007-10-01 | Noven Pharma | Crystallization inhibition of drugs in transdermal drug delivery systems and methods of use |
| DE10060550C1 (de) * | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten |
| DE10103860B4 (de) | 2001-01-30 | 2004-12-23 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System für die Verabreichung carboxylgruppenhaltiger, nichtsteroidaler Antiphlogistika, sowie Verfahren zu seiner Herstellung |
| DE10121471A1 (de) * | 2001-05-02 | 2002-11-07 | Beiersdorf Ag | Oberflächendotierte wirkstoffhaltige Pflaster |
| US20050100588A1 (en) * | 2001-06-13 | 2005-05-12 | Beiersdorf Ag | Self-adhesive matrix plaster containing an active ingredient and based on polyurethane gels |
| US20050085652A1 (en) * | 2003-04-08 | 2005-04-21 | Algorx Pharmaceuticals, Inc. | Preparation and purification of synthetic capsaicin |
| AU2004235794B8 (en) * | 2003-04-30 | 2009-07-23 | Purdue Pharma L.P. | Tamper-resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer |
| US8790689B2 (en) | 2003-04-30 | 2014-07-29 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
| WO2006058140A2 (en) * | 2004-11-24 | 2006-06-01 | Algorx Pharmaceuticals, Inc. | Capsaicinoid gel formulation and uses thereof |
| ITMI20050084A1 (it) * | 2005-01-21 | 2006-07-22 | Biofarmitalia Spa | Tessuto composito flessibile traspirante formato da strati di materiale tessile separati e tra di loro accoppiati da uno strato di polimero adesivo |
| HRP20171260T1 (hr) * | 2007-01-11 | 2017-10-20 | Drossapharm Ag | Medicinski aktivni flaster |
| US12186426B2 (en) | 2009-10-30 | 2025-01-07 | Ix Biopharma Ltd. | Solid dosage form |
| ES2712989T3 (es) | 2009-10-30 | 2019-05-17 | Ix Biopharma Ltd | Forma de dosificación sólida de disolución rápida |
| DE102012000369A1 (de) | 2012-01-11 | 2013-07-11 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System mit Cholinesterase-Hemmer |
| US20140083878A1 (en) * | 2012-09-21 | 2014-03-27 | Mylan Inc. | Transdermal drug delivery device |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5843368B2 (ja) * | 1980-10-30 | 1983-09-27 | 日東電工株式会社 | 消炎鎮痛貼付剤 |
| JPS5910513A (ja) * | 1982-07-12 | 1984-01-20 | Nitto Electric Ind Co Ltd | 医薬製剤 |
| JPS60123417A (ja) * | 1983-12-07 | 1985-07-02 | Nitto Electric Ind Co Ltd | 薬物投与部材 |
| HU197847B (en) * | 1984-03-01 | 1989-06-28 | Sandoz Ag | Process for producing therapeutical preparations suitable for transdermatic treating |
| JPS60224638A (ja) * | 1984-04-23 | 1985-11-09 | Kao Corp | 経皮吸収促進剤およびこれを含有する外用剤 |
| JPS60252412A (ja) * | 1984-05-29 | 1985-12-13 | Nichiban Co Ltd | 貼布治療製剤 |
| DE3634016A1 (de) * | 1986-04-17 | 1987-10-29 | Lohmann Gmbh & Co Kg | Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung |
| EP0249343B1 (en) * | 1986-06-13 | 1992-01-08 | Alza Corporation | Moisture activation of transdermal drug delivery system |
| DE3629304A1 (de) * | 1986-08-28 | 1988-03-24 | Lohmann Gmbh & Co Kg | Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung |
| JPS63201119A (ja) * | 1987-02-17 | 1988-08-19 | Kao Corp | 貼付剤組成物 |
| DE3714140A1 (de) * | 1987-04-28 | 1988-11-10 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges pflaster zur kontrollierten verabreichung von wirkstoffen an die haut, seine verwendung sowie verfahren zur gesteuerten verabreichung von wirkstoffen an die haut |
| US4956181A (en) * | 1987-05-08 | 1990-09-11 | Eastman Kodak | Nitrate therapy for angina pectoris |
| DE3743946A1 (de) * | 1987-09-01 | 1989-03-09 | Lohmann Gmbh & Co Kg | Vorrichtung zur abgabe von nitroglycerin an die haut, verfahren zu ihrer herstellung sowie ihre verwendung |
| US4994267A (en) * | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Transdermal acrylic multipolymer drug delivery system |
| DE3807283A1 (de) * | 1988-03-05 | 1989-09-14 | Basf Ag | Verfahren zur herstellung eines pflasters zur transdermalen anwendung pharmazeutischer wirkstoffe |
| DE3843238C1 (es) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
| DE3843239C1 (es) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
| DE3901551A1 (de) * | 1989-01-20 | 1990-07-26 | Lohmann Therapie Syst Lts | Superfizielles therapeutisches system mit einem gehalt an einem antineoplastischen wirkstoff, insbesondere 5-fluoruracil |
-
1990
- 1990-06-25 DE DE4020144A patent/DE4020144A1/de active Granted
-
1991
- 1991-06-21 US US07/718,668 patent/US5306503A/en not_active Expired - Lifetime
- 1991-06-24 CA CA002045290A patent/CA2045290C/en not_active Expired - Lifetime
- 1991-06-24 AT AT91110409T patent/ATE164769T1/de not_active IP Right Cessation
- 1991-06-24 DK DK91110409T patent/DK0464573T3/da active
- 1991-06-24 DE DE59108962T patent/DE59108962D1/de not_active Expired - Lifetime
- 1991-06-24 NO NO912466A patent/NO301049B1/no not_active IP Right Cessation
- 1991-06-24 FI FI913072A patent/FI111338B/fi not_active IP Right Cessation
- 1991-06-24 JP JP3151275A patent/JP2700362B2/ja not_active Expired - Lifetime
- 1991-06-24 IE IE218191A patent/IE912181A1/en not_active IP Right Cessation
- 1991-06-24 EP EP91110409A patent/EP0464573B1/de not_active Expired - Lifetime
- 1991-06-24 ES ES91110409T patent/ES2116989T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE4020144A1 (de) | 1992-01-09 |
| JPH04230212A (ja) | 1992-08-19 |
| NO912466L (no) | 1991-12-27 |
| EP0464573B1 (de) | 1998-04-08 |
| NO301049B1 (no) | 1997-09-08 |
| FI913072L (fi) | 1991-12-26 |
| CA2045290A1 (en) | 1991-12-26 |
| DK0464573T3 (da) | 1999-01-11 |
| US5306503A (en) | 1994-04-26 |
| FI913072A0 (fi) | 1991-06-24 |
| DE4020144C2 (es) | 1993-07-29 |
| NO912466D0 (no) | 1991-06-24 |
| CA2045290C (en) | 2002-02-05 |
| EP0464573A1 (de) | 1992-01-08 |
| IE912181A1 (en) | 1992-01-01 |
| FI111338B (fi) | 2003-07-15 |
| ATE164769T1 (de) | 1998-04-15 |
| JP2700362B2 (ja) | 1998-01-21 |
| DE59108962D1 (de) | 1998-05-14 |
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