ES2115968T3 - Procedimiento para la obtencion de pirazol y sus derivados. - Google Patents

Procedimiento para la obtencion de pirazol y sus derivados.

Info

Publication number
ES2115968T3
ES2115968T3 ES94925456T ES94925456T ES2115968T3 ES 2115968 T3 ES2115968 T3 ES 2115968T3 ES 94925456 T ES94925456 T ES 94925456T ES 94925456 T ES94925456 T ES 94925456T ES 2115968 T3 ES2115968 T3 ES 2115968T3
Authority
ES
Spain
Prior art keywords
pct
formula
hydrazine
derivatives
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94925456T
Other languages
English (en)
Inventor
Hans Rupert Merkle
Erich Fretschner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of ES2115968T3 publication Critical patent/ES2115968T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA LA PREPARACION DE PIRAZOLES Y SUS DERIVADOS DISPONIENDO DE LA FORMULA (I) DONDE LOS RESTOS R{SUP,1}, R{SUP,2}, R{SUP,3} Y R{SUP,4} SON HIDROGENO, HALOGENO, NITRO, CARBOXILO, SULFONILO O RESTOS C ORGANICOS, A PARTIR DE COMPUESTOS CARBONILO ALFA, BETA, NO SATURADOS TENIENDO LA FORMULA (II) Y A PARTIR DE HIDRACINA O DERIVADOS DE HIDRACINA TENIENDO LA FORMULA (III). EL PROCESO SE CARACTERIZA DE TAL FORMA QUE UN COMPUESTO CARBONIL ALFA, BETA - NO SATURADO TENIENDO LA FORMULA (II) ES REACCIONADO PRIMERA SIN ADICION DE AGENTES DE DILUCION CON HIDRACINA O DERIVADOS DE HIDRACINA TENIENDO LA FORMULA (III), Y LA MEZCLA DE REACCION ASI OBTENIDA REACCIONA EN UNA ETAPA DE REACCION ADICIONAL CON UNA MEZCLA DE ACIDO SULFURICO E IODINA O UN COMPUESTO DE LIBERACION DE IODINA O YODURO DE HIDROGENO.
ES94925456T 1993-08-23 1994-08-13 Procedimiento para la obtencion de pirazol y sus derivados. Expired - Lifetime ES2115968T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4328228A DE4328228A1 (de) 1993-08-23 1993-08-23 Verfahren zur Herstellung von Pyrazol und dessen Derivaten

Publications (1)

Publication Number Publication Date
ES2115968T3 true ES2115968T3 (es) 1998-07-01

Family

ID=6495762

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94925456T Expired - Lifetime ES2115968T3 (es) 1993-08-23 1994-08-13 Procedimiento para la obtencion de pirazol y sus derivados.

Country Status (19)

Country Link
US (1) US5569769A (es)
EP (1) EP0715622B1 (es)
JP (1) JP3717177B2 (es)
KR (1) KR100342146B1 (es)
CN (1) CN1069637C (es)
AT (1) ATE165348T1 (es)
AU (1) AU7536194A (es)
CA (1) CA2169380C (es)
CZ (1) CZ288738B6 (es)
DE (2) DE4328228A1 (es)
ES (1) ES2115968T3 (es)
HU (1) HU216078B (es)
IL (1) IL110461A (es)
RU (1) RU2130930C1 (es)
SK (1) SK280883B6 (es)
TW (1) TW252108B (es)
UA (1) UA47392C2 (es)
WO (1) WO1995006036A1 (es)
ZA (1) ZA946357B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19500838A1 (de) * 1995-01-13 1996-07-18 Basf Ag Verfahren zur Herstellung von 3,5-Diarylpyrazolen
DE19645313A1 (de) 1996-11-04 1998-05-07 Basf Ag Substituierte 3-Benzylpyrazole
JP2002502379A (ja) * 1997-05-22 2002-01-22 ジー．ディー．サール アンド カンパニー ｐ３８キナーゼインヒビターとしての３（５）−ヘテロアリール置換ピラゾール
US6979686B1 (en) 2001-12-07 2005-12-27 Pharmacia Corporation Substituted pyrazoles as p38 kinase inhibitors
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
AU7726898A (en) 1997-05-22 1998-12-11 G.D. Searle & Co. Pyrazole derivatives as p38 kinase inhibitors
US6087496A (en) 1998-05-22 2000-07-11 G. D. Searle & Co. Substituted pyrazoles suitable as p38 kinase inhibitors
ES2219935T3 (es) * 1997-06-23 2004-12-01 Basf Aktiengesellschaft Procedimiento para la produccion de pirazoles sustituidos.
US7057049B2 (en) 2001-09-25 2006-06-06 Pharmacia Corporation Process for making substituted pyrazoles
CN1321644C (zh) * 2001-09-25 2007-06-20 法玛西雅公司 制备取代的吡唑的方法
US7682601B2 (en) * 2003-04-15 2010-03-23 Mallinckrodt Inc. Bifunctional tridentate pyrazolyl containing ligands for re and tc tricarbonyl complexes
CA2605413C (en) 2005-04-21 2014-06-10 Orphan Medical, Inc. Ultrapure 4-methylpyrazole
US20110009463A1 (en) * 2007-10-17 2011-01-13 Yuri Karl Petersson Geranylgeranyl transferase inhibitors and methods of making and using the same
WO2009131886A1 (en) 2008-04-21 2009-10-29 Albemarle Corporation Processes for producing n-alkylpyrazole
DE102009060150B4 (de) * 2009-12-23 2013-06-06 K+S Aktiengesellschaft Verfahren zur Herstellung von Säureadditionssalzen von Pyrazolen
EP2607358A4 (en) 2010-08-19 2014-01-29 Univ Tokyo NEW ANTI-INFLAMMATORY METABOLITE DERIVED FROM OMEGA-3 TYPE FATTY ACID
CN102558057B (zh) * 2012-01-16 2014-04-02 兰州大学 多取代吡唑制备方法
JP6911143B2 (ja) 2018-11-07 2021-07-28 福建永晶科技股▲ふん▼有限公司Ｆｕｊｉａｎ Ｙｏｎｇｊｉｎｇ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ ピラゾール又はピリミジノンの新しい製造方法
CN110386900A (zh) * 2019-08-21 2019-10-29 温州市华润医药化工有限公司 一种3-甲基吡唑的制备方法
CN112321507A (zh) * 2020-09-18 2021-02-05 武威金仓生物科技有限公司 一种3,4-二甲基吡唑及其磷酸盐的制备方法
CN115028582B (zh) * 2022-06-23 2024-04-12 曲靖师范学院 一种n-芳基吡唑类药物e-52862的制备方法及其产品

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH615384A5 (es) * 1978-12-07 1980-01-31 Buss Ag
DE2922591A1 (de) * 1979-06-02 1980-12-04 Basf Ag Verfahren zur herstellung von pyrazolen
GB8824400D0 (en) * 1988-10-18 1988-11-23 Glaxo Group Ltd Chemical compounds
JP2861103B2 (ja) * 1988-10-26 1999-02-24 日産化学工業株式会社 ４―メチルピラゾール類の製造方法
DE3918979A1 (de) * 1989-06-10 1990-12-13 Basf Ag Verfahren zur herstellung von pyrazol und dessen derivaten
DE4028393A1 (de) * 1990-09-07 1992-03-12 Basf Ag Verfahren zur herstellung von 3-methylpyrazol

Also Published As

Publication number Publication date
CA2169380A1 (en) 1995-03-02
CN1131943A (zh) 1996-09-25
EP0715622B1 (de) 1998-04-22
UA47392C2 (uk) 2002-07-15
KR960703866A (ko) 1996-08-31
CN1069637C (zh) 2001-08-15
DE59405805D1 (de) 1998-05-28
AU7536194A (en) 1995-03-21
EP0715622A1 (de) 1996-06-12
TW252108B (es) 1995-07-21
SK23596A3 (en) 1996-10-02
JP3717177B2 (ja) 2005-11-16
CZ288738B6 (cs) 2001-08-15
KR100342146B1 (ko) 2002-11-22
JPH09501686A (ja) 1997-02-18
WO1995006036A1 (de) 1995-03-02
CZ52096A3 (en) 1996-05-15
CA2169380C (en) 2004-10-19
RU2130930C1 (ru) 1999-05-27
HUT74479A (en) 1997-01-28
ATE165348T1 (de) 1998-05-15
US5569769A (en) 1996-10-29
ZA946357B (en) 1996-02-22
HU9600419D0 (en) 1996-04-29
SK280883B6 (sk) 2000-09-12
IL110461A0 (en) 1994-10-21
DE4328228A1 (de) 1995-03-02
IL110461A (en) 1998-07-15
HU216078B (hu) 1999-04-28

Similar Documents

Publication Publication Date Title
ES2115968T3 (es) Procedimiento para la obtencion de pirazol y sus derivados.
ES2159283T3 (es) Complejos que contienen glicosil-fosfatidilinositol-proteinas y derivados de acido colanico, procedimiento para su preparacion y su utilizacion.
IL80560A0 (en) 4-benzyl-1-(2h)-phthalazinone derivatives,their preparation and pharmaceutical compositions containing them
ATE60582T1 (de) Oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte.
RU96105941A (ru) Способ получения пиразола и его производные
ATE221872T1 (de) Herstellung von tri-iodo-benzol-verbindungen
DE59611302D1 (de) Verfahren zur herstellung von 3,5-diarylpyrazolen
DK659188D0 (da) Fremgangsmaade til fremstiling af isothiazoloner
JP3024105B2 (ja) 新規な２−ヒドロキシアルキルパラフェニレンジアミン、その合成法、酸化染色のためのその使用、それを含む染色組成物およびそれを用いた染色法
AR248396A1 (es) Procedimiento para la obtencion de 1, 5-diaril pirazoles utiles como antiinflamatorios y compuestos intermediarios para su uso exclusivo en el procedimiento.
ATE259785T1 (de) Verfahren zur herstellung von 2-alkylthio- substituierten benzoesäurederivaten
ES8103050A1 (es) Un procedimiento para la preparacion de un derivado de pira-zol
DK0417875T3 (da) 1-methoxypyrimidinyl-1H-1,2,4-triazol-3-sulfonsyrenitroanilider, fremgangsmåde til fremstilling heraf og deres anvendelse som middel med herbicid virkning
GR3024366T3 (en) INDOLE DERIVATIVES AS STEROID 5-g(a)-REDUCTASE INHIBITORS
US5824807A (en) Preparations of azabicylobutane precursors and related compositions
ATE32063T1 (de) Iminosulfonamide und verfahren zu ihrer herstellung, die pharmazeutische praeparate solche verbindungen enthalten, sowie die verbindungen zur verwendung.
NO954410L (no) Fremgangsmåte og fremstilling av NG-monoalkyl-L-arginin og beslektede forbindelser
IT1270834B (it) Disolfuro chinolico
ES2107042T3 (es) Procedimiento para preparar 1-metil-3-ceto-delta1,4-esteroides.
ATE120729T1 (de) Zwischenprodukte für die herstellung von 4,5- difluoroanthranilsäure.
JPH0940656A (ja) オキサジリジンの光学活性体分離法
NO20011822D0 (no) Fremgangsmåte for fremstilling av (+)-exo-6-fenyl-3- azabicyklo-[3.2.0]heptaner

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 715622

Country of ref document: ES