ES2113860T3 - Peptidos con grupos tioles de cisteina protegidos, utiles en los ensayos inmunologicos. - Google Patents
Peptidos con grupos tioles de cisteina protegidos, utiles en los ensayos inmunologicos.Info
- Publication number
- ES2113860T3 ES2113860T3 ES90911054T ES90911054T ES2113860T3 ES 2113860 T3 ES2113860 T3 ES 2113860T3 ES 90911054 T ES90911054 T ES 90911054T ES 90911054 T ES90911054 T ES 90911054T ES 2113860 T3 ES2113860 T3 ES 2113860T3
- Authority
- ES
- Spain
- Prior art keywords
- peptides
- protected
- thyol
- useful
- immunological tests
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 230000001900 immune effect Effects 0.000 title 1
- 235000018102 proteins Nutrition 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 241001430294 unidentified retrovirus Species 0.000 abstract 2
- DJQYYYCQOZMCRC-UHFFFAOYSA-N 2-aminopropane-1,3-dithiol Chemical group SCC(N)CS DJQYYYCQOZMCRC-UHFFFAOYSA-N 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 206010020460 Human T-cell lymphotropic virus type I infection Diseases 0.000 abstract 1
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 abstract 1
- 241000714259 Human T-lymphotropic virus 2 Species 0.000 abstract 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 1
- 241000713340 Human immunodeficiency virus 2 Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PEPTIDOS INMUNOREACTIVOS CON ANTICUERPOS PARA LAS PROTEINAS NATIVAS, Y QUE POSEEN AL MENOS DOS RESIDUOS CISTEINAS QUE CONTRIBUYEN A MIMETIZAR UN EPITOPE DE LA PROTEINA, PREPARADOS CON LOS GRUPOS DE TIOL CISTEINA PROTEGIDOS. CUANDO SE DESPROTEGEN, LOS PEPTIDOS HAN AUMENTADO LA INMUNOREACTIVIDAD. LOS PEPTIDOS SON PARTICULARMENTE UTILES PARA DETECTAR ANTICUERPOS O ANTIGENOS ASOCIADOS CON RETROVIRUS, INCLUYENDO LOS RETROVIRUS LINFOTROPICOS CLINICAMENTE IMPORTANTES HIV-1, HIV-2, HTLV-I, Y HTLV-II.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36051389A | 1989-06-02 | 1989-06-02 | |
PCT/US1990/003148 WO1990015071A1 (en) | 1989-06-02 | 1990-06-04 | Cysteine thiol-protected peptides for use in immunoassays |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2113860T3 true ES2113860T3 (es) | 1998-05-16 |
Family
ID=23418295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90911054T Expired - Lifetime ES2113860T3 (es) | 1989-06-02 | 1990-06-04 | Peptidos con grupos tioles de cisteina protegidos, utiles en los ensayos inmunologicos. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0474789B1 (es) |
JP (1) | JP3404035B2 (es) |
KR (1) | KR960013600B1 (es) |
AT (1) | ATE162799T1 (es) |
AU (1) | AU652919B2 (es) |
CA (1) | CA2056381C (es) |
DE (1) | DE69032009T2 (es) |
DK (1) | DK0474789T3 (es) |
ES (1) | ES2113860T3 (es) |
FI (1) | FI102834B (es) |
NO (1) | NO304151B1 (es) |
WO (1) | WO1990015071A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5459060A (en) * | 1989-08-24 | 1995-10-17 | Bioclonetics Incorporated | Human monoclonal antibodies directed against the transmembrane glycoprotein (gp41) of human immunodeficiency virus-1 (HIV-1) |
US6083504A (en) * | 1989-08-24 | 2000-07-04 | Bioclonetics Incorporated | Human monoclonal antibodies directed against the transmembrane glycoprotein (GP41) of human immunodeficiency virus-1 (HIV-1) |
US6008044A (en) * | 1989-08-24 | 1999-12-28 | Bioclonetics | Human monoclonal antibodies directed against the transmembrane glycoprotein (gp41) of human immunodeficiency virus-1 (HIV-1) and detection of antibodies against epitope (GCSGKLIC) |
DE69129207T2 (de) * | 1990-01-16 | 1998-10-08 | Orgenics Ltd | Peptide, von Virus-HIV-Hüllen-Glycoproteinen abstammend, deren Verwendung zum Nachweis einer Infektion dieser Viren und für die Impfung gegen AIDS |
MXPA02004052A (es) * | 1999-10-27 | 2002-11-07 | Innogenetics Nv | Proteinas de hcv reversibles por redox con conformacion pseudo-nativa. |
JP5182069B2 (ja) * | 2008-12-24 | 2013-04-10 | Jnc株式会社 | チオール基を有する刺激応答性磁性微粒子及びその利用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4111924A (en) * | 1976-01-05 | 1978-09-05 | Takeda Chemical Industries, Ltd. | Method for removal of thiol-protecting groups |
FR2525592B1 (es) * | 1982-04-26 | 1984-09-14 | Pasteur Institut | |
US4689398A (en) * | 1984-06-20 | 1987-08-25 | Ortho Diagnostic Systems Inc. | HTLV test using synthetic peptides |
ATE98376T1 (de) * | 1986-03-24 | 1993-12-15 | Ortho Pharma Corp | Synthetische htlv-iii-peptid-zusammensetzungen und ihre verwendung. |
DE3789633T2 (de) * | 1986-05-27 | 1994-08-04 | Hoffmann La Roche | HTLV-III(LAV)Decke-Peptide. |
GB8828097D0 (en) * | 1988-12-01 | 1989-01-05 | Wellcome Found | Peptides |
-
1990
- 1990-06-04 DE DE69032009T patent/DE69032009T2/de not_active Expired - Fee Related
- 1990-06-04 EP EP90911054A patent/EP0474789B1/en not_active Expired - Lifetime
- 1990-06-04 WO PCT/US1990/003148 patent/WO1990015071A1/en active IP Right Grant
- 1990-06-04 AT AT90911054T patent/ATE162799T1/de not_active IP Right Cessation
- 1990-06-04 ES ES90911054T patent/ES2113860T3/es not_active Expired - Lifetime
- 1990-06-04 KR KR1019910701744A patent/KR960013600B1/ko not_active IP Right Cessation
- 1990-06-04 CA CA002056381A patent/CA2056381C/en not_active Expired - Lifetime
- 1990-06-04 JP JP51045090A patent/JP3404035B2/ja not_active Expired - Lifetime
- 1990-06-04 AU AU60532/90A patent/AU652919B2/en not_active Expired
- 1990-06-04 DK DK90911054T patent/DK0474789T3/da active
-
1991
- 1991-11-29 FI FI915649A patent/FI102834B/fi active
- 1991-11-29 NO NO914725A patent/NO304151B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU6053290A (en) | 1991-01-07 |
CA2056381C (en) | 2000-08-22 |
AU652919B2 (en) | 1994-09-15 |
EP0474789B1 (en) | 1998-01-28 |
DK0474789T3 (da) | 1998-09-28 |
KR960013600B1 (ko) | 1996-10-09 |
NO914725L (no) | 1992-01-29 |
EP0474789A1 (en) | 1992-03-18 |
DE69032009D1 (de) | 1998-03-05 |
JPH04505623A (ja) | 1992-10-01 |
JP3404035B2 (ja) | 2003-05-06 |
KR920701236A (ko) | 1992-08-11 |
FI102834B1 (fi) | 1999-02-26 |
EP0474789A4 (en) | 1992-06-03 |
NO914725D0 (no) | 1991-11-29 |
NO304151B1 (no) | 1998-11-02 |
ATE162799T1 (de) | 1998-02-15 |
FI102834B (fi) | 1999-02-26 |
WO1990015071A1 (en) | 1990-12-13 |
CA2056381A1 (en) | 1990-12-03 |
DE69032009T2 (de) | 1998-07-23 |
FI915649A0 (fi) | 1991-11-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI870447A0 (fi) | Htlv-iii-hoeljepeptider. | |
SE8704185L (sv) | Nya peptider, artificiella antigener och immunoanalystestsatser | |
EA200100943A1 (ru) | Вич-пептиды, антигены, вакцинные композиции, набор для иммуноанализа и способ определения вич-индуцированных антител | |
NO881151L (no) | Syntetisk hiv-1-antigen. | |
ES2113860T3 (es) | Peptidos con grupos tioles de cisteina protegidos, utiles en los ensayos inmunologicos. | |
ES2080047T3 (es) | Peptidos hiv y metodos para la deteccion de hiv. | |
ES2054769T3 (es) | Polipeptidos hiv-2 recombinantes. | |
DE68921360D1 (de) | Monoklonale Antikörper von Mäusen gegen das gp41 Protein von menschlichem Immunmangelsyndrom-Virus. | |
DE69015708D1 (de) | Künstliche peptid-zusammensetzungen mit immunoreaktiven antikörpern von htlv-1. | |
ES2058259T3 (es) | Antigenos sinteticos para la deteccion de enfermedad relacionada con sida causada por lav-2. | |
GR900100608A (el) | Κυστέϊνο ?ειολο-προστατευμένα πεπτίδια γιά χρήση σε ανοσοδοκιμασίες. | |
Blake et al. | Cysteine thiol-protected peptides for use in immunoassays | |
ES2129358A1 (es) | Procedimiento de deteccion en una sola prueba de anticuerpos anti-virus de la hepatitis c, de la inmunodeficiencia humano y antigeno de superficie del virus de la hepatitis b". |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 474789 Country of ref document: ES |